Paget disease .ppt
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Paget's disease is a non-inflammatory bone condition characterized by increased and irregular bone remodeling leading to weakened and deformed bones. It affects approximately 3% of the European population over age 40. The pathogenesis may involve a slow virus infection. Clinical features range from being asymptomatic to bone pain, fractures, deformities, neurological symptoms, and high output heart failure. Diagnosis involves clinical assessment, blood tests, imaging studies showing three distinct phases of bone involvement. Treatment focuses on pain relief, drug therapy to slow bone turnover, and surgery for complications like fractures or joint deformities.
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Paget disease
This document provides information on Paget's disease, including:
- It is a chronic bone disorder characterized by abnormal bone remodeling that can cause bone deformities and fractures.
- The cause is unknown but may involve viruses or genetic factors. It most commonly affects older adults and bones like the pelvis and spine.
- Symptoms can include bone pain, stiffness, fractures, and hearing loss. Lab tests show elevated alkaline phosphatase levels. Imaging like x-rays are used for diagnosis.
- The disease involves abnormal bone breakdown and formation seen on imaging as thickened and misshapen bones. While often asymptomatic, treatment with medications may be used for painful symptoms.
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Paget's disease
Paget's disease is a chronic bone disorder characterized by increased and abnormal bone remodeling. It involves excessive bone breakdown by osteoclasts followed by abnormal new bone formation by osteoblasts, leading to weakened, deformed bones. The cause is unknown but may involve viral infection or genetic factors. Symptoms range from none to bone pain, fractures, deformities, and neurological or cardiovascular complications depending on the bones affected. Diagnosis involves blood tests showing elevated alkaline phosphatase levels and imaging studies demonstrating abnormal bone structure. While there is no cure, treatment focuses on relieving symptoms.
pagetdisease3-120520105713-phpapp02.pdf
Paget's disease is a chronic bone disorder characterized by increased and abnormal bone remodeling. The cause is unknown but may involve viral infection or genetic predisposition. It most commonly affects older adults and causes bones to break down more rapidly than normal followed by faster than normal bone formation, resulting in deformed and fragile bones. Symptoms can include bone pain, fractures, skeletal deformities, and neurological or cardiovascular complications. Diagnosis involves blood tests showing elevated alkaline phosphatase levels and imaging tests demonstrating abnormal bone structure. While there is no cure, treatment focuses on managing symptoms.
A Case of Paget's Disease
A 45-year-old woman presented with knee pain, low back pain, thigh pain, and breathlessness for the past year. Examination found fixed flexion deformities in the hips and kyphosis. Laboratory tests showed elevated alkaline phosphatase and markers consistent with Paget's disease. A bone biopsy confirmed Paget's disease. Paget's disease is a chronic disorder causing abnormal bone remodeling that can cause pain, deformities, and fractures. Treatment options include bisphosphonates like zoledronate to control symptoms and slow disease progression.
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Paget disease
This document provides information on Paget's disease, including:
- It is a chronic bone disorder characterized by abnormal bone remodeling that can cause bone deformities and fractures.
- The cause is unknown but may involve viruses or genetic factors. It most commonly affects older adults and bones like the pelvis and spine.
- Symptoms can include bone pain, stiffness, fractures, and hearing loss. Lab tests show elevated alkaline phosphatase levels. Imaging like x-rays are used for diagnosis.
- The disease involves abnormal bone breakdown and formation seen on imaging as thickened and misshapen bones. While often asymptomatic, treatment with medications may be used for painful symptoms.
Diseases Of Bone Manifested in Jaw
Fibro-osseous Lesions of Medullary Bone Origin ,Fibro-osseous Lesions of Periodontal Origin and Other Lesions Of Bone
Paget's disease
Paget's disease is a chronic bone disorder characterized by increased and abnormal bone remodeling. It involves excessive bone breakdown by osteoclasts followed by abnormal new bone formation by osteoblasts, leading to weakened, deformed bones. The cause is unknown but may involve viral infection or genetic factors. Symptoms range from none to bone pain, fractures, deformities, and neurological or cardiovascular complications depending on the bones affected. Diagnosis involves blood tests showing elevated alkaline phosphatase levels and imaging studies demonstrating abnormal bone structure. While there is no cure, treatment focuses on relieving symptoms.
pagetdisease3-120520105713-phpapp02.pdf
Paget's disease is a chronic bone disorder characterized by increased and abnormal bone remodeling. The cause is unknown but may involve viral infection or genetic predisposition. It most commonly affects older adults and causes bones to break down more rapidly than normal followed by faster than normal bone formation, resulting in deformed and fragile bones. Symptoms can include bone pain, fractures, skeletal deformities, and neurological or cardiovascular complications. Diagnosis involves blood tests showing elevated alkaline phosphatase levels and imaging tests demonstrating abnormal bone structure. While there is no cure, treatment focuses on managing symptoms.
A Case of Paget's Disease
A 45-year-old woman presented with knee pain, low back pain, thigh pain, and breathlessness for the past year. Examination found fixed flexion deformities in the hips and kyphosis. Laboratory tests showed elevated alkaline phosphatase and markers consistent with Paget's disease. A bone biopsy confirmed Paget's disease. Paget's disease is a chronic disorder causing abnormal bone remodeling that can cause pain, deformities, and fractures. Treatment options include bisphosphonates like zoledronate to control symptoms and slow disease progression.
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Adverse Reactions.ppt
This document discusses adverse drug reactions (ADRs), including definitions, classifications, mechanisms, risk factors, and prevention strategies. It defines ADRs as noxious changes suspected to be caused by a drug. ADRs can be classified as type A (predictable, dose-related) or type B (unpredictable, immune-mediated). Risk factors for ADRs include polypharmacy, older age, multiple illnesses, and malnutrition. Prevention strategies include appropriate dosing, monitoring for new symptoms, and considering drug interactions and patient history. The document also covers topics like drug dependence, teratogenicity, and the role of pharmacovigilance in monitoring ADRs.
EOral-Obesity.ppt
This document provides an overview and update on obesity. It begins by defining obesity based on BMI and body fat distribution. The physiology of obesity and factors regulating energy balance like leptin are described. Environmental and genetic causes of positive energy balance leading to obesity are discussed. Various endocrine conditions that can cause obesity are listed. The medical risks of obesity and approaches to treatment including prevention, diet, exercise, drugs, and surgery are summarized.
Drug interactions.ppt
This document discusses drug interactions, which occur when two drugs administered together modify each other's effects. It describes several types of interactions, including pharmacokinetic interactions that affect absorption, distribution, metabolism and excretion of drugs, and pharmacodynamic interactions that occur at receptor sites. Specific drug combinations that can increase risks are provided as examples. The mechanisms of various interactions like enzyme inhibition and induction are explained. It emphasizes the importance of considering potential interactions when patients receive multiple medications from different doctors or have other risk factors.
diploma HEALTH SYSTEM MANAGEMENT.pptx
This document provides an overview of the first module of a health system management diploma program. It includes 5 units that will be covered: leadership and management, organization of health services, human resource management, communication and networking, and commodity and supplies management. The learning outcomes are also outlined. The first topic within the leadership and management unit is an introduction to management, which defines management, discusses management concepts and theories, and explains the importance of studying management. It provides details on scientific management, administrative management theory, and the bureaucratic theory of management.
Parmacodynamics.pptx
Pharmacodynamics is the study of how drugs act on the body and their mechanisms of action. It includes the biochemical and physiological effects of drugs. A key concept is that drugs can act as agonists, partial agonists, antagonists, or inverse agonists depending on if they mimic endogenous compounds and what receptor states they stabilize. The potency and efficacy of a drug depends on its affinity for and ability to activate receptors. Factors like tolerance, resensitization, and downregulation also impact a drug's effects over time. Understanding pharmacodynamics is important for determining dosages, maximizing therapeutic effects, and minimizing adverse reactions.
DIPLOMA OTM HSM1.ppt
This document provides an overview of a health system management module. The module aims to develop learners' competency in strengthening health care systems. Key topics covered include leadership and management principles, roles and functions; organization and coordination of the health sector; human resource management; medico-legal issues; and communication and networking. The document outlines learning outcomes, module content, and definitions and concepts related to leadership, management, and the roles and skills required of managers at different levels within a health system.
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Paget disease .ppt
- 1. PAGET’S DISEASE ( Osteitis deformans) July 2012 DR. FRANTZEN
- 2. DEFINITION • Non-inflammatory condition of bone • Furious bone resorption • Chaotic bone deposition Sir John Paget (1876) July 2012 DR. FRANTZEN
- 3. INCIDENCE • Some 3% of European population ( 90% asymptomatic ) • RSA : - 1.3% among black population - 2.4% among white population • Prevalence increases with age (> 40) • Male:Female ratio = 3:2 July 2012 DR. FRANTZEN
- 4. Pathogenesis Slow virus infection : Paramyxovirus July 2012 DR. FRANTZEN
- 5. CLINICAL FEATURES • Initially asymptomatic • Bone pain • Stress fractures • Increasing head size • Blindness • Deafness • Bowing of legs • Kyphosis • High output cardiac failure July 2012 DR. FRANTZEN
- 6. July 2012 DR. FRANTZEN
- 7. PATHOLOGY • 3 PHASES 1. Osteolytic or hot phase 2. Mixed or intermediate phase 3. Sclerotic or cool phase July 2012 DR. FRANTZEN
- 8. SKELETAL DISTRIBUTION • Virtually any bone can be affected Pelvis and tibia most common Next femur, skull, spine and clavicle July 2012 DR. FRANTZEN
- 9. CLINICAL • Asymptomatic in 70% • Bone pain • Limb feels warm • Deformities • Neurological symptoms • High output heart failure July 2012 DR. FRANTZEN
- 10. COMPLICATIONS Micro fractures Bowing of femurs and tibias Secondary OA of joints Malignant transformation Compression fractures of spine High output heart failure July 2012 DR. FRANTZEN
- 11. DIAGNOSIS • Clinical picture • Radiographs • S-ALP , u-DPD, u-Hydroxyproline • Bone scan July 2012 DR. FRANTZEN
- 12. RADIOLOGY • OSTEOLYTIC PHASE Active bone resorption Large areas of radiolucency Destruction of cortex and cancellous bone July 2012 DR. FRANTZEN
- 13. RADIOLOGY • INTERMEDIATE PHASE Thickening of cortex and course trabeculation of cancellous bone Trabecular thickening along stress lines July 2012 DR. FRANTZEN
- 14. RADIOLOGY • SCLEROTIC PHASE Enlargement and widening of bone, marked cortical thickening with blurring of cortex-spongiosa demarcation July 2012 DR. FRANTZEN
- 15. TREATMENT • Treatment does not cure Pagets, but provides prolonged periods of remission July 2012 DR. FRANTZEN
- 16. TREATMENT • Pain relief – NSAIDS - Paracetamol - Opioids • Pharmacotherapy - Biphosphonates - Calcitonin - Calcium 1000mg/d - vit D - exercise July 2012 DR. FRANTZEN
- 17. TREATMENT • Surgery indicated : 1. Unstable # and delayed union 2. OA for joint replacement 3. Osteotomy for deformities 4. Nerve compression in spine July 2012 DR. FRANTZEN