This document summarizes two blood parasites that can infect dogs: Dirofilaria immitis and Dipetalonema reconditum. Dirofilaria immitis causes heartworm disease in dogs and spreads via mosquitoes, residing in the heart and lungs and causing symptoms like coughing. Diagnosis involves blood tests and x-rays. Prevention relies on monthly preventative medications while treatment is difficult and stressful for the dog. Dipetalonema reconditum resides subcutaneously and spreads via fleas, producing microfilariae but not causing disease. It is differentiated from Dirofilaria immitis by microfilariae size and characteristics under microscopy.