In this lecture, presented on August 15, 2014 for the USI Mid-America institute on Aging, Dr. Cady covered the under appreciated physiology of micronutrients and deficiency syndrome, the concept of the "Triage Theory of Aging" from Dr. Bruce Ames, and reviewed the literature on nutritional supplementation. This covered carotenoids, peer-reviewed studies on carotenoids and mortality, peer-reviewed studies on carotenoids and risk of breast cancer, peer review articles on lipid preoccupation, antioxidants, and the chances of survival in the institutionalized elderly, Raman spectroscopy as a marker of antioxidant nutritional deficiency, the explosion of obesity in our population in the US, and optimal antiaging strategies. The "Seven Secrets of Optimizing Body Composition" was reviewed at the end. References are attached.
HOW TO SAVE MONEY ON YOUR HEALTHCARE: An Integrative Medicine ApproachLouis Cady, MD
In this webinar, the fourth in a series of five from Dr. Louis Cady and the Cady Wellness Institute, we focus on the actual dollars and cents of health care expenditures, and the societal and PERSONAL costs of poor health maintenance behavior. We examine the essentially passive US medical system, that would rather drug a symptom than fix the underlying problem.
Great attention is paid on not shaming the patient or the doctors as they exist in the current system. Both groups "do not know what they do not know." Confirmation bias is rampant.
This webinar points the way to living a more vital, energetic life, with a minimum of cost, grief, and misery.
Hemp Oil: What Can It Do For You? Lebanon, TN 04 06 2018Louis Cady, MD
In this presentation, Dr. Cady reviews the peer-reviewed medical literature for the endocannibinoid system, the concept of endocannibinoid deficiency syndrome (now well established), and citations dealing with the multiplicity of health conditions for which a full spectrum hemp oil should be considered as a reasonable supportive strategy. The difference between the generic "CBD Oil" that is available at health food stores compared to the Zilis products is touched on. The Zilis products appear to have better absorbability, faster onset of action, and scientific studies elucidating the true duration of action of CBD levels in blood serum.
This presentation was given to a very appreciative audience at the Friendship Church in Lebanon, TN (a suburb of Nashville).
This lecture was presented on March 29, 2019 in Rapid Citry, South Dakota, for the conference co-sponsored by the Manlove Psychiatric Group and the Brain Injury Center.
It reviews the uptick in diagnosis of ADHD, the raiontale for its concern, causative factors, and how it can be worked up holistically and in a balanced, not necessarily medication-oriented way.
Use of high dose fish oil, iron supplementation, and how to overrcome nutritional deficiencies are discussed.
The Do It To Yourself Treatment of Depression - Webinar #3Louis Cady, MD
This is the third in a series of five webinars. The first was on staying alive by boosting your immunity during COVID 19. The second was on not screwing yourself up inside your head. This third one encompasses a romp through the peer reviewed medical literature looking for supplements and nutrients that you could use to self treat depression at home, CAREFULLY. Numerous cautions and warnings are included.
The driving impetus to this program is that many people - due to social isolation and their mental health care, or medical practitioners' offices being closed down - have not been able to get help or succeed in optimizing their treatment for depression. There are multiple useful nutrients for both depression and anxiety in nature's abundant pharmacopeia, and this webinar touches on just a few of them.
I hope you enjoy it.
This document provides an overview of a presentation on optimizing neurovascular aging through nutritional and weight management techniques. The presentation discusses the importance of micronutrient adequacy and macronutrient balance in diet and their relationship to neurovascular health issues. It also discusses how our functioning as we age and freedom from disease and depression is dependent on our diet and behaviors. The presentation provides information on common micronutrient deficiencies in North America, physiological effects of deficiencies, and the role of antioxidants in brain and body health.
Dr. Cady deconstructs some the medical literature about the use of nutrients - and the evidence of what happens in the presence of their insufficiency. Everything for decreased viral replication to decrease brain shrinkage is covered. The role of antioxidant and carotenoids, measured by the Pharmanex Biophotonic Scanner, is reviewed.
Please note - there is no representation that any nutrient or supplement can treat, prevent, mitigate, or cure any medical condition. It does seem, however, upon reflecting on the medical literature, that there seems to be a lot of evidence for therapeutic effect in the presence of good levels of nutrient, and harm to patients if they have insufficient levels.
CORONOFOBIA - Passos práticos para equilibrar as defesas do corpo e da menteLouis Cady, MD
Esta palestra, apresentada em 29 de maio de 2021 para o Congresso de Medicina Integrativa para a Saúde Mental 2020, promovido pelo Laboratório Great Plains no Brasil, enfocou coisas simples e de bom senso que os pacientes (e seus médicos) podem fazer para se manter seguros e viver durante o Pandemia do covid.
Os seguintes conceitos holísticos foram revisados:
- sono adequado e por que é tão importante;
- o uso de melatonina, cientificamente validada como tendo atividade antiviral (referências citadas);
- a importância de diminuir o estresse e técnicas para fazê-lo;
- a necessidade de "comer frutas e vegetais" como sua mãe e sua avó ensinaram devido à ingestão de carotenóides e antioxidantes ((referências citadas);
- o uso adequado de suplementos vitamínicos / nutricionais (referências citadas).
O foco desta apresentação não foram medidas heróicas para salvar vidas na unidade de terapia intensiva para pacientes gravemente enfermos com COVID, mas, sim, técnicas de bom senso, práticas, baratas e (em alguns casos) GRATUITAS para melhorar você e seus pacientes 'saúde e resistência às doenças.
Natural Treatments for ADHD - December 7th, 2016 - Saint Marys HospitalLouis Cady, MD
This lecture, presented December 7th, 2016 for the Parent Support Group for children with ADHD and Sensory Processing Disorders, was presented at Saint Marys Hospital in Evansville, Indiana. In this one hour presentation, Dr. Cady broke down some of the alternative treatments for ADHD, grounded in the peer-reviewed literature, that do not involve the prescription of typical psychiatric medication for ADHD. He emphasized, natural, holistic treatments to treat deficiencies and restore balance of nutrients and specific essential fatty acids.
HOW TO SAVE MONEY ON YOUR HEALTHCARE: An Integrative Medicine ApproachLouis Cady, MD
In this webinar, the fourth in a series of five from Dr. Louis Cady and the Cady Wellness Institute, we focus on the actual dollars and cents of health care expenditures, and the societal and PERSONAL costs of poor health maintenance behavior. We examine the essentially passive US medical system, that would rather drug a symptom than fix the underlying problem.
Great attention is paid on not shaming the patient or the doctors as they exist in the current system. Both groups "do not know what they do not know." Confirmation bias is rampant.
This webinar points the way to living a more vital, energetic life, with a minimum of cost, grief, and misery.
Hemp Oil: What Can It Do For You? Lebanon, TN 04 06 2018Louis Cady, MD
In this presentation, Dr. Cady reviews the peer-reviewed medical literature for the endocannibinoid system, the concept of endocannibinoid deficiency syndrome (now well established), and citations dealing with the multiplicity of health conditions for which a full spectrum hemp oil should be considered as a reasonable supportive strategy. The difference between the generic "CBD Oil" that is available at health food stores compared to the Zilis products is touched on. The Zilis products appear to have better absorbability, faster onset of action, and scientific studies elucidating the true duration of action of CBD levels in blood serum.
This presentation was given to a very appreciative audience at the Friendship Church in Lebanon, TN (a suburb of Nashville).
This lecture was presented on March 29, 2019 in Rapid Citry, South Dakota, for the conference co-sponsored by the Manlove Psychiatric Group and the Brain Injury Center.
It reviews the uptick in diagnosis of ADHD, the raiontale for its concern, causative factors, and how it can be worked up holistically and in a balanced, not necessarily medication-oriented way.
Use of high dose fish oil, iron supplementation, and how to overrcome nutritional deficiencies are discussed.
The Do It To Yourself Treatment of Depression - Webinar #3Louis Cady, MD
This is the third in a series of five webinars. The first was on staying alive by boosting your immunity during COVID 19. The second was on not screwing yourself up inside your head. This third one encompasses a romp through the peer reviewed medical literature looking for supplements and nutrients that you could use to self treat depression at home, CAREFULLY. Numerous cautions and warnings are included.
The driving impetus to this program is that many people - due to social isolation and their mental health care, or medical practitioners' offices being closed down - have not been able to get help or succeed in optimizing their treatment for depression. There are multiple useful nutrients for both depression and anxiety in nature's abundant pharmacopeia, and this webinar touches on just a few of them.
I hope you enjoy it.
This document provides an overview of a presentation on optimizing neurovascular aging through nutritional and weight management techniques. The presentation discusses the importance of micronutrient adequacy and macronutrient balance in diet and their relationship to neurovascular health issues. It also discusses how our functioning as we age and freedom from disease and depression is dependent on our diet and behaviors. The presentation provides information on common micronutrient deficiencies in North America, physiological effects of deficiencies, and the role of antioxidants in brain and body health.
Dr. Cady deconstructs some the medical literature about the use of nutrients - and the evidence of what happens in the presence of their insufficiency. Everything for decreased viral replication to decrease brain shrinkage is covered. The role of antioxidant and carotenoids, measured by the Pharmanex Biophotonic Scanner, is reviewed.
Please note - there is no representation that any nutrient or supplement can treat, prevent, mitigate, or cure any medical condition. It does seem, however, upon reflecting on the medical literature, that there seems to be a lot of evidence for therapeutic effect in the presence of good levels of nutrient, and harm to patients if they have insufficient levels.
CORONOFOBIA - Passos práticos para equilibrar as defesas do corpo e da menteLouis Cady, MD
Esta palestra, apresentada em 29 de maio de 2021 para o Congresso de Medicina Integrativa para a Saúde Mental 2020, promovido pelo Laboratório Great Plains no Brasil, enfocou coisas simples e de bom senso que os pacientes (e seus médicos) podem fazer para se manter seguros e viver durante o Pandemia do covid.
Os seguintes conceitos holísticos foram revisados:
- sono adequado e por que é tão importante;
- o uso de melatonina, cientificamente validada como tendo atividade antiviral (referências citadas);
- a importância de diminuir o estresse e técnicas para fazê-lo;
- a necessidade de "comer frutas e vegetais" como sua mãe e sua avó ensinaram devido à ingestão de carotenóides e antioxidantes ((referências citadas);
- o uso adequado de suplementos vitamínicos / nutricionais (referências citadas).
O foco desta apresentação não foram medidas heróicas para salvar vidas na unidade de terapia intensiva para pacientes gravemente enfermos com COVID, mas, sim, técnicas de bom senso, práticas, baratas e (em alguns casos) GRATUITAS para melhorar você e seus pacientes 'saúde e resistência às doenças.
Natural Treatments for ADHD - December 7th, 2016 - Saint Marys HospitalLouis Cady, MD
This lecture, presented December 7th, 2016 for the Parent Support Group for children with ADHD and Sensory Processing Disorders, was presented at Saint Marys Hospital in Evansville, Indiana. In this one hour presentation, Dr. Cady broke down some of the alternative treatments for ADHD, grounded in the peer-reviewed literature, that do not involve the prescription of typical psychiatric medication for ADHD. He emphasized, natural, holistic treatments to treat deficiencies and restore balance of nutrients and specific essential fatty acids.
Killer Drugs and the Supplement Hall of FameLouis Cady, MD
In the fourth and final lecture of his series at the IMMH Conference in Chicago, IL at McCormick Place, September 22, 2013, Dr. Cady covers the "for sure" interactions to watch out for between specific drugs and their common points of interaction.
After examining those potentially toxic interaction, he continues into a review of peer-reviewed evidence for the appropriate, thoughtful, and precise use of specific supplements in a targeted approach. The role of good basic antioxidant protection is discussed, as is the need for B-vitamins, Omega 3 fatty acids, and several others.
Natural Treatments for ADHD - April 11, 2018Louis Cady, MD
This presentation will be delivered April 11, 2018 on recorded webinar for the Autism Global Conference. It was my pleasure to prepare and present this lecture (in webinar form), outlining a coherent philosophy of finding biological underpinnings that can cause or contribute to, or exacerbate, mental dysfunction. In the case of this presentation, the question is "How much of ADHD symptomatology is caused by a lack of a good medication, or, rather, lack of a coherent strategy for finding and fixing underlying biological abnormalities?"
Those biological abnormalities in this presentation include MTHFR polymorphisms, COMT polymorphisms, elemental deficiencies (lithium, magnesium, zinc, iron, and copper), essential fatty acid deficiencies, the confound of high fructose corn syrup, and many others.
Rational strategies for nutraceutical intervention are reviewed.
Natural Treatments for ADHD (TADH) in Sao Paulo, Brazil, for Laboratorio Grea...Louis Cady, MD
In this presentation, given at UNIP (Campus Paraiso - Sao Paulo, SP Brazo) for the 2019 Congresso de Saude Mental (Conference on Mental Health), Dr. Cady reviewed the prevalence, inheritability, and social ramifications of ADHD (TADH in Brazil). He specifically reviewed multiple holistic interventions, including limiting "electric screen time,"good quality diet with adequate amounts of essential fatty acids and critically important trace elements, and the use of pharmacogenomic testing as well as functional, integrative medicine testing, all to better characterize logical and reeasonmable points for holistic intervention.
This presentation was simultaneously translated into Portugue for the attendees, but unfortunately the slides were not available in translated form.
For further information in Brazil on this topic, or to order a video/audio recording of the conference (in Portuguese),contact Luiz Dias of Laboratorio Great Plains in Brazil.
Medicine: A State of CRISIS, a State of CHANGELouis Cady, MD
Dr. Cady returns this year to repeat and update one of the most talked about presentations of the 2015 IMMH conference. In this presentation, Dr. Cady deconstructs the pressures and challenges facing patients, physicians, and all health care practitioners in today's practice environment. The role of integrated practice and functional medicine as a "differentiating factor" in one's practice is reviewed. The need for patients to adapt a healthy life style and take responsibility for their health for their own economic self-preservation is also touched on.
Caring for all in the last year of life: making a difference.Bruce Mason
Inaugural presentation by Prof. Scott A. Murray, St Columba's Hospice Chair of Primary Palliative Care, Primary Palliative Care Research Group, Centre for Population Health Sciences: General Practice Section, University of Edinburgh. April 21, 2009
- A study on fruit flies found that restricting eating to a 12-hour period each day led to better sleep, less weight gain, and healthier hearts compared to those that ate throughout the day, despite eating similar amounts.
- A small study on humans with type 2 diabetes found that eating a larger breakfast and smaller dinner helped control blood sugar levels throughout the day.
- Research shows that zinc lozenges may help shorten the duration of cold symptoms like nasal discharge and cough if started within 24 hours for periods under two weeks.
1) Dual process theory describes two modes of thinking: System 1 thinking is intuitive, quick, and based on pattern recognition. System 2 thinking is slow, analytical, and deliberate.
2) A 59-year-old man presented with chest pain and elevated cardiac troponin. Initial diagnosis was non-ST elevation myocardial infarction (NSTEMI) based on System 1 thinking.
3) Further examination revealed new cardiac murmurs, neurological symptoms, and asymmetric blood pressure, inconsistent with NSTEMI. This triggered a transition to System 2 thinking and a new diagnosis of aortic dissection was made.
How to Transition from Allopathic to Integrated Practice - IMM Brazil 2015Louis Cady, MD
In this lecture, Dr. Cady compares and contrasts the significance differences, both conceptually and practically, between the conventional practice of medicine and a more rational, functional, integrated approach. Tactical concepts and didactic tools to make the transition are reviewed.
This case describes a 60-year-old woman presenting with choreiform movements, weight loss, and dysarthria over the past 6 months. Imaging showed T1 hyperintensity in the basal ganglia. She tested positive for anti-CRMP-5 antibodies, which are associated with malignancy in over 90% of cases. Further workup revealed a small cell lung cancer. Her symptoms improved with cancer treatment and decreasing antibody levels, indicating this was a paraneoplastic neurological syndrome.
"Killer Drugs & The Supplement Hall of Fame" - IMMH Brazil, 2015Louis Cady, MD
In this presentation, the third of three lectures Dr. Cady delivered in São Paulo, Brazil, Dr. Cady reviews the critical patterns of interactions with numerous frequently prescribed psychotropic medications (and others). Emphasis is given on how not to commit an obvious drug-drug interaction as well as avoiding more subtle ones. The focus then shifts to supplements: which ones are the best, which ones have mental health benefits, and how to avoid interactions between conventionally used supplements and psychiatric medications.
This document discusses an evolutionary medicine approach to mental health and resilience. It argues that existing mental health treatments are only partially effective and that a new approach is needed. Mental illnesses are linked to differences between our current lifestyle and our hunter-gatherer past, and are influenced by genes, stress, diet, and inflammation. Adopting a lifestyle focused on nutrient-dense foods, stress management, sleep, exercise and social connection could help build resilience against mental illness by better matching our biology. However, randomized trials of this evolutionary approach are still needed.
- Healthy brain aging is important due to the rising prevalence of age-related cognitive disorders like Alzheimer's disease.
- Brain aging is influenced by both modifiable and non-modifiable risk factors. Engaging in heart-healthy habits, cognitive activities, and social interaction may help promote healthy brain aging.
- When discussing brain health with older patients, physicians should evaluate risk factors and encourage lifestyle changes like exercise, a healthy diet, cognitive stimulation, and social engagement.
In his fourth and concluding lecture of the IMMH Conference in San Antonio, 2014, Dr. Cady reviews the statistics, epidemiology, biological nature and pharmacologic treatment of ADHD. The first part of the presentation was absolutely conventional allopathic psychiatry, inclusive of brain imaging.
The second part of the presentation considered: "If we are thinking about biological, psychological, and behavioral interventions for a 'psychiatric' patient, shouldn't we be considering the TWO biological levels?" The most normal biological level that "biologically trained psychiatrists" consider is medications and medication effectiveness. However, sometimes even the most vigorous, precise, and heroic efforts do not work. The potential confound it the underlying physiological, hormonal, nutrient, antioxidant, PUFA-rich state associated with optimal health and well being.
In the final analysis, shouldn't we make sure that we have BOTH of these biological foundations right?
We hope that you enjoy this provocative slide presentation.
A diagnostic schema is a cognitive tool that allows clinicians to systematically approach a clinical problem by providing an organizing scaffold. A commonly used schema for acute kidney injury (AKI) separates this problem into pre-renal, intrinsic, and post-renal causes. By approaching AKI using these categories, clinicians can systematically access and explore individual illness scripts as potential diagnoses.
1) The document discusses the evolution of problem representation during a clinical encounter as more information is gathered. It provides an example of a case of a young woman initially presenting with fatigue and abdominal pain whose problem representation changes as additional symptoms of rash and facial palsy emerge.
2) Over the course of several visits and with additional testing revealing panuveitis and lung nodules, the problem representation evolves to that of a sexually active young woman with systemic symptoms consistent with acute sarcoidosis.
3) She is ultimately diagnosed with acute sarcoidosis and her symptoms resolve with corticosteroid treatment.
Carle General Surgery Grand Rounds presentation on palliative care symptom management, specifically pain, nausea, constipation, and malignant bowel obstruction.
Healthy Brain Aging: Exercise, Nutrition, and Preventing ADDUKE
This document discusses ways to promote healthy brain aging and reduce the risk of Alzheimer's disease. It emphasizes controlling health conditions like diabetes and high blood pressure through diet and exercise. Regular mental and physical activity are also recommended, such as puzzles, games, and social engagement to exercise the brain and reduce stress. A healthy diet with fruits and vegetables can help protect the brain from oxidative stress and reduce risk of cardiovascular disease.
Steve Jobs was diagnosed with pancreatic cancer at age 48 in 2003, with symptoms starting at age 24. He died from the disease at age 56 in 2011. Vitamin D from moderate sun exposure without sunscreen may help lower the risk of certain cancers like pancreatic, as it is nearly 50% less likely in those with higher vitamin D levels from sun exposure. While surgery, radiation, and chemotherapy have been standard cancer treatments for decades, they have shown little improvement in overall survival rates for all cancers in the last 55 years. Alternative non-toxic treatments exist but are suppressed.
Women are diagnosed with bipolar disorder on average 3.2 years later than men and are more likely to experience a delay in seeking treatment. They are also more likely to have a depressive first episode and experience more rapid cycling of moods. Women tend to have more severe depressive episodes and mixed episodes than men. Improving recognition of gender differences and barriers to recovery such as unemployment, lack of social support and exploitation could help enhance quality of life and management of symptoms for women living with bipolar disorder.
Toluwalase Ajayi MD presented on palliative care for patients with dementia. Key points include:
- Dementia prevalence is increasing as the population ages and life expectancy rises.
- Palliative care aims to improve quality of life for patients and families dealing with dementia.
- Management involves a multidisciplinary team and focuses on both pharmacological and non-pharmacological approaches.
- Advance care planning is important to help families navigate challenging end-of-life decisions as the disease progresses.
The Physician In Spite of Himself (returns!) -San Antonio 2014Louis Cady, MD
In this first of four lectures delivered at the IMMH Conference in San Antonio, Texas - September 19, 2014 - Dr. Cady touches on themes from last year's presentation and introduces fun and exciting new ways to look at function medicine. This year's talk heavily emphasizes the role of nutritional supplementation in supporting the structure and function of the human body. Updates from clinical cases encountered last year are also covered. General topics in this presentation include:
- the importance of evaluating and balancing the thyroid axis
- the importance of sex steroids and DHEA
- the importance of antioxidants, mineral, multivitamins, and essential fatty acids in optimal health
- the need to clearly identify, articulate, and treat the differences between something that is a pure "psychiatric" condition and the covert masqueraders which may actually represent undiagnosed and untreated physiological/medical conditions until addressed.
This document provides a summary of a presentation on vitamin supplementation and essential nutrients. It discusses declining nutrient levels in foods and soils, the importance of antioxidants and micronutrients for health, and evidence that supplementation can help address deficiencies and support overall wellness. Studies are cited showing the benefits of supplements for conditions like cardiovascular health, testosterone levels, and depression.
Killer Drugs and the Supplement Hall of FameLouis Cady, MD
In the fourth and final lecture of his series at the IMMH Conference in Chicago, IL at McCormick Place, September 22, 2013, Dr. Cady covers the "for sure" interactions to watch out for between specific drugs and their common points of interaction.
After examining those potentially toxic interaction, he continues into a review of peer-reviewed evidence for the appropriate, thoughtful, and precise use of specific supplements in a targeted approach. The role of good basic antioxidant protection is discussed, as is the need for B-vitamins, Omega 3 fatty acids, and several others.
Natural Treatments for ADHD - April 11, 2018Louis Cady, MD
This presentation will be delivered April 11, 2018 on recorded webinar for the Autism Global Conference. It was my pleasure to prepare and present this lecture (in webinar form), outlining a coherent philosophy of finding biological underpinnings that can cause or contribute to, or exacerbate, mental dysfunction. In the case of this presentation, the question is "How much of ADHD symptomatology is caused by a lack of a good medication, or, rather, lack of a coherent strategy for finding and fixing underlying biological abnormalities?"
Those biological abnormalities in this presentation include MTHFR polymorphisms, COMT polymorphisms, elemental deficiencies (lithium, magnesium, zinc, iron, and copper), essential fatty acid deficiencies, the confound of high fructose corn syrup, and many others.
Rational strategies for nutraceutical intervention are reviewed.
Natural Treatments for ADHD (TADH) in Sao Paulo, Brazil, for Laboratorio Grea...Louis Cady, MD
In this presentation, given at UNIP (Campus Paraiso - Sao Paulo, SP Brazo) for the 2019 Congresso de Saude Mental (Conference on Mental Health), Dr. Cady reviewed the prevalence, inheritability, and social ramifications of ADHD (TADH in Brazil). He specifically reviewed multiple holistic interventions, including limiting "electric screen time,"good quality diet with adequate amounts of essential fatty acids and critically important trace elements, and the use of pharmacogenomic testing as well as functional, integrative medicine testing, all to better characterize logical and reeasonmable points for holistic intervention.
This presentation was simultaneously translated into Portugue for the attendees, but unfortunately the slides were not available in translated form.
For further information in Brazil on this topic, or to order a video/audio recording of the conference (in Portuguese),contact Luiz Dias of Laboratorio Great Plains in Brazil.
Medicine: A State of CRISIS, a State of CHANGELouis Cady, MD
Dr. Cady returns this year to repeat and update one of the most talked about presentations of the 2015 IMMH conference. In this presentation, Dr. Cady deconstructs the pressures and challenges facing patients, physicians, and all health care practitioners in today's practice environment. The role of integrated practice and functional medicine as a "differentiating factor" in one's practice is reviewed. The need for patients to adapt a healthy life style and take responsibility for their health for their own economic self-preservation is also touched on.
Caring for all in the last year of life: making a difference.Bruce Mason
Inaugural presentation by Prof. Scott A. Murray, St Columba's Hospice Chair of Primary Palliative Care, Primary Palliative Care Research Group, Centre for Population Health Sciences: General Practice Section, University of Edinburgh. April 21, 2009
- A study on fruit flies found that restricting eating to a 12-hour period each day led to better sleep, less weight gain, and healthier hearts compared to those that ate throughout the day, despite eating similar amounts.
- A small study on humans with type 2 diabetes found that eating a larger breakfast and smaller dinner helped control blood sugar levels throughout the day.
- Research shows that zinc lozenges may help shorten the duration of cold symptoms like nasal discharge and cough if started within 24 hours for periods under two weeks.
1) Dual process theory describes two modes of thinking: System 1 thinking is intuitive, quick, and based on pattern recognition. System 2 thinking is slow, analytical, and deliberate.
2) A 59-year-old man presented with chest pain and elevated cardiac troponin. Initial diagnosis was non-ST elevation myocardial infarction (NSTEMI) based on System 1 thinking.
3) Further examination revealed new cardiac murmurs, neurological symptoms, and asymmetric blood pressure, inconsistent with NSTEMI. This triggered a transition to System 2 thinking and a new diagnosis of aortic dissection was made.
How to Transition from Allopathic to Integrated Practice - IMM Brazil 2015Louis Cady, MD
In this lecture, Dr. Cady compares and contrasts the significance differences, both conceptually and practically, between the conventional practice of medicine and a more rational, functional, integrated approach. Tactical concepts and didactic tools to make the transition are reviewed.
This case describes a 60-year-old woman presenting with choreiform movements, weight loss, and dysarthria over the past 6 months. Imaging showed T1 hyperintensity in the basal ganglia. She tested positive for anti-CRMP-5 antibodies, which are associated with malignancy in over 90% of cases. Further workup revealed a small cell lung cancer. Her symptoms improved with cancer treatment and decreasing antibody levels, indicating this was a paraneoplastic neurological syndrome.
"Killer Drugs & The Supplement Hall of Fame" - IMMH Brazil, 2015Louis Cady, MD
In this presentation, the third of three lectures Dr. Cady delivered in São Paulo, Brazil, Dr. Cady reviews the critical patterns of interactions with numerous frequently prescribed psychotropic medications (and others). Emphasis is given on how not to commit an obvious drug-drug interaction as well as avoiding more subtle ones. The focus then shifts to supplements: which ones are the best, which ones have mental health benefits, and how to avoid interactions between conventionally used supplements and psychiatric medications.
This document discusses an evolutionary medicine approach to mental health and resilience. It argues that existing mental health treatments are only partially effective and that a new approach is needed. Mental illnesses are linked to differences between our current lifestyle and our hunter-gatherer past, and are influenced by genes, stress, diet, and inflammation. Adopting a lifestyle focused on nutrient-dense foods, stress management, sleep, exercise and social connection could help build resilience against mental illness by better matching our biology. However, randomized trials of this evolutionary approach are still needed.
- Healthy brain aging is important due to the rising prevalence of age-related cognitive disorders like Alzheimer's disease.
- Brain aging is influenced by both modifiable and non-modifiable risk factors. Engaging in heart-healthy habits, cognitive activities, and social interaction may help promote healthy brain aging.
- When discussing brain health with older patients, physicians should evaluate risk factors and encourage lifestyle changes like exercise, a healthy diet, cognitive stimulation, and social engagement.
In his fourth and concluding lecture of the IMMH Conference in San Antonio, 2014, Dr. Cady reviews the statistics, epidemiology, biological nature and pharmacologic treatment of ADHD. The first part of the presentation was absolutely conventional allopathic psychiatry, inclusive of brain imaging.
The second part of the presentation considered: "If we are thinking about biological, psychological, and behavioral interventions for a 'psychiatric' patient, shouldn't we be considering the TWO biological levels?" The most normal biological level that "biologically trained psychiatrists" consider is medications and medication effectiveness. However, sometimes even the most vigorous, precise, and heroic efforts do not work. The potential confound it the underlying physiological, hormonal, nutrient, antioxidant, PUFA-rich state associated with optimal health and well being.
In the final analysis, shouldn't we make sure that we have BOTH of these biological foundations right?
We hope that you enjoy this provocative slide presentation.
A diagnostic schema is a cognitive tool that allows clinicians to systematically approach a clinical problem by providing an organizing scaffold. A commonly used schema for acute kidney injury (AKI) separates this problem into pre-renal, intrinsic, and post-renal causes. By approaching AKI using these categories, clinicians can systematically access and explore individual illness scripts as potential diagnoses.
1) The document discusses the evolution of problem representation during a clinical encounter as more information is gathered. It provides an example of a case of a young woman initially presenting with fatigue and abdominal pain whose problem representation changes as additional symptoms of rash and facial palsy emerge.
2) Over the course of several visits and with additional testing revealing panuveitis and lung nodules, the problem representation evolves to that of a sexually active young woman with systemic symptoms consistent with acute sarcoidosis.
3) She is ultimately diagnosed with acute sarcoidosis and her symptoms resolve with corticosteroid treatment.
Carle General Surgery Grand Rounds presentation on palliative care symptom management, specifically pain, nausea, constipation, and malignant bowel obstruction.
Healthy Brain Aging: Exercise, Nutrition, and Preventing ADDUKE
This document discusses ways to promote healthy brain aging and reduce the risk of Alzheimer's disease. It emphasizes controlling health conditions like diabetes and high blood pressure through diet and exercise. Regular mental and physical activity are also recommended, such as puzzles, games, and social engagement to exercise the brain and reduce stress. A healthy diet with fruits and vegetables can help protect the brain from oxidative stress and reduce risk of cardiovascular disease.
Steve Jobs was diagnosed with pancreatic cancer at age 48 in 2003, with symptoms starting at age 24. He died from the disease at age 56 in 2011. Vitamin D from moderate sun exposure without sunscreen may help lower the risk of certain cancers like pancreatic, as it is nearly 50% less likely in those with higher vitamin D levels from sun exposure. While surgery, radiation, and chemotherapy have been standard cancer treatments for decades, they have shown little improvement in overall survival rates for all cancers in the last 55 years. Alternative non-toxic treatments exist but are suppressed.
Women are diagnosed with bipolar disorder on average 3.2 years later than men and are more likely to experience a delay in seeking treatment. They are also more likely to have a depressive first episode and experience more rapid cycling of moods. Women tend to have more severe depressive episodes and mixed episodes than men. Improving recognition of gender differences and barriers to recovery such as unemployment, lack of social support and exploitation could help enhance quality of life and management of symptoms for women living with bipolar disorder.
Toluwalase Ajayi MD presented on palliative care for patients with dementia. Key points include:
- Dementia prevalence is increasing as the population ages and life expectancy rises.
- Palliative care aims to improve quality of life for patients and families dealing with dementia.
- Management involves a multidisciplinary team and focuses on both pharmacological and non-pharmacological approaches.
- Advance care planning is important to help families navigate challenging end-of-life decisions as the disease progresses.
The Physician In Spite of Himself (returns!) -San Antonio 2014Louis Cady, MD
In this first of four lectures delivered at the IMMH Conference in San Antonio, Texas - September 19, 2014 - Dr. Cady touches on themes from last year's presentation and introduces fun and exciting new ways to look at function medicine. This year's talk heavily emphasizes the role of nutritional supplementation in supporting the structure and function of the human body. Updates from clinical cases encountered last year are also covered. General topics in this presentation include:
- the importance of evaluating and balancing the thyroid axis
- the importance of sex steroids and DHEA
- the importance of antioxidants, mineral, multivitamins, and essential fatty acids in optimal health
- the need to clearly identify, articulate, and treat the differences between something that is a pure "psychiatric" condition and the covert masqueraders which may actually represent undiagnosed and untreated physiological/medical conditions until addressed.
This document provides a summary of a presentation on vitamin supplementation and essential nutrients. It discusses declining nutrient levels in foods and soils, the importance of antioxidants and micronutrients for health, and evidence that supplementation can help address deficiencies and support overall wellness. Studies are cited showing the benefits of supplements for conditions like cardiovascular health, testosterone levels, and depression.
In this presentation, Dr. Cady builds on previous lectures dealing with anti-oxidants and vitamin, mineral, and soil depletion to add discussions of vinpocetine and Bacopa monieri, as well as a discussion of the Medhya Rasayana approach from centuries old Aryuvedic practice in India. There is an emphasis on obtaining solid multivitamin, multi-mineral, and antioxidant support. References for two supplements lines (Physiologics and Metagenics) are given.
An overview of the practice of Louis B. Cady, MD and the Cady Wellness Institute for Business Networking International - Network Exchange Chapter - May 20, 2010 - Evansville, IN
New Concepts in Micronutrient Adequacy and Health Optimization - Cady = May 1...Louis Cady, MD
In this presentation, Dr. Cady revisits the BioPhotonic Scanner and current concepts in lack of nutrient adequacy in the contemporary diet. The role of appropriate supplementation with vitamins, minerals, and antioxidants is reviewed.
This is the lecture delivered by Dr. Cady at the Evansville Public LIbrary on February 27, 2013. My apologies for the lateness. I attempted to post this once and it didn't "take."
this lecture will be repeated, with some updates, on April 4th, 2013, again at the downtown Evansville Public LIbrary. The room is extraordinarily good in which to present. LIve attendance is encouraged and invited!
This document discusses various topics related to cancer, including increasing cancer rates, flaws in conventional cancer treatments, and alternative natural treatments. It notes that cancer rates have increased significantly in recent decades and survival rates have not improved much in 55 years. It questions the suppression of alternative cancer cures and discusses how various foods, drugs, and other toxins may contribute to cancer development and rates. Natural alternative treatments for cancer are presented, along with cases of cancer being cured without conventional treatments.
The document summarizes key topics from Chapter 1 of the textbook "Gerontological Nursing" including demographics of aging populations, leading causes of death and disability, theories of aging, and healthy aging. It discusses how the population over age 60 is projected to double globally in the next 50 years. Common causes of death among older adults are heart disease, cancer, stroke and chronic lung/kidney disease. Theories of aging include biological, psychological, and sociological perspectives.
This document discusses lifestyle medicine and the formation of a lifestyle medicine interest group at UCSF. It provides background on lifestyle medicine, including its focus on using lifestyle interventions like nutrition, exercise, and stress management to treat and manage disease. It summarizes evidence that lifestyle factors account for the majority of chronic disease risk and that lifestyle changes can significantly reduce risks. The interest group aims to help members develop expertise in lifestyle medicine, practice healthy living themselves, and do outreach and coaching to others. Meetings will include discussions, speakers, and health education on various topics related to lifestyle and chronic disease.
CDC Health Disparities and Inequalities Report — United StatMaximaSheffield592
CDC Health Disparities and Inequalities Report —
United States, 2013
Supplement / Vol. 62 / No. 3 November 22, 2013
U.S. Department of Health and Human Services
Centers for Disease Control and Prevention
Morbidity and Mortality Weekly Report
Supplement
The MMWR series of publications is published by the Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention (CDC),
U.S. Department of Health and Human Services, Atlanta, GA 30333.
Suggested Citation: Centers for Disease Control and Prevention. [Title]. MMWR 2013;62(Suppl 3):[inclusive page numbers].
Centers for Disease Control and Prevention
Thomas R. Frieden, MD, MPH, Director
Harold W. Jaffe, MD, MA, Associate Director for Science
Joanne Cono, MD, ScM, Acting Director, Office of Science Quality
Chesley L. Richards, MD, MPH, Deputy Director for Public Health Scientific Services
MMWR Editorial and Production Staff
Ronald L. Moolenaar, MD, MPH, Editor, MMWR Series
Christine G. Casey, MD, Deputy Editor, MMWR Series
Teresa F. Rutledge, Managing Editor, MMWR Series
David C. Johnson, Lead Technical Writer-Editor
Jeffrey D. Sokolow, MA, Catherine B. Lansdowne, MS,
Denise Williams, MBA, Project Editors
Martha F. Boyd, Lead Visual Information Specialist
Maureen A. Leahy, Julia C. Martinroe,
Stephen R. Spriggs, Terraye M. Starr
Visual Information Specialists
Quang M. Doan, MBA, Phyllis H. King
Information Technology Specialists
MMWR Editorial Board
William L. Roper, MD, MPH, Chapel Hill, NC, Chairman
Matthew L. Boulton, MD, MPH, Ann Arbor, MI
Virginia A. Caine, MD, Indianapolis, IN
Barbara A. Ellis, PhD, MS, Atlanta, GA
Jonathan E. Fielding, MD, MPH, MBA, Los Angeles, CA
David W. Fleming, MD, Seattle, WA
William E. Halperin, MD, DrPH, MPH, Newark, NJ
King K. Holmes, MD, PhD, Seattle, WA
Timothy F. Jones, MD, Nashville, TN
Rima F. Khabbaz, MD, Atlanta, GA
Dennis G. Maki, MD, Madison, WI
Patricia Quinlisk, MD, MPH, Des Moines, IA
Patrick L. Remington, MD, MPH, Madison, WI
William Schaffner, MD, Nashville, TN
Asthma Attacks Among Persons with Current Asthma —
United States, 2001–2010 .......................................................................... 93
Diabetes — United States, 2006 and 2010 ............................................ 99
Health-Related Quality of Life — United States, 2006 and 2010 .... 105
HIV Infection — United States, 2008 and 2010 .................................. 112
Obesity — United States, 1999–2010 .................................................... 120
Periodontitis Among Adults Aged ≥30 Years —
United States, 2009–2010 ........................................................................ 129
Preterm Births — United States, 2006 and 2010 ............................... 136
Potentially Preventable Hospitalizations — United States,
2001–2009 .................................................................................................... 139
Prevalence of Hypertension and Contr ...
Cancer 101 provides an overview of cancer including definitions, statistics, risk factors, and lifestyle measures for prevention. It reviews that cancer is abnormal cell growth, the second leading cause of death, and risk is increased by certain lifestyle behaviors like poor nutrition, lack of exercise, stress, sleep issues, and toxic exposures. Maintaining a healthy lifestyle through diet, exercise, managing stress, adequate sleep, and avoiding toxins can help lower cancer risks.
“THE GLOBAL CASE FOR ACTION: ACKNOWLEDGING POVERTY AS A DETERMINANT OF MEN’S HEALTH”
SCIENTIFIC PROGRAMME DAY THREE
THIRD JAPAN-ASEAN MEN’S HEALTH AND AGING CONFERENCE
03 DECEMBER 2008
SINGAPORE
Plenary 8: jmh and ISMH Joint Lecture
Dr. April M. W. Young
Jefferson University Hospitals' April 2013 Cancer Survivorship Conference Pre...jeffersonhospital
At Jefferson University Hospitals' Cancer Survivorship Conference on April 12, 2013, Mary McCabe of Memorial Sloan-Kettering Cancer Center gave the keynote address. Jefferson's new Survivorship platform includes biannual conferences featuring keynote speakers and several breakout sessions to give cancer patients, survivors and caregivers a better understanding of survivorship and what comes next after a cancer diagnosis. This is a free event open to all cancer patients and survivors. Learn more: http://www.jeffersonhospital.org/departments-and-services/kimmel-cancer-center/cancer-survivorship-program
HSC PDHPE Core 1: Health Priorities in AustraliaVas Ratusau
This document discusses health priorities in Australia. It begins by outlining how priority health issues are identified through measuring a population's health status using epidemiology. Key measures include mortality, infant mortality, morbidity, and life expectancy. Priority issues are also identified by considering social justice principles and groups experiencing health inequities such as Aboriginal and Torres Strait Islanders, those in rural/remote areas, and lower socioeconomic groups. The document then discusses Australia's main health priorities as being cardiovascular disease, cancer, mental health issues, and diabetes. It emphasizes the role prevention and early intervention can play in addressing these priorities.
This document summarizes a presentation by Magda Peck on women's health advocacy. It discusses leading causes of death for women in the US including heart disease and cancer. It also provides statistics on health conditions affecting US women such as obesity and smoking rates. The document reviews recommendations from reports on improving women's health research and access to preventive services. It discusses the importance of annual well-woman visits and expanded insurance coverage of women's healthcare under the Affordable Care Act. The presentation emphasizes the role of women in making health decisions and advocating for their own health and the health of others.
This document discusses gender differences in cardiac care. It summarizes findings from a study that used MRI scans to analyze how male and female hearts change with age. The study found significant differences: the male heart muscle grows thicker with age while the female heart retains its size or gets slightly smaller. This has implications for the types of heart failure seen in each gender and indicates a need for gender-specific treatments. Currently, diagnostics and treatments are often developed based on the male heart model. The study suggests men and women may develop heart disease for different reasons.
Osteoporosis is common in nursing home residents, affecting around 86% of residents. It is associated with higher rates of fractures. Treatment focuses on calcium, vitamin D, bisphosphonates, denosumab, and teriparatide depending on mobility and swallowing ability. Treatment aims to increase bone mineral density and reduce fractures, but medications also need to be considered based on renal function and goals of care including end of life care.
| Jose Poulose | Preventive health services by Dr jose poulose |Dr. Jose Poulose
Doctors of internal medicine concern on adult medicine and also had special study and best training focusing on the prevention and treatment of adult diseases or sickness
Carlos Pellegrini: From Success to SignificanceNIHACS2015
Carlos Pellegrini, MD, is Past President of the American College of Surgeons and Chairman of the Department of Surgery at the University of Washington in Seattle, where he developed the Center for Videoendoscopic Surgery, the Center for Esophageal and Gastric Surgery, and the Institute for Simulation and Interprofessional Studies (ISIS).
He delivered a keynote presentation entitled, “From Success to Significance."
Similar to Optimized Aging with Nutritional & Weight Management Techniques (20)
SEND IN THE SHRINKS - 2009 Oliver CME seminarLouis Cady, MD
This one was fun.
I was invited by Dr. Randalll Oliver, MD, Founder of the Oliver Heachache and Pain Clinic in Evansville, to present to an audience of primary care practitioners about how to use pysychiatric mediations ("psychopharmacology") in clinical practice.
Along the way, I covered, ADHD and treatments, depression, anxiety, erectile dysfunction, hypoadrenia, and even touched on hypothyroidism. Although this presentation was in 2009, all of the drugs covered are stills in use, and, at times.... stupidly.
This presentation deconstructs the intricacies of selecting and antidepressant, particularly in the SSRI class.
What is the nature of QUALITY in medicine -for ASQ 11 14 2023.pptLouis Cady, MD
In this presentation, Dr. Cady deconstructs the tensions and stressors on both patients and health care providers in today's system.
This presentation reviews checklists foe liminating mistakes, the actual number of mistakes that are being made in medical practice, and what patients and their loved ones can do for self protection.
This isn't a "bash the doctor" presentation. It's a thoughtful, careful exploration of stresses and ramifications to the current US healthcare system.
This document provides information about a presentation given by Dr. Louis B. Cady on transcranial magnetic stimulation (TMS) as a treatment for depression. It begins with Dr. Cady's credentials and commercial disclosure stating he has received honoraria from several companies but that this presentation is not being underwritten by any company. The presentation then covers how TMS works, its safety and effectiveness compared to antidepressant medications and electroconvulsive therapy (ECT), and its inclusion in treatment guidelines for depression.
Hormones and Mental Health - Thyroid and Testosterone.pptxLouis Cady, MD
In this presentation for the Psychiatry Redefined program, Dr.
Cady breaks down and deconstructs the accepted, unthinking, "practice guideline based" notions of thyroid and tesotsterone, with there seemingly "normal" levels and dosing, versus what the actual peer reviewed medical literature says. In this presentation, do use of all forms of thyroid, and all forms of testosterone are reviewed. The idiocy of "T4 only treatment" is covered. The use of T4, T3, a combination of T4 and T3, and all of the porcine and compounded products is review.
In terms of testosterone, dr. Katie reviews the concept of "do you want to be optimal or do you want to be normal." He notes that it is "normal" for oil in cars to deteriorate and break down with age. It's also "normal" for men's and women's testosterone (as well as thyroid) to go down with age. The question is, "do we want to do anything about it?"
Logical ways of intervening in both the thyroid and female and male gonadal axes are covered. There is scrupulous attention paid to the thyroid hormone pathways, and the relevance of reverse T3 versus free T3. Similarly, in terms of women, the downstream effect of estradiol coming from testosterone is also reviewed.
The Moral Imperative of Integrative Medicine 2022.pptLouis Cady, MD
The document discusses the case of a 16-year-old teenager with a long history of treatment-resistant depression and anxiety. Previous medication trials with SSRIs, SNRIs, atypical antipsychotics, and lamotrigine had failed to provide sustained relief. Upon further evaluation, the doctor found potential contributing factors including an undiagnosed MTHFR gene mutation and hormonal imbalances. The doctor adjusted the teenager's supplements and medications, focusing on addressing the underlying functional issues. At follow-up several months later, the teenager reported significantly improved mood with only brief periods of low mood, though menstrual irregularities persisted.
THE MORAL IMPERATIVE OF INTEGRATIVE MEDICINE - O IMPERATIVO MORAL DA MEDICINA...Louis Cady, MD
Neste programa, o Dr. Cady baseia-se em uma série de casos clínicos para ilustrar a necessidade absoluta e moral do tratamento de precisão de nossos pacientes com todas as ferramentas disponíveis para uso por meio da medicina integrativa.
O uso de testes de polimorfismo MTHFR, testes convencionais e laboratoriais e testes farmacogenômicos foram revisados.
Os casos apresentados ilustram a trágica dificuldade de um menino com deficiência de MTHFR que estava prestes a desviar sua vida; um paciente esquizofrênico com vários problemas de medicina funcional que precisavam ser resolvidos (levedura, glúten, sensibilidade alimentar de IgG); uma estudante universitária a quem foi dito "não há nada de errado com você; seus laboratórios estão bem", embora ela tenha manifestado todos os sintomas relevantes de hipotireoidismo; e um CEO do sexo masculino de 42 anos que estava "tão cansado que parecia morrer" e que, na verdade, estava funcionalmente com pouco testosterona. O último caso revisado foi de um adorável garotinho que tinha autismo e foi recuperado por meio de uma abordagem focada e intensa de medicina integrativa.
Subtitle: The Moral Imperative of Integrative Medicine
This presentation, two hours in length, was delivered to the A4m MMI Audience in their Frontiers of Neurology - Module 3.
The following topics are reviewed:
- ADHD, Autism, Depression, Schizophrenia
- the impact of neuroinflammation on all of these.
- confounding factors and the ways to mitigate them: Omega6/Omega 3 imbalance in the Western diet, MTHFR polymorphism, the use of elemental lithium, the presence of intestinal dysbiosis and the role of gluten/dairy IgG Food allergies.
- pharmacogenomic testing
The Moral Imperative of Integrative Medicine - IMMH 2020Louis Cady, MD
IN this presentation, Dr. Cady reviews several of the handful of functional, integrative medicine techniques required for a holistic and comprehensive management of psychiatric issues. MTHFR, hormone balance, diagnosis and treating intestinal dysbiosis, need for trace elements, and hormones (including thyroid, testosterone and estradiol) are reviewed.
This brief webinar, a gift to the local Jewish community and Temple Adath B'Nai Israel here in Evansville, IN, reviews the tradition of mindfulness and the interdigitation of Buddhist practices with some Jewish traditions. Dr. Cady reviews the downstream effects of stress, how meditation and mindfulness are useful tools and techniques, and actually how to practice it. Multiple references without being complicated or overdone are provided.
Webinar 5: Designing Your Future: WHAT'S COMING NEXT?Louis Cady, MD
In this capstone webinar presentation, closing out Dr. Cady's series on dealing with COVID 19, he turns his attention to a nunmber of interesting thems:
- what's the REAL case fatality rate of COVID 19
- How is it likely that society will reopen?
- What's going to happen in education and medicine?
- What's going to happen when the robots and AI arrive?
- What's the future going to be out 500 years?
HOW TO COPE WITH THE PSYCHOLOGICAL IMPACT OF COVID 19 AND SOCIAL DISTANCINGis...Louis Cady, MD
In this presentation, Dr. Cady will review:
- What did Sparky learn about not being an emotional support animal?
- "Do it to yourself psychotherapy." Learn the following:
- What are the wrong - and the RIGHT ways of any sort of "behavioral therapy"?
- How to use a journal to think RATIONALLY and “get out of your head.”
- How to get out of your HEAD and into your LIFE.
- We'll cover all 10 of David Burns’ cognitive distortions, customized and gift-wrapped for dealing with COVID 19.
- We will cover actionable examples of how to reprogram yourself.
We will review What are the 3 P's of Positive Psychology and Learned Optimism?
The Cady 5 "5P’s” and “How to shrink yourself."
Can we find the GOOD in COVID?
This presentation is meant to be provocative and to challenge you mentally, intellectually, and emotionally. Some of the great thinkers and exemplars of human performance and possibility are featured.
BOOSTING YOUR IMMUNITY During the COVID 19 PandemicLouis Cady, MD
In this presentation, presented as a live webinar on Monday, April 27th, Dr. Louis Cady of the Cady Wellness Institute reviewed practical, common-sense things that can be done to boost your immunity, with documentation from the peer-reviewed medical literature. Dr. Cady also reviews supplements and nutrients that are established in the peer-reviewed medical literature as having antiviral capabilities. These include Vitamins C,D, and E, Zinc, carotenoids and antioxidants, probiotics, the reishi mushroom, elderberry, cannabidiol (CBD - not marijuana or weed!).
Points presented are scrupulously documented from the medical literature. This presentation does not guarantee or represent that using ANY of these nutrients will "keep you from getting infected or dying" from COVID 19. They are presented for your thoughtful consideration.
Tratamento holistica de ezschizophrenia - São Paulo, Brazil April 20, 2019Louis Cady, MD
Esta é a versão em inglês da apresentação do Dr. Cady feita na UNIP (Campus Paraiso - São Paulo, SP Brasil) para o Congresso de Saúde Mental de 2019 (Conferência sobre Saúde Mental). Foi entregue em 20 de abril de 2019.
Nesta apresentação, o Dr. Cady analisa brevemente a história da esquizofrenia, a falha do bloqueio do receptor de dopamina D2 como uma cura universal na esquizofrenia, e várias intervenções holísticas que podem impactar forte e positivamente os sintomas da esquizofrenia. Incluídos na pesquisa do Dr. Cady estavam o papel dos ácidos graxos essenciais, deficiências nutricionais (particularmente vitaminas do complexo B), o perigo de supercrescimento da cândida, testes farmacogenômicos, polimorfismos da MTHFR e muito mais.
Foi uma honra e um privilégio entregar esta apresentação em
São Paulo.
Para mais informações no Brasil sobre este tema, ou para solicitar uma gravação em vídeo / áudio da conferência, entre em contato com Luiz Dias do Laboratório Grandes Planícies no Brasil.
Slides, até o apêndice, são traduzidos por Luiz Dias.
The integrative treatment of schizophrenia brazil 2019Louis Cady, MD
This is the English language version of Dr. Cady's presentation given at UNIP (Campus Paraiso - Sao Paulo, SP Brazil) for the 2019 Congresso de Saude Mental (Conference on Mental Health). It was delivered April 20, 2019.
This presentation also includes extra slides in the appendix that were not presented, and, unfortunately, these slides of the appendix have not been translated in the Portuguse version of this presentation.
In this presentation (Portuguese presentation will also be posted next), Dr. Cady briefly reviews the history of schizophrenia, the failure of the dopamine D2 receptor blockage as a universal cure-all in schizophrenia, and various holistic interventions which can strongly and positively impact symptoms of schizophrenia. Included in Dr. Cady's survey were the role of essential fatty acids, nutrient deficiencies (particularly B vitamins), the danger of overgrowth of candida , pharmacogenomic testing, MTHFR polymorphisms, and more.
It was an honor and a privilege to deliver this presentation in
São Paulo,.
For further information in Brazil on this topic, or to order a video/audio recording of the conference (in Portuguese),contact Luiz Dias of Laboratorio Great Plains in Brazil.
Thyroid, Adrenals, and Sex Steroids - A Balancing ActLouis Cady, MD
This was the second presentation gibven on MZarch 29, 2019 at the Manlove Psychiagtric Group and Brain Injury Institute spring conference in Rapid City, SD.
In this presentation, Dr. Cady carefully goes over the necessity of integrating and overview and awareness of hormones and their levels in the elucidation of what truly is going on with the patient.
This was an overview lecture only. Dr. Cady will be presenting a 16 hour CME program in Austin Texas on June 22 and 23 for the National Procedures Institute, and will explore all aspects of all relevant hormones and what can be done to manage and optimize them.
Medical Discussion of the Endocannabinoid SystemLouis Cady, MD
This document contains a slide deck presentation on hemp oil and the endocannabinoid system. It discusses the history of research on cannabis, the endogenous cannabinoid system, and how various interventions can upregulate this system. Throughout, it stresses that the information is for educational purposes only and that no claims are being made about Zilis products treating, preventing, or curing any diseases.
This document provides an overview of a lecture on thyroid health. It begins with the speaker, Louis Cady, MD, disclosing commercial relationships and interests. It then outlines the structure of the lecture, which will cover thyroid basics, practical information, and conclusions. The document discusses conventional thyroid testing and its limitations. It also reviews factors that affect thyroid hormone production and conversion. Overall, the document introduces topics to be covered in the lecture regarding thyroid function and testing.
The document summarizes a presentation on the holistic medicine approach to treating schizophrenia. It discusses the multiple domains affected by schizophrenia, including positive and negative symptoms, cognitive dysfunction, and social deficits. It reviews the etiology and pathogenesis of schizophrenia. It then presents a case study of a patient with schizophrenia who was treated holistically over many years with integrative testing to identify deficiencies and allergies, dietary changes, supplements, low dose lithium, and antifungals. The patient showed significant improvement with this approach.
THE ENDOCANNABINOID SYSTEM - Cady Wellness InstituteLouis Cady, MD
This lecture, presented on February 2, 2018 at the Cady Wellness Institute in Newburgh, IN, represented Dr. Cady's review of the current peer-reviewed medical literature current as of that morning. The concepts of "endocannabinoids" vs. "phytocannabinoids" were reviewed. Themes in the medical literature were explored, including the relationship of the endocannabinoid system and CB! and CB2 receptors to modulate hippocampal neurogenesis, cause apoptosis in breast cancer cells, and many other interesting correlations. A careful review of legal vs illegal options for obtaining plant phytocannabinoids in the state of Indiana was emphasized.
A abordagem da Medicina Integrativa para o Tratamento da EsquizofreniaLouis Cady, MD
This is the presentation that Dr. Cady gave in São Paulo, Brazil, in October of 2017 on the integrtive treatment of schizophrenia. The one in English is already posted. My thanks to Luiz Dias, of Laboratorio Great Plans in Brazil, for his impeccable translation.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Identification and nursing management of congenital malformations .pptx
Optimized Aging with Nutritional & Weight Management Techniques
1. Optimized Aging With Nutritional
& Weight Management Techniques
presented for USI Mid-America Institute on Aging
August 15, 2014
Louis B. Cady, M.D., FAPA
CEO, Founder – Cady Wellness Institute
Newburgh, Indiana
2. H - 2
“There are two objects of medical education: to heal
the sick and to advance the science.”
- Dr. Charles H. Mayo, MD
“The glory of medicine is that it is always moving
forward, that there is always more to learn.”
- Dr. William J. Mayo
3. “If some real disaster impends in the city, it is not because
parking spaces are hard to find, because architecture is
bad, because department store sales are declining, or even
because taxes are rising. If there is a genuine
crisis, it has to do with the essential welfare
of individuals or with the good health of the
society, not merely with comfort, convenience,
amenity, and business advantage, important as these
are.”
from The Unheavenly City, Edward C. Banfield, 1968, 1970
Disaster awaits.
4. Theses for this presentation:
• What we eat is important.
– Micronutrient adequacy
– Macronutrient reasonableness
• Weight issues are related to type, amount,
and quantity consumed, as well as
micronutrient adequacy, physical exercise
and hormonal stability.
• Our functioning as we age and our freedom
from disease and depression is a function of
our diet and behavior.
5. Human nutritional physiology in one slide
• Macronutrients – provide calories:
– Carbs (can be made from proteins by gluconeogenisis)
• C,H, O atoms
– fat – some are essential and cannot be synthesized
– (large amounts of processed vegetable oils skew Omega 6:3 ratio)
– protein – (C, H, O, and N – nitrogen containing
essential & non-essential amino acids)
– fiber, water
• Micronutrients:
– Minerals – both essential and trace
– Vitamins
• Less well established: antioxidants /phytochemicals
7. North America 85%
South America 76%
Asia 76%
Africa 74%
Europe 72%
Australia 55%
% Mineral depletion from the soil
during the past 100 years, by continent
Source: UN Earth Summit Report 1992
8. % of US Resident >/= 2 years of age
who are deficient
• Vitamin A 34% deficient
• Vitamin C 25% deficient
• Vitamin D 70% deficient
• Vitamin E 60% deficient
• Calcium 38% deficient
• Magnesium 45% deficient
“Without enrichment and/or fortification and
supplementation, many Americans did not achieve
the recommended [bare minimum] micronutrient
intake levels…”
[Fulgoni, V, et al. J Nutr. 2011 Oct]
9. “Pending strong evidence …from randomized trials, it
appears prudent for all adults to take vitamin
supplements.” Fletcher & Fairfield, JAMA 2002
10. Bruce Ames, Ph.D.
395 citations in
PubMed, May 1952-
June 2014.
Most recent is
“Enough is Enough”
Ann Intern Med
2014 Jun 3, with
Frei, Blumberg and
Willett
November 2, 2012
11.
12. Ames & Micronutrient Triage -
deconstructed
1. Inadequate dietary intakes of vitamins/minerals are
widespread.
– Excessive consumption of energy-rich, micronutrient-poor, refined
food
1. Deficiencies in many micronutrients cause DNA damage
in cultured or living human cells.
2. Proposal: DNA damage and late onset disease are
consequences of a triage allocation based on
micronutrient scarcity.
– Natural selection favors short-term survival at expense of long-
term health.
Ames B. Proc Natl Acad Sci U S A. 2006 Nov
21;103(47):17589-94. Epub 2006 Nov 13.
13. Ames & Micronutrient Triage -
deconstructed
4. If proposal is correct, “micronutrient deficiencies
that trigger the triage response would accelerate
cancer, aging, and neural decay but would leave
critical metabolic functions, such as ATP
production, intact.”
5. “A multivitamin-mineral supplement is one low-
cost way to ensure intake of the Recommended
Dietary Allowance of micronutrients throughout
life.”
Ames B. Proc Natl Acad Sci U S A. 2006 Nov
21;103(47):17589-94. Epub 2006 Nov 13.
14. 44 million inpatients, 460 sites, 2000-2010 = 20%
of all US inpatient episodes (1.6% were on ONS
during the inpatient episode.)
44 million inpatients, 460 sites, 2000-2010 = 20%
of all US inpatient episodes (1.6% were on ONS
during the inpatient episode.)
>/= 18 years. No terminal patients, tube feedings.>/= 18 years. No terminal patients, tube feedings.
RESULTS for “ONS”:
•2.3 day shorter length of stay
•Decreased cost of $4,734 / episode
•2.3% reduced probability of early readmission.
RESULTS for “ONS”:
•2.3 day shorter length of stay
•Decreased cost of $4,734 / episode
•2.3% reduced probability of early readmission.
CONCLUSIONS: “Use of ONS decreases length of
stay, episode cost, and 30 day readmission risk in the
inpatient population.”
CONCLUSIONS: “Use of ONS decreases length of
stay, episode cost, and 30 day readmission risk in the
inpatient population.”
Tomas J, et al. Am J Manag Care. 2013;19(2):121-
15. Magnesium mementos
• One of the first minerals to disappear with:
– Processed food
– Stress
• Decreased by EtOH, caffeine, sodas, meds
• Considered “anti-stress” mineral
– Decreases cortisol (rel to sleep disruption)
– Relaxes muscles, prevents cramps (sleep
disruption)
– Decreases anxiety; improves sleep
16. Symptoms of Magnesium Deficiency
PSYCHIATRIC ISSUES:
•Difficulty with memory
and concentration
•Depression, apathy
•Emotional lability
•Irritability, nervousness,
anxiety
•Insomnia
Autism
ADHD
Migraine headaches
PMS
Dysmenorrhea
Fibromyalgia
Fatigue
CONSTIPATION
Health Conditions Associated
with Magnesium Deficiency
17. SELENIUM DEFICIENCY in FASEB:
• “Adaptive dysfunction of
selenoproteins from the
perspective of the ‘triage’
theory: why modest
selenium deficiency
may increase risk
of diseases of
aging.”
Foundation of American
Societies for Experimental
Biology
McCann, J, Ames BM. FASEB J.
2011 Jun;25(6):1793-814.
19. “The concomitant evolution between plasma Se
decrease over a 9-year period and cognitive decline
suggested that optimal Se status is potentially
important to maintain neuropsychological
functions in aging people.”
“The concomitant evolution between plasma Se
decrease over a 9-year period and cognitive decline
suggested that optimal Se status is potentially
important to maintain neuropsychological
functions in aging people.”
20. Negative downstream effects from
selenium deficiency:
“…cancer, heart disease, and
immune dysfunction are prospectively
associated with modest selenium
deficiency…. suggesting that
Se deficiency could be a
CAUSATIVE factor.”
McCann, J, Ames BM. FASEB J. 2011 Jun;25(6):1793-814.
21. November 2009
“Alpha Male” issue
Observational study of randomly selected men –
Boston
3 cohorts of men: 1987-1989; 1995-1997; 2002
-2004.
1374, 906, and 489 men, respectively.
“Age independent decline in T that does not appear to
be attributable to observed changes in explanatory
factors, including lifestyle characteristics such as
smoking and obesity.”
“Recent years have seen a SUBSTANTIAL, and as
yet UNRECOGNIZED age-independent population-
level decrease in T in American men.”
Travison, Araujo, et al. Jrnl of Clin. Endocrinol & Metabol 92:1; 196-202.
22. Fast food (low Zn) is bad for you.
• Fast food = high energy density = low essential
micronutrient density, ESPECIALLY ZINC
• Antioxidant processes are dependent on Zinc
• Fast food = severe decrease in antioxidant
vitamins and zinc, correlating with
inflammation in testicular tissue – with
underdevelopment of testicular tissue and
decreased testosterone levels
23. Special needs - Zinc
• Low Zinc- associated with low testosterone
– Found in meat, seafood, oysters & dairy
– Vegetarians at highest risk for zinc deficiency
– Per USDA, 60% of US men between 20 – 49
years of age do not get enough.
– (N.B.: Do not supplement with > 50 mg daily
-can interfere with Cu+ metabolism)
• Tsai, E.C., Boyko, E.J., Leonetti, D.L., & Fujimoto, W.Y. (2000). Low
serum testosterone level as a predictor of increased visceral fat in
Japanese-American men.
International Journal of Obesity and Related Metabolic Disorders,
24, 485-491
24. T vs. Cognitive Function
• 400 independently living men, 40-80yo
– 100 in each age decade
– TT: 208-1141ng/dL; Bio-avail T 78-470ng/dL
• HIGHER T = better cognitive performance in
OLDEST AGE category
• Men with lowest 1/5 T = worse than men with
highest 1/5 T
• Highest Bio-available T more
significant than TT, age, intelligence
level, mood, smoking, and alcohol.
Muller M, et al. Neurology. 2005 Mar;64(5): 866-71
25. T vs. Mood in men
• Study: 278 men, >45yo, followed 2 years
• Compared to eugonadal patients,
hypogonadal men w/TT <200ng/dL had
– 4-fold increase risk of depression
– Significantly shorter time to depression
diagnosis
• Depression risk inversely
related to TT w/statistical significance
<280ng/dL
Shores MM, Arch Gen Psychiatry. 61(2004):162-7
26. Balanced presentation inclusive of
women…
• Oral zinc raises testosterone levels in women.
– Vecchio M, et. Al. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD007747.
doi: 10.1002/14651858.CD007747.pub2.
• Transdermal testosterone improves:
– Sexual desire, arousal, orgasm frequency, and sexual
satisfaction in premenopausal and post-menopausal
women.
– Also associated with favorable effects on body
composition, bone, cardiovascular fxn, and COGNITION
• Davis SR. Androgen therapy in women, beyond libido.
Climacteric. 2013 Aug;16 Suppl 1:18-24. doi:
10.3109/13697137.2013.801736. Epub 2013 May 27.
27. SHIFT: Vitamins
• They are essential nutrients (except Vit D)
• Deficiencies result in classic/obvious
diseases:
– Goiter, scurvy, osteoporosis, pernicious anemia,
impaired immune function, disorders of cell
metabolism, some forms of cancer, premature
aging, poor psychological health (including
eating disorders)
• Shils et al. (2005). Modern Nutrition in Health and Disease. Lippincott Williams and
Wilkins. ISBN 0-7817-4133-5.
28. • Irritability
• Apathy
• Personality changes
• Depression
• Memory loss
• Dementia
• Hallucinations
• Violent behavior
• Anxiety
Symptoms of B12 Deficiency
• Diminished sense
of touch and pain
• Clumsiness
• Weakness
• Pernicious anemia
• Chronic fatigue
• Tremors
• GI problems
Mental Physical
29. The Effects of high dose B vitamins
on stress at work
• “Occupational stress is increasing in Western societies.”
• 3 month, double blind, placebo control, randomized study
• Measured: Personality, work demands, mood, anxiety, and
strain
• After variances in personality and work demands were
controlled, the vitamin B complex treated
group reported significantly lower personal
strain and a reduction in confusion and
depressed/dejected mood after 12 weeks.
Strough C et al. The effect of 90 day administration of a high dose vitamin B-
coplex on work stress. Hum Psychopharmacol. 2011 Sept 8. doi
10.1002/hup.1229 (Swinburne University of Technology – Hawhorn, Victoria,
Australia.)
30. Vitamin/mineral supplementation & cancer,
cardiovascular, and all-cause mortality
(EPIC-Heidelberg) Li K, Kaaks R., et al. Eur J Nutri July 2011
• Purpose: evaluate vitamin/mineral
supplementation with CA, CV dz, and mortality
• Methods:
– 23,943 healthy participants, followed x 11 years
– Baseline and “new-use” supplementation noted
• Results: 513 CA deaths, 264 CV deaths
– “No MVI supplement had any significant effect”
– Baseline users of antioxidant supplements
had significantly reduced risk of cancer [HR
0.52] and all cause mortality [0.58]
• “sick user” phenomenon discussed.
31. “Homocysteine lowering by B-Vitamins slows the rate of
accelerated brain atrophy in MCI”…
Smith AD, Smith SM, de Jager CA, Whitbread P, et al. (2010) Homocysteine-Lowering by B Vitamins Slows the
Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial. PLoS ONE
5(9): e12244. doi:10.1371/journal.pone.0012244
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0012244
CONCLUSIONS: “The
accelerated rate of brain
atrophy in elderly with MCI can
be slowed by treatment with
homocysteine-lowering B-
vitamins.”
32. Regional loss of grey matter volume reduced
with B-vitamins
Douad G, et al. preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin
treatment. Proc Natl Acad Sci U S A. Jun 4, 2013; 110(23): 9523–9528.
33. OK. It slows shrinkage. But are they sharper?
[deJager CA et al. Int J Geriatr Psychiatry. 2012 June;27(6):592-600]
“B-vitamins appear to slow cognitive and clinical
decline in people with MCI.”
34. The role of antioxidants in the brain and
body
35. Generation of free radicals in electron transport chain
http://www.nature.com/nm/journal/v11/n6/fig_tab/nm0605-598_F1.html
Aging; mitochondrial DNA damage
36. What causes oxidative stress?
• Environmental Toxins
– Heavy metals
– Pesticides/herbicides
– Preservatives
– PCB’s, Dioxins, Phthalates
• Toxins produced in (or injected into) the body
– Yeast and bacteria
– Products of cellular metabolism
– Dental amalgams/vaccines (Hb)
• Emotional Stress
– Anxiety/Tension
– Fear
– Anger
38. WILL an apple a day keep the doctor
away?
• Liu S, et al. Intake of vegetables rich in carotenoids and risk of coronary heart disease in
men: The Physician’s Health Study. Int. J Epidemiol. 2001 Feb;30(1):130-5.
• Findings adjusted for age, randomized treatment,
BMI, smoking, alcohol intake, physical activity, DM
history, HTN history, high cholesterol, use of
(conventional) MVI’s..
• 2.5 servings/day of vegetables had a
“RR (relative risk) of 0.77” for CAD vs.
men in lowest category
– (<1 serving per day)
(c) 2013 Louis B. Cady, M.D. - all
rights reserved
39. 15,318 US adults in 3rd
National Health and Nutrition Examination
Follow-up study. (Different lifestyles and health risk factors were
accounted for in the study)
“serum alpha-carotene concentrations were
inversely associated with risk of death from all
causes, CVD, cancer, and all other causes[sic].”
40.
41. • Study population:
– N=1,389; age range {59-71 yoa}
– 9 year study
• Relative risks:
– all cause mortality at 2.94X in men in lowest
quintile (95% CI, P=0.03)
– cancer 1.72X in men (95% CI, P=0.01
• “Total plasma carotenoids levels
were independently associated
with mortality risk in men.”
Epidemiology of Vascular Aging (EVA)
42. Circulating Carotenoids and Risk of Breast Cancer
• STUDY: pooled analysis of 8 cohort studies
– 80% of the world’s published prospective data on
plasma/serum carotenoids and breast cancer
• 3055 case subjects
• 3,956 matched controls.
• CONCLUSIONS: This comprehensive prospective
analysis suggests women with higher circulating
levels of α-carotene, β-carotene,
lutein+zeaxanthin, lycopene, and total carotenoids
may be at reduced risk of breast cancer.
Eliassen AH, et al. Circulating Carotenoids and Risk of Breast Cancer: Pooled Analysis of Eight Prospective
Studies. J Natl Cancer Inst. 2012 Dec 19;104(24):1905-16. doi: 10.1093/jnci/djs461.
43. Eliassen AH, et al. Circulating Carotenoids and Risk of Breast Cancer: Pooled Analysis of Eight
Prospective Studies. J Natl Cancer Inst. 2012 Dec 19;104(24):1905-16. doi: 10.1093/jnci/djs461.
44. Lipid peroxidation, antioxidant status
& survival in institutionalized elderly
• Plasma MDA
predicted mortality
independently of all
other variables.
• B-carotene and
alpha tocopherol
were independently
associated with
survival. Huerta JM et al. Free Radical Research
2006, vol 40, no 6. pp 571-578.
47. Everett Napier, an unemployed miner, said he pawned various items while he has
been looking for work, including rifles, tools, jewelry and two guitars he used to
play at church. 'I just swallowed my pride and quit playing. That's all you can do.'
David Stephenson for The Wall Street Journal. November 26, 2013
50. “F as in Fat – How Obesity Threatens America’s
Future 2012” – Robert Wood Johnson foundation
IN, IL
obesity
rates: 20 –
30%
KY – 30 –
40%
http://healthyamericans.org/report/100/
http://healthyamericans.org/report/100/
51. “F as in Fat – How Obesity Threatens America’s
Future 2012” – Robert Wood Johnson foundation
2030 …
IN, IL
obesity
rates: 50-
60%
KY: >60%
http://healthyamericans.org/report/100/
52. Year 1900 2010
Sugar 5 lbs/year 200 lbs/year
Oils/fat 4 lbs/year 74.1 lbs/year
Cheese 2 lbs/year 30 lbs/year
Meat 140 lbs/year 210 lbs/year
Fruit/Veget. 131 lbs/year
homegrown
11 pounds/year
homegrown
Calories 2100 2757
Nutrient
Density
40-60%
Soft drinks 0 53 Gallons
TV 0 4 hours/day
Sources: USDA, FoodReview: Major Food Trends a Century in Review 2000
What Happened?
53. Change your DIET, change
your GENES:
Changes in prostate gene expression in
men undergoing an intensive nutrition
and lifestyle intervention. Ornish, Dean
et al. Proc Natl Acad Sci USA
2008 June 17; 105(24):8369-8374
Pre-invention gene
expression
Post-intervention gene
expression
TRANSLATION: What you eat
talks to your genes and
CHANGES THEIR
EXPRESSION.
59. To boldly age where no man has aged
before…
William Shatner as James T. Kirk,
and himself…
60. The Seven Secrets of
Optimizing Body Composition
1. Control blood sugar.
2. Eat more small meals.
3. Eat more protein.
4. Get hormones (thyroid, etc.) checked.
5. Make it idiot proof.
6. Balanced supplementation, as needed.
7. EXERCISE –it’s the “fountain of youth.”
61. Cady Wellness Institute Synergy:
The Five Point Plan
1) GET ALL THE LABS YOU
NEED.
2) Rx: Hormones, if needed.
3) MONITOR ANTIOXIDANT &
vitamins/minerals.
SUPPLEMENT AS NEEDED.
4) RATIONAL EATING
5) RATIONAL EXERCISING.
Mind
Body
Actions
64. “Probably the most interesting period of
medicine has been that of the last few
decades. So rapid has been this advance, as
new knowledge developed, that the truth
of each year was necessarily
modified by new evidence, making
the truth an ever-changing factor.”
- Charles Mayo, MD “Dr. Charlie”
65. • Louis B. Cady, M.D. – citations for USI presentation
• Ames, BN. Low micronutrient intake may accelerate the degenerative diseases of aging through
allocation of scarce micronutrients by triage. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17589-
94.
• Bailey RL et al. Examination of vitamin intakes among US adults by dietary supplement use. J Acad
Nutr Diet. 2012 May;112(5):657-663.e4. doi: 10.1016/j.jand.2012.01.026. Epub 2012 Apr 25.
• Berr C, et al. Selenium and cognitive impairment: a brief-review based on results from the EVA stdy.
Biofactors. 2012 Mar-Apr;38(2):139-44. doi: 10.1002/biof.1003.
• deJager CA, et al. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in
mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry. 2012 Jun;27(6):592-
600. doi: 10.1002/gps.2758. Epub 2011 Jul 21.
• Eliassen, AH et al. Circulating carotenoids and risk of breast cancer: pooled analysis of eight
prospective studies. J Natl Cancer Inst. 2012 Dec 19;104(24):1905-16. doi: 10.1093/jnci/djs461.
• Fletcher KM , Fairfield KM. Vitamins for chronic disease prevention in adults: clinical applications.
JAMA. 2002 Jun 19;287(23):3127-9.
• Fulgoni VL et al. Foods, fortificants, and supplements: Where do Americans get their nutrients? . J
Nutr. 2011 Oct;141(10):1847-54. doi: 10.3945/jn.111.142257. Epub 2011 Aug 24.
• Houston, M. The role of cellular micronutrient analysis, nutraceuticals, vitamins, antioxidants and
minerals in the prevention and treatment of hypertension and cardiovascular disease. Ther Adv
Cardiovasc Dis. 2010 DOI: 10.1177/1753944710368205
• (continued – next slide)
66. • Louis B. Cady, M.D. – citations for USI presentation, cont.
• Mayne ST et al. Resonance Raman spectroscopic evaluation of skin carotenoids as a biomarker of
carotenoid status for human studies. Arch Biochem Biophys. 2013 Nov 15;539(2):163-70. doi:
10.1016/j.abb.2013.06.007. Epub 2013 Jun 30.
• McCann, J, Ames BM. Adaptive dysfunction of selenoproteins from the perspective of the ‘triage’
theory: why modest selenium deficiency may increase risk of diseases of aging. FASEB J. 2011
Jun;25(6):1793-814.
• Ramirez-Velez, et al. Non-invasive assessment of β-carotene levels in the skin of Colombian adults.
Endocrinol Nutr. 2012 May;59(5):304-10. doi: 10.1016/j.endonu.2012.03.001. Epub 2012 Apr 13.
• Smith AD et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in
mild cognitive impairment: a randomized controlled trial. PLoS One. 2010 Sep 8;5(9):e12244. doi:
10.1371/journal.pone.0012244.
• Taube, G. Why We Get Fat. Random House, 2010.
Editor's Notes
When repleted - results pretty quickly. “If if spasms, think magnesium” – bowel, bronchial.
RIA (in-house after diethylether extraction)
Total testosterone - T (RIA)
208-1141ng/dL, average 536+/-153ng/dL
Bioavailable testosterone - BT (calculated)
78-470ng/dL, average 236+/-63ng/dL
Hypogonadal if
TT &lt;200ng/dL or
FT &lt;0.9ng/dL
METHODS:
In the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg), which was recruited in 1994-1998, 23,943 participants without pre-existing cancer and myocardial infarction/stroke at baseline were included in the analyses. Vitamin/mineral supplementation was assessed at baseline and during follow-up. Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
RESULTS:
After an average follow-up time of 11 years, 1,101 deaths were documented (cancer deaths = 513 and cardiovascular deaths = 264). After adjustment for potential confounders, neither any vitamin/mineral supplementation nor multivitamin supplementation at baseline was statistically significantly associated with cancer, cardiovascular, or all-cause mortality. However, baseline users of antioxidant vitamin supplements had a significantly reduced risk of cancer mortality (HR: 0.52; 95% CI: 0.28, 0.97) and all-cause mortality (HR: 0.58; 95% CI: 0.38, 0.88). In comparison with never users, baseline non-users who started taking vitamin/mineral supplements during follow-up had significantly increased risks of cancer mortality (HR: 1.74; 95% CI: 1.09, 2.77) and all-cause mortality (HR: 1.58; 95% CI: 1.17, 2.14).
CONCLUSIONS:
Based on limited numbers of users and cases, this cohort study suggests that supplementation of antioxidant vitamins might possibly reduce cancer and all-cause mortality. The significantly increased risks of cancer and all-cause mortality among baseline non-users who started taking supplements during follow-up may suggest a &quot;sick-user effect,&quot; which researchers should be cautious of in future observational studies.
Regional loss of GM volume in placebo and B-vitamin groups. Placebo- and B-vitamin–treated groups showed significant reduction of GM volume over the 2-y period in similar regions (in yellow, P &lt; 0.001 FWE-corrected for multiple comparisons, overlaid onto the average of all 156 GM volume images; Montreal Neurological Institute (MNI) coordinates in mm: x = −12, y = 4, z = −18). The extent and significance of volume loss appeared markedly greater in the placebo group compared with the B-vitamin group and is confirmed by direct statistical comparison (text and Fig. 2).
We additionally show that the beneficial effect of B vitamins is confined to participants with high homocysteine (above the median, 11 µmol/L) and that, in these participants, a causal Bayesian network analysis indicates the following chain of events: B vitamins lower homocysteine, which directly leads to a decrease in GM atrophy, thereby slowing cognitive decline.
we showed that high-dose B-vitamin treatment (folic acid 0.8 mg, vitamin B6 20 mg, vitamin B12 0.5 mg) slowed shrinkage of the whole brain volume over 2 y.
Here, we go further by demonstrating that B-vitamin treatment reduces, by as much as seven fold, the cerebral atrophy in those gray matter (GM) regions specifically vulnerable to the AD process, including the medial temporal lobe.
Figure 1. Powering up lifespan.
The electron transport chain of mitochondria is the major source of free radicals in the cell. Because of electron leak, free radicals react with oxygen (O2) to generate superoxide radicals (O2 ). The major sites of generation includes the iron-sulfur clusters of complex I, coenzyme Q associated with complex III, and components of the tricarboxylic acid cycle, including -ketoglutarate dehydrogenase. Superoxide radicals are dismutated by manganese superoxide dismutase in the mitochondrial matrix to generate O2 and hydrogen peroxide (H2O2). H2O2 is then converted to H2O by either catalase or glutathione peroxidase (GPx) which uses glutathione (GSH). Aging is associated with increased mitochondrial production of H2O2, leading to oxidative damage and mitochondrial DNA mutations. Schriner et al. find that they can substantially extend lifespan in mice and reduce age-associated disease by overexpressing catalase in mitochondria in mice.