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Obesity hypoventilation syndrome HY

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Rickettsia Rickettsii
Rickettsia Rickettsii

Obesity hypoventilation syndrome

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Obesity hypoventilation syndrome Diagnostic criteria • Obesity with BMI ≥30 kg/m2 • Awake daytime hypercapnia (PaCO2 >45 mm Hg) • No alternate cause of hypoventilation Workup • ABG on room air (hypercapnia, normal A-a gradient) • No intrinsic pulmonary disease on chest x-ray • Restrictive pattern on PFTs • Normal TSH • Polysomnography Treatment • Nocturnal positive pressure ventilation as first-line therapy • Weight loss (bariatric surgery in select cases) • Avoidance of sedative medications • Respiratory stimulants (eg, acetazolamide) as last resort

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Obesity hypoventilation syndrome HY

  • 1. Obesity hypoventilation syndrome Diagnostic criteria • Obesity with BMI ≥30 kg/m2 • Awake daytime hypercapnia (PaCO2 >45 mm Hg) • No alternate cause of hypoventilation Workup • ABG on room air (hypercapnia, normal A-a gradient) • No intrinsic pulmonary disease on chest x-ray • Restrictive pattern on PFTs • Normal TSH • Polysomnography Treatment • Nocturnal positive pressure ventilation as first-line therapy • Weight loss (bariatric surgery in select cases) • Avoidance of sedative medications • Respiratory stimulants (eg, acetazolamide) as last resort