Oncolytic virotherapy uses viruses that selectively infect and kill cancer cells. Viruses are engineered to target features of cancer cells like overexpression of certain receptors. The viruses infect and replicate within cancer cells, causing them to lyse and release new virus particles to infect neighboring cancer cells. This repeats to destroy the tumor. Additionally, the viral infection stimulates anti-tumor immune responses. Oncolytic viruses show potential as a cancer therapy but challenges remain around the immune system clearing viruses too quickly and risks of new viral strains emerging.