Ho-Chou Tu, PhD, is our 2014 Lisa Fund Awardee; Postdoctoral at Children’s Hospital in Boston - discussed lin28 Molecular Player review of research.

1. LIN28 is a Novel Molecular Player
Involved in Colorectal Cancer Development
Ho-Chou Tu, Ph.D
Laboratory of George Q. Daley
Boston Children’s Hospital/Harvard Medical School
Fight Colorectal Cancer Advocacy Workshop
03/16/2015

2. Genetics Changes During CRC Development
Kerr et al., Nature Reviews of Cancer (2003)
Wnt Signaling

3. Our Goals to Improve the Current Field
of CRC Research
1. Generate a late-stage CRC animal model
2. Identify and characterize novel molecular targets
for more specific therapeutic design

4. Viswanathan and Daley, Cell (2010)
Cancer Behaves Very Much Like Embryos

5. LIN28ALIN28B
Ziron Qian
Aberrant Expression of LIN28A and
LIN28B in Human Colorectal Cancer

6. Generation of Gut-Specific LIN28
Transgenic Animals

7. Induction of LIN28 Drives Tumors in
the Mouse Intestines

8. Human Colon Adenocarcinoma
http://en.wikipedia.org/
LIN28-driven Tumors are Adenocarcinoma
Resembling Human CRC
Lin28a
Tumors
LIN28B
Tumors

9. LIN28A/B Status Correlates with Invasive
Pathology in Human Colorectal Cancers
Ziron Qian

10. LIN28A/B Expression Predicts
Poorer Long Term Survival Rate
Ziron Qian

11. LIN28
Molecular mechanisms
Interacting pathways
In vivo platform for developing new therapeutics
LIN28: Novel Onco-proteins in
Colorectal Cancer Development

12. Acknowledgement
The Daley lab
-George
-Sarah Schwitalla
-Grace LaPier
-Alena Yermalovich
-Sam Ross
-Achia Urbach
-John Powers
-all Daley lab members
-Charlie Fuchs
-Shugi Ogino
-Ziron Qian
DFCI
Rodent Path Core
-Rod Bronson
-Gavin Meredith
-Jeffery Ku
-Shann-Ching Chen