1. Paediatric musculoskeletal (MSK) examination is unique and focuses on differentiating normal from abnormal findings. It relies on inspection, palpation, and assessment of range of motion.
2. The paediatric MSK evaluation includes observation, palpation, range of motion testing, strength testing, and functional assessment. It follows the "look, feel, move" approach.
3. The paediatric Gait, Arms, Legs, and Spine (pGALS) assessment is a simple and rapid screening tool to detect musculoskeletal problems in children. It involves observation of gait and movement of various joints followed by focused examination of affected areas.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. PRELUDE
• Paediatric musculoskeletal (MSK) examination stands out to be unique by its’
essence.
• The key is to differentiate NORMAL from ABNORMAL.
• Universal challenges: - Three way communication
- Age appropriate interpretation of results
• Manifestation of musculoskeletal problems: - Primary diseases
- Secondary afflictions
YUVA CME, W.B.A.P. 2
3. • Importance of history taking before MSK examination:
- Ante-natal history
- Birth history
- Developmental history
- Family history
YUVA CME, W.B.A.P. 3
Figure 1.
Figure 2.
4. SALIENT FEATURES
• It is of utmost importance to know the developmental status of the child.
• The status quo for MSK examination primarily relies upon:
– Inspection (Observation)
– Palpation (Functional assessment)
• Fundamental operational principle for MSK examination is based on:
“Look, Feel & Move”
YUVA CME, W.B.A.P. 4
Foster H, Kay L, May C, Rapley T. Pediatric regional examination of the musculoskeletal system: A practice‐and consensus‐based approach. Arthritis Care Res. 2011;63:1503-
10.
6. • Age dependent normal appearance of joints shall be kept in view while
documenting locomotor history and examination findings.
• Pediatric MSK evaluation includes observation, palpation, range of motion,
strength testing, and functional assessment.
• Observation (look) focuses on swelling, rashes, nail changes, wasting, posture,
body symmetry, disproportions, deformities, dysmorphism and different
movements.
• Palpation (feel. move and functional assessment) includes the skin, muscles,
spine and joints.
YUVA CME, W.B.A.P. 6
Foster HE, Cabral DA. Is musculoskeletal history and examination so different in paediatrics?. Best Pract Res Clin Rheumatol. 2006;20:241-62.
7. Spine and joints
• Tenderness,
• Swelling,
• Temperature,
• Synovial thickening,
• Range of motion: active &
passive.
YUVA CME, W.B.A.P. 7
Palpation
Muscles
• Size,
• Bulk,
• Tenderness,
• Tone.
Skin
• Elasticity,
• Rashes,
• Nodules,
papules etc.
11. • The spine and back examination:
- It includes an assessment of the bones and muscular components,
along with the postural assessment.
- Evaluation includes, having the child stand and/or sit while the
back is examined.
- The height of the shoulders, position of scapula, and height of the
pelvis should be assessed.
- The child is asked to bend forward in order to look for rib and back
asymmetries.
YUVA CME, W.B.A.P. 11
12. APPROACH
YUVA CME, W.B.A.P. 12
Preliminary
Screening
examination (triage)
Focussed formal
assessment of the
involved joint or limb
13. SCREENING
pMSK screening in Neonates and Infants:
• The Infants are usually examined on the Mother's lap.
• Observation of the general body contour, symmetry and proportion, and record
anthropometry.
• Evaluation of tone and reflexes.
• Observation of spontaneous movements.
• ‘Toe to tip’ examination including the back to look for congenital anomaly.
YUVA CME, W.B.A.P. 13
14. pMSK screening in Children and adolescents:
• The child shall be adequately exposed, bare footed and preferably in presence
of a parent.
• ‘Top to toe’ examination including assessment of mobility of different axial and
peripheral joints.
• Forward bending test – mobility and symmetry.
• Assessment of gait, Trendelenberg’s test.
• Evaluation of the arch of the foot with toe walking.
• Look for limb length discrepancy by Coleman Block Test.
• Evidence of signs of any acute or chronic inflammation.
YUVA CME, W.B.A.P. 14
15. P-GALS
• While only a few decades ago where we were in a desperate search of a
comprehensible schedule for MSK examination in children, pGALS has turned
out to be the one to look forward for the purpose since the earlier part of this
century.
• It has come out of age to its’ present state from the adult counterpart of this
scheme.
• The clinical scheme has been validated through different multicentric study
and has shown to have formidable sensitivity as a screening tool in detecting
various joint pathologies.
YUVA CME, W.B.A.P. 15
16. • Paediatric Gait, Arms, Leg and Spine (pGALS) assessment is a simple and
rapid scheme of MSK examination.
• It helps in quick detection of musculoskeletal problems in a child and
warrants for in detail examination of the afflicted joint or region.
• The clinical tool comprises of a set questionnaires and some sequential
steps to perform.
YUVA CME, W.B.A.P. 16
17. SCREENING QUESTIONS:
• Do you have any pain or stiffness in your joints, muscles or your back?
• Do you have any difficulty getting yourself dressed without any help?
• Do you have any difficulty going up and down stairs?
GAIT:
• Observe the child standing (front, side and back).
• Observe the child walking.
• “Walk on your heels / walk on your tip-toes ”
YUVA CME, W.B.A.P. 17
Figure 6.
Foster HE, Jandial S. pGALS–paediatric Gait Arms Legs and Spine: a simple examination of the musculoskeletal system. Pediatr Rheumatol.
2013;11:1-7.
18. ARMS:
• “Put your hands out in front of you”
• “Turn your hands over and make a fist”
• “Pinch your index finger and thumb together”
• “Touch the tips of your fingers with your thumb”
• Squeeze the metacarpophalangeal joints.
• “Put your hands together and back to back”
• “Reach up and touch the sky”
• “Look at the ceiling”
• “Put your hands behind your neck”
YUVA CME, W.B.A.P. 18
Figure 7.
19. LEGS:
• Feel for effusion at the knee.
• “Bend and then straighten your knee”
(Active movement of knees while examiner
feels for crepitus)
• Passive flexion of 90º with internal rotation of
hip
YUVA CME, W.B.A.P. 19
Figure 8.
20. SPINE:
• “Open your mouth and put 3 of your (child’s own)
fingers in your mouth”
• Lateral flexion of cervical spine – “Try and touch
your shoulder with your ear”
• Observe the spine from behind.
• “Can you bend and touch your toes?” Observe
curve of the spine from side and behind
YUVA CME, W.B.A.P. 20
Figure 9.
21. For the ease of executing the pGALS examination:
• Check that the child is comfortable, ask about pain, and explain what you intend to
do.
• Observe the child walking in the room, getting undressed, & at play with adequate
exposure.
• Get the child to copy you doing the manoeuvres.
• Look for verbal and non-verbal clues of discomfort.
• Look for asymmetry and consider clinical patterns
YUVA CME, W.B.A.P. 21
22. Red flag signs:
• Fever and systemic signs
• Lymphadenopathy
• Organomegaly
• Bone pain
• Persistent night waking
• Dysmorphic features
• Incongruence between
history and physical
findings
YUVA CME, W.B.A.P. 22
23. YUVA CME, W.B.A.P. 23
Growing pain in pMSK screening
Inclusion criteria Exclusion criteria
Frequency and
duration
Intermittent pains once or
twice per week, individual
episodes lasting for 30 min to 2
hours
Persisting pain or
increasing in severity
with time
Site Usually in the calf muscles,
sometimes anterior thigh
muscles, shins and popliteal
fossa and affects both the limbs
Pain involving joints
Or occurring only in one limb
Time Evening and nights Day time pain and persisting
nocturnal pains
Physical
examination
Normal Signs of inflammation
24. YUVA CME, W.B.A.P. 24
• M/C pMSK complaint:
Growing pain
• M/C functional abnormality:
Hypermobility
Sabui TK, Samanta M, Mondal RK, Banerjee I, Saren A, Hazra A. Survey of musculoskeletal abnormalities in school‐going children of
hilly and foothill regions of Eastern Himalayas using the pediatric Gait, Arms, Legs, Spine screening method. Int J Rheum Dis.
2018;21:1127-34.
25. BEIGHTON SCORE
• One point if while standing forward bending
you can place palms on the ground with legs
straight
• One point for each elbow that bends
backwards
• One point for each knee that bends backwards
• One point for each thumb that touches the
forearm when bent backwards
• One point for each little finger that bends
backwards beyond 90 degrees.
• Can you now (or could you ever) place your
hands flat on the floor without bending your
knees?
• Can you now (or could you ever) bend your
thumb to touch your forearm?
• As a child did you amuse your friends by
contorting your body into strange shapes OR
could you do the splits?
• Dislocation of shoulder or kneecap on more
than one occasion?
• Do you consider yourself double-jointed?
YUVA CME, W.B.A.P. 25
Total score: 0-9; Cut-off score: 4
Beighton P, Solomon L, Soskolne CL. Articular mobility in an African population. Ann Rheum Dis.
1973;32:413–8.
26. FOCUSSED ASSESSMENT
• A through inspection shall be done relevant to the clues obtained from the
pMSK screening examination.
• Observation of the child from
- Front: Posture, Symmetry (limb length discrepancy)
- Sides: Curvature of spine
- Back: Posture, Symmetry (Shoulder level, Scapula, Iliac crest,
Sacral dimples), Central abnormalities
• The child is asked to squat on the floor and then to stand up.
• Assessing the gait and mechanics of walking: Push off, follow through & heel
strike.
YUVA CME, W.B.A.P. 26
27. Measuring limb length:
Δ Apparent leg length – Umbilicus → Medial malleolus/heel
Δ Actual leg length – ASIS → Medial malleolus/heel
Δ Arm length – Acromion process → Olecranon process
Δ Total (Upper) limb length – Acromion process → Tip of middle finger
Δ Arm span, US:LS
Δ Proximal segment of upper limb – Asking the child to touch the shoulder with the
thumb with flexed elbow
YUVA CME, W.B.A.P. 27
28. Examination of hand and wrist:
All the small joints of hand (PIP, DIP, MCP joints) including wrist joint shall
be examined
Δ Look – Nail changes, muscle wasting, swelling and effusion of joint,
deformity.
Δ Feel – Skin temperature, eliciting tenderness, tendon thickening and
bulk of thenar and hypothenar eminences, nodules, crepitations on joint
movement.
Δ Move – ROM (active & passive), Restriction of movement, stress
pain.
Δ Functional assessment - Grip and pinch, picking up small object,
writing or drawing, testing individual muscle power, hypermobility
assessment.
YUVA CME, W.B.A.P. 28
*nail fold capillaroscopy
29. Examination of elbow:
Δ Look – Carrying angle, scars, rashes, deformity, muscle wasting,
contracture, swelling and effusion of joint.
Δ Feel – Skin temperature, tenderness, tendon thickening, nodules,
crepitations on joint movement. Palpate joint line, head of radius, ulnar
border, medial and lateral epicondyles.
Δ Move – ROM (active & passive), Restriction of movement.
Δ Functional assessment - Hand to nose or mouth, hands behind head,
testing power of individual muscle groups.
YUVA CME, W.B.A.P. 29
30. Examination of shoulder:
Δ Look (front & back) – Normal contour, scars, rashes, muscle wasting,
swelling and joint effusion, shoulder height, position of scapula.
Δ Feel – Skin temperature, tenderness, bony landmarks, nodules,
crepitations on joint movement. Palpate clavicle, costochondral,
sternoclavicular and acromioclavicular joint, axilla.
Δ Move – ROM (active & passive), Restriction of movement.
Δ Functional assessment – Raise arms over the head, hands behind the
neck, hands behind the back, abduction against resistance, testing power of
individual muscle groups.
YUVA CME, W.B.A.P. 30
31. Examination of temporomandibular (TM) joint and spine:
Δ Look – Swelling anterior to the tragus of ear, normal curvatures of
spine from side and behind, lumber hollow, symmetry, scars, sinus, swelling
and muscle wasting, natal cleft, breach in continuity of skin and deformities.
Δ Feel – Skin temperature, tenderness, crepitations on joint movement,
paraspinal muscles spasm. Palpate mandibular condyles, spinal processes,
sacroiliac joint and other bony landmarks.
Δ Move – ROM (active & passive), Restriction of movement.
Δ Functional assessment – Putting child’s own three fingers into
mouth, look at the celling, bend the neck laterally to touch the shoulder with
ear, thoracic rotation, touch the toes with finger, stork test.
YUVA CME, W.B.A.P. 31
32. Examination of hip:
Δ Look (front, side & back) – Scars, sinus, rashes, muscle wasting,
contracture, swelling, asymmetry, sub gluteal skin crease, fixed deformity.
Δ Feel – Skin temperature, tenderness, muscle bulk, crepitation on
joint movement, muscle spasm. Palpation of grater trochanter, sacroiliac
joint and other bony landmarks.
Δ Move – ROM (active & passive), Restriction of movement.
Δ Functional assessment – Straight leg rising test, Trendelenberg test,
Thomas test, gait with turning and running, ancillary movements.
YUVA CME, W.B.A.P. 32
*Ortolani test for new-born
33. YUVA CME, W.B.A.P. 33
External rotation of
hip
Internal rotation of hip
Figure 10. Figure 11.
Available from: https://musculoskeletalkey.com/examination-of-the-pediatric-patient/
34. Examination of knee:
Δ Look – Scars, sinus, rashes, muscle wasting, contracture, swelling,
joint effusion, fixed deformity.
Δ Feel – Skin temperature, joint line tenderness, muscle bulk,
crepitation on joint movement, synovial thickening, joint stability. Palpation
of patellar border, tibial tuberosity, popliteal fossa.
Δ Move – ROM (active & passive), Restriction of movement.
Δ Functional assessment – Drawyer test, patellar tap and cross
fluctuation.
YUVA CME, W.B.A.P. 34
35. Examination of ankle and feet:
Δ Look – Skin changes, muscle wasting, contracture, swelling, joint
effusion, arch of the foot, fixed deformity.
Δ Feel – Skin temperature, elicit tenderness, nodules, crepitation on
joint movement, muscle bulk, tendon thickening and bony landmarks.
Palpation of ankle joint line, subtalar, mid-tarsal, metatarsophalangeal
(MTP) joints and Achilles tendon at the insertion.
Δ Move – ROM (active & passive), Restriction of movement.
Δ Functional assessment - Thigh-foot angle, Gait cycle (heel strike,
stance, toe off or push off), running and turning, ancillary movement.
YUVA CME, W.B.A.P. 35
37. LIMITATIONS
• Age appropriate pMSK examination scheme
• Appearance of secondary ossification centres
• Overlap in mode of presentation of diseases
• Subtle signs and symptoms
• Apprehensive parents
YUVA CME, W.B.A.P. 37
Kay LJ, Baggott G, Coady DA, Foster HE. Musculoskeletal examination for children and adolescents: do standard textbooks contain enough information?. Rheumatol (Oxford). 2003;42:1423-
5.