In this presentation, given at UNIP (Campus Paraiso - Sao Paulo, SP Brazo) for the 2019 Congresso de Saude Mental (Conference on Mental Health), Dr. Cady reviewed the prevalence, inheritability, and social ramifications of ADHD (TADH in Brazil). He specifically reviewed multiple holistic interventions, including limiting "electric screen time,"good quality diet with adequate amounts of essential fatty acids and critically important trace elements, and the use of pharmacogenomic testing as well as functional, integrative medicine testing, all to better characterize logical and reeasonmable points for holistic intervention.
This presentation was simultaneously translated into Portugue for the attendees, but unfortunately the slides were not available in translated form.
For further information in Brazil on this topic, or to order a video/audio recording of the conference (in Portuguese),contact Luiz Dias of Laboratorio Great Plains in Brazil.
Medical Discussion of the Endocannabinoid SystemLouis Cady, MD
In this lecture, given in Evansville, IN, on April 22nd, Dr. Cady reviews the scientific rersearch on the endocannabinoid system and the rationale for appropriately using it as a nmodality to optimize the structure and function of the body. This is a NON-BRANDED presentationb, and deals ONLY with the "ECS."
The Do It To Yourself Treatment of Depression - Webinar #3Louis Cady, MD
This is the third in a series of five webinars. The first was on staying alive by boosting your immunity during COVID 19. The second was on not screwing yourself up inside your head. This third one encompasses a romp through the peer reviewed medical literature looking for supplements and nutrients that you could use to self treat depression at home, CAREFULLY. Numerous cautions and warnings are included.
The driving impetus to this program is that many people - due to social isolation and their mental health care, or medical practitioners' offices being closed down - have not been able to get help or succeed in optimizing their treatment for depression. There are multiple useful nutrients for both depression and anxiety in nature's abundant pharmacopeia, and this webinar touches on just a few of them.
I hope you enjoy it.
This is the lecture delivered on September 8th, 2018 in Dallas Texas for the 2018 IMMH Conference. It's always a thrill to present there.
In this presentation, I cover the "conventional" way practitioners look at thyroid, contrasting it with a different OPTIMIZING approach. Risks vs. benefits of thyroid supplementation are reviewed. Specific thyroid meds and doses are cited.
Subtitle: The Moral Imperative of Integrative Medicine
This presentation, two hours in length, was delivered to the A4m MMI Audience in their Frontiers of Neurology - Module 3.
The following topics are reviewed:
- ADHD, Autism, Depression, Schizophrenia
- the impact of neuroinflammation on all of these.
- confounding factors and the ways to mitigate them: Omega6/Omega 3 imbalance in the Western diet, MTHFR polymorphism, the use of elemental lithium, the presence of intestinal dysbiosis and the role of gluten/dairy IgG Food allergies.
- pharmacogenomic testing
Thyroid, Adrenals, and Sex Steroids - A Balancing ActLouis Cady, MD
This was the second presentation gibven on MZarch 29, 2019 at the Manlove Psychiagtric Group and Brain Injury Institute spring conference in Rapid City, SD.
In this presentation, Dr. Cady carefully goes over the necessity of integrating and overview and awareness of hormones and their levels in the elucidation of what truly is going on with the patient.
This was an overview lecture only. Dr. Cady will be presenting a 16 hour CME program in Austin Texas on June 22 and 23 for the National Procedures Institute, and will explore all aspects of all relevant hormones and what can be done to manage and optimize them.
The integrative treatment of schizophrenia brazil 2019Louis Cady, MD
This is the English language version of Dr. Cady's presentation given at UNIP (Campus Paraiso - Sao Paulo, SP Brazil) for the 2019 Congresso de Saude Mental (Conference on Mental Health). It was delivered April 20, 2019.
This presentation also includes extra slides in the appendix that were not presented, and, unfortunately, these slides of the appendix have not been translated in the Portuguse version of this presentation.
In this presentation (Portuguese presentation will also be posted next), Dr. Cady briefly reviews the history of schizophrenia, the failure of the dopamine D2 receptor blockage as a universal cure-all in schizophrenia, and various holistic interventions which can strongly and positively impact symptoms of schizophrenia. Included in Dr. Cady's survey were the role of essential fatty acids, nutrient deficiencies (particularly B vitamins), the danger of overgrowth of candida , pharmacogenomic testing, MTHFR polymorphisms, and more.
It was an honor and a privilege to deliver this presentation in
São Paulo,.
For further information in Brazil on this topic, or to order a video/audio recording of the conference (in Portuguese),contact Luiz Dias of Laboratorio Great Plains in Brazil.
This lecture was presented on March 29, 2019 in Rapid Citry, South Dakota, for the conference co-sponsored by the Manlove Psychiatric Group and the Brain Injury Center.
It reviews the uptick in diagnosis of ADHD, the raiontale for its concern, causative factors, and how it can be worked up holistically and in a balanced, not necessarily medication-oriented way.
Use of high dose fish oil, iron supplementation, and how to overrcome nutritional deficiencies are discussed.
The Moral Imperative of Integrative Medicine - IMMH 2020Louis Cady, MD
IN this presentation, Dr. Cady reviews several of the handful of functional, integrative medicine techniques required for a holistic and comprehensive management of psychiatric issues. MTHFR, hormone balance, diagnosis and treating intestinal dysbiosis, need for trace elements, and hormones (including thyroid, testosterone and estradiol) are reviewed.
Medical Discussion of the Endocannabinoid SystemLouis Cady, MD
In this lecture, given in Evansville, IN, on April 22nd, Dr. Cady reviews the scientific rersearch on the endocannabinoid system and the rationale for appropriately using it as a nmodality to optimize the structure and function of the body. This is a NON-BRANDED presentationb, and deals ONLY with the "ECS."
The Do It To Yourself Treatment of Depression - Webinar #3Louis Cady, MD
This is the third in a series of five webinars. The first was on staying alive by boosting your immunity during COVID 19. The second was on not screwing yourself up inside your head. This third one encompasses a romp through the peer reviewed medical literature looking for supplements and nutrients that you could use to self treat depression at home, CAREFULLY. Numerous cautions and warnings are included.
The driving impetus to this program is that many people - due to social isolation and their mental health care, or medical practitioners' offices being closed down - have not been able to get help or succeed in optimizing their treatment for depression. There are multiple useful nutrients for both depression and anxiety in nature's abundant pharmacopeia, and this webinar touches on just a few of them.
I hope you enjoy it.
This is the lecture delivered on September 8th, 2018 in Dallas Texas for the 2018 IMMH Conference. It's always a thrill to present there.
In this presentation, I cover the "conventional" way practitioners look at thyroid, contrasting it with a different OPTIMIZING approach. Risks vs. benefits of thyroid supplementation are reviewed. Specific thyroid meds and doses are cited.
Subtitle: The Moral Imperative of Integrative Medicine
This presentation, two hours in length, was delivered to the A4m MMI Audience in their Frontiers of Neurology - Module 3.
The following topics are reviewed:
- ADHD, Autism, Depression, Schizophrenia
- the impact of neuroinflammation on all of these.
- confounding factors and the ways to mitigate them: Omega6/Omega 3 imbalance in the Western diet, MTHFR polymorphism, the use of elemental lithium, the presence of intestinal dysbiosis and the role of gluten/dairy IgG Food allergies.
- pharmacogenomic testing
Thyroid, Adrenals, and Sex Steroids - A Balancing ActLouis Cady, MD
This was the second presentation gibven on MZarch 29, 2019 at the Manlove Psychiagtric Group and Brain Injury Institute spring conference in Rapid City, SD.
In this presentation, Dr. Cady carefully goes over the necessity of integrating and overview and awareness of hormones and their levels in the elucidation of what truly is going on with the patient.
This was an overview lecture only. Dr. Cady will be presenting a 16 hour CME program in Austin Texas on June 22 and 23 for the National Procedures Institute, and will explore all aspects of all relevant hormones and what can be done to manage and optimize them.
The integrative treatment of schizophrenia brazil 2019Louis Cady, MD
This is the English language version of Dr. Cady's presentation given at UNIP (Campus Paraiso - Sao Paulo, SP Brazil) for the 2019 Congresso de Saude Mental (Conference on Mental Health). It was delivered April 20, 2019.
This presentation also includes extra slides in the appendix that were not presented, and, unfortunately, these slides of the appendix have not been translated in the Portuguse version of this presentation.
In this presentation (Portuguese presentation will also be posted next), Dr. Cady briefly reviews the history of schizophrenia, the failure of the dopamine D2 receptor blockage as a universal cure-all in schizophrenia, and various holistic interventions which can strongly and positively impact symptoms of schizophrenia. Included in Dr. Cady's survey were the role of essential fatty acids, nutrient deficiencies (particularly B vitamins), the danger of overgrowth of candida , pharmacogenomic testing, MTHFR polymorphisms, and more.
It was an honor and a privilege to deliver this presentation in
São Paulo,.
For further information in Brazil on this topic, or to order a video/audio recording of the conference (in Portuguese),contact Luiz Dias of Laboratorio Great Plains in Brazil.
This lecture was presented on March 29, 2019 in Rapid Citry, South Dakota, for the conference co-sponsored by the Manlove Psychiatric Group and the Brain Injury Center.
It reviews the uptick in diagnosis of ADHD, the raiontale for its concern, causative factors, and how it can be worked up holistically and in a balanced, not necessarily medication-oriented way.
Use of high dose fish oil, iron supplementation, and how to overrcome nutritional deficiencies are discussed.
The Moral Imperative of Integrative Medicine - IMMH 2020Louis Cady, MD
IN this presentation, Dr. Cady reviews several of the handful of functional, integrative medicine techniques required for a holistic and comprehensive management of psychiatric issues. MTHFR, hormone balance, diagnosis and treating intestinal dysbiosis, need for trace elements, and hormones (including thyroid, testosterone and estradiol) are reviewed.
Introduction to Integrative Medicine for Mental HealthLouis Cady, MD
This is the first of three lectures that Dr. Cady will present in Sao Paulo, Brazil, for Laboratorio Great Plains. In it, he reviews key concepts of integrative medicine, functional testing, and a rational style of thinking through a patient's problems down to the fundamental level. IgG food allergies, depression, low testosterone, and nutrient deficiencies are all covered
Hemp Oil: What Can It Do For You? Lebanon, TN 04 06 2018Louis Cady, MD
In this presentation, Dr. Cady reviews the peer-reviewed medical literature for the endocannibinoid system, the concept of endocannibinoid deficiency syndrome (now well established), and citations dealing with the multiplicity of health conditions for which a full spectrum hemp oil should be considered as a reasonable supportive strategy. The difference between the generic "CBD Oil" that is available at health food stores compared to the Zilis products is touched on. The Zilis products appear to have better absorbability, faster onset of action, and scientific studies elucidating the true duration of action of CBD levels in blood serum.
This presentation was given to a very appreciative audience at the Friendship Church in Lebanon, TN (a suburb of Nashville).
In this Grand Rounds presentation, delivered to the Dept. of Psychiatry of the University of Cincinnati, Dr. Cady reviews the multiplicity of potential causes, as well as the multiplicity of pharmacological, psychological, and holistic interventions.
Among the topics covered are the following:
- the multidimensional matrix of causality posited to be relevant for schizophrenia
- the deficiency of the "dopamine hypothesis of schizophrenia and the overly simplistic mental model that has been programmed into at least two generations of practitioners
- the rationale for looking at other things besides "drugs" or "psych meds"
- an admonition to the practitioner to not forsake the origins of our profession where the dyadic relationship is honored; further, to be aware of how therapeutic impasses with schizophrenic patients may be frustrating to the practitioner and interfere with treatment;
- the relevant exploration and use of Vitamin D, omega e fatty acids, N-acetyl cysteine, gluten & casein free diets, *elemental* lithium, antifungals.
Natural Treatments for ADHD - December 7th, 2016 - Saint Marys HospitalLouis Cady, MD
This lecture, presented December 7th, 2016 for the Parent Support Group for children with ADHD and Sensory Processing Disorders, was presented at Saint Marys Hospital in Evansville, Indiana. In this one hour presentation, Dr. Cady broke down some of the alternative treatments for ADHD, grounded in the peer-reviewed literature, that do not involve the prescription of typical psychiatric medication for ADHD. He emphasized, natural, holistic treatments to treat deficiencies and restore balance of nutrients and specific essential fatty acids.
This brief webinar, a gift to the local Jewish community and Temple Adath B'Nai Israel here in Evansville, IN, reviews the tradition of mindfulness and the interdigitation of Buddhist practices with some Jewish traditions. Dr. Cady reviews the downstream effects of stress, how meditation and mindfulness are useful tools and techniques, and actually how to practice it. Multiple references without being complicated or overdone are provided.
HOW TO SAVE MONEY ON YOUR HEALTHCARE: An Integrative Medicine ApproachLouis Cady, MD
In this webinar, the fourth in a series of five from Dr. Louis Cady and the Cady Wellness Institute, we focus on the actual dollars and cents of health care expenditures, and the societal and PERSONAL costs of poor health maintenance behavior. We examine the essentially passive US medical system, that would rather drug a symptom than fix the underlying problem.
Great attention is paid on not shaming the patient or the doctors as they exist in the current system. Both groups "do not know what they do not know." Confirmation bias is rampant.
This webinar points the way to living a more vital, energetic life, with a minimum of cost, grief, and misery.
How to Transition from Allopathic to Integrated Practice - IMM Brazil 2015Louis Cady, MD
In this lecture, Dr. Cady compares and contrasts the significance differences, both conceptually and practically, between the conventional practice of medicine and a more rational, functional, integrated approach. Tactical concepts and didactic tools to make the transition are reviewed.
Integrating the Functional, Psychodynamic, and Immunologic Matrix: New Advent...Louis Cady, MD
In this presentation (here represented in English before translation) Dr. Cady deconstructs the curious and sometimes perplexing manifestations of delayed sensitivity food allergy testing, supporting it with citations from the peer-reviewed medical literature and extensive bibliographic references. The importance of understanding the potential immunologic contribution to a patient's mental state is reviewed.
In his third of five lectures, Dr. Cady reviews the concepts of food allergy testing with IgG and IgE antibodies, traces the development of this body of knowledge from the 1960's, and reviews two illustrative cases.
Optimized Aging with Nutritional & Weight Management TechniquesLouis Cady, MD
In this lecture, presented on August 15, 2014 for the USI Mid-America institute on Aging, Dr. Cady covered the under appreciated physiology of micronutrients and deficiency syndrome, the concept of the "Triage Theory of Aging" from Dr. Bruce Ames, and reviewed the literature on nutritional supplementation. This covered carotenoids, peer-reviewed studies on carotenoids and mortality, peer-reviewed studies on carotenoids and risk of breast cancer, peer review articles on lipid preoccupation, antioxidants, and the chances of survival in the institutionalized elderly, Raman spectroscopy as a marker of antioxidant nutritional deficiency, the explosion of obesity in our population in the US, and optimal antiaging strategies. The "Seven Secrets of Optimizing Body Composition" was reviewed at the end. References are attached.
"Killer Drugs & The Supplement Hall of Fame" - IMMH Brazil, 2015Louis Cady, MD
In this presentation, the third of three lectures Dr. Cady delivered in São Paulo, Brazil, Dr. Cady reviews the critical patterns of interactions with numerous frequently prescribed psychotropic medications (and others). Emphasis is given on how not to commit an obvious drug-drug interaction as well as avoiding more subtle ones. The focus then shifts to supplements: which ones are the best, which ones have mental health benefits, and how to avoid interactions between conventionally used supplements and psychiatric medications.
THE ENDOCANNABINOID SYSTEM - Cady Wellness InstituteLouis Cady, MD
This lecture, presented on February 2, 2018 at the Cady Wellness Institute in Newburgh, IN, represented Dr. Cady's review of the current peer-reviewed medical literature current as of that morning. The concepts of "endocannabinoids" vs. "phytocannabinoids" were reviewed. Themes in the medical literature were explored, including the relationship of the endocannabinoid system and CB! and CB2 receptors to modulate hippocampal neurogenesis, cause apoptosis in breast cancer cells, and many other interesting correlations. A careful review of legal vs illegal options for obtaining plant phytocannabinoids in the state of Indiana was emphasized.
New Adventures in Food Allergy Testing! 09 21 2013Louis Cady, MD
This is the second of four CME lectures delivered by Dr. Cady at the 4rth Annual Integrated Medicine For Mental Health Conference in Chicago, IL at McCormick Place, September 21, 2013. In it, he traces the development of the concept of "non-atopic" food allergies and the inflammatory mechanisms behind through which food to which patients have become sensitized can harm them.
A review of the medical literature, from headaches, to depression to ADHD, to brain inflammation in autism is traced to these IgG mediated food sensitivities.
At the end of this presentation, the viewer will have a much greater appreciation of the fact that children, adolescents, and adults, can have SEVERE food sensitivities that do not necessarily turn up "positive" on scratch testing or RAST testing.
The scientific literature, quoted right up to the day before the conference started, is extensive and well sourced.
Any practicing physician, and certainly any interested patient(s) should familiarize himself or herself with this content.
la presentación se base en el análisis de 2 noticias: una es sobre el mal que hace dormir de noche y la otra sobre la determinación temprana el genoma de los bebes
Prof. Dr. Vladimir Trajkovski - Health issues and health care in ASD Vladimir Trajkovski
Prof. Dr. Vladimir Trajkovski presented topic: Health issues and health care in persons with autism spectrum disorders at international autism conference held in Krakow September 27th, 2018.
Natural Treatments for ADHD - April 11, 2018Louis Cady, MD
This presentation will be delivered April 11, 2018 on recorded webinar for the Autism Global Conference. It was my pleasure to prepare and present this lecture (in webinar form), outlining a coherent philosophy of finding biological underpinnings that can cause or contribute to, or exacerbate, mental dysfunction. In the case of this presentation, the question is "How much of ADHD symptomatology is caused by a lack of a good medication, or, rather, lack of a coherent strategy for finding and fixing underlying biological abnormalities?"
Those biological abnormalities in this presentation include MTHFR polymorphisms, COMT polymorphisms, elemental deficiencies (lithium, magnesium, zinc, iron, and copper), essential fatty acid deficiencies, the confound of high fructose corn syrup, and many others.
Rational strategies for nutraceutical intervention are reviewed.
In his fourth and concluding lecture of the IMMH Conference in San Antonio, 2014, Dr. Cady reviews the statistics, epidemiology, biological nature and pharmacologic treatment of ADHD. The first part of the presentation was absolutely conventional allopathic psychiatry, inclusive of brain imaging.
The second part of the presentation considered: "If we are thinking about biological, psychological, and behavioral interventions for a 'psychiatric' patient, shouldn't we be considering the TWO biological levels?" The most normal biological level that "biologically trained psychiatrists" consider is medications and medication effectiveness. However, sometimes even the most vigorous, precise, and heroic efforts do not work. The potential confound it the underlying physiological, hormonal, nutrient, antioxidant, PUFA-rich state associated with optimal health and well being.
In the final analysis, shouldn't we make sure that we have BOTH of these biological foundations right?
We hope that you enjoy this provocative slide presentation.
Introduction to Integrative Medicine for Mental HealthLouis Cady, MD
This is the first of three lectures that Dr. Cady will present in Sao Paulo, Brazil, for Laboratorio Great Plains. In it, he reviews key concepts of integrative medicine, functional testing, and a rational style of thinking through a patient's problems down to the fundamental level. IgG food allergies, depression, low testosterone, and nutrient deficiencies are all covered
Hemp Oil: What Can It Do For You? Lebanon, TN 04 06 2018Louis Cady, MD
In this presentation, Dr. Cady reviews the peer-reviewed medical literature for the endocannibinoid system, the concept of endocannibinoid deficiency syndrome (now well established), and citations dealing with the multiplicity of health conditions for which a full spectrum hemp oil should be considered as a reasonable supportive strategy. The difference between the generic "CBD Oil" that is available at health food stores compared to the Zilis products is touched on. The Zilis products appear to have better absorbability, faster onset of action, and scientific studies elucidating the true duration of action of CBD levels in blood serum.
This presentation was given to a very appreciative audience at the Friendship Church in Lebanon, TN (a suburb of Nashville).
In this Grand Rounds presentation, delivered to the Dept. of Psychiatry of the University of Cincinnati, Dr. Cady reviews the multiplicity of potential causes, as well as the multiplicity of pharmacological, psychological, and holistic interventions.
Among the topics covered are the following:
- the multidimensional matrix of causality posited to be relevant for schizophrenia
- the deficiency of the "dopamine hypothesis of schizophrenia and the overly simplistic mental model that has been programmed into at least two generations of practitioners
- the rationale for looking at other things besides "drugs" or "psych meds"
- an admonition to the practitioner to not forsake the origins of our profession where the dyadic relationship is honored; further, to be aware of how therapeutic impasses with schizophrenic patients may be frustrating to the practitioner and interfere with treatment;
- the relevant exploration and use of Vitamin D, omega e fatty acids, N-acetyl cysteine, gluten & casein free diets, *elemental* lithium, antifungals.
Natural Treatments for ADHD - December 7th, 2016 - Saint Marys HospitalLouis Cady, MD
This lecture, presented December 7th, 2016 for the Parent Support Group for children with ADHD and Sensory Processing Disorders, was presented at Saint Marys Hospital in Evansville, Indiana. In this one hour presentation, Dr. Cady broke down some of the alternative treatments for ADHD, grounded in the peer-reviewed literature, that do not involve the prescription of typical psychiatric medication for ADHD. He emphasized, natural, holistic treatments to treat deficiencies and restore balance of nutrients and specific essential fatty acids.
This brief webinar, a gift to the local Jewish community and Temple Adath B'Nai Israel here in Evansville, IN, reviews the tradition of mindfulness and the interdigitation of Buddhist practices with some Jewish traditions. Dr. Cady reviews the downstream effects of stress, how meditation and mindfulness are useful tools and techniques, and actually how to practice it. Multiple references without being complicated or overdone are provided.
HOW TO SAVE MONEY ON YOUR HEALTHCARE: An Integrative Medicine ApproachLouis Cady, MD
In this webinar, the fourth in a series of five from Dr. Louis Cady and the Cady Wellness Institute, we focus on the actual dollars and cents of health care expenditures, and the societal and PERSONAL costs of poor health maintenance behavior. We examine the essentially passive US medical system, that would rather drug a symptom than fix the underlying problem.
Great attention is paid on not shaming the patient or the doctors as they exist in the current system. Both groups "do not know what they do not know." Confirmation bias is rampant.
This webinar points the way to living a more vital, energetic life, with a minimum of cost, grief, and misery.
How to Transition from Allopathic to Integrated Practice - IMM Brazil 2015Louis Cady, MD
In this lecture, Dr. Cady compares and contrasts the significance differences, both conceptually and practically, between the conventional practice of medicine and a more rational, functional, integrated approach. Tactical concepts and didactic tools to make the transition are reviewed.
Integrating the Functional, Psychodynamic, and Immunologic Matrix: New Advent...Louis Cady, MD
In this presentation (here represented in English before translation) Dr. Cady deconstructs the curious and sometimes perplexing manifestations of delayed sensitivity food allergy testing, supporting it with citations from the peer-reviewed medical literature and extensive bibliographic references. The importance of understanding the potential immunologic contribution to a patient's mental state is reviewed.
In his third of five lectures, Dr. Cady reviews the concepts of food allergy testing with IgG and IgE antibodies, traces the development of this body of knowledge from the 1960's, and reviews two illustrative cases.
Optimized Aging with Nutritional & Weight Management TechniquesLouis Cady, MD
In this lecture, presented on August 15, 2014 for the USI Mid-America institute on Aging, Dr. Cady covered the under appreciated physiology of micronutrients and deficiency syndrome, the concept of the "Triage Theory of Aging" from Dr. Bruce Ames, and reviewed the literature on nutritional supplementation. This covered carotenoids, peer-reviewed studies on carotenoids and mortality, peer-reviewed studies on carotenoids and risk of breast cancer, peer review articles on lipid preoccupation, antioxidants, and the chances of survival in the institutionalized elderly, Raman spectroscopy as a marker of antioxidant nutritional deficiency, the explosion of obesity in our population in the US, and optimal antiaging strategies. The "Seven Secrets of Optimizing Body Composition" was reviewed at the end. References are attached.
"Killer Drugs & The Supplement Hall of Fame" - IMMH Brazil, 2015Louis Cady, MD
In this presentation, the third of three lectures Dr. Cady delivered in São Paulo, Brazil, Dr. Cady reviews the critical patterns of interactions with numerous frequently prescribed psychotropic medications (and others). Emphasis is given on how not to commit an obvious drug-drug interaction as well as avoiding more subtle ones. The focus then shifts to supplements: which ones are the best, which ones have mental health benefits, and how to avoid interactions between conventionally used supplements and psychiatric medications.
THE ENDOCANNABINOID SYSTEM - Cady Wellness InstituteLouis Cady, MD
This lecture, presented on February 2, 2018 at the Cady Wellness Institute in Newburgh, IN, represented Dr. Cady's review of the current peer-reviewed medical literature current as of that morning. The concepts of "endocannabinoids" vs. "phytocannabinoids" were reviewed. Themes in the medical literature were explored, including the relationship of the endocannabinoid system and CB! and CB2 receptors to modulate hippocampal neurogenesis, cause apoptosis in breast cancer cells, and many other interesting correlations. A careful review of legal vs illegal options for obtaining plant phytocannabinoids in the state of Indiana was emphasized.
New Adventures in Food Allergy Testing! 09 21 2013Louis Cady, MD
This is the second of four CME lectures delivered by Dr. Cady at the 4rth Annual Integrated Medicine For Mental Health Conference in Chicago, IL at McCormick Place, September 21, 2013. In it, he traces the development of the concept of "non-atopic" food allergies and the inflammatory mechanisms behind through which food to which patients have become sensitized can harm them.
A review of the medical literature, from headaches, to depression to ADHD, to brain inflammation in autism is traced to these IgG mediated food sensitivities.
At the end of this presentation, the viewer will have a much greater appreciation of the fact that children, adolescents, and adults, can have SEVERE food sensitivities that do not necessarily turn up "positive" on scratch testing or RAST testing.
The scientific literature, quoted right up to the day before the conference started, is extensive and well sourced.
Any practicing physician, and certainly any interested patient(s) should familiarize himself or herself with this content.
la presentación se base en el análisis de 2 noticias: una es sobre el mal que hace dormir de noche y la otra sobre la determinación temprana el genoma de los bebes
Prof. Dr. Vladimir Trajkovski - Health issues and health care in ASD Vladimir Trajkovski
Prof. Dr. Vladimir Trajkovski presented topic: Health issues and health care in persons with autism spectrum disorders at international autism conference held in Krakow September 27th, 2018.
Natural Treatments for ADHD - April 11, 2018Louis Cady, MD
This presentation will be delivered April 11, 2018 on recorded webinar for the Autism Global Conference. It was my pleasure to prepare and present this lecture (in webinar form), outlining a coherent philosophy of finding biological underpinnings that can cause or contribute to, or exacerbate, mental dysfunction. In the case of this presentation, the question is "How much of ADHD symptomatology is caused by a lack of a good medication, or, rather, lack of a coherent strategy for finding and fixing underlying biological abnormalities?"
Those biological abnormalities in this presentation include MTHFR polymorphisms, COMT polymorphisms, elemental deficiencies (lithium, magnesium, zinc, iron, and copper), essential fatty acid deficiencies, the confound of high fructose corn syrup, and many others.
Rational strategies for nutraceutical intervention are reviewed.
In his fourth and concluding lecture of the IMMH Conference in San Antonio, 2014, Dr. Cady reviews the statistics, epidemiology, biological nature and pharmacologic treatment of ADHD. The first part of the presentation was absolutely conventional allopathic psychiatry, inclusive of brain imaging.
The second part of the presentation considered: "If we are thinking about biological, psychological, and behavioral interventions for a 'psychiatric' patient, shouldn't we be considering the TWO biological levels?" The most normal biological level that "biologically trained psychiatrists" consider is medications and medication effectiveness. However, sometimes even the most vigorous, precise, and heroic efforts do not work. The potential confound it the underlying physiological, hormonal, nutrient, antioxidant, PUFA-rich state associated with optimal health and well being.
In the final analysis, shouldn't we make sure that we have BOTH of these biological foundations right?
We hope that you enjoy this provocative slide presentation.
This chapter is from Drugging Our Children (Olfman & Robbins, 2012), a great book about the epidemic prescription of antipsychotics to children, especially poor children and children of color.
CHAPTER NINEMedicating ChildrenThis chapter is divided into se.docxDinahShipman862
CHAPTER NINE
Medicating Children
This chapter is divided into seven sections. Section One is an overview that discusses current trends in medicating children, problems the trends cause, and directions for the future. It also discusses developmental issues. Section Two focuses on stimulant medication and the diagnosis of attention deficit hyperactivity disorder (ADHD). Section Three focuses on research on combined interventions and particularly the Multimodal Treatment Study (MTA study) of Children with ADHD. Section Four focuses on children taking mood stabilizers. Section Five focuses on antipsychotics and children. Sections Six and Seven focus on anxiolytics and antidepressants in children, respectively.
SECTION ONE: PERSPECTIVES, DILEMMAS, AND FUTURE PARADIGMS
Learning Objectives
• Understand the problematic increase in psychotropic medications for children despite a dearth of evidence of the effectiveness of these drugs.
• Have a general understanding of the impact of the FDA Modernization Act and the Best Pharmaceuticals Act for Children.
• Be able to state the “developmental unknowns” associated with giving kids psychotropic medications.
Thus far, we have explored the medical model and psychological, cultural, and social perspectives as they relate to psychopharmacology. In this chapter, we demonstrate that using psychotropic medications with children and adolescents raises particular problems and concerns from several perspectives. As discussed in Chapter Three, we frequently see explanations and justifications from the medical model perspective used to reduce childhood disorders to chemical and genetic problems, excluding crucial consideration of environmental traumas, developmental foreclosures, or life stressors.
We explore child and adolescent psychopharmacology primarily from the medical model perspective but complement this approach with information from the other perspectives (psychological, cultural, and social). We set the stage by exploring the current status of the treatment of children and adolescents with mental and emotional disorders. This chapter is structured differently from the others in this book. We begin by discussing the context from the social and cultural perspectives and the problems with prescribing psychotropic medications to children. Then we cover an introduction to stimulants used to treat symptoms of ADHD. Finally, we give the status of their current use since the last edition of the book if that is possible.
THE COMPLEX STATE OF THERAPY
Dr. Frank O'Dell, Professor Emeritus of Counseling in the College of Education and Human Services at Cleveland State University, has argued in all his lectures on counseling children and adolescents that the United States is an “anti-kid” society (Personal Communication, 2001). By that he means fewer and fewer therapists and psychiatrists choose to treat or continue to work with children in counseling. To support his argument, O'Dell points out that resources for childre.
New Concepts in the Epidemiology, Diagnosis and Precision Treatment of ADHD i...Louis Cady, MD
This is the Grand Rounds Presentation at Saint Mary's Hospital here in Evansville, IN. In it, Dr. Cady covers the notable uptick in the diagnosis of ADHD, reviews societal effects contributing to the increased diagnosis, and reviews the precision diagnosis and treatment of ADHD. He presents a rigorous grounding in diagnostic fundamentals, notes the contribution of SPECT imaging toward our understanding of ADHD, and reviews the precise pharmacotherapeutic treatment of ADHD to avoid side effects and control symptoms.
This presentation is the one that was actually presented (with updated title slide to reflect the weather outside this morning), and has the seven "true/false" questions at the end with the correct answers indicated.
Never Fall Behind: Early Action for Babies + Young Children with Delays: Febr...Vicky Sarmiento (She/Her)
In our first of a series of webinars curated for the provider community by fellow child healthcare professionals, Dr. Emily and Dr. Jin Lee talk about the importance of early action and intervention, how to recognize delays, and best practices in neuropsychological testing and evaluation.
This presentation can be supplemented with our video recording on BabyNoggin's Youtube. The video webinar recording will be available 3/2/18. Thank you!
This article applies a critical flaw analysis to psychiatric drugs for children and concludes the evidence does not support drugs as a first line choice.
1Proposal Effectiveness of non-pharmacological in Compari.docxdurantheseldine
1
Proposal: Effectiveness of non-pharmacological in Comparison to
Methylphenidate Stimulant Therapy
Barbara Maclure
9/18/2022
2
Effectiveness of non-pharmacological in Comparison to
Methylphenidate Stimulant Therapy
Introduction
Attentive–deficit hyperactivity is a psychological disorder that is well known, affecting
both children and adults. Some of the associated symptoms that are associated with ADHD include
inattention, hyperactivity, impulsivity, and difficulty in focusing. It is reported that in the United
States, about 8.5% of children are affected by ADHD. In the treatment process, several ways have
been put into place. Despite the treatment, many studies reported that some treatment methods
have side effects. Therefore, knowing the method that least has the side effects is crucial. This
research proposal will play an essential role as it will identify whether non-pharmacological
intervention, behavioral therapy, and stimulant therapy have the same results in children aged 4 to
8.
Background of the study
Dr. George first identified ADHD when he was a pediatrician. He noted that his patients
had uncontrollable impulsive behavior. There was an introduction of the drug Benzedrine, which
was approved as it showed to improve ADHD symptoms in children. In 1950 there was the
introduction of Ritalin drugs which were used in ADHD treatment in both children and
adolescents. (Holland & Higuera (2017). The drug that is used in the treatment of ADHD to date is
Ritalin. Despite the doctors treating patients with ADHD symptoms from the 1930s, there was no
actual definition of ADHD. Still, it was given much attention in 1987 when the American
Psychiatric Association (APA) redefinition of the disorder.
3
By 2020, approximately 7.1 million young children aging between 2-17 years with ADHD
had been diagnosed. (Garbe (2018). Despite the prevalence of the disorder among children and
adolescents, ADHD is also present in adulthood. In most cases, this disorder is noted when the
child gets into the class and starts issues of failing to focus on the classroom. There are different
forms of ADHD which entails hyperactive/impulsive type, inattentive type, or a combination of the
two. There is a criterion that is customarily utilized in the treatment of ADHD. The parents and the
teacher are required to document the children's symptoms for a period of six months. Research
shows that ADHD is more common in males than women. One of the interventions utilized is
stimulant therapy, considered standard treatment for children after reaching an appropriate age.
The stimulus, for example, the medication, is said to have side effects which can be either mild or
severe. Some noticeable side effects include upset stomach, appetite change, heart abnormalities,
tics, and weight loss. Although the treated symbols are 70-80% treated, there can be the utilization
of.
Iacapap workshop on PRESCRIBING FOR CHILDREN AND ADOLESCENTS: PERSPECTIVE FR...Devashish Konar
Discusses the best way to reach the minimum important information to professionals who deal with mental health of children and adolescents and prescribe psychotropic medicines to them.
SEND IN THE SHRINKS - 2009 Oliver CME seminarLouis Cady, MD
This one was fun.
I was invited by Dr. Randalll Oliver, MD, Founder of the Oliver Heachache and Pain Clinic in Evansville, to present to an audience of primary care practitioners about how to use pysychiatric mediations ("psychopharmacology") in clinical practice.
Along the way, I covered, ADHD and treatments, depression, anxiety, erectile dysfunction, hypoadrenia, and even touched on hypothyroidism. Although this presentation was in 2009, all of the drugs covered are stills in use, and, at times.... stupidly.
This presentation deconstructs the intricacies of selecting and antidepressant, particularly in the SSRI class.
What is the nature of QUALITY in medicine -for ASQ 11 14 2023.pptLouis Cady, MD
In this presentation, Dr. Cady deconstructs the tensions and stressors on both patients and health care providers in today's system.
This presentation reviews checklists foe liminating mistakes, the actual number of mistakes that are being made in medical practice, and what patients and their loved ones can do for self protection.
This isn't a "bash the doctor" presentation. It's a thoughtful, careful exploration of stresses and ramifications to the current US healthcare system.
This was a Grand Rounds program for St. Marys Hospital (now Ascension St. Vincent) in Evansville delivered on April 2, 2014. It is uploaded to my slideshare site as a public service to patients and mental health practitioners.
We are actually no longer using TMS at Cady Wellness, having transitioned to the attempting maximum stabilization of our patients with nutraceuticals, hormones, and the latest advance in psychopharmacology. This includes intramuscularly administered ketamine, which has been transformative in many of our patients.
Hormones and Mental Health - Thyroid and Testosterone.pptxLouis Cady, MD
In this presentation for the Psychiatry Redefined program, Dr.
Cady breaks down and deconstructs the accepted, unthinking, "practice guideline based" notions of thyroid and tesotsterone, with there seemingly "normal" levels and dosing, versus what the actual peer reviewed medical literature says. In this presentation, do use of all forms of thyroid, and all forms of testosterone are reviewed. The idiocy of "T4 only treatment" is covered. The use of T4, T3, a combination of T4 and T3, and all of the porcine and compounded products is review.
In terms of testosterone, dr. Katie reviews the concept of "do you want to be optimal or do you want to be normal." He notes that it is "normal" for oil in cars to deteriorate and break down with age. It's also "normal" for men's and women's testosterone (as well as thyroid) to go down with age. The question is, "do we want to do anything about it?"
Logical ways of intervening in both the thyroid and female and male gonadal axes are covered. There is scrupulous attention paid to the thyroid hormone pathways, and the relevance of reverse T3 versus free T3. Similarly, in terms of women, the downstream effect of estradiol coming from testosterone is also reviewed.
The Moral Imperative of Integrative Medicine 2022.pptLouis Cady, MD
Presented to Psychiatry Redefined Meeting - September 10, 2022
Three cases are reviewed - two with MTHFR deficiencies and pharmcotherapy challenges; one case with schizophrenia solidly treated with clozapine but also with additional antidepressant (vortioxetine) and functional, integrative medicine techniques.
CORONOFOBIA - Passos práticos para equilibrar as defesas do corpo e da menteLouis Cady, MD
Esta palestra, apresentada em 29 de maio de 2021 para o Congresso de Medicina Integrativa para a Saúde Mental 2020, promovido pelo Laboratório Great Plains no Brasil, enfocou coisas simples e de bom senso que os pacientes (e seus médicos) podem fazer para se manter seguros e viver durante o Pandemia do covid.
Os seguintes conceitos holísticos foram revisados:
- sono adequado e por que é tão importante;
- o uso de melatonina, cientificamente validada como tendo atividade antiviral (referências citadas);
- a importância de diminuir o estresse e técnicas para fazê-lo;
- a necessidade de "comer frutas e vegetais" como sua mãe e sua avó ensinaram devido à ingestão de carotenóides e antioxidantes ((referências citadas);
- o uso adequado de suplementos vitamínicos / nutricionais (referências citadas).
O foco desta apresentação não foram medidas heróicas para salvar vidas na unidade de terapia intensiva para pacientes gravemente enfermos com COVID, mas, sim, técnicas de bom senso, práticas, baratas e (em alguns casos) GRATUITAS para melhorar você e seus pacientes 'saúde e resistência às doenças.
THE MORAL IMPERATIVE OF INTEGRATIVE MEDICINE - O IMPERATIVO MORAL DA MEDICINA...Louis Cady, MD
Neste programa, o Dr. Cady baseia-se em uma série de casos clínicos para ilustrar a necessidade absoluta e moral do tratamento de precisão de nossos pacientes com todas as ferramentas disponíveis para uso por meio da medicina integrativa.
O uso de testes de polimorfismo MTHFR, testes convencionais e laboratoriais e testes farmacogenômicos foram revisados.
Os casos apresentados ilustram a trágica dificuldade de um menino com deficiência de MTHFR que estava prestes a desviar sua vida; um paciente esquizofrênico com vários problemas de medicina funcional que precisavam ser resolvidos (levedura, glúten, sensibilidade alimentar de IgG); uma estudante universitária a quem foi dito "não há nada de errado com você; seus laboratórios estão bem", embora ela tenha manifestado todos os sintomas relevantes de hipotireoidismo; e um CEO do sexo masculino de 42 anos que estava "tão cansado que parecia morrer" e que, na verdade, estava funcionalmente com pouco testosterona. O último caso revisado foi de um adorável garotinho que tinha autismo e foi recuperado por meio de uma abordagem focada e intensa de medicina integrativa.
Dr. Cady deconstructs some the medical literature about the use of nutrients - and the evidence of what happens in the presence of their insufficiency. Everything for decreased viral replication to decrease brain shrinkage is covered. The role of antioxidant and carotenoids, measured by the Pharmanex Biophotonic Scanner, is reviewed.
Please note - there is no representation that any nutrient or supplement can treat, prevent, mitigate, or cure any medical condition. It does seem, however, upon reflecting on the medical literature, that there seems to be a lot of evidence for therapeutic effect in the presence of good levels of nutrient, and harm to patients if they have insufficient levels.
Webinar 5: Designing Your Future: WHAT'S COMING NEXT?Louis Cady, MD
In this capstone webinar presentation, closing out Dr. Cady's series on dealing with COVID 19, he turns his attention to a nunmber of interesting thems:
- what's the REAL case fatality rate of COVID 19
- How is it likely that society will reopen?
- What's going to happen in education and medicine?
- What's going to happen when the robots and AI arrive?
- What's the future going to be out 500 years?
HOW TO COPE WITH THE PSYCHOLOGICAL IMPACT OF COVID 19 AND SOCIAL DISTANCINGis...Louis Cady, MD
In this presentation, Dr. Cady will review:
- What did Sparky learn about not being an emotional support animal?
- "Do it to yourself psychotherapy." Learn the following:
- What are the wrong - and the RIGHT ways of any sort of "behavioral therapy"?
- How to use a journal to think RATIONALLY and “get out of your head.”
- How to get out of your HEAD and into your LIFE.
- We'll cover all 10 of David Burns’ cognitive distortions, customized and gift-wrapped for dealing with COVID 19.
- We will cover actionable examples of how to reprogram yourself.
We will review What are the 3 P's of Positive Psychology and Learned Optimism?
The Cady 5 "5P’s” and “How to shrink yourself."
Can we find the GOOD in COVID?
This presentation is meant to be provocative and to challenge you mentally, intellectually, and emotionally. Some of the great thinkers and exemplars of human performance and possibility are featured.
BOOSTING YOUR IMMUNITY During the COVID 19 PandemicLouis Cady, MD
In this presentation, presented as a live webinar on Monday, April 27th, Dr. Louis Cady of the Cady Wellness Institute reviewed practical, common-sense things that can be done to boost your immunity, with documentation from the peer-reviewed medical literature. Dr. Cady also reviews supplements and nutrients that are established in the peer-reviewed medical literature as having antiviral capabilities. These include Vitamins C,D, and E, Zinc, carotenoids and antioxidants, probiotics, the reishi mushroom, elderberry, cannabidiol (CBD - not marijuana or weed!).
Points presented are scrupulously documented from the medical literature. This presentation does not guarantee or represent that using ANY of these nutrients will "keep you from getting infected or dying" from COVID 19. They are presented for your thoughtful consideration.
Tratamento holistica de ezschizophrenia - São Paulo, Brazil April 20, 2019Louis Cady, MD
Esta é a versão em inglês da apresentação do Dr. Cady feita na UNIP (Campus Paraiso - São Paulo, SP Brasil) para o Congresso de Saúde Mental de 2019 (Conferência sobre Saúde Mental). Foi entregue em 20 de abril de 2019.
Nesta apresentação, o Dr. Cady analisa brevemente a história da esquizofrenia, a falha do bloqueio do receptor de dopamina D2 como uma cura universal na esquizofrenia, e várias intervenções holísticas que podem impactar forte e positivamente os sintomas da esquizofrenia. Incluídos na pesquisa do Dr. Cady estavam o papel dos ácidos graxos essenciais, deficiências nutricionais (particularmente vitaminas do complexo B), o perigo de supercrescimento da cândida, testes farmacogenômicos, polimorfismos da MTHFR e muito mais.
Foi uma honra e um privilégio entregar esta apresentação em
São Paulo.
Para mais informações no Brasil sobre este tema, ou para solicitar uma gravação em vídeo / áudio da conferência, entre em contato com Luiz Dias do Laboratório Grandes Planícies no Brasil.
Slides, até o apêndice, são traduzidos por Luiz Dias.
A abordagem da Medicina Integrativa para o Tratamento da EsquizofreniaLouis Cady, MD
This is the presentation that Dr. Cady gave in São Paulo, Brazil, in October of 2017 on the integrtive treatment of schizophrenia. The one in English is already posted. My thanks to Luiz Dias, of Laboratorio Great Plans in Brazil, for his impeccable translation.
Endocannabinoid System - Literature ReviewLouis Cady, MD
In this brief review of the literature, Dr. Louis Cady of the Cady Wellness Institute reviews the endocannabinoid system and the role it plays in bridging the connection between mind and body, modulating anxiety, inflammation, memory and other physiological processes. Nothing in this presentation suggests that any of the products mentioned are appropriate for the treatment, remediation, cure, or prevention of any disease or illness. It does appear, however, that this natural, indwelling, genetically passed down endocannabinoid system may have major implications for holistic physicians and health care practitioners, and for the patients that they serve.
The Integrative Medicine Treatment of SchizophreniaLouis Cady, MD
This is the third of three lectures that Dr. Cady did in Sao Paulo, Brazil, for Laboratorio Great Plains. Dr. Cady dispenses with the "Dopamine hypothesis of schizophrenia" quickly, and notes that the most powerful drug for schizophrenia, clozapine, is actually only a weak blocker at that receptor. Using the concepts of Dale Bredesen, MD, Dr. Cady advances the idea that there is no "one magic bullet" approach to the treatment of schizophrenia, but that, rather, multiple possibile causes of schizophrenia exist, multiple nutritional laboratory values exist, multiple other physiological perturbations exist (including gluten sensitivyt), and that the thoughtful practitioner's approach should be to attempt to identify, integrate, and address all possible causes and exacerbating influences on the causes, and treatments of schizophrenia. Obviously, this is not a comprehensive treatment on the subject - which would take days - but does scratch the surface at other ways to look at schizophrenia and approach its treatment.
This is the second of three lectures Dr. Cady gave in Brazil. This is an update his previous thyroid talk, focusing more particularly on mental effects and the assessment of thyroid axes, and thyroid use, in mental healthj
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Natural Treatments for ADHD (TADH) in Sao Paulo, Brazil, for Laboratorio Great Plains
1. Louis B. Cady, MD, FAPA – CEO & Founder – Cady Wellness InstituteLouis B. Cady, MD, FAPA – CEO & Founder – Cady Wellness Institute
Adjunct Clinical Lecturer – Indiana University School of Medicine
Department of Psychiatry
Functional & Integrative Neuropsychiatry – Evansville, Indiana
The Natural Treatment of ADHD:
New Hope and New Directions
For
Laboratorio Great Plains – April 13, 2019
Sao Paulo, Brazil
5. Increased methylphenidate usage for
attention deficit disorder in the 1990’s.
Safer DJ et al. Pediatrics. 1996 Dec; 98(6 Pt 1):1084-8}
• 2.5 X increase in MPH tx between 1990 and 1995
– 2.8% (1.5 million) US youths aged 5-18 received this
medication in mid-1995
• “The increase in methylphenidate…appears
largely related to
– an increased duration of treatment;
– More girls, adolescents and inattentive youths on the
medication
– And a recent improved public image of medication
treatment.”
6. ADHD Prevalence in Brazilian children
• 1,013 students aged 12 – 14 years at 64
state schools tested using a screening
instrument.
– 5.8% met diagnostic criteria for ADHD
– ”affected youths are at high risk for impairment
and dysfunction in multiple domains.”
• Rhode LA et al. ( Drs. Zimmermann, Schmitz, Martins, and
Tamontina were residents in Child & Adolescent Psychiatry at
Federal University of Rio Gramnde do Sul, Brazil.) Journal of
the American Academy of Child & Adolescent Psychiatry June
1999, volume 38, issue 6, pages 716-722.
7. ADHD and Mental Health Status in
Brazilian school-age children
• Objectives: assess prevalence, mental health
status, and risk factors.
• Methods: children aged 5 – 13 years in public
elementary school.
• Prevalence rate was 5.1% (95% confidence
interval)
• Diagnosis influenced by: maternal educational
status, income class, and prenatal tobacco
exposure.
Arruda MA, et al. J Atten Disord. 2015 Jan;19(1):11-7. doi: 10.1177/1087054712446811.
8. “ADHD is undertreated in Brazil”
Mattos P et al. Revista Brasileira Psiquiatria. Sao Paulo, Dec. 2012
• Letter to the editor:
• Conservative analysis of prevalence – 0.9%
– 5.3% of youths and 2.5% of adults worldwide are more
common estimates.
• Number of doses of methylphenidate sold:
– 2009: 1,413,460 boxes of methylphenidate
-represents 32,986,110 pills
– 2010: 1,674,372 boxes of methylphenidate -
represents 40,585,870 pills
FULL TEXT of the article http://www.scielo.br/scielo.php?
script=sci_arttext&pid=S1516-44462012000400023&lng=en&nrm=iso&tlng=en
9. “ADHD is undertreated in Brazil”
Mattos P et al. Revista Brasileira Psiquiatria. Sao Paulo, Dec. 2012, cont.
• 924,732 Braziledos would be estimated to be
affected, using the 0.9% prevalence.
• Calculation: number of likely cases divided by
number of pills required for continuous treatment.
• Conclusions:
– Only 16.2% in 2008, and 19.9% in 2010 who would be
appropriately treated got it.
• Also noted: 30% of ADHD patients do not
respond to stimulants…
10. For both groups of people hearing
this presentation --
• Clinicians treating patients
with straight ADD/ADHD
– Medications are not
necessarily evil
– Holistic “bio-med”
interventions are more
desirable.
– Some interventions that
patients with autism receive
(and all functional testing)
may ALL be relevant in
terms of remediating
biological symptoms
exacerbating ADHD.
• Clinicians treating patients with
autism spectrum disorder &
ADD/ADHD
– Select the most disabling set of
symptoms & start stabilizing them
first.
– Medications should be used with
CAUTION and, unless absolutely
necessary, not for “chemical
restraint.”
– EVERY biomedical intervention and
diagnostic modality should be
considered. (Resources: every other
presentation at this Congresso).
12. The recent literature
• Prenatal exposure to substances resulted in more mental
health symptoms assoc. with ADHD and ASD, compared
to controls.
– Sandtorv LB et al. Subst Abuse. 2018 Mar 22;12:1178221818765773. doi:
10.1177/1178221818765773. eCollection 2018.
• Use of augmented reality smartglasses – the Empowered Brain system
– a behavioral and social communication aid for child, adolescents,
and young aduts with ASD and high ADHD symptoms. The study
showed initial evidence of the potential of this system to “reduce ADHD
related symptoms… with ASD.”
– Vahabzadeh A et al. JMIR Ment Health. 2018 Mar 24;5(2):e25. doi:
10.2196/mental.9631
• Children with both ASD and ADHD have an increased risk of anxiety
and mood disorders. Physicians who care for children with ASD should
be aware of the coexistence of these treatable conditions.
– Gordon-Lipken E et al. Pediatrics. 2018 Apr;141(4). pii: e20171377. doi:
10.1542/peds.2017-1377
13. www.billfoster.com - Reviving American Manufacturing, accessed 1 27 2014www.billfoster.com - Reviving American Manufacturing, accessed 1 27 2014
21. Genetic etiologies
• Genes most commonly associated with ADHD
involve dopamine.
– Faraone SV, Perlis RH, Doyle AE, et al. Molecular genetics of attention-
deficit/hyperactivity disorder. Biol Psychiatry. 2005;57:1313-1323.
• PET studies show excess DAT in presynaptic
neuron (15% higher than in controls)
– Spencer TJ, Biederman J, Ciccone PE, et al. PET study examining
pharmacokinetics, detection and likeability, and dopamine transporter
receptor occupancy of short- and long-acting oral methylphenidate. Am J
Psychiatry. 2006;163(3):387-395.
23. Faraone SV et al. Biol Psychiatry 2005 June 1;57(11):1313-
1323.
Graphic from CNS Spectr. 2007;12:4 (Suppl 6): 6- 7
24. Integrated: how to avoid over-reliance
on meds
• Holistic evaluation, treatment, and
supplementation!
• Smart prescribing!
• School:
– Excellent working relationships with school
– Good teaching
• HOME:
– Diminish “electronic screens” effect
– Good home discipline
– Good sleep/wake schedules
– Good diet AND NUTRITION
– Adequate exercise
• Parent training: parenting, stress tips
25. What the peer-reviewed literature says
• Internet game playing was associated with lower white
matter density in brain regions that are involved in
decision-making, behavioral inhibition and emotional
regulation.
• Structural brain imaging studies showed alterations in the
volume of the ventral striatum that is an important part of
the brain's reward mechanisms.
• Videogame playing was associated
with dopamine release similar in magnitude to those of
drugs of abuse and lower dopamine transporter
and dopamine receptor D2 occupancy indicating sub-
sensitivity of dopamine reward mechanisms.
Weinstein A, et al. Neurosci Biobehav Res. April 2017
26.
27. Death by video game
• 2005 – S. Korean, addicted to StarCraft – lost job,
girlfriend. Spent all money at an internet. 14-18
hours at a time.
– One day, went 50 hours nonstop, collapsed, and died
from exhaustion and dehydration.
• 2015 – Taiwan man – dead from cardiac failure
after a three-day online gaming binge.
• 2007 – 15 year old boy shot both parents over his
video game (Halo 3) being confiscated
• 17 year old Philippine teen murdered his 68 year
old GM for interrupting his game in an internet
café.
28. New diagnostic codes and treatment
facilities
• ICD-10 Diagnostic codes:
– Y93.C1 – keyboard playing video games
– Y93.C2 – video games including cell phones,
communication devices (tablets) and other interactive
devices.
• Treatment facilities
– McLean Hospital in Belmont MA has set up Computer
Addiction Services.
– Chinese Government operates several clinics to treat
those suffering from overuse of online games, chatting,
and web surfing. “Electrical shock treatments” used.
29.
30. Di Chiara, G et al. Neuropharmacology, 47(1), Supl 1, 2004:227-241
• Addictive drugs increase extracellular dopamine in
nucleus accumbens.
• Brain imaging studies: have demonstrated
correlation between psychostimulant induced
increase of extracellular CA and self-reported
measures of liking and “high”(euphoria).
31. Emergence of diagnoses of game
playing pathology
• “Internet gaming disorder”
– Now listed in DSM5 research appendix as a
“condition for further study.”
• “GAMING DISORDER”
– World Health Organization, 2018
– Applies on online and offline gaming.
33. Do stimulant drugs work in children
with ASD and ADHD?
• Meta-analysis of four cross-over studies, with 113 children
ages 5 – 13 (83% boys)
• “We found that short-term use of methylphenidate might
improve symptoms of hyperactivity and possibly inattention
in children with ASD who are tolerant of the medication,
although the low quality of evidence means that we cannot
be certain of the true magnitude of any effect. There was
no evidence that methylphenidate has a negative impact
on the core symptoms of ASD, or that it improves social
interaction, stereotypical behaviours, or overall ASD.”
– Sturman N et al. Methylphenidate of children and adolescents with autism
spectrum disorder. Cochrane Database Syst Rev. 2017 Nov
21;11:CD011144. doi: 10.1002/14651858.CD011144.pub2.
35. • The present study found that 53 subjects with ADHD had
significantly lower concentrations of key fatty acids in the
plasma polar lipids (20:4n-6, 20:5n-3, and 22:6n-3) and in red
blood cell total lipids (20:4n-6 and 22:4n-6) than did the 43
control subjects
• “…but the precise reason for lower fatty acid concentrations in
some children with ADHD is not clear.”
• The present study found that 53 subjects with ADHD had
significantly lower concentrations of key fatty acids in the
plasma polar lipids (20:4n-6, 20:5n-3, and 22:6n-3) and in red
blood cell total lipids (20:4n-6 and 22:4n-6) than did the 43
control subjects
• “…but the precise reason for lower fatty acid concentrations in
some children with ADHD is not clear.”
36. • “We argue that a change in the ratio of n-6/n-3,
especially during early life, may induce
developmental changes in brain connectivity,
synaptogenesis, cognition and behavior that are
directly related to ASD.”
• “We argue that a change in the ratio of n-6/n-3,
especially during early life, may induce
developmental changes in brain connectivity,
synaptogenesis, cognition and behavior that are
directly related to ASD.”
37. • Western diet: omega 3 fatty acid deficiency and increased
fructose intake.
• “Both promote brain insulin resistance and increase the
vulnerability to cognitive dysfunction.”
• “Multiple cognitive domains are affected by metabolic
syndrome in adults and in obese adolescents, with volume
losses in the hippocampus and frontal lobe, affecting
executive function.”
• Western diet: omega 3 fatty acid deficiency and increased
fructose intake.
• “Both promote brain insulin resistance and increase the
vulnerability to cognitive dysfunction.”
• “Multiple cognitive domains are affected by metabolic
syndrome in adults and in obese adolescents, with volume
losses in the hippocampus and frontal lobe, affecting
executive function.”
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775234/
38. • In Adults with ADHD:
• DECREASED DHA, AA, and DHGLA
• “We could demonstrate that a lack of polyunsaturated
FAs in blood serum of subjects with ADHD persists
into adulthood. Furthermore, we could show that adult
ADHD symptomatology positively correlates with
elevated levels of saturated stearic and
monounsaturated FAs.HGLA were lower than
controls.”
• In Adults with ADHD:
• DECREASED DHA, AA, and DHGLA
• “We could demonstrate that a lack of polyunsaturated
FAs in blood serum of subjects with ADHD persists
into adulthood. Furthermore, we could show that adult
ADHD symptomatology positively correlates with
elevated levels of saturated stearic and
monounsaturated FAs.HGLA were lower than
controls.”
39. Reduced Levels of Omega-3 Fatty
Acids are Associated with ADHD
Antalis et al., Prostaglandins Leukot Essent Fatty Acids,
2006. 75(4-5): p. 299-308.
40. This summary demonstrates that a deficiency in brain
PUFAs will lead to cognitive deficits, while
supplementation of PUFAs can rehabilitate cognitive
deficits, as manifested in attention deficit hyperactivity
disorder, stress/anxiety, and aging.
This summary demonstrates that a deficiency in brain
PUFAs will lead to cognitive deficits, while
supplementation of PUFAs can rehabilitate cognitive
deficits, as manifested in attention deficit hyperactivity
disorder, stress/anxiety, and aging.
41. PUFA’s as cognitive enhancers
• Low dose PUFA supplementation study
• French community dwellers aged 70 or over
reporting subjective memory complaints;
NOT DEMENTED.
• PUFA – 800 mg DHA / 225 mg EPA
• Less cognitive decline over 36 months.
Hooper C et al. Cognitive changes with omega-3
polyunsaturated fatty acids in non-demented older adults with
low omega-3 index. J Nutr Health Aging. 2017; 21(9):968-
993
42. PUFA + Methylphenidate (Ritalin)
• 40 children with ADHD in study, 2014.
– 82.5% boys, 17.5% girls
• Two groups:
– MPH + PUFA
– MPH + placebo
• Response to treatment (reduction of at least
25% of signs)
– MPH + Placebo 60%
– MPH + PUFA 90%
Moghaddam MF et al. Effectiveness of methylphenidate and PUFA for the treatment
of patients with ADHD” a double-blinded randomized clinical trial. Electron
Physician. 2017 May25;9(5):4412-4418
43. HOW TO DO IT
• Key principles of essential fatty acid
supplementation are:
– Do not use large doses of a generic omega 6 or omega
3 fish oil and presume that you are going to get
adequate amounts of EPA and DHA out the bottom of
the pathways.
– The only two sources of fish oil high in PUFA’s that we
get are from eating fish or taking fish oil. Period. If we
don’t eat fish, we should probably be on fish oil.
– We DO have the ability to synthesize the critical
PUFA’s, including EPA and DHA, from precursors, but
in order to do so, we must have adequate amounts of
the critical trace minerals.
44.
45. NOTE: The essential elements
portion of this test include:
•Elemental lithium
•Iron
•Magnesium
•Zinc
•copper
NOTE: The essential elements
portion of this test include:
•Elemental lithium
•Iron
•Magnesium
•Zinc
•copper
46. IRON - Most common of all nutrient deficiencies in U.S.
school-aged children
Murray & Pizzorno. Encyclopedia of Natural medicine. Rocklin, CA: Prima Publishing; 1998.
• Deficiency associated with:
markedly decreased attentiveness,
narrower attention span, decreased
persistence, and lowered activity
level – all of which respond
positively to supplementation.
• Kidd. ADHD in Children: Rationale
for Its Integrative Management. Alt
Med Review 2000; 5(5):402-427.
• 30% improvement in Conners
ADHD Rating Scale following iron
supplementation [(Ferrocal), 5
mg/kg/day for 30 days] in one
uncontrolled Israeli study of boys.
• Sever et al. Iron treatment in
children with attention deficit
hyperactivity disorder. A preliminary
report. Neuropyshcobiology
1997;35:178-180.
0
5
10
15
20
25
30
35
40
45
serum
ferritin
Conners
before
after
Significant increase in serum ferritin
levels (from 25.9 +/- 9.2 to 44.6 +/- 18
ng/ml) and a significant decrease on the
parents' Connors Rating Scale scores
(from 17.6 +/- 4.5 to 12.7 +/- 5.4).
47. Iron & ADHD – 2018 data
• Meta-analysis to compare ADHD symptoms and
iron levels/iron deficiency (ID)
– 17 articles met search criteria.
• “Peripheral serum ferritin levels were significantly
lower in ADHD children, but with no significant
difference in iron or transferrin levels. (!!!)
• “Our results suggest that ADHD is
associated with lower serum ferritin
levels and ID (iron deficiency).”
Tseng PT et al. Peripheral iron levels in children with attention-deficit hyperactivity
disorder: a systematic review and meta-analysis. Sci Rep. 2018, Jan 15;8(1):788.
48. Zinc link --- and friends
• Psychiatr Pol 1994 May-Jun;28(3):345-53
[Deficiency of certain trace elements in children with hyperactivity]
[Article in Polish]Kozielec T, Starobrat-Hermelin B, Kotkowiak L.
Zakladu Medycyny Rodzinnej Pomorskiej Akademii Medycznej.
• The magnesium, zinc, copper, iron and calcium
level of plasma, erythrocytes, urine and hair in 50 children aged from 4 to 13
years with hyperactivity, were examined by AAS. The average concentration of
all trace elements was lower compared with the control group--healthy children
from Szczecin. The highest deficit was noted in hair.
• Our results show that it is necessary to
supplement trace elements in children
with hyperactivity.
50. Della Lucia CM et al. Nutrients. 2016 May 14;8(5).
Methods and results
• 99 children 2-6 years; 42.6% male.
• 2 preschools – one with UltraRice® (UR®) and
one with polished (unfortified) Rice.
• The fortified rice improved: level of Zinc, Thiamine,
Folic acid, mean corpuscular hemoglobin, mean
corpuscular hemoglobin concentration.
• Inadequacies of thiamine, folic acid and IRON
were lower among the test preschool.
51. Assessment of magnesium levels in children with
attention deficit hyperactivity disorder (ADHD)
• 116 children with ADHD
• Magnesium deficiency was found in 95 per cent of
those examined:
– most frequently in hair (77.6 per cent)
– in red blood cells (58.6 per cent)
– and in blood serum (33.6 per cent)
• CONCLUSIONS: magnesium deficiency in children
with ADHD occurs more frequently than in healthy
children. Analysis of the material indicated the
correlation between levels of magnesium and the
quotient of development to freedom from
distractibility.
Kozielec T, Starobrat-Hermelin B. Magnes Res 1997 Jun;10(2):143-8
52.
53. The effects of magnesium physiological supplementation
on hyperactivity in children with ADHD. Positive
response to magnesium oral loading test.
• Examined:
– Treatment group: 50 hyperactive children, ages 7-12
years, per DSM IV criteria for ADHD.
– Control group- 25 children
– Treated group – 25 children 200 mg Magnesium per
day.
• Results:
– “an increase in magnesium contents in hair and a
significant decrease of hyperactivity of those examined
has been achieved, compared to their clinical state
before supplementation.”
Starobrat-Hermelin BN, et al. Magnesium Research. 1997 Jun;10(2):149-56
54. Putting it all together with new
technology…
One illustrative cases
55. The adorable rager – parents
concerned; interested in natural
treatment
• 7 years of age
• Generally sweet
• Unpredictable rages
• Assaultive
• Intermittently totally unmanageable
62. THEREFORE:
informed treatment decisions
• Diet – eliminate dairy and wheat
• L-Methylfolate support to bypass MTHFR
• Vayarin for membrane stabilization
• 5HTP to supply more raw material for
serotonin synthesis
• Lithium – 10 drops = 0.5 mg
63. Crocus sativus (saffron) vs. methylphenidate in
treatment of children with ADHD
• 6 week randomized
double-blind study, n=
54 (children 6 – 17
years), with DSM5
diagnosis of ADHD.
• RX:
– 20 – 30 mg per day
methylphenidate
– 20 – 30 mg saffron
capsules.
“Short term therapy with
saffron capsule showed the
same efficacy compared with
methylphenidate.”
Baziar S et al. J Child Adolescent Psychopharmacology. 2019 Feb 11.
64. Treatment of side effects:
• Folic acid appears to stimulate appetite in
ADHD children treated with MPH
• Randomized, double blind clinical trial with
70 outpatients, ages 6 – 1 2 years.
– Group 1 – 1 mg/kg MPH plus 5 mg folic acid/day
– Group 2 – 1 mg/kg MPH plus placebo.
• “Appetite was significantly improved in group 1”
Riahi F et al. Effects of folic acid on appetite in children with attention deficit
hyperactivity disorder treated with methylphenidate: a randomized double-blind
clinical trial. Iran J Med Sci. 2018 Jan;43(1):9-17.
66. Summary – WHAT YOU CAN DO
• Get rid of/stop playing video games. Beware
computer/internet addiction
• Get functional medicine testing:
– IgG Food Allergies, organic acid testing, hair analysis,
pharmacogenomics (esp. MTHFR and COMT). Conventional (but
sophisticated) labs, e.g. RBC Mg, RBC Zn, etc. B12 AND
Methylmalonic acid. Ferritin.
• Avoid over-reliance on medication
• Holistic:
– Address ANY MTHFR deficiencies.
– Fish oil (good quality EPA/DHA), replace elemental deficiencies
(magnesium, zinc, copper, iron), & replenish gut microbiota with
probiotics
– Consider low dose lithium, rhodiola (if indicated); saffron
– Consider precursor loading therapy (l-phenylalanine, l-tyrosine, 5-
dydroxytrptophan)
67. “There are things
known and there are
things unknown, and
in between are the
doors.”
- Jim Morrison
68. Contact information:
Louis B. Cady, M.D.
www.cadywellness.com
Office: 812-429-0772
E-mail: lcady@cadywellness.com
4727 Rosebud Lane – Suite F
Interstate Office Park
Newburgh, IN 47630 (USA)
Link to all slides from this presentation:
www.slideshare.net/lcadymd