The document summarizes key components and structures of nucleic acids. It describes that nucleic acids are made up of nucleotides, which consist of a nitrogen-containing base, a pentose sugar, and a phosphate group. The two types of nucleic acids are DNA and RNA. DNA contains the bases adenine, guanine, cytosine, and thymine, while RNA contains adenine, guanine, cytosine, and uracil instead of thymine. Nucleotides are linked by phosphodiester bonds to form single-stranded nucleic acids. In DNA, the strands wind together to form the double helix structure, with bases on one strand hydrogen bonding to complementary bases on the other strand.
Nucleic acids are biopolymers, macromolecules, essential to all known forms of life. They are composed of nucleotides, which are the monomer components: a 5-carbon sugar, a phosphate group and a nitrogenous base. The two main classes of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). If the sugar is ribose, the polymer is RNA; if the sugar is the ribose derivative deoxyribose, the polymer is DNA.
Nucleic acids are naturally occurring chemical compounds that serve as the primary information-carrying molecules in cells and make up the genetic material. Nucleic acids are found in abundance in all living things, where they create, encode, and then store information of every living cell of every life-form on Earth. In turn, they function to transmit and express that information inside and outside the cell nucleus to the interior operations of the cell and ultimately to the next generation of each living organism. The encoded information is contained and conveyed via the nucleic acid sequence, which provides the 'ladder-step' ordering of nucleotides within the molecules of RNA and DNA. They play an especially important role in directing protein synthesis.
Strings of nucleotides are bonded to form helical backbones—typically, one for RNA, two for DNA—and assembled into chains of base-pairs selected from the five primary, or canonical, nucleobases, which are: adenine, cytosine, guanine, thymine, and uracil. Thymine occurs only in DNA and uracil only in RNA. Using amino acids and the process known as protein synthesis,[2] the specific sequencing in DNA of these nucleobase-pairs enables storing and transmitting coded instructions as genes. In RNA, base-pair sequencing provides for manufacturing new proteins that determine the frames and parts and most chemical processes of all life forms.
This article covers the chemistry of nucleic acids, describing the structures and properties that allow them to serve as the transmitters of genetic information. For a discussion of the genetic code, see heredity, and for a discussion of the role played by nucleic acids in protein synthesis, see metabolism.
Nucleic acids are biopolymers, or small biomolecules, essential to all known forms of life. They are composed of nucleotides, which are monomers made of three components: a 5-carbon sugar, a phosphate group and a nitrogenous base. If the sugar is a compound ribose, the polymer is RNA (ribonucleic acid); if the sugar is derived from ribose as deoxyribose, the polymer is DNA(deoxyribonucleic acid).
Nucleic acids are biopolymers, macromolecules, essential to all known forms of life. They are composed of nucleotides, which are the monomer components: a 5-carbon sugar, a phosphate group and a nitrogenous base. The two main classes of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). If the sugar is ribose, the polymer is RNA; if the sugar is the ribose derivative deoxyribose, the polymer is DNA.
Nucleic acids are naturally occurring chemical compounds that serve as the primary information-carrying molecules in cells and make up the genetic material. Nucleic acids are found in abundance in all living things, where they create, encode, and then store information of every living cell of every life-form on Earth. In turn, they function to transmit and express that information inside and outside the cell nucleus to the interior operations of the cell and ultimately to the next generation of each living organism. The encoded information is contained and conveyed via the nucleic acid sequence, which provides the 'ladder-step' ordering of nucleotides within the molecules of RNA and DNA. They play an especially important role in directing protein synthesis.
Strings of nucleotides are bonded to form helical backbones—typically, one for RNA, two for DNA—and assembled into chains of base-pairs selected from the five primary, or canonical, nucleobases, which are: adenine, cytosine, guanine, thymine, and uracil. Thymine occurs only in DNA and uracil only in RNA. Using amino acids and the process known as protein synthesis,[2] the specific sequencing in DNA of these nucleobase-pairs enables storing and transmitting coded instructions as genes. In RNA, base-pair sequencing provides for manufacturing new proteins that determine the frames and parts and most chemical processes of all life forms.
This article covers the chemistry of nucleic acids, describing the structures and properties that allow them to serve as the transmitters of genetic information. For a discussion of the genetic code, see heredity, and for a discussion of the role played by nucleic acids in protein synthesis, see metabolism.
Nucleic acids are biopolymers, or small biomolecules, essential to all known forms of life. They are composed of nucleotides, which are monomers made of three components: a 5-carbon sugar, a phosphate group and a nitrogenous base. If the sugar is a compound ribose, the polymer is RNA (ribonucleic acid); if the sugar is derived from ribose as deoxyribose, the polymer is DNA(deoxyribonucleic acid).
Chap-7 Nucleic acid Power point presentationMegersa4
Nucleic acids
Get their name because they were first found in the nucleus of cells, but they have since been discovered also to exist outside the nucleus (cytoplasm).
Are the molecules within a cell that are responsible for ability to produce exact replicas of themselves. It is called ‘molecules of heredity’.
Are the principle genetic materials of all living organisms.
It contains C, H, O, N (10%) and P (15%).
Are condensation polymers of nucleotides.
Are the polynucleotides having high molecular weight.
It is a polymer in which the monomer units are nucleotides.
Nucleotides: Phosphoric acid esters of nucleosides.
Nucleotides = nucleoside + phosphate
Nucleotides are carbon ring structures containing nitrogen linked to a 5-carbon sugar.
5-carbon sugar is either a ribose or a deoxy-ribose making the nucleotide either a ribonucleotide or a deoxyribonucleotide.
Nucleosides are compounds in which nitrogenous bases (purines and pyrimidines) are conjugated to the pentose sugars (ribose or deoxyribose) by a β-glycosidic linkage.
Ribose (RNA) is a sugar, like glucose, but with only five carbon atoms in its molecule.
Deoxyribose (DNA) is almost the same but lacks one oxygen atom.
In both types of nucleotides the pentoses exist in their ß-furanose (closed five-membered ring) forms.
Both molecules may be represented by the symbol:
Despite the complexity and diversity of life the structure of DNA is dependent on only 4 different nucleotides.
Diversity is dependent on the nucleotide sequence.
All nucleotides are 2 ring structures composed of:
Despite the complexity and diversity of life the structure of DNA is dependent on only 4 different nucleotides.
Diversity is dependent on the nucleotide sequence.
All nucleotides are 2 ring structures composed of:
A nucleoside consists of a nitrogen base linked by a glycosidic bond to C1’ of a ribose or deoxyribose.
Nucleosides are named by changing the nitrogen base ending to -osine for purines and –idine for pyrimidines
A nucleotide is a nucleoside that forms a phosphate ester with the C5’ OH group of ribose or deoxyribose
Nucleotides are named using the name of the nucleoside followed by 5’-monophosphate
DNA and RNA molecules are linear polymers built from individual units called nucleotides connected by bonds called phosphodiester linkages. DNA and RNA are used to store and pass genetic information from one generation to the next.
chemistry of nucleic acids,
history --> Discovered by JOHANN FRIEDRICH MIESCHER
central dogma of life
components of nucleic acids-->Nitrogenous base +pentose sugar +phosphate group.
structure of nucleotides --> purines and pyrimidens
minor bases in nucleic acids are 5-methylcytosine,N4-acetylcytosine, N6-methylsdenine, N6,N6-dimethyladenine, pseudouracil.
Biologically importanat Bases-->Hypoxanthine, Xanthine, uric acid.
Purines bases of plant --> caffeine,theophylline, theobromine
blood supply to the cardiac muscle in different areas of the heart is not the same. On the surface of the cardiac muscle, there are large epicardial arteries supplying more blood to those areas whereas in the subendocardial region blood supply is less because it is supplied by smaller intramuscular arteries and plexus of the subendocardial artery the diameter of which are less. This blood supply to the subendocardial plexus is further reduced during systole. Therefore the subendocardial region is more prone to myocardial infarction. Again as the left ventricular thickness is much more than that of the right ventricle the occlusion is more severe in the left ventricle. For this region LV subendocardial region is more prone to MI.Q.22 What are the importance of anastomotic channels in heart muscle?In the normal heart, there are some collaterals among the smaller arteries which become active under abnormal conditions like myocardial ischemia. They open up within a few seconds after the sudden occlusion of the larger artery and become double in number by the end of 2nd or 3rd day and reach to normal by one month. When atherosclerosis causes constriction of coronary arteries slowly over a period of many years, collateral vessels develop restoring normal blood and thus the patient never experiences acute episodes of cardiac dysfunction.Q.23 What is the importance of autoregulation in blood supply in heart muscle?Like some other organs, the heart has the capacity to regulate its own blood flow up to a certain limit in order to maintain an almost constant blood flow to the cardiac musculature in spite of any alteration of systemic blood flow. This is known as autoregulation of coronary blood supply.
DNA = deoxyribonucleic acid.
DNA carries the genetic information in the cell – i.e. it carries the instructions for making all the structures and materials the body needs to function.
DNA is capable of self-replication.
Most of the cell’s DNA is carried in the nucleus – a small amount is contained in the mitochondria.
Chap-7 Nucleic acid Power point presentationMegersa4
Nucleic acids
Get their name because they were first found in the nucleus of cells, but they have since been discovered also to exist outside the nucleus (cytoplasm).
Are the molecules within a cell that are responsible for ability to produce exact replicas of themselves. It is called ‘molecules of heredity’.
Are the principle genetic materials of all living organisms.
It contains C, H, O, N (10%) and P (15%).
Are condensation polymers of nucleotides.
Are the polynucleotides having high molecular weight.
It is a polymer in which the monomer units are nucleotides.
Nucleotides: Phosphoric acid esters of nucleosides.
Nucleotides = nucleoside + phosphate
Nucleotides are carbon ring structures containing nitrogen linked to a 5-carbon sugar.
5-carbon sugar is either a ribose or a deoxy-ribose making the nucleotide either a ribonucleotide or a deoxyribonucleotide.
Nucleosides are compounds in which nitrogenous bases (purines and pyrimidines) are conjugated to the pentose sugars (ribose or deoxyribose) by a β-glycosidic linkage.
Ribose (RNA) is a sugar, like glucose, but with only five carbon atoms in its molecule.
Deoxyribose (DNA) is almost the same but lacks one oxygen atom.
In both types of nucleotides the pentoses exist in their ß-furanose (closed five-membered ring) forms.
Both molecules may be represented by the symbol:
Despite the complexity and diversity of life the structure of DNA is dependent on only 4 different nucleotides.
Diversity is dependent on the nucleotide sequence.
All nucleotides are 2 ring structures composed of:
Despite the complexity and diversity of life the structure of DNA is dependent on only 4 different nucleotides.
Diversity is dependent on the nucleotide sequence.
All nucleotides are 2 ring structures composed of:
A nucleoside consists of a nitrogen base linked by a glycosidic bond to C1’ of a ribose or deoxyribose.
Nucleosides are named by changing the nitrogen base ending to -osine for purines and –idine for pyrimidines
A nucleotide is a nucleoside that forms a phosphate ester with the C5’ OH group of ribose or deoxyribose
Nucleotides are named using the name of the nucleoside followed by 5’-monophosphate
DNA and RNA molecules are linear polymers built from individual units called nucleotides connected by bonds called phosphodiester linkages. DNA and RNA are used to store and pass genetic information from one generation to the next.
chemistry of nucleic acids,
history --> Discovered by JOHANN FRIEDRICH MIESCHER
central dogma of life
components of nucleic acids-->Nitrogenous base +pentose sugar +phosphate group.
structure of nucleotides --> purines and pyrimidens
minor bases in nucleic acids are 5-methylcytosine,N4-acetylcytosine, N6-methylsdenine, N6,N6-dimethyladenine, pseudouracil.
Biologically importanat Bases-->Hypoxanthine, Xanthine, uric acid.
Purines bases of plant --> caffeine,theophylline, theobromine
blood supply to the cardiac muscle in different areas of the heart is not the same. On the surface of the cardiac muscle, there are large epicardial arteries supplying more blood to those areas whereas in the subendocardial region blood supply is less because it is supplied by smaller intramuscular arteries and plexus of the subendocardial artery the diameter of which are less. This blood supply to the subendocardial plexus is further reduced during systole. Therefore the subendocardial region is more prone to myocardial infarction. Again as the left ventricular thickness is much more than that of the right ventricle the occlusion is more severe in the left ventricle. For this region LV subendocardial region is more prone to MI.Q.22 What are the importance of anastomotic channels in heart muscle?In the normal heart, there are some collaterals among the smaller arteries which become active under abnormal conditions like myocardial ischemia. They open up within a few seconds after the sudden occlusion of the larger artery and become double in number by the end of 2nd or 3rd day and reach to normal by one month. When atherosclerosis causes constriction of coronary arteries slowly over a period of many years, collateral vessels develop restoring normal blood and thus the patient never experiences acute episodes of cardiac dysfunction.Q.23 What is the importance of autoregulation in blood supply in heart muscle?Like some other organs, the heart has the capacity to regulate its own blood flow up to a certain limit in order to maintain an almost constant blood flow to the cardiac musculature in spite of any alteration of systemic blood flow. This is known as autoregulation of coronary blood supply.
DNA = deoxyribonucleic acid.
DNA carries the genetic information in the cell – i.e. it carries the instructions for making all the structures and materials the body needs to function.
DNA is capable of self-replication.
Most of the cell’s DNA is carried in the nucleus – a small amount is contained in the mitochondria.
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2. 2
Nucleic Acids
Nucleic acids are:
• molecules that store information for
cellular growth and reproduction.
• deoxyribonucleic acid (DNA) and
ribonucleic acid (RNA).
• large molecules consisting of long
chains of monomers called
nucleotides.
3. 3
Nucleic Acids
The nucleic acids DNA and
RNA
consist of monomers
called
nucleotides that consist of
a
• pentose sugar.
• nitrogen-containing
base.
• phosphate.
nucleotide
5. 5
Nitrogen-Containing Bases in DNA
and RNA
DNA contains the nitrogen bases
• Cytosine (C)
• Guanine (G) same in both DNA and RNA
• Adenine (A)
• Thymine (T) different in DNA than RNA
RNA contains the nitrogen bases
• Cytosine (C)
• Guanine (G) same in both DNA and RNA
• Adenine (A)
• Uracil (U) different in DNA than RNA
6. 6
Pentose Sugars
The pentose (five-carbon) sugar
• in RNA is ribose.
• in DNA is deoxyribose with no O atom on carbon 2’.
• has carbon atoms numbered with primes to distinguish
them from the atoms in nitrogen bases.
7. 7
HO
A nucleoside
• has a nitrogen base linked
by a glycosidic bond to C1’
of a sugar (ribose or
deoxyribose).
• is named by changing the
the nitrogen base ending to
-osine for purines and
–idine for pyrimidines.
Nucleosides
8. 8
A nucleotide
• is a nucleoside that
forms a phosphate ester
with the C5’ –OH group
of a sugar (ribose or
deoxyribose).
• is named using the
name of the nucleoside
followed by
5’-monophosphate.
Nucleotides
9. 9
Formation of a Nucleotide
A nucleotide forms when the −OH on C5’ of a
sugar bonds to phosphoric acid.
deoxycytidine monophosphate (dCMP)
O-
O-
O
P O CH2
O
NH2
N
N
OH
O
O-
O-
O
P OH +
deoxycytidine and phosphate
HO CH2
O
NH2
N
N
OH
O
5’
5’
15. 15
Primary Structure of Nucleic Acids
In the primary structure of nucleic acids
• nucleotides are joined by phosphodiester bonds.
• the 3’-OH group of the sugar in one nucleotide
forms an ester bond to the phosphate group on the
5’-carbon of the sugar of the next nucleotide.
17. 17
A nucleic acid
• has a free 5’-phosphate
group at one end and a free
3’-OH group at the other
end.
• is read from the free 5’-end
using the letters of the
bases.
• This example reads
—A—C—G—T—.
Structure of Nucleic Acids
21. 21
DNA Double Helix
A double helix
• is the structure of DNA.
• has two strands of nucleotides that wind together.
• is held in place by of two hydrogen bonds that form
between the base pairs A-T.
• is held in place by three hydrogen bonds that form
between the base pairs G-C.
22. 22
Complementary Base Pairs
DNA contains complementary base pairs in which
• Adenine is always linked by two hydrogen bonds
with thymine (A−T).
• Guanine is always linked by three hydrogen with
Cytosine (G−C).
28. 28
RNA
RNA
• transmits information from DNA to make proteins.
• has several types
Messenger RNA (mRNA) carries genetic
information from DNA to the ribosomes.
Transfer RNA (tRNA) brings amino acids to the
ribosome to make the protein.
Ribosomal RNA (rRNA) makes up 2/3 of
ribosomes where protein synthesis takes
place.
30. 30
tRNA
Each tRNA
• has a triplet called an
anticodon that
complements a codon
on mRNA.
• bonds to a specific
amino acid at the
acceptor stem.
Anticodon