How life originated on earth is still a very tough question. We have found many evidences, we have a lots of hypothesis, but still we have miles to go. This PPT summarizes the findings of research on origin of life on earth.
This is a summary of a presentation our CEO has given at Northwestern University, Chicago - U.S.A. in 2003. Many aspects of protein targeting and membrane trafficking in eukaryotic cells are discussed.
Tags: Gokay-BIOTECH, K.Erden Gokay, Cell Biology, protein sorting, endotubin
Structure and function of plasma membrane 2ICHHA PURAK
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The presentation consists of 72 slides,describes following heads
DEFINITION : STRUCTURE OF PLASMA MEMBRANE
COMPONENTS OF PLASMA MEMBRANE ( (BIOCHEMICAL PROPERTIES)
LIPID BILAYER
PROTEINS
CARBOHYDRATES
CHOLESTEROL
MODELS EXPLAINING STRUCTURE OF BIO MEMBRANE
FLUID MOSAIC MODEL
MOBILITY OF MEMBRANE
GLYCOCALYX : GLYCOPROTEINS AND GLYCOLIPIDS
TRANSPORT OF IONS AND MOLECULES ACROSS PLASMA MEMBRANE
FUNCTIONS OF PLASMA MEMBRANE
DIVERSITY OF CELL MEMBRANES
SITE OF ATPASE ION CARRIER CHANNELS AND PUMPS-RECEPTORS
Origin Of Life: Are we here by chance? Theories on origin of life, Scientific and Special Creation. Different Theories of life's origin including Aristotle's theory, Pasteur, Redi and Leuwenhook experiment, Abiogenesis, etc.
Fossils and its evolutionary significance.
Introduction to Life Science and The Theories on the Origin of LifeSimple ABbieC
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I. Introduction to Life Science
II. The Concept of Life
III. Characteristics of Life
IV. Theories on the Origin of Life
V. Unifying Themes in the Study of Life
Origin of life-where did life come fromArosek Padhi
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this chapter prompts you to wonder where did life as we know it came from. this is a presentation from Dr.Tithi Parija (asst professor) from KIIT school of biotechnology including different theories from different thinkers and scientists
This is a summary of a presentation our CEO has given at Northwestern University, Chicago - U.S.A. in 2003. Many aspects of protein targeting and membrane trafficking in eukaryotic cells are discussed.
Tags: Gokay-BIOTECH, K.Erden Gokay, Cell Biology, protein sorting, endotubin
Structure and function of plasma membrane 2ICHHA PURAK
Â
The presentation consists of 72 slides,describes following heads
DEFINITION : STRUCTURE OF PLASMA MEMBRANE
COMPONENTS OF PLASMA MEMBRANE ( (BIOCHEMICAL PROPERTIES)
LIPID BILAYER
PROTEINS
CARBOHYDRATES
CHOLESTEROL
MODELS EXPLAINING STRUCTURE OF BIO MEMBRANE
FLUID MOSAIC MODEL
MOBILITY OF MEMBRANE
GLYCOCALYX : GLYCOPROTEINS AND GLYCOLIPIDS
TRANSPORT OF IONS AND MOLECULES ACROSS PLASMA MEMBRANE
FUNCTIONS OF PLASMA MEMBRANE
DIVERSITY OF CELL MEMBRANES
SITE OF ATPASE ION CARRIER CHANNELS AND PUMPS-RECEPTORS
Origin Of Life: Are we here by chance? Theories on origin of life, Scientific and Special Creation. Different Theories of life's origin including Aristotle's theory, Pasteur, Redi and Leuwenhook experiment, Abiogenesis, etc.
Fossils and its evolutionary significance.
Introduction to Life Science and The Theories on the Origin of LifeSimple ABbieC
Â
I. Introduction to Life Science
II. The Concept of Life
III. Characteristics of Life
IV. Theories on the Origin of Life
V. Unifying Themes in the Study of Life
Origin of life-where did life come fromArosek Padhi
Â
this chapter prompts you to wonder where did life as we know it came from. this is a presentation from Dr.Tithi Parija (asst professor) from KIIT school of biotechnology including different theories from different thinkers and scientists
Life, living matter are those that shows certain attributes that include responsiveness, growth, metabolism, energy transformation and reproduction.
In biology origin of life or abiogenesis is the natural process by which life has arisen from non-living matter, such as simple organic compounds.
It means the emergence of heritable and evolvable self-reproduction.
It is a complex subject and oftentimes controversial.
Several attempts have been made from time to time to explain the origin of life on earth.
There are several theories which offer their own explanation on the possible mechanism of origin of life.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Richard's aventures in two entangled wonderlandsRichard Gill
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Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called âsmallâ because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.SĂŠrgio Sacani
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The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
2. DEFINITION OF LIFE
⢠There is not a single, perfect definition of life, because life is a
process, it is not a substance.
⢠One popular definition is that organisms are open systems that
maintain homeostasis, are composed of cells, have a life cycle,
undergo metabolism, can grow, adapt to their environment, respond
to stimuli, reproduce and evolve.
⢠According to NASA, life is âa self-sustaining chemical system capable
of Darwinian evolution:.
⢠More simply, life is âmatter that can reproduce itself and evolveâ
6. BIOMOLECULES
⢠Biomolecules are special molecules of Carbon.
⢠Carbohydrates, lipids, proteins and nucleic acids are the main
classes of biomolecules.
⢠Carbohydrates provide energy, lipids are the main structural
components of cell membranes, proteins are the building
blocks and catalyst.
⢠DNA and RNA are the peculiar class of biomolecule that can
reproduce and replicate themselves. They also act as the
genetic and hereditary material.
7.
8. ORIGIN OF LIFE
⢠Almost every religion believe God created the earth and all the organisms.
⢠Charles Darwin was the first person to challenge the God as the creator and
he postulated that all the organisms on the earth evolved through natural
selection from a single common ancestor who existed long long ago.
⢠Some people believe the seed of life on earth came from other parts of the
universe along with meteorites and this theory is called the âpanspermiaâ
theory.
⢠Till today, our Earth alone is known to host life. There may be billions of
earth like places in the universe with more advanced civilizations, or may
not be. Titan and Europa, two moons of Saturn are strongly believed to be
home of living forms in our solar system.
9. THE PREBIOTIC EARTH
⢠Our solar system originated about 4.567 billion years ago.
⢠During the first billion years, earth was inhospitable to life. It
was very hot, there was no water, soil, oxygen.
⢠The oldest fossil till discovered dated 3.8 billion years ago.
⢠It is now impossible to recreate the original environment of
earth in laboratory. It is unknown where and when exactly the
first life originated on earth.
10. THE ABIOGENESIS THEORY
⢠Oparin and Haldane(1929) postulated that life originated in the primitive
environment of earth from simple inorganic substances.
⢠Different lighter atoms like Hydrogen, oxygen, nitrogen, carbon etc.
combined to each other to form inorganic compounds like NH3, H2O, H2S
etc. The energy required for such chemical reaction was obtained from
sunlight, volcanic activity, thunderstorm etc.
⢠These simple inorganic molecules further reacted with each other to form
some simple organic molecules like amino acids, sugars, nucleotides etc.
⢠Small organic molecules polymerized to form large biomolecules like
carbohydrates, lipids, protein, nucleic acids etc. These molecules later
organized themselves to form the first cell-like structure which can
reproduce and evolve.
11. UREY AND MILLERâS EXPERIMENT
⢠Experimental proof to the abiogenesis theory was provided by Urey
and Miller(1951)
⢠They tried to recreate the primitive environment of earth in
laboratory. CH4, NH3, H2 and H20 was kept in a specially designed
chamber for almost a week, provided with heat and electric shock.
⢠They analysed the water after the completion of the experiment and
confirmed the presence of simple amino acids, sugars etc.
⢠This experiment proved that the biomolecules necessary for life
process were created from simple inorganic molecules in primitive
environment of earth.
12.
13. ⢠Almost all scientists now a days believe this theory of inorganic
origin of life.
⢠Darwin postulated hot primitive ponds to be origin of life.
⢠Some scientist believe under surface uranium-rich pockets served
as the home for primordial life.
⢠Underwater volcanos, hot springs etc are also believed to be the
first place where life first originated.
16. LUCA (LAST UNIVERSAL COMMON
ANCESTOR)
⢠With the help of tools of molecular biology, the probable
ancestor of all life forms on present day earth has been traced,
and found to be an organism who lived almost 3.8 billion years
ago. But no fossil evidence found till date.
⢠It shares almost 350 genes with all life forms.
⢠It was an unicellular prokaryotic microbe.
⢠It was chemotrophic.
⢠It had RNA as genetic material.
18. EVOLUTION
⢠Evolution is the process by which one life form gradually changes to
a different one. It is a very slow but continuous process.
⢠All the living organisms on earth are the result of evolution. All
organism, including human, continue to evolve.
⢠Evolution started from the point of formation of first organic material
on earth. Hence, organic evolution.
⢠Forces behind evolution include mutation, chromosomal
abberrations, natural selection, bottleneck effect, genetic drift etc.