Presentation on the EC mandate on Open Access to publications in H2020 (part of the webinar "H2020 policies on Open Access and Research Data" delivered on June 12, 2019)
OpenAIRE webinar. Services and tools to support compliance; Open Science Help...OpenAIRE
Presentation on the services and tools, including the Open Science helpdesk and training materials, OpenAIRE provides to support the compliance to H2020 mandates (part of the webinar "H2020 policies on Open Access and Research Data" delivered on June 12, 2019)
OpenAIRE webinar. Open Research Data in H2020OpenAIRE
Presentation on the EC mandate on Open Access to research data in H2020 (part of the webinar "H2020 policies on Open Access and Research Data" delivered on June 12, 2019)
Making your Repository or Open Access Journal OpenAIRE compatible with OA Hor...OpenAIRE
Webinar: "Making your OA repository or OA journal OpenAIRE compatible with OA Horizon 2020 requirements" - Thursday 26 November 2015, 11:00am - 12:00pm.
The webinar is a part of FOSTER e-learning course “Making your OA repository or OA journal OpenAIRE compatible with OA Horizon 2020 requirements”.
OpenAIRE webinar. Services and tools to support compliance; Open Science Help...OpenAIRE
Presentation on the services and tools, including the Open Science helpdesk and training materials, OpenAIRE provides to support the compliance to H2020 mandates (part of the webinar "H2020 policies on Open Access and Research Data" delivered on June 12, 2019)
OpenAIRE webinar. Open Research Data in H2020OpenAIRE
Presentation on the EC mandate on Open Access to research data in H2020 (part of the webinar "H2020 policies on Open Access and Research Data" delivered on June 12, 2019)
Making your Repository or Open Access Journal OpenAIRE compatible with OA Hor...OpenAIRE
Webinar: "Making your OA repository or OA journal OpenAIRE compatible with OA Horizon 2020 requirements" - Thursday 26 November 2015, 11:00am - 12:00pm.
The webinar is a part of FOSTER e-learning course “Making your OA repository or OA journal OpenAIRE compatible with OA Horizon 2020 requirements”.
OpenAIRE webinar: Horizon 2020 Open Science Policies and beyond, with Emilie ...OpenAIRE
The global shift towards making research findings available free of charge and sharing and opening up the research process, so-called 'Open Science’, has been a core strategy in the European Commission to improve knowledge circulation and innovation.
It is illustrated in particular by the Open Science policies for the ECs framework programme.
In this webinar, I will talk about the OS policies for open access to scientific publications and the pilot for research data in Horizon 2020, followed by a preview of what to expect for Open Science in the new Horizon Europe programme.
---
The 2019 International Open Access Week will be held October 21-27, 2019. This year’s theme, “Open for Whom? Equity in Open Knowledge,” builds on the groundwork laid during last year’s focus of “Designing Equitable Foundations for Open Knowledge.”
As has become a tradition of sorts, OpenAIRE organises a series of webinars during this week, highlighting OpenAIRE activities, services and tools, and reach out to the wider community with relevant talks on many aspects of Open Science.
European Research at UGent: how to comply with open access mandateOpenAccessBelgium
How to comply with the open access mandate and the open research data pilot of European funded projects as a researcher of the University of Ghent, Belgium.
This webinar will provide an overview of the OpenAIRE Guidelines for data source managers who operate literature repositories, data archives or current research information systems.
The general principle of these guidelines is to improve interoperability of bibliographic information exchange between repositories, e-journals, CRIS and research infrastructures. In particular they are a means to help content providers to comply with Open Access policies and enable reporting of research output from public funding, e.g. the European Commission Open Access mandate in Horizon2020. An important aspect of the continuous development of these guidelines includes the use of established authority files and controlled vocabularies.
OSFair2017 Training | OpenAIRE monitoring services, EC FP7 & H2020 & other na...Open Science Fair
Pedro Principe presents OpenAIRE monitoring services.
Workshop title: Fostering the practical implementation of Open Science in Horizon 2020 and beyond
Workshop overview:
This workshop will showcase some of the elements required for the transition to Open Science: services and tools, policies as guidance for good practices, and the roles of the respective actors and their networks.
DAY 2 - PARALLEL SESSION 4 & 5
Presented at the Open Science Fair, Athens 6-8 September 2017, at the FOSTER Plus "Fostering the practical implementation of Open Science in Horizon 2020 and beyond" workshop http://www.opensciencefair.eu/training/parallel-day-2-2/fostering-the-practical-implementation-of-open-science-in-horizon-2020-and-beyond
The EC FP7 Post-Grant Open Access Pilot Implementation in the UKOpenAIRE
Slides presented at the FP7 Post-Grant OA Pilot national webinar for the UK on Jan 19th, 2015. The presentation provides a description of the funding initiative and its results so far, making emphasis on its current implementation in the UK. A demo is also provided on how the system for collecting and processing funding requests works.
OpenAIRE webinar: Open Access to Publications in Horizon 2020 (May 2017)OpenAIRE
OpenAIRE webinar - May 29th, 2017.
The Open Access mandate in H2020, what is expected of projects with regards to the OA policies in H2020 and how OpenAIRE can help. Webinar led by Eloy Rodrigues and Pedro Príncipe (UMinho)
This presentation provides an introduction to the Open Access policies and requirements in Horizon 2020. It explains what the requirements are, how to choice between publishing in an open access journal or depositing in an open access repository and it gives information on costs and journal policies. OpenAIRE is an information infrastructure and network that promotes and facilitates Open Science in Europe.
- Find a list of qualitative OA journals on https://doaj.org/
- Find information on APCs per journal on the Open APC project: https://treemaps.intact-project.org/apcdata/openapc/#journal/
- Find a repository: http://v2.sherpa.ac.uk/opendoar, http://roar.eprints.org/, https://explore.openaire.eu/participate/deposit-publications
- EC’s model amendment to publishing agreements: http://ec.europa.eu/research/participants/data/ref/h2020/other/hi/oa-pilot/h2020-oa-guide-model-for-publishing-a_en.pdf
- Check publishers policy: http://www.sherpa.ac.uk/romeo/index.php
- How to comply with H2020 mandate OA publications: https://www.openaire.eu/how-to-comply-to-h2020-mandates-for-publications
- For further questions and help, contact us at: https://www.openaire.eu/support/helpdesk
- For further information, check: https://www.openaire.eu/
OpenAIRE webinar: Plan S compliance for Open Access Journals - what we know s...OpenAIRE
In September 2018 when cOAlition S put out their Plan S for making Open Access an immediate reality, there was concern about how journals would become compliant in the short time available and what exactly was required to do that. The guidance mentioned that being indexed in DOAJ is necessary but that is only one criteria of many. There are other, new criteria which are additional to the DOAJ ones. DOAJ, among others, is mentioned as a key player in the certification process so the DOAJ Team have looked very carefully at what is being asked. One of the problems is that the exact data to be captured for those requirements have not yet been set and work by cOAlition S to do that is only slated to start imminently. In this presentation, I will explain what those extra Plan S criteria might be and how we think that they might be measured and captured. I will explain how we think the certification process, at least at DOAJ, might go and what the difference is between DOAJ certification and Plan S certification.
Webinar on Open Access to Publications in Horizon 2020OpenAIRE
Joint Webinar FOSTER and OpenAIRE: Open Access to Publications in Horizon 2020, presented by Antónia Correia (FOSTER, University of Minho) and Pedro Príncipe, (OpenAIRE, University of Minho).
The aim of this Webinar was to present:
- Open Access in H2020: summary of requirements;
- Open Access in H2020: practical implementation;
- Supporting the compliance: OpenAIRE services and tools.
This Webinar was part of the FOSTER moderated Course on Open Access to Publications in Horizon 2020. More information available at: https://www.openaire.eu/item/course-on-open-access-to-publications-in-horizon-2020 and https://www.fosteropenscience.eu/node/2618.
OpenAIRE webinar: Horizon 2020 Open Science Policies and beyond, with Emilie ...OpenAIRE
The global shift towards making research findings available free of charge and sharing and opening up the research process, so-called 'Open Science’, has been a core strategy in the European Commission to improve knowledge circulation and innovation.
It is illustrated in particular by the Open Science policies for the ECs framework programme.
In this webinar, I will talk about the OS policies for open access to scientific publications and the pilot for research data in Horizon 2020, followed by a preview of what to expect for Open Science in the new Horizon Europe programme.
---
The 2019 International Open Access Week will be held October 21-27, 2019. This year’s theme, “Open for Whom? Equity in Open Knowledge,” builds on the groundwork laid during last year’s focus of “Designing Equitable Foundations for Open Knowledge.”
As has become a tradition of sorts, OpenAIRE organises a series of webinars during this week, highlighting OpenAIRE activities, services and tools, and reach out to the wider community with relevant talks on many aspects of Open Science.
European Research at UGent: how to comply with open access mandateOpenAccessBelgium
How to comply with the open access mandate and the open research data pilot of European funded projects as a researcher of the University of Ghent, Belgium.
This webinar will provide an overview of the OpenAIRE Guidelines for data source managers who operate literature repositories, data archives or current research information systems.
The general principle of these guidelines is to improve interoperability of bibliographic information exchange between repositories, e-journals, CRIS and research infrastructures. In particular they are a means to help content providers to comply with Open Access policies and enable reporting of research output from public funding, e.g. the European Commission Open Access mandate in Horizon2020. An important aspect of the continuous development of these guidelines includes the use of established authority files and controlled vocabularies.
OSFair2017 Training | OpenAIRE monitoring services, EC FP7 & H2020 & other na...Open Science Fair
Pedro Principe presents OpenAIRE monitoring services.
Workshop title: Fostering the practical implementation of Open Science in Horizon 2020 and beyond
Workshop overview:
This workshop will showcase some of the elements required for the transition to Open Science: services and tools, policies as guidance for good practices, and the roles of the respective actors and their networks.
DAY 2 - PARALLEL SESSION 4 & 5
Presented at the Open Science Fair, Athens 6-8 September 2017, at the FOSTER Plus "Fostering the practical implementation of Open Science in Horizon 2020 and beyond" workshop http://www.opensciencefair.eu/training/parallel-day-2-2/fostering-the-practical-implementation-of-open-science-in-horizon-2020-and-beyond
The EC FP7 Post-Grant Open Access Pilot Implementation in the UKOpenAIRE
Slides presented at the FP7 Post-Grant OA Pilot national webinar for the UK on Jan 19th, 2015. The presentation provides a description of the funding initiative and its results so far, making emphasis on its current implementation in the UK. A demo is also provided on how the system for collecting and processing funding requests works.
OpenAIRE webinar: Open Access to Publications in Horizon 2020 (May 2017)OpenAIRE
OpenAIRE webinar - May 29th, 2017.
The Open Access mandate in H2020, what is expected of projects with regards to the OA policies in H2020 and how OpenAIRE can help. Webinar led by Eloy Rodrigues and Pedro Príncipe (UMinho)
This presentation provides an introduction to the Open Access policies and requirements in Horizon 2020. It explains what the requirements are, how to choice between publishing in an open access journal or depositing in an open access repository and it gives information on costs and journal policies. OpenAIRE is an information infrastructure and network that promotes and facilitates Open Science in Europe.
- Find a list of qualitative OA journals on https://doaj.org/
- Find information on APCs per journal on the Open APC project: https://treemaps.intact-project.org/apcdata/openapc/#journal/
- Find a repository: http://v2.sherpa.ac.uk/opendoar, http://roar.eprints.org/, https://explore.openaire.eu/participate/deposit-publications
- EC’s model amendment to publishing agreements: http://ec.europa.eu/research/participants/data/ref/h2020/other/hi/oa-pilot/h2020-oa-guide-model-for-publishing-a_en.pdf
- Check publishers policy: http://www.sherpa.ac.uk/romeo/index.php
- How to comply with H2020 mandate OA publications: https://www.openaire.eu/how-to-comply-to-h2020-mandates-for-publications
- For further questions and help, contact us at: https://www.openaire.eu/support/helpdesk
- For further information, check: https://www.openaire.eu/
OpenAIRE webinar: Plan S compliance for Open Access Journals - what we know s...OpenAIRE
In September 2018 when cOAlition S put out their Plan S for making Open Access an immediate reality, there was concern about how journals would become compliant in the short time available and what exactly was required to do that. The guidance mentioned that being indexed in DOAJ is necessary but that is only one criteria of many. There are other, new criteria which are additional to the DOAJ ones. DOAJ, among others, is mentioned as a key player in the certification process so the DOAJ Team have looked very carefully at what is being asked. One of the problems is that the exact data to be captured for those requirements have not yet been set and work by cOAlition S to do that is only slated to start imminently. In this presentation, I will explain what those extra Plan S criteria might be and how we think that they might be measured and captured. I will explain how we think the certification process, at least at DOAJ, might go and what the difference is between DOAJ certification and Plan S certification.
Webinar on Open Access to Publications in Horizon 2020OpenAIRE
Joint Webinar FOSTER and OpenAIRE: Open Access to Publications in Horizon 2020, presented by Antónia Correia (FOSTER, University of Minho) and Pedro Príncipe, (OpenAIRE, University of Minho).
The aim of this Webinar was to present:
- Open Access in H2020: summary of requirements;
- Open Access in H2020: practical implementation;
- Supporting the compliance: OpenAIRE services and tools.
This Webinar was part of the FOSTER moderated Course on Open Access to Publications in Horizon 2020. More information available at: https://www.openaire.eu/item/course-on-open-access-to-publications-in-horizon-2020 and https://www.fosteropenscience.eu/node/2618.
Horizon 2020 Open Access to Publications Mandate: OpenAIRE Webinar (Oct. 22, ...OpenAIRE
Eloy Rodrigues (University of Minho) on the Open Access to Publications Mandate in H2020 (in collaboration with FOSTER) - Date: Wednesday, October 22 2014.
OpenAIRE webinar on Open Access in H2020 (OAW2016)OpenAIRE
OpenAIRE Webinar for project coordinators and researchers on Open Access to publications in H2020 - By Eloy Rodrigues and Pedro Principe (University of Minho, OpenAIRE Helpdesk & Training managers). Open Access Week 2016 initiatives.
Open Access to publications in H2020: FOSTER workshop integrated on the Europ...Pedro Príncipe
OpenAIRE presentations at the FOSTER project workshop integrated on the 5th Portuguese Young Chemists Meeting (5th PYCheM) and 1st European Young Chemists Meeting (1st EYCheM) - Guimarães, 26 April 2016, Portugal.
“By 2020 scientific publications that result from research funded by public grants provided by participating national and European research councils and funding bodies, must be published in compliant Open Access Journals or on compliant Open Access Platforms.”
- Overview of Plan S
- Key Principles and Purpose
- Key Issues of interest to authors
- Chance to provide your feedback, ask questions
The FP7 Post-Grant Open Access Pilot: An All-Encompassing Gold Open Access Fu...OpenAIRE
A year into the EC FP7 Post-Grant Open Access Pilot, this presentation delivered at the LIBER Annual Conference 2016 in Helsinki shows the current progress of this funding initiative. This Gold OA Pilot has currently two funding worklines, a main one for APC/BPC payments for post-grant manuscripts arising from finished FP7 projects and an alternative funding mechanism for supporting APC-free OA journals and platforms. Detailed figures are provided for the APC payments made so far, together with a number of findings the initiative has already come upon.
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology, published by Wiley-VCH. Slides were presented on 17 February 2020 at the Technical University of Braunschweig.
Publishing Scientific Research & How to Write High-Impact Research Papersjjuhlrich
Presentation on publishing scientific research and how to write high-impact scientific papers by Dr. John Uhlrich as the Editor-in-Chief of Energy Technology, published by Wiley-VCH. Slides were presented on 07 February 2020 at Justus-Liebig-Universität Gießen.
“By 2020 scientific publications that result from research funded by public grants provided by participating national and European research councils and funding bodies, must be published in compliant Open Access Journals or on compliant Open Access Platforms.”
- Overview of Plan S
- Key Principles and Purpose
- Key Issues of interest to authors
- Chance to provide your feedback, ask questions
As part of a webinar series on Open Research in Ireland, the National Open Research Forum (NORF) presented a webinar focused on Open Access to research publications on 4 May 2021. This presentation on the French national Open Access policy was delivered by Marin Dacos (Open Science Advisor, French Ministry of Higher Education, Research and Innovation).
OpenAIRE Content Providers Community Call, November 4th, 2020
This call was focused on the PROVIDE future developments, functionalities wishlist and PROVIDE service in EOSC.
Was also an opportunity to share the most recent updates and novelties in the OpenAIRE Content Provider Dashboard, and to get feedback from community.
Recordings: https://youtu.be/wY4fOS767Us
Follow the Community activities at https://www.openaire.eu/provide-community-calls
OpenAIRE in the European Open Science Cloud (EOSC)OpenAIRE
Openness is the success factor for EOSC. OpenAIRE has been working in delivering an open access scholarly communication in Europe for the past 10 years and we now present how our work fits into the EOSC core developments
OpenAIRE Content Providers Community Call, October 7th, 2020
This call was focused on the OpenAIRE Broker Service, specifying how the service works to deploy the enrichment events to the Content Providers managers.
Was also an opportunity to share the most recent updates and novelties in the OpenAIRE Content Provider Dashboard, and to get feedback from community.
Recording: https://youtu.be/3sF4B58EGcs
Follow the Community activities at https://www.openaire.eu/provide-community-calls
OpenAIRE Content Providers Community Call, July 1st, 2020
This call was focused on Data Repositories namely the OpenAIRE Research Graph and Data Repositories, the OpenAIRE Content Acquisition Policy, and the Guidelines for Data Archive Managers.
Was also an opportunity to share the most recent updates and novelties in the OpenAIRE Content Provider Dashboard, and to get feedback from community.
Follow the Community activities at https://www.openaire.eu/provide-community-calls
OpenAIRE Content Providers Community Call. May 6th, 2020.
This Call focused the presentation of the new User Interface of Provide Dashboard and the presentation of 4 use cases using the Provide service.
Was also an opportunity to share the most recent updates and novelties in the OpenAIRE Content Provider Dashboard, and to get feedback from community.
Recording available here: https://youtu.be/J4m_ryRxtnY
20200504_OpenAIRE Legal Policy Webinar: GDPR and Sharing DataOpenAIRE
Presentation by Jacques Flores Dourojeanni (Research Data Management Consultant Utrecht University Library), as delivered during the OpenAIRE Legal Policy Webinar series on May 4th 2020.
More information and recordings: https://www.openaire.eu/item/openaire-legal-policy-webinars
20200504_Research Data & the GDPR: How Open is Open?OpenAIRE
Presentation by Prodromos Tsiavos (Senior Legal Advisor - ARC/ Director - Onassis Group) as delivered during the OpenAIRE Legal Policy Webinar series on May 4th 2020.
More information and recordings: https://www.openaire.eu/item/openaire-legal-policy-webinars
20200504_Data, Data Ownership and Open ScienceOpenAIRE
Presentation by Thomas Margoni (Senior Lecturer in Intellectual Property and Internet Law, Co-director, CREATe, University of Glasgow) as delivered during the OpenAIRE Legal Policy Webinar series on May 4th 2020.
More information and recordings: https://www.openaire.eu/item/openaire-legal-policy-webinars
20200429_Research Data & the GDPR: How Open is Open? (updated version)OpenAIRE
Presentation by Prodromos Tsiavos (Senior Legal Advisor - ARC/ Director - Onassis Group) as delivered during the OpenAIRE Legal Policy Webinar series on April 29th 2020.
More information and recordings: https://www.openaire.eu/item/openaire-legal-policy-webinars
20200429_Data, Data Ownership and Open ScienceOpenAIRE
Presentation by Thomas Margoni (Senior Lecturer in Intellectual Property and Internet Law, Co-director, CREATe, University of Glasgow) as delivered during the OpenAIRE Legal Policy Webinar series on April 29th 2020.
More information and recordings: https://www.openaire.eu/item/openaire-legal-policy-webinars
20200429_OpenAIRE Legal Policy Webinar: GDPR and Sharing DataOpenAIRE
Presentation by Jacques Flores Dourojeanni (Research Data Management Consultant Utrecht University Library), as delivered during the OpenAIRE Legal Policy Webinar series on April 29th 2020.
More information and recordings: https://www.openaire.eu/item/openaire-legal-policy-webinars
COVID-19: Activities, tools, best practice and contact points in GreeceOpenAIRE
Presentation from the webinar organized by the Greek OpenAIRE and RDA Nodes (Athena RC) and Elixir-GR to inform participants of EU and national efforts, in collaboration with the following research organizations: Flemming, CERTH, HEAL-Link, Demokritos, Univ. of Athens (Medical School).
Presentation of the 2nd Content Providers Community Call, targeting the following topics: 1) OpenAIRE Content provider dashboard updates; Main topic: DSpace-CRIS for OpenAIRE: implementation of the CRIS guidelines and beyond; 3) Community questions & comments.
Presentation of the 2nd Content Providers Community Call, targeting the following topics: 1) OpenAIRE Content provider dashboard updates;
2) OpenAIRE aggregation and enrichment processes: specifications and good practices;
3) Community questions & comments.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
2. ‘Everyone on the road to Open Science’ by Patrick Hochstenbach CC-BY 4.0 by Patrick Hochstenbach
3. Aim
OpenAIRE Webinar OA to publications in H2020 – 12/06/2019
- To optimize the impact of publicly-funded scientific research, both at European (FP7, Horizon 2020) and
Member State level
- Results of publicly-funded research should be disseminated more broadly and faster, for the benefit of
researchers, innovative industry and citizens. improve quality, greater transparency and faster progress.
- All beneficiaries must deposit their peer-reviewed publications to ensure open access
4. • TheGrantAgreementstates(29.2):
Open Access Policy
OpenAIRE Webinar OA to publications in H2020 – 12/06/2019
“Ensure open access…
as soon as possible and at the latest on
publication, deposit a machine-readable
electronic copy of the published version
or final peer-reviewed manuscript
accepted for publication in a repository
for scientific publications together with
bibliographic metadata providing the
name of the action, acronym & grant
number”
5. 1. Publish in any journal of your choice
How make your publication OA?
Subscription based
Open Access Journal
ALWAYS deposit a version in a repository
OpenAIRE WebinarOAtopublicationsinH2020 –12/06/2019
+ Add metadata: funder, grant ID number, acronym, publication date….
Deposit in a repository and provide
access
Deposit in a repository and provide
access
6. Which way to choose?
• Any subscription
based journal
Open Access Journal
OpenAIRE WebinarOAtopublicationsinH2020 –12/06/2019
Self-archive
in repository
• No fees
• Possibility of an
embargo period
• Direct Open Access
• Retain copyright
(sometimes)
• Possible costs (APC)
PROS CONS
+ -
7. • Directory of Open Access Journals: DOAJ
doaj.org/
• Article Processing Charge (APC)
Publishing in an OA journal
Finding an OA journal:
OpenAIRE Webinar OA to publications in H2020 – 12/06/2019
8. • Both for OA journals AND subscriptions-based journals that offer
the possibility of making individual articles openly accessible
(hybrid journals)
Are Article Processing Charges (APCs)
supported?
Yes
OpenAIRE Webinar OA to publications in H2020 – 12/06/2019
but…
• Are eligible for reimbursement during the duration of the action.
9. What budget to consider in proposal?
• What to budget? Average APC x number of publications
• Publication costs dissemination costs
• APCs vary widely
How?
OpenAIRE Webinar OA to publications in H2020 – 12/06/2019
1. Look up APCs for specific journals: ask librarians, consult publishers website
2. based on average APC
10. Average APCs APCsvarywidely
OpenAIRE Webinar OA to publications in H2020 – 12/06/2019
Average:
• 1378 €1 - 1 978 €2
• 1186 / 1 754 € (OA journal) - 2 280 € (hybrid journal)3
• 1 479 € (OA journal) – 2 493 € (hybrid journal)4
1. Open access central funds in UK universities. Learned Publishing, [online] 25(2). Pinfield, S., and Middleton, C., 2012
2. Figure 1: APC pricing distribution. Article processing charges (APCs) and subscriptions. Shamash , K. , 2016
3. A study of open access journals using article processing charges. Journal of the American Society for Information Science and Technology, 63(8), pp.1485–1495. Solomon, D.J., and Björk, B.-C., 2012
4. https://treemaps.intact-project.org/page/about.html
Information on APCs per publisher and journal
openAPC project
Both types of OA publication cost can be reimbursed in H2020
projects.
Currently, there is no price-cap for APCs.
11. Issues to consider
OpenAIRE Webinar OA to publications in H2020 – 12/06/2019
1. Publishing ALL articles in APC based OA journals is probably
not the right solution as it can lead to a substantial amount of the
project budget. a mix of depositing articles and publishing in
OA journals is highly recommended.
2. The growing OA market comes with some challenges.
lots of new publishers/journals some of questionable quality.
Consult white list such as https://doaj.org/
12. • Institutional repository
• Disciplinary (arXiv, Europe PubMed Central…)
• Or use Zenodo.org: EC-cofounded, multidisciplinary, free
repository
Where to deposit?
• The Directories of Open Access Repositories:
OpenAIRE Webinar OA to publications in H2020 – 12/06/2019
• v2.sherpa.ac.uk/opendoar
• roar.eprints.org
• Explore.openaire.eu
13. • Final peer-reviewed manuscript
OR
• Published version
+ metadata: funder, grant ID number, acronym, publication date….
What to deposit?
OpenAIRE Webinar OA to publications in H2020 – 12/06/2019
Apply to all kind of publication, but emphasis on peer-reviewed
journal articles
14. When to deposit?
As soon as possible, and at the latest on publication
When to provide Open Access?
• Immediately or
• After embargo period:
• at most 6 months (12 months for publications in the social sciences and humanities)*
OpenAIRE Webinar OA to publications in H2020 – 12/06/2019
*EC’s model amendment to publishing agreements:
http://ec.europa.eu/research/participants/data/ref/h2020/other/hi/oa-pilot/h2020-oa-
guide-model-for-publishing-a_en.pdf
15. • SHERPA/ROMEO: www.sherpa.ac.uk/romeo
• Overview of copyright policies and self-archiving
permissions
Checkpublisherspolicies
What can I deposit?
OpenAIRE Webinar OA to publications in H2020 – 12/06/2019
16. Sherpa/Romeo vocabulary
Embargo: Period during which access to the articles limited (6/12 months
permitted)
OpenAIRE WebinarOAtopublicationsinH2020 –12/06/2019
17. Researcher
decides where
to publish
Check publishers
policies on
www.sherpa.ac.uk/romeo
Open Access Journals:
doaj.org
Self-archive in repository
Check for Article
Processing Charges
Subscription-based
journal
In short:
This is a derivative based on a scheme by “www.fosteropenscience.eu”, used under CC BY.
Immediate OA
Immediate or
delayed OA
18. Plan S and Horizon Europe?
• Plan S:
“With effect from 2021, all scholarly publications on the results from research funded by public or
private grants[…], must be published in Open Access Journals, on Open Access Platforms, or made
immediately available through Open Access Repositories without embargo.”
• Authors or their institutions retain copyright to their publications and articles must be
published under an open license.
• Open Access publication fees are covered by the Funders or research institutions, not by
individual researchers. Fees must be transparent.
• No support for hybrid models.
Implication for Horizon Europe? Programme is still being negotiated.
For further information on Plan S: https://www.coalition-s.org/principles-and-implementation/
19. Faqs
• What if there is no Open Access journal available in my domain?
You are not limited to Open Access journals, you can provide access through a repository
• What if the embargo period of the journal is longer then 6 (for STEM) or 12 months (for HSS)?
Exception on copyright law (Secondary publication right in Belgium (6/12 months), The Netherlands, France
(6/12 months),Germany(12 months/non-commercial)) which allow you to provide Open Access through a
repository within the embargo period EVEN if otherwise stipulated in a contract.
In case there is no such exception: contact publisher and ask for an amendment to the publishing
agreement: to provide support concerning compliance with Horizon 2020 embargo periods the
Commission offers a model amendment to publishing agreement
• Other funders have negotiated agreements with publishers on embargo lengths, which are then
available in funder-specific PDFs. Does H2020 have anything like this?
No.
• Are there sanctions for not complying with OA requirements?
Yes. Grant may be reduced.