On the Isle of Man off the coast of Ireland, a curious cat referred to as a manx cat was described in 1845. It had long hind legs and a short tail. Further work showed that the manx characteristics were the result of a dominant M allele at a single locus. An MM zygote would not survive, but Mm genotypes produced the manx characteristics. Imagine a scenario where the M allele arises by mutation on the Isle of Man. Explain how genetic drift could cause the M allele to reach a relatively high frequency (freq(M) > 0.25), even though it has harmful effects on fitness. Solution Genetic drift is the force of evolution which causes separation of individuals of a species due to geographical isolation. This causes these organisms to survive as a separate species and evolve at their respective geographical locations. According to the information, the dominant allele M is lethal to the organisms. Inspite of this fact, the frequency of allele M is increasing on the geographical area separated due to genetic drift. This suggests that the individuals on this geographical area might possess any kind of adaptability soleley due to presence of this dominant M allele. Nevertheless, it remains highly unlikely that the homozygous MM individuals will survive even on this island due to biological failures. However, individuals with heterozygous Mm genotype must have biological benefits against any stressor/stimulus at this new location. This benefit must be promoting these individuals to survive better than any of the individuals with homozyogous genotype. Thus, this particular case of fixation of higher allele frequency of geotype M in heterozygous conditions deviates from the Hardy-Weinberg law, hence there are individuals with relatively higher frequency of allele M..