Neurox Pharmaceuticals is developing drugs to cure Alzheimer's disease by stimulating growth and connectivity between injured brain cells. The company has identified 12 existing drugs that can rescue brain cells in vitro. Neurox will test these drugs in animal models and license them to pharmaceutical companies. The company was founded by Harvard neurobiologists and has secured licensing rights to its high-throughput drug screening technology, putting it in the lead to develop the first anti-Alzheimer's treatments.
How Brain Activity Monitoring can Help Manage Asperger’s Syndromeandfaulkner
Using electroencephalography (a neuroimaging technique) to track mood, anxiety, stimulation level, cognitive functioning, concentration, and stress. Using feedback based on information provided by brain data (neurofeedback) to recommend therapies for Asperger's. Training and improving coping responses to states of overstimulation in Asperger's using neurofeedback-assisted mindfulness meditation. Sharing of self-collected brain data with medical professionals to improve Asperger's treatment.
JH Alzheimer's and Parkinson's disease meeting presentation Florence March 2013John Harrison
This presentation was made at the AD/PD meeting in Florence on 8th March 2013. In the presentation I discuss early patterns of cognitive dysfunction in patients with Parkinson's disease and Alzheimer's disease. I describe the tests traditionally used to measure cognitive impairment and propose the use of an assessment with the potential to be used successfully in both indications. I propose also that the same collection of measures can profitably be used in other CNS indications. I stress that selection is best made on the basis not of specific tests, but instead on the use of good tests that meet current best practice guidance for measuring cognitive change.
The document summarizes the Maria Hertogh Riots that occurred in Singapore in 1950. Maria Hertogh was born in Java in 1937 to Dutch parents but was cared for by a Malay family during World War 2. In 1950, a custody battle began over whether she should be returned to her biological parents or remain with the Malay family she was raised by. The court ultimately ruled she should return to her biological parents, angering the Muslim community. In December 1950, riots broke out after one of the custody appeals was rejected, with mobs attacking Europeans and burning vehicles over three days until a curfew was imposed. The riots resulted in 18 deaths and 173 injuries.
Solar power works by converting sunlight into electricity through either photovoltaic cells or concentrated solar power systems. Large solar power plants discussed in the document include the Olmedilla Photovoltaic Park in Spain which produces 60 megawatts, the Puertollano Photovoltaic Park in Spain which produces 50 megawatts, and the Waldpolenz Solar Park in Germany which uses thin film technology to produce 40 megawatts. While New Zealand does not have large utility-scale solar power plants, many homes use rooftop solar panels for electricity generation.
The document discusses the conventions and design elements used in creating a magazine, including a large masthead in the center, curly writing aimed at the target audience, large headings and small subheadings linking to features. It describes basing the magazine on the style of Fabulous magazine as it appeals to both lower and upper classes. Photoshop was used to enhance photos by increasing contrast and brightness to highlight features like makeup that reflect personality and tell the audience how to feel.
The combination of the main Bamford soap and its ancillary texts like magazines and posters is effective at representing the target demographic of 15-30 year olds. Visual elements like fonts, colors, and logos from the E4 channel are used to maintain brand identity across the materials. Imagery of teenagers in casual clothes and realistic storylines about social issues help the audience relate to the characters. Consistent use of the town name "Bamford" provides a regional setting that audiences can associate with like they do for other British soaps.
How Brain Activity Monitoring can Help Manage Asperger’s Syndromeandfaulkner
Using electroencephalography (a neuroimaging technique) to track mood, anxiety, stimulation level, cognitive functioning, concentration, and stress. Using feedback based on information provided by brain data (neurofeedback) to recommend therapies for Asperger's. Training and improving coping responses to states of overstimulation in Asperger's using neurofeedback-assisted mindfulness meditation. Sharing of self-collected brain data with medical professionals to improve Asperger's treatment.
JH Alzheimer's and Parkinson's disease meeting presentation Florence March 2013John Harrison
This presentation was made at the AD/PD meeting in Florence on 8th March 2013. In the presentation I discuss early patterns of cognitive dysfunction in patients with Parkinson's disease and Alzheimer's disease. I describe the tests traditionally used to measure cognitive impairment and propose the use of an assessment with the potential to be used successfully in both indications. I propose also that the same collection of measures can profitably be used in other CNS indications. I stress that selection is best made on the basis not of specific tests, but instead on the use of good tests that meet current best practice guidance for measuring cognitive change.
The document summarizes the Maria Hertogh Riots that occurred in Singapore in 1950. Maria Hertogh was born in Java in 1937 to Dutch parents but was cared for by a Malay family during World War 2. In 1950, a custody battle began over whether she should be returned to her biological parents or remain with the Malay family she was raised by. The court ultimately ruled she should return to her biological parents, angering the Muslim community. In December 1950, riots broke out after one of the custody appeals was rejected, with mobs attacking Europeans and burning vehicles over three days until a curfew was imposed. The riots resulted in 18 deaths and 173 injuries.
Solar power works by converting sunlight into electricity through either photovoltaic cells or concentrated solar power systems. Large solar power plants discussed in the document include the Olmedilla Photovoltaic Park in Spain which produces 60 megawatts, the Puertollano Photovoltaic Park in Spain which produces 50 megawatts, and the Waldpolenz Solar Park in Germany which uses thin film technology to produce 40 megawatts. While New Zealand does not have large utility-scale solar power plants, many homes use rooftop solar panels for electricity generation.
The document discusses the conventions and design elements used in creating a magazine, including a large masthead in the center, curly writing aimed at the target audience, large headings and small subheadings linking to features. It describes basing the magazine on the style of Fabulous magazine as it appeals to both lower and upper classes. Photoshop was used to enhance photos by increasing contrast and brightness to highlight features like makeup that reflect personality and tell the audience how to feel.
The combination of the main Bamford soap and its ancillary texts like magazines and posters is effective at representing the target demographic of 15-30 year olds. Visual elements like fonts, colors, and logos from the E4 channel are used to maintain brand identity across the materials. Imagery of teenagers in casual clothes and realistic storylines about social issues help the audience relate to the characters. Consistent use of the town name "Bamford" provides a regional setting that audiences can associate with like they do for other British soaps.
This document provides information on training and retreat programs offered by TrueMaisha Training Company in 2015. It lists 7 training programs on topics like personal leadership, entrepreneurship, and social entrepreneurship. It also describes 2 retreat programs on back to life retreats and corporate retreats. The training programs range from 3-5 days and provide expected outcomes, learning objectives, and details on who should attend. The document encourages readers to register online or contact TrueMaisha for more tailored or private training events.
The document provides details for an assignment on pre-production for a short film. Students must plan the production of their short film, exploring sound recording in different environments. They need to research crew roles and equipment, create a budget, develop scripts and storyboards, and record dialogue in various locations. Recordings must then be edited with effects and into a sequenced piece demonstrating editing skills. The goal is to enhance organizational and sound manipulation skills through practical pre-production tasks for a short film.
This document summarizes four American poets from the 19th century: Henry Wadsworth Longfellow, John Greenleaf Whittier, James Russell Lowell, and Oliver Wendell Holmes. It provides biographical details and notes their contributions to poetry, including Longfellow popularizing poetry in America, Whittier writing from a Quaker perspective, and Holmes' poem "Old Ironsides" saving a historic battleship from destruction. The document also defines poetic terms like meter, foot, and iamb.
The document contains a list of English words and their Chinese translations related to hotel amenities and services. It then provides examples of conversations between hotel staff and guests in Chinese with English translations. In the conversations, guests ask about bus schedules and maps of the local lake, and the staff responds that they will provide the requested information shortly.
The document discusses promotional strategies for The Amazing Spider Man. It targets children with toys so they can pretend to be their role model Spider Man. It also has a smartphone game targeting older audiences since games are more advanced than toys for children. The free game expands the target audience to include those who can't afford paid games.
The students need their pencil and semester cooperative project that was picked up last Friday. They must check that their names are on the poster and model and staple their packet of papers, which includes assignments on the periodic table, Bohr model, Lewis dot structures, Cornell notes, a current event article and summary, a rough draft of their poster, and a compound model. Their entire project is due by the end of the class period.
The document lists materials and assignments needed for an upcoming chemistry class and lab. Students need a pencil, volume and mass worksheets picked up yesterday, and a progress notice signed and due tomorrow. The class will have an online component and notes on the chemistry final. On Monday there will be a written test and a binder check. The document provides cleaning instructions for the lab and lists supplies needed for upcoming labs on volume, mass, density, and other chemistry topics. Assignments include turning in progress notices, completing volume and mass labs, and taking the final exam.
Today's class will involve completing volume and mass labs worksheets and updating an online log. Students should bring a pencil, the volume and mass labs worksheets stapled together, and their log #4. On Friday, students will complete an online component and take 1/2 page of notes on what to know for the chemistry final. Their binder will be checked on Monday for test #2 part 2. Labs must be cleaned up properly or 10 points will be deducted, including cleaning sinks, counters, tables, and organizing supplies. Students may work with a partner for extra credit by stapling their packets together. Various labs will be completed involving measurements, formulas, and chemical reactions. Signed progress notices are due Thursday and the
The document discusses the life cycle of monarch butterflies. It explains that caterpillars live on and eat milkweed plants. The caterpillars then form a pupae and undergo metamorphosis. Eventually, a beautiful butterfly emerges from the pupae. The summary concludes by noting that viewers can observe this process by catching a caterpillar and watching it transform in a jar.
The document introduces students from John Mills School located near Chicago, Illinois. It provides details about the suburb of Elmwood Park where most houses are bungalow-style. John Mills School has over 700 students from grades 1 through 6 across 4-5 classes of around 28 students each. Students study core subjects and have special classes each week for art, music, physical education, and technology. The school emphasizes technology in learning and each class visits the computer lab weekly.
The document discusses reasons for criminal behavior among minors in Bulgaria. It shows that the most common crimes committed by minors are theft, assault, and hooliganism, which together account for over 60% of crimes. Drug usage and dealing by minors has also increased over time. The reasons for criminal behavior among minors include family problems, personal issues, peer influence, and societal factors. Solutions proposed include cultivating a positive attitude, support from family and friends, counseling, government assistance programs, and intervention by juvenile courts.
The document discusses Java interfaces. It explains that interfaces declare methods but do not provide implementations, and that classes implement interfaces to provide those method implementations. It provides examples of how to declare an interface and how a class implements an interface. It also discusses why interfaces are useful for allowing classes to have multiple roles and behave in standard ways.
These are my slides from the Internet Researcher's Conference (#IR15.0) in Daegu, Korea in October 2014... you can read more about it at my research blog over at www.incitestories.com.au
The document provides information about cooperative group roles and an introduction to density. It defines density as a ratio of mass to volume and explains that density remains the same even if the volume of a substance changes. It lists common materials and their densities and includes sample density problems and a chart to complete.
La ralentización de la economía mundial al inicio de 2016 se está caracterizando por el retorno de los pesimistas, de los agoreros que vaticinan próximas calamidades económicas de mayor o menor intensidad. Y, sin embargo, los datos que presenta nuestra economía en su conjunto no son malos. El PIB crece a tasas superiores al 3%, se recupera el empleo, disminuye el paro, mejora la entrada de viajeros y los pasajeros en el aeropuerto, las perspectivas del comercio minorista son buenas… También es verdad que el comercio exterior y la compraventa de viviendas se ha ralentizado, que se incrementa la precariedad del empleo y que la creación de empresas no termina de coger ritmo positivo pero,
de momento, siempre y cuando las condiciones y expectativas
actuales se mantenga, las previsiones para nuestra economía en 2016 continúan siendo positivas.
The document describes the process of pre-clinical trials for testing new drugs. It involves:
1) Identifying a drug target through basic research and applying that knowledge through applied research.
2) Developing a bioassay, usually using animal or cell models, to test the drug's safety and effectiveness.
3) Establishing the effective and toxic doses of the drug through screening in the bioassay system.
4) Filing for approval as an Investigational New Drug with the FDA if results show promise, allowing tests in human clinical trials. The goal of pre-clinical trials is to determine if a new drug or medical device is safe and effective before testing in humans using the scientific method.
The pre-clinical trial process involves testing new drugs on animal and cell bioassays before human testing to determine if they are safe and effective. It begins with basic research to identify a drug target related to a disease. Researchers then develop a bioassay and screen drug candidates to find ones that act on the target as intended without toxicity. Effective and toxic doses are established, and approval is sought from the FDA to begin clinical trials on humans by filing an Investigational New Drug application. The goal of pre-clinical trials is to apply findings from basic research on biochemical pathways and identify promising drug candidates ready for initial human testing.
This document provides information on training and retreat programs offered by TrueMaisha Training Company in 2015. It lists 7 training programs on topics like personal leadership, entrepreneurship, and social entrepreneurship. It also describes 2 retreat programs on back to life retreats and corporate retreats. The training programs range from 3-5 days and provide expected outcomes, learning objectives, and details on who should attend. The document encourages readers to register online or contact TrueMaisha for more tailored or private training events.
The document provides details for an assignment on pre-production for a short film. Students must plan the production of their short film, exploring sound recording in different environments. They need to research crew roles and equipment, create a budget, develop scripts and storyboards, and record dialogue in various locations. Recordings must then be edited with effects and into a sequenced piece demonstrating editing skills. The goal is to enhance organizational and sound manipulation skills through practical pre-production tasks for a short film.
This document summarizes four American poets from the 19th century: Henry Wadsworth Longfellow, John Greenleaf Whittier, James Russell Lowell, and Oliver Wendell Holmes. It provides biographical details and notes their contributions to poetry, including Longfellow popularizing poetry in America, Whittier writing from a Quaker perspective, and Holmes' poem "Old Ironsides" saving a historic battleship from destruction. The document also defines poetic terms like meter, foot, and iamb.
The document contains a list of English words and their Chinese translations related to hotel amenities and services. It then provides examples of conversations between hotel staff and guests in Chinese with English translations. In the conversations, guests ask about bus schedules and maps of the local lake, and the staff responds that they will provide the requested information shortly.
The document discusses promotional strategies for The Amazing Spider Man. It targets children with toys so they can pretend to be their role model Spider Man. It also has a smartphone game targeting older audiences since games are more advanced than toys for children. The free game expands the target audience to include those who can't afford paid games.
The students need their pencil and semester cooperative project that was picked up last Friday. They must check that their names are on the poster and model and staple their packet of papers, which includes assignments on the periodic table, Bohr model, Lewis dot structures, Cornell notes, a current event article and summary, a rough draft of their poster, and a compound model. Their entire project is due by the end of the class period.
The document lists materials and assignments needed for an upcoming chemistry class and lab. Students need a pencil, volume and mass worksheets picked up yesterday, and a progress notice signed and due tomorrow. The class will have an online component and notes on the chemistry final. On Monday there will be a written test and a binder check. The document provides cleaning instructions for the lab and lists supplies needed for upcoming labs on volume, mass, density, and other chemistry topics. Assignments include turning in progress notices, completing volume and mass labs, and taking the final exam.
Today's class will involve completing volume and mass labs worksheets and updating an online log. Students should bring a pencil, the volume and mass labs worksheets stapled together, and their log #4. On Friday, students will complete an online component and take 1/2 page of notes on what to know for the chemistry final. Their binder will be checked on Monday for test #2 part 2. Labs must be cleaned up properly or 10 points will be deducted, including cleaning sinks, counters, tables, and organizing supplies. Students may work with a partner for extra credit by stapling their packets together. Various labs will be completed involving measurements, formulas, and chemical reactions. Signed progress notices are due Thursday and the
The document discusses the life cycle of monarch butterflies. It explains that caterpillars live on and eat milkweed plants. The caterpillars then form a pupae and undergo metamorphosis. Eventually, a beautiful butterfly emerges from the pupae. The summary concludes by noting that viewers can observe this process by catching a caterpillar and watching it transform in a jar.
The document introduces students from John Mills School located near Chicago, Illinois. It provides details about the suburb of Elmwood Park where most houses are bungalow-style. John Mills School has over 700 students from grades 1 through 6 across 4-5 classes of around 28 students each. Students study core subjects and have special classes each week for art, music, physical education, and technology. The school emphasizes technology in learning and each class visits the computer lab weekly.
The document discusses reasons for criminal behavior among minors in Bulgaria. It shows that the most common crimes committed by minors are theft, assault, and hooliganism, which together account for over 60% of crimes. Drug usage and dealing by minors has also increased over time. The reasons for criminal behavior among minors include family problems, personal issues, peer influence, and societal factors. Solutions proposed include cultivating a positive attitude, support from family and friends, counseling, government assistance programs, and intervention by juvenile courts.
The document discusses Java interfaces. It explains that interfaces declare methods but do not provide implementations, and that classes implement interfaces to provide those method implementations. It provides examples of how to declare an interface and how a class implements an interface. It also discusses why interfaces are useful for allowing classes to have multiple roles and behave in standard ways.
These are my slides from the Internet Researcher's Conference (#IR15.0) in Daegu, Korea in October 2014... you can read more about it at my research blog over at www.incitestories.com.au
The document provides information about cooperative group roles and an introduction to density. It defines density as a ratio of mass to volume and explains that density remains the same even if the volume of a substance changes. It lists common materials and their densities and includes sample density problems and a chart to complete.
La ralentización de la economía mundial al inicio de 2016 se está caracterizando por el retorno de los pesimistas, de los agoreros que vaticinan próximas calamidades económicas de mayor o menor intensidad. Y, sin embargo, los datos que presenta nuestra economía en su conjunto no son malos. El PIB crece a tasas superiores al 3%, se recupera el empleo, disminuye el paro, mejora la entrada de viajeros y los pasajeros en el aeropuerto, las perspectivas del comercio minorista son buenas… También es verdad que el comercio exterior y la compraventa de viviendas se ha ralentizado, que se incrementa la precariedad del empleo y que la creación de empresas no termina de coger ritmo positivo pero,
de momento, siempre y cuando las condiciones y expectativas
actuales se mantenga, las previsiones para nuestra economía en 2016 continúan siendo positivas.
The document describes the process of pre-clinical trials for testing new drugs. It involves:
1) Identifying a drug target through basic research and applying that knowledge through applied research.
2) Developing a bioassay, usually using animal or cell models, to test the drug's safety and effectiveness.
3) Establishing the effective and toxic doses of the drug through screening in the bioassay system.
4) Filing for approval as an Investigational New Drug with the FDA if results show promise, allowing tests in human clinical trials. The goal of pre-clinical trials is to determine if a new drug or medical device is safe and effective before testing in humans using the scientific method.
The pre-clinical trial process involves testing new drugs on animal and cell bioassays before human testing to determine if they are safe and effective. It begins with basic research to identify a drug target related to a disease. Researchers then develop a bioassay and screen drug candidates to find ones that act on the target as intended without toxicity. Effective and toxic doses are established, and approval is sought from the FDA to begin clinical trials on humans by filing an Investigational New Drug application. The goal of pre-clinical trials is to apply findings from basic research on biochemical pathways and identify promising drug candidates ready for initial human testing.
The document describes the process of pre-clinical trials for testing new drugs. It involves:
1) Identifying a drug target based on basic research findings. Researchers determine targets associated with disease processes.
2) Developing a bioassay system like cell cultures or animal models to test the drug's safety and effectiveness.
3) Screening candidate drug compounds in the bioassay to determine if they interact safely and effectively with the target.
4) Establishing the effective and toxic dosage levels of any promising compounds before filing for approval to begin human clinical trials. The goal is to use the scientific method to evaluate drugs in living systems before testing in humans.
The document discusses neuro-inflammation and chronic pain, and the challenges of developing new drugs to treat diseases of the nervous system. It notes that animal models often fail because human brains are uniquely different. The organization ARHD has established a program providing human nervous system specimens to researchers developing new anti-inflammatory drugs, with the goal of identifying safer and more effective treatments for conditions like chronic pain, depression, dementia and traumatic brain injury.
This slide is about the basic theories of Neurotechnology.
It shows
1. An overview of this area
- Market value, etc
2. Basic knowledge
- Types of neurotechnologies
- Basics of neuroscience
- software engineering.
3. Use cases with neurotechnologies.
Therapeutic Potential of Designer Receptors, Gary Aston-Jones, PhDSCTR Institute
The document discusses novel techniques for selectively controlling neuronal activity, including designer receptors and photosensitive ion channels. Designer receptors like DREADDs allow more specific neuronal modulation than conventional pharmacology. Photosensitive channels like channelrhodopsin allow photostimulation of neurons for more targeted effects than deep brain stimulation. These proteins can be expressed in specific neurons using viral vectors and cell-type specific promoters for applications like modulating brain circuits involved in arousal, reward, and eating.
SMi’s 10th annual conference on Clinical Trials in CNS will bring together leading industry experts to explore the current and future opportunities within CNS drug development. With 35% of the global disease burden due to CNS disorders, this event addresses a vital area of research.
The document discusses using semantic web technologies to create a Translational Medicine Ontology and Knowledge Base (TMOKB) for integrating personalized medicine data. It describes how the TMOKB links terms from existing ontologies and data sources to answer questions about Alzheimer's disease genes, biomarkers, drug repurposing opportunities, and clinical trials. The TMOKB demonstrates how a high-level ontology can connect specialized domain ontologies and data to provide integrated answers across personalized medicine.
Brain Science and Technology - 6 start-ups to keep in mindDylan Taylor
Six innovative startups are combining neurotechnology and brain science to advance the field. Neuralink aims to develop brain-computer interfaces to enable superhuman cognition. Kernel has developed a portable brain-scanning helmet to analyze neurons and reveal how the brain works. Synchron is developing minimally-invasive brain-computer interface technology to diagnose neurological disorders. Flow Neuroscience created a wireless depression treatment headset using brain stimulation and behavioral therapy. Headsafe's portable device can quickly assess brain function to diagnose concussions. Thync developed wearable devices using electrical stimulation to reduce stress and improve sleep.
A Call to Action: Improving brain & mental health via digital platforms,...SharpBrains
(Session held at the 2014 SharpBrains Virtual Summit; October 28-30th, 2014)
8:15–9:45am. A Call to Action: Improving brain & mental health via digital platforms, neuroplasticity research and the White House BRAIN initiative
- Dr. Thomas Insel, Director of the National Institute of Mental Health (NIMH)
- Dr. Adam Gazzaley, Director of UCSF Neuroscience Imaging Center and Co-founder of Akili Interactive Labs
- Dr. Daphne Bavelier, Head of the Brain & Learning Lab at the University of Geneva & U. of Rochester
- Jack Young, Head of Qualcomm Life Fund
- Chair: Alvaro Fernandez, CEO of SharpBrains
Learn more here:
http://sharpbrains.com/summit-2014/agenda/
The document discusses using gene therapy to slow the progression of Alzheimer's disease. It proposes using an experimental drug called CERE-110, which contains the gene for human nerve growth factor (NGF), to restore degenerated neurons in the brain affected by Alzheimer's. The methodology involves surgically injecting CERE-110 into the nucleus basalis of the brain in 25 human subjects with mild to moderate Alzheimer's. It is expected that the NGF will be produced, protecting neurons from further degeneration and potentially reducing symptoms and slowing disease progression.
Pacitane nanoparticles drug release for brain disorderIJSRED
This document summarizes research on using nanoparticles to deliver drugs to the brain and treat brain disorders. It discusses how nanoparticles carrying drugs can be administered orally and pass through the gastrointestinal tract and bloodstream to reach the brain. Specifically, it describes an experiment where pacitane nanoparticles were prepared and tested as a potential delivery system for treating brain disorders like Parkinson's disease and schizophrenia. The nanoparticles were characterized and tested for drug release in vitro. The results showed 80% of the drug was released within 24 hours. The conclusion is that nanoparticle drug delivery could provide an effective therapy for brain disorders.
McLean Hospital is a Harvard-affiliated psychiatric hospital in Belmont, Mass. This document contains descriptions of select McLean inventions that are available for licensing, with links to more detailed descriptions and the complete list of McLean's invention portfolio.
Dr. Kilts' presentation to the PRI Advisory BoardTim Taylor
The document discusses the UAMS/PRI Brain Imaging Research Center (BIRC). It provides an overview of the center's goals, focus areas, and accomplishments. The BIRC seeks to advance understanding of psychiatric disorders through brain imaging research. Its goals are to develop brain imaging technologies, apply them to clinical problems, and train the next generation of imaging scientists. The center focuses on outcomes related to early life adversity, brain development, women's health, cognition, and drug addiction. It aims to enhance understanding of how the brain relates to behavior and illness.
Webinar about stem cell therapies for spinal cord injury_Oct2014Jennifer French
Consumer oriented webinar presentation about stem cell therapies for spinal cord injury/disorder. Original broadcast with the United Spinal Association on Oct 23, 2014
Ilsi conference biomed presentation brain game change israel leadership in c...Howard Sterling
Summary:
Neuro-cognitive and degenerative (CNS) diseases, with Alzheimer’s leading, are among the most intractable and costly and distressing diseases. Without effective therapies with minimal side effects, these diseases will break the healthcare systems, patients and caregivers.
Current therapies are inadequate and so many standard pharmaceutical responses have failed in late stage trials.
Only the most innovative solutions will yield effective therapies.
Israel, with its history & culture of scientific innovative innovation, government support & early recognition of the challenges of CNS, is poised to be a leader in effective CNS therapies.
How can we make Israel’s leadership known to the world?
The document discusses chemical imbalances in the brain and their relationship to mental disorders. It acknowledges that while chemical imbalances have not been pinpointed as the direct causes of specific disorders, they are real factors that can contribute to neural dysfunction. Treatment and prevention of chemical imbalances early on may help avoid full symptoms of mental conditions. The document also examines various brain imaging techniques and neurotransmitters implicated in disorders like depression.
Brain game changer presentation -israeli leadership in cns ilsi iata biomed ...Howard Sterling
Neuro-cognitive and degenerative (CNS) diseases, with Alzheimer’s leading, are among the most intractable and costly and distressing diseases. Without effective therapies with minimal side effects, these diseases will break the healthcare systems, patients and caregivers.
Current therapies are inadequate and so many standard pharmaceutical responses have failed in late stage trials.
Only the most innovative solutions will yield effective therapies.
Israel, with its history & culture of scientific innovative innovation, Government support & early recognition of the challenges of CNS, is poised to be a leader in effective CNS therapies.
How can we make Israel’s leadership known to the world?
Innowave Freedom Clearing House /freedom Nano users can have single-click access to Neuroshield™,
Neuroshield™ is a Clinical Decision Support Tool for Neurological Disorders, A comprehancive tool to
evealuate Qualitative and Quantitative conditions of the Human Brain. Neuroshield™ is a product from
“In-Med Prognostics“Is a company with leadership in, reliable and data-driven brain health diagnostic and
prognostic tools
RespireRx Pharmaceuticals Inc. Publishes Compelling Scientific Evidence Demon...RespireRX
Press Release: Glen Rock, N.J., December 18 2017 /Globe Newswire – RespireRx Pharmaceuticals Inc. (OTCQB: RSPI) (“RespireRx” or the “Company”), is pleased to announce that a paper detailing the neurobiologic safety of the ampakine CX717 has been accepted for publication by Toxicological Sciences, the Journal of the American Society of Toxicology. The paper, co-authored by RespireRx scientists in conjunction with expert pathologists from around the country who contributed to an extensive neuropathology research program presents clear scientific evidence that vacuoles that were discovered upon histological evaluation of brain tissue samples from animals treated with high doses of CX717, and which halted the company’s promising CX717 clinical development effort, were actually an artifact of tissue processing rather than a toxic drug effect.
How to Make a Field Mandatory in Odoo 17Celine George
In Odoo, making a field required can be done through both Python code and XML views. When you set the required attribute to True in Python code, it makes the field required across all views where it's used. Conversely, when you set the required attribute in XML views, it makes the field required only in the context of that particular view.
Leveraging Generative AI to Drive Nonprofit InnovationTechSoup
In this webinar, participants learned how to utilize Generative AI to streamline operations and elevate member engagement. Amazon Web Service experts provided a customer specific use cases and dived into low/no-code tools that are quick and easy to deploy through Amazon Web Service (AWS.)
Walmart Business+ and Spark Good for Nonprofits.pdfTechSoup
"Learn about all the ways Walmart supports nonprofit organizations.
You will hear from Liz Willett, the Head of Nonprofits, and hear about what Walmart is doing to help nonprofits, including Walmart Business and Spark Good. Walmart Business+ is a new offer for nonprofits that offers discounts and also streamlines nonprofits order and expense tracking, saving time and money.
The webinar may also give some examples on how nonprofits can best leverage Walmart Business+.
The event will cover the following::
Walmart Business + (https://business.walmart.com/plus) is a new shopping experience for nonprofits, schools, and local business customers that connects an exclusive online shopping experience to stores. Benefits include free delivery and shipping, a 'Spend Analytics” feature, special discounts, deals and tax-exempt shopping.
Special TechSoup offer for a free 180 days membership, and up to $150 in discounts on eligible orders.
Spark Good (walmart.com/sparkgood) is a charitable platform that enables nonprofits to receive donations directly from customers and associates.
Answers about how you can do more with Walmart!"
A Visual Guide to 1 Samuel | A Tale of Two HeartsSteve Thomason
These slides walk through the story of 1 Samuel. Samuel is the last judge of Israel. The people reject God and want a king. Saul is anointed as the first king, but he is not a good king. David, the shepherd boy is anointed and Saul is envious of him. David shows honor while Saul continues to self destruct.
This presentation was provided by Racquel Jemison, Ph.D., Christina MacLaughlin, Ph.D., and Paulomi Majumder. Ph.D., all of the American Chemical Society, for the second session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session Two: 'Expanding Pathways to Publishing Careers,' was held June 13, 2024.
This presentation was provided by Rebecca Benner, Ph.D., of the American Society of Anesthesiologists, for the second session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session Two: 'Expanding Pathways to Publishing Careers,' was held June 13, 2024.
1. Neurox Pharmaceuticals, Inc.
A Harvard Startup for Curing Alzheimer’s
H. Rock Liao, PhD
Co-Founder / CEO
Woburn, MA 01801
http://neurox.us
rockliao@neurox.us
2. Neurox Pharmaceuticals, Inc.
Our Mission
Neurox plans to develop the world’s first anti-Alzheimer’s
drugs that restore the growth of injured brain cells to
improve learning and memory.
Neurox is positioned to be the leader in supplying early anti-
Alzheimer’s drugs to the pharmaceutical industry.
3. Neurox Pharmaceuticals, Inc.
Who We Are
All three founders are Harvard neurobiologists who specialize in
brain development:
Michael E. Greenberg, PhD / Non-Executive Chairman
Chair & Professor of Dept of Neurobiology, Harvard Medical School, 2008-Present
Professor & Director, Neurobiology Program, Children’s Hospital Boston, 1994-2008
Member, American Academy of Arts and Sciences
Member, National Academy of Arts and Sciences
Inventor of “Brain Cell-Based In Vitro Synapse Assay”
Chair, Neuroscience Advisory Board, Roche, 2010
Consultant, Constellation Pharmaceuticals
Advisory Board, Upstate Biotechnology Inc, 1996-2006
Advisory Board, Cogent Neuroscience Inc, 1998-2002
Advisory Board, Helicon Inc, 1991-2001
H. Rock Liao, PhD / CEO
Postdoctoral research, Department of Neurobiology, Harvard Medical School, 2007-Present
Predoctoral research, Department of Neuroscience, The Johns Hopkins University, 2001-2006
Inventor of Neurox’s core technologies “High-Throughput, Brain Cell-Based Drug-Screening System” & “Targeted Imaging”
Founder and Developer of TheApps4U.com - an iPhone/iPod/iPad Apps Development company, 2009-Present
Seth S. Margolis, PhD / Chief Scientific Advisor
Assistant Professor, Department of Biochemistry, The Johns Hopkins University School of Medicine, Scheduled for 2012
Postdoctoral research, Department of Neurobiology, Harvard Medical School, 2006-Present
Predoctoral research, Department of Pharmacology and Cancer Biology, Duke University Medical Center, 2000-2005
4. Neurox Pharmaceuticals, Inc.
The Problem We Are Trying to Solve
Alzheimer’s Disease (AD) is a progressive brain
disease. It starts by destroying connections between
brain cells and ultimately leads to the loss of brain
cells. Learning and memory are therefore impaired.
High impact:
35 million AD patients worldwide.
Annual cost to economy exceeds $145B.
Unmet medical need:
There is currently no known cure.
5. Neurox Pharmaceuticals, Inc.
Why Conventional Anti-AD Strategies Do Not Work
The industry has long been focusing on removing toxic substances
(e.g., amyloid beta and tau aggregates) from AD brains.
Why they don’t work:
Normally brain cells form connections with each other to
communicate. However, when a patient is diagnosed with AD,
the connections between brain cells are long gone. The injured
brain cells are unable to re-grow processes and re-make
connections on their own even after disease-causing factors
are removed. Cells eventually die.
What’s missing:
The injured brain cells need additional help (e.g., stimulation)
to re-grow. The industry has not yet found a solution.
6. Neurox Pharmaceuticals, Inc.
Why Our Innovative Strategy Works
We identify drugs that can stimulate the growth and
connectivity of injured AD brain cells.
BEFORE AFTER
Cells re-grow processes and re-make connections
Injured AD brain cells lost processes and connections after drug (2090N12) treatment
Green: Processes of brain cells
Red: Nucleus (center of cell)
7. Neurox Pharmaceuticals, Inc.
Drugs That Revolutionize AD Therapies
We have found, tested, and verified 12 such drugs to date.
They work differently, but all can rescue the growth of the
injured AD brain cells in vitro.
We are the first in the world to show that AD is curable and
its neurodegeneration is reversible. Most importantly, we
already have these drugs identified and tested.
We know what these drugs are and how they work. At
Neurox, we will test these drugs in AD animals to evaluate
their effect on improving cognitive functions.
After animal testing, qualified drugs will be ready for sales
(preclinical drug licensing).
No clinical trials are required in our business model as we will
be a supplier of early drugs to other pharmaceutical
companies in filling their downstream drug pipelines.
8. Neurox Pharmaceuticals, Inc.
Leading the Field
Enabling technology:
In addition to our innovative strategy, we have built a technology that
enables large-scale drug screening using authentic brain cells,
leading to very high-confidence results. The technology is a high-
throughput version of a well-established in vitro assay where
nearly all resulting findings were verified in vivo.
Our technology employs automated high-speed imaging for important
neuronal markers to quantify the fine structures of drug-treated
brain cells and to evaluate a drug’s therapeutic effect on restoring
the growth and connectivity of injured AD brain cells.
Drug Bioimaging
Enhanced growth
& connectivity
Green: Processes of brain cells
Red, Blue: Connections between brain cells
9. Neurox Pharmaceuticals, Inc.
Leading the Field
Lead compounds:
We have verified 12 anti-AD drugs (and counting):
• 9 known/repurposed drugs (FDA-approved, clinical,
or off-patent)
• 3 natural compounds
These compounds have the following advantages:
Already verified (by us) in rescuing AD brain cells (well-
established in vitro model)
Relatively safe
Known target/mechanism
Higher success rate in animal testing
Straightforward development of novel
compounds based on known drugs
10. Neurox Pharmaceuticals, Inc.
Intellectual Properties
Technology:
Drs. Greenberg and Liao, inventors of the drug-screening technology,
have obtained the verbal agreement (licensing contingent upon
funding) with Harvard for an exclusive commercial license. The
technology will be kept as a trade secret (i.e., without patent filing)
as it relies heavily on the expertise of the principals.
Lead compounds:
The compounds we’ve identified, to date, are existing drugs and many are
covered by third-party’s patents. Instead of filing patents for the novel
anti-AD use on these known drugs through Harvard (which may or
may not be feasible, depending on each drug’s patent claims), we will
identify novel, better, patentable compounds based on the known
structures of these drugs. The novel-drug screening (using the same,
licensed technology) and new patent filing will be carried out at
Neurox, not Harvard, to save costs and time.
11. Neurox Pharmaceuticals, Inc.
How We Find New, Patentable Drugs Based on A Known Drug
Finding novel therapeutic compounds based on a known drug is
straightforward. With our powerful drug-screening platform, we screen a
collection of random molecules (commercially available) that are structurally
similar to the known drug. An example is drug S008-0063, a novel, patentable
molecule similar to a market drug named imipramine (an FDA-approved anti-
depressant also known to enhance connectivity between brain cells).
S008-0063 was identified in just a month and shown to be very effective and
even better than its reference drug imipramine in enhancing brain cell’s
connectivity.
3.0
O
2.5
Index of Neuronal
N
N
H
Connectivity
2.0 No Drug Treatment
O
N
1.5 Imipramine
S008-0063 Imipramine S008-0063
1.0
0.5
0.0 Note: Both drugs are capable of enhancing connectivity only in normal
but not AD brain cells. They are only for demonstrating the principle
of new drug discovery. Due to confidentiality consideration, our anti-
AD drugs are not shown here, but the same principle applies.
12. Neurox Pharmaceuticals, Inc.
How Do We Generate Revenue?
Products / Revenue:
Neurox will sell preclinical anti-AD drugs to other pharmaceutical
companies through licensing. The revenue includes upfront cash,
milestone payments and royalties.
Customers:
Pharmaceutical companies that R&D drugs for AD
Facts:
The top 50 pharmaceutical companies, by number of drugs,
develop 60% of their formulas in-house and acquire the remaining 40%
from external sources through licensing, M&A, or forming alliances.
Price tag:
The average upfront cash for early drug licensing (including preclinical
and Phase-I drugs) ranges from $25 Mil to $42 Mil. We conservatively
price our product (preclinical drug) at $10 Mil per licensing, not
including milestone payments and royalties.
13. Neurox Pharmaceuticals, Inc.
Time to Revenue
Our niche – early drug supplier feeding the drug R&D pipeline in industry:
Neurox focuses on the preclinical phase of drug development (green
area below). It will take, on average, 2 years (mostly animal testing)
to finalize an end product. We expect to make our first sales (3 anti-
AD preclinical drugs) by the end of the 2nd year.
Our business model has the following advantages:
No risky, costly and lengthy clinical trials
No hurdles of FDA approval
Time to revenue is much shorter
Sales /
Where we are End product:
now Preclinical drug
2 years
Clinical Development
Basic Drug Preclinical FDA
Research Discovery Development Approval
Phase I Phase II Phase III
Animal models
of disease
14. Neurox Pharmaceuticals, Inc.
Cash Flow
Neurox will continue to generate new, patentable anti-AD drugs, with a total
of 36 preclinical drugs for sale within 5 years. Note that from the 3rd year on
(after attaining profitability) we will increase the output capacity through
purchasing additional equipment, hiring more staff and re-allocating
resources.
We plan to raise $5 Mil and $10 Mil in Series A and B, respectively, to
fund the operations in the first 2 years. The company will be self-
sustaining financially from the 3rd year.
Capital (Series A) (Series B)
input $5 Mil $10 Mil Profitable
300
Million ($USD)
Revenue
200
1st year 2nd year 3rd year 4th year 5th year
100 Gross Margin
0 Net Profit after
Revenue $30 Mil $42 Mil $77 Mil $255 Mil
Tax
(3 drugs) (4 drugs) (7 drugs) (22 drugs)
Note that only upfront cash from licensing is included in the financial analysis shown here. Milestone
payments and royalties are beyond the 5-year scope.
15. Neurox Pharmaceuticals, Inc.
Exit Strategy
Cash dividends:
Neurox plans to distribute 30% of the net profit (after tax) among
shareholders annually.
FY2012 FY2013 FY2014 FY2015 FY2016
Cash Dividend ($Mil) - 5.9 8.1 15.4 54.0
Company sale:
We plan to grow the company to be highly profitable in preparation for a
sale in 5 years. Its unadjusted equity book value (lower-end estimate of
company’s value) is expected to reach $340 Mil. However, comparable
sales have reached $500 Mil to $650 Mil in the past.
Note that the milestone payments and royalties (not realizable within 5
years) will potentially reach a total value of $1.4B at the time of sale.
16. Neurox Pharmaceuticals, Inc.
Conclusion
Neurox is positioned to be the leader in supplying anti-AD preclinical
drugs. We are ready to show the world, for the very first time, that
AD is curable. While the industry still employs conventional
approaches and continues to suffer from the lack of progress in
treating AD, Neurox has found the solution. Our drugs are about to
revolutionize AD therapies.
Early drug development particularly depends on high level of
intellectual input. Our Harvard team brings in the best expertise,
experience and innovation to guarantee Neurox’s success.
It is our intention to enhance and extend the lives of millions, and in
that process, create a successful company.