SlideShare a Scribd company logo
Neural Cell Lines
TEL: 1-631-357-2254
E-mail: info@creative-biolabs.com
SUITE 203, 17 Ramsey Road, Shirley, NY 11967, USA
neuros.creative-biolabs.com
Cutting Edge Tools for Neuroscience Research
In 2005, Creative Biolabs opened its doors offering neuroscience research antibodies with the goal of putting customers first.
From day one, our vision has been to provide products you can trust. We stand behind our products—leading us to create our
policy of replacing or refunding reagents or cells that do not meet expectations.
As our number of loyal and satisfied customers grow, so do our offerings. Our selection of antibodies has expanded, along
with other products, including human cells, specialized media, sera, and cell models. We continue to assess the needs of the
neuroscience research field and add new resources to our neuroscience range to add to our cutting edge technologies.
Currently, Creative Biolabs offers a range of specific tools & reagents to allow you stay at the forefront of your field. Creative
Biolabs is your source for neural cells, media and supplements including iPSC-derived cells. Our large range of substrates
and matrices including natural extracellular matrices and artificial scaffolds gives you numerous options to develop your in
vitro system. We also offer innovative neural tracers and customized technical services that help researchers explore
questions about genes, neurons, circuitry structure, function of brain network, mechanism and treatment of diseases. We
also have an extensive biorepository with neural tissue from numerous species. We will always offer proven reagents for
results you can trust and understand.
Cutting Edge Tools for Neuroscience Research
Neural Cell Lines
Neural Stem Cells
Neural Progenitor Cells
Neurons
Astrocytes
Microglial Cells
Oligodendrocytes
Schwann Cells
Neurological Disease Cell Models
Neural Tissues
Neural Cell Culture Media and Supplements
Neural Cell Culture Matrices
Neural Cell Transfection
Neural Cell Cryopreservation
Cutting Edge Tools for Neuroscience Research
Table of Contents
Cellular models are highly important tools for numerous applications in neuroscience, for example the study of
neurodegeneration, neurogenesis and developmental diseases. There is also a growing sense of the importance of studying
the behaviour of neurons, glial cells and neural stem cells within a physiologically relevant context. Creative Biolabs offers a
range of cryopreserved human, mouse and rat neural cells and neurological disease models to allow you stay at the forefront
of your field. With years of experience in primary neural cell isolation, Creative Biolabs offers ready-to use, high quality primary
neural cells for your research. Extensive testing and optimization provides quality and performance of our neural cells with
every batch produced. Creative Biolabs' portfolio also includes reliable neural media products (see page 16 ) that are
optimized and tested specifically with our neural cells. Creative Biolabs guarantees the performance of its cells when cultured
with the recommended medium and following the protocol.
Neuron Microglia Astrocyte
Oligodendrocyte
Neural Stem Cell
Neural Progenitor Cell
Neural Cell Lines
Cutting Edge Tools for Neuroscience Research
Neural stem cells are undifferentiated cells found within the brain. They were first described in the subventricular zone (SVZ) by
Sally Temple in 1-8- but were not isolated until 1--2 from adult striatal tissue by Brent Reynolds. Like mesenchymal stem cells,
neural stem cells have the capacity to undergo extensive cell divisions in vitro and are multipotent in nature.
Human iPSC-derived Neural Stem Cells from Healthy Donors
Cat. Product Name Starting Material Quantity
NCL-2101-ZP01 Human iPSC-Derived Neural Stem Cells (Male), Source Cord Blood CD34+ Cells Cord Blood CD34+ Cells
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP02
Human iPSC-Derived Neural Stem Cells (Male), Source Cord Blood CD34+ Cells,
Validated
Cord Blood CD34+ Cells
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP03 Human iPSC-Derived Neural Stem Cells (Female), Source Cord Blood CD34+ Cells Cord Blood CD34+ Cells
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP04
Human iPSC-Derived Neural Stem Cells (Male), Source Fibroblasts (74 Yr Donor),
Validated
Fibroblasts (74 Yr Donor)
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP05 Human iPSC-Derived Neural Stem Cells (Female), Source Fibroblasts (64 Yr Donor) Fibroblasts (64 Yr Donor)
1.5 million cells & Neural Plating-XF
Medium
Human iPSC-derived Neural Stem Cells from Patient Donors
Cat. Product Name Starting Material Quantity
NCL-2101-ZP06 Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (APOE4 HOM) Fibroblasts (87 Yr Female)
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP07 Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 L286V) Fibroblasts (38 Yr Female)
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP08 Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 M146L) Fibroblasts (53 Yr Male)
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP0- Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 A246E) Fibroblasts (31 Yr Female)
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP10 Human iPSC-Derived Neural Stem Cells - Huntington's Disease Patient Fibroblasts (48 Yr Female)
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP11 Human iPSC-Derived Neural Stem Cells - Epilepsy Patient Fibroblasts (5 Mo Female)
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP12 Human iPSC-Derived Neural Stem Cells - Trisomy X Patient Fibroblasts (74 Yr Female)
1.5 million cells & Neural Plating-XF
Medium
CRIGEM™ Genetically Edited Human iPSC-derived Neural Stem Cells
Cat. Product Name Starting Material Quantity
NCL-2101-ZP05 Human iPSC-Derived Neural Stem Cells (Female), Source Fibroblasts (64 Yr Donor) Fibroblasts (64 Yr Donor)
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP14 CRIGEM™ iPSC-Derived Neural Stem Cells LRRK2 G201-S HOM Fibroblasts (64 Yr Donor)
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP15 CRIGEM™ iPSC-Derived Neural Stem Cells LRRK2 G201-S HET Fibroblasts (64 Yr Donor)
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP16 CRIGEM™ iPSC-Derived Neural Stem Cells MAPT R406W HET Fibroblasts (64 Yr Donor)
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP17 CRIGEM™ iPSC-Derived Neural Stem Cells MAPT V337M HOM Fibroblasts (64 Yr Donor)
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP18 CRIGEM™ iPSC-Derived Neural Stem Cells MAPT V337M HET Fibroblasts (64 Yr Donor)
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP1- CRIGEM™ iPSC-Derived Neural Stem Cells MAPT P301L HOM Fibroblasts (64 Yr Donor)
1.5 million cells & Neural Plating-XF
Medium
NCL-2101-ZP20 CRIGEM™ iPSC-Derived Neural Stem Cells MAPT P301L HET Fibroblasts (64 Yr Donor)
1.5 million cells & Neural Plating-XF
Medium
Cat. Product Name Cell Type
NCL-2105-P205-AM Mouse Embryo Neural Stem Cells, Immortalized Immortalized Cell
NCL-2108P23 Mouse Neural Stem Cells Ne-4C Immortalized Cell
NCL-2108P25 Mouse Neural Stem Cells C17.2 Immortalized Cell
NCL-2105-C356 Mouse Neural Stem Cells, Adult Primary Cell
NCL-2105-F356 Mouse Neural Stem Cells, Fetal Primary Cell
NCL-2108-P016 Mouse Cortical Neural Stem Cells Primary Cell
NCL-2108-P017 Mouse Spinal Cord Neural Stem Cells Primary Cell
NCL-2105-P242-AM Rat Neural Stem Cells (1464R), Immortalized Immortalized Cell
NCL-2108-P01- Rat Neural Stem Cells, Adult Primary Cell
NCL-2108-F01- Rat Neural Stem Cells, Fetal Primary Cell
NCL-2108-C001 Rat Neural Stem Cells Fetal (E14 cortex) Primary Cell
Neural Cell Lines
Mouse/Rat Neural Stem Cells
Cutting Edge Tools for Neuroscience Research
Human iPSC-Derived Neural Stem Cells
Since the discovery that neural progenitor cells (NPCs) from induced pluripotent stem cells (iPSCs) can proliferate or
differentiate into neurons, oligodendrocytes, or astrocytes, NPCs are becoming an attractive in vitro model to study
neurological development and neurotoxicity and to model diseases.
Creative Biolabs’ NPCs are derived from a collection of well-characterized, integration-free reprogrammed iPSCs. For
investigators looking to reduce the time from initial culture to experiment readout, our NPCs can eliminate the 4 to 8 weeks for
iPSCs to differentiate into NPCs.
Creative Biolabs provides a complete system of NPC solutions for investigating development, degeneration and regeneration,
neurogenetics, neural excitability, nervous system disorders, neurotransmitters, and screening therapeutics.
• Normal and neurological disease iPSC-derived NPCs
• Gene-edited, lineage-specific reporter NPCs
• Expansion and differentiation media kits
• Validated growth and differentiation protocols
Cat. Product Name Cell Type
NCL-2108-P001 Human Neural Progenitor Cells, Fully Validated Primary Cell
NCL-21P6-17- Human Neural Progenitor Cell Line, Cortical Derived Primary Cell
NCL-2105-P11-HP NeuCell™ Human GABAergic Neural Progenitor Cells (GPC), 1M Primary Cell
NCL-2105-P17-HP NeuCell™ Human Motor Neural Progenitor Cells (MPC), 1M Primary Cell
NCL-2105-P2--HP NeuCell™ Human Dopaminergic Neural Progenitor Cells (DPC), 1M Primary Cell
NCL-2105-P33-HP NeuCell™ Human Glutamatergic Neural Progenitor Cells (GPC), 1M Primary Cell
NCL200506ZP Human Oligodendrocyte Progenitor Cells Primary Cell
NCL-2105-P187-AM Human Cranial Suture Progenitor Cells (iSuPs), Immortalized Immortalized Cell
NCL-2108P147 Human Neuron Progenitor Cells (Neu41), Immortalized Immortalized Cell
NCL200501ZP Human Neural Progenitor Cell Line, Cortical Derived, Immortalized Immortalized Cell
NCL-21P6-212 Human Neural Progenitor Cell Line, Ventral Mesencephalon Derived, Immortalized Immortalized Cell
NCL-2108-P002 NeuCELL™ VM Human Neural Progenitor Cell Line, Immortalized Immortalized Cell
NCL-2108-P003 NeuCELL™ CX Human Neural Progenitor Cell Line, Immortalized Immortalized Cell
NCL-2105-P211-AM Mouse Neural Progenitor Cells, Immortalized Immortalized Cell
NCL-2105-P276-AM Mouse Pituitary Progenitor Cells (αT1-1), Immortalized Immortalized Cell
NCL-2105-P247-AM Rat Sympathoadrenal Progenitor Cells (MAH-A3), Immortalized Immortalized Cell
NCL-2108-P007 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone A4H1 Disease Model
NCL-2108-P008 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone D4 Disease Model
NCL-2108-P00- Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone B2 Disease Model
NCL-2108-P010 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone 3C1 Disease Model
NCL-2108-P011 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone A5 Disease Model
NCL-2108-P012 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone E6F4 Disease Model
NCL-2108-P013 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone H10 Disease Model
Neural Progenitor Cells
Selected Neural Progenitor Cell Lines
Cutting Edge Tools for Neuroscience Research
Neurons (also called neurones or nerve cells) are the fundamental units of the brain and nervous system, the cells responsible
for receiving sensory input from the external world, for sending motor commands to our muscles, and for transforming and
relaying the electrical signals at every step in between.
Creative Biolabs supplies a number of high viability cryopreserved and live primary neurons which are ideal for studying
mechanisms of developmental neurobiology, disease progression, neurotoxicology and other areas of neuroscience.
Human Neurons
Cat. Product Name Cell Type
NCL-2103-P71 iNeu™ Human iPSC-derived Motor Neurons Primary Cell
NCL-2103-P77 iNeu™ Human iPSC-derived Dopaminergic Neurons Primary Cell
NCL-2103-P78 iNeu™ Human iPSC-derived Cortical Neurons Primary Cell
NCL-2103-P62 iNeu™ Human iPSC-derived Sensory Neurons Primary Cell
NCL-21P6-001 iNeu™ Human iPSC-derived Spinal Motor Neurons Primary Cell
NCL-21P6-002 iNeu™ Human iPSC-derived Layer V Glutamatergic Neurons Primary Cell
NCL-21P6-003 iNeu™ Human iPSC-derived Midbrain Dopaminergic Neurons Primary Cell
NCL-21P6-004 iNeu™ Human iPSC-derived Cortical GABAergic Neurons Primary Cell
NCL-21P6-005 iNeu™ Human iPSC-derived Cortical Glutamatergic Neurons Primary Cell
NCL-21P6-007 iNeu™ Human iPSC-derived Mixed Cortical Neurons Primary Cell
NCL-21P6-008 iNeu™ Human iPSC-derived Medium Spiny Neurons Primary Cell
NCL-21P6-025 Human Hippocampus-derived Neurons Primary Cell
NCL-21P6-172 Human Midbrain-derived Neurons Primary Cell
NCL-21P6-027 Human Brain Stem-derived Neurons Primary Cell
NCL2110P18- Human Cortical-derived Neurons Primary Cell
NCL-2105-P130-IX Human iPSC-derived Motor Neurons (Amyotrophic Lateral Sclerosis Patient, Sporadic) Disease Model
NCL-2105-P133-IX Human iPSC-derived Motor Neurons (SOD1 mutant, A4V, HOM) Disease Model
NCL-2105-P134-IX Human iPSC-derived Motor Neurons (TDP-43 mutation, M337V, HET) Disease Model
NCL-2105-P135-IX Human iPSC-derived Motor Neurons (TDP-43 mutation, Q331K, HET) Disease Model
NCL-2105-P136-IX Human iPSC-derived Motor Neurons (TDP-43 mutation, M337V, HOM) Disease Model
NCL-2105-P137-IX Human iPSC-derived Motor Neurons (TDP-43 mutation, Q331K, HOM) Disease Model
NCL-2105-P138-IX Human iPSC-derived Motor Neurons (TDP43 mutation, N352S, HET) Disease Model
Neurons
Selected Neurons
Cutting Edge Tools for Neuroscience Research
Neurons
Rat Neurons
Cat. Product Name Cell Type
NCL-21P6-08- Rat Substantia Nigra-derived Neurons Primary Cell
NCL-21P6-0-1 Rat Ventral Spinal Cord-derived Neurons Primary Cell
NCL-21P6-0-2 Rat Dorsal Spinal Cord-derived Neurons Primary Cell
NCL-21P6-0-3 Rat Spinal Cord-derived Neurons Primary Cell
NCL-2103-P15 Rat Cortical Neurons (RCoN) Primary Cell
NCL-2103-P16 Rat Dorsal Root Ganglion Neurons (DRG) Primary Cell
NCL-2103-P17 Rat Hindbrain Neurons (RHbN) Primary Cell
NCL-2103-P18 Rat Hippocampal Neurons (RHiN) Primary Cell
NCL-2103-P21 Rat Midbrain Neurons Primary Cell
NCC20--PZ15 Rat Dorsal Root Ganglion (DRG) Neurons, Neonatal Primary Cell
NCC20--PZ20 Rat Embryonic Dorsal Root Ganglion (eDRG) Neurons Primary Cell
NCC20--PZ5- Rat Brain Striatum Neurons Primary Cell
NCC20--PZ60 Rat Cerebellar Granular Neurons Primary Cell
Live Ready-To-use Neurons
Cat. Product Name Cell Type
N100200-AM E18 Hippocampal Neurons 1 M cells/vial
N200200-AM E18 Cortical Neurons 1 M cells/vial
N300200-AM P8 Cerebellar Neurons 4 Pairs
N400200-AM E18 Hypothalamus Neurons 1 Pair
N500200-AM E18 Striatal Neurons 1 Pair
N600200-AM E18 Spinal Cord Neurons 1 Cord
N700200-AM E18 Midbrain Cells 1 Midbrain
Mouse Neurons
Cat. Product Name Cell Type
NCL-21P6-051 Mouse C57 Brain Hippocampus Neurons Primary Cell
NCC20--PZ47 Mouse CD1 Brain Hippocampus Neurons Primary Cell
NCC20--PZ48 Mouse C57 Brain Cortex Neurons Primary Cell
NCC20--PZ52 Mouse CD1 Brain Cortex Neurons Primary Cell
NCC20--PZ53 Mouse C57 Brain Striatum Neurons Primary Cell
NCC20--PZ56 Mouse CD1 Brain Striatum Neurons Primary Cell
NCL-21P6-044 Mouse CD1 Brain Raphe-derived Neurons Primary Cell
NCL-21P6-045 Mouse C57 Brain Raphe-derived Neurons Primary Cell
NCL-21P6-052 Mouse CD1 Substantia Nigra-derived Neurons Primary Cell
NCL-21P6-053 Mouse C57 Substantia Nigra-derived Neurons Primary Cell
NCL-21P6-055 Mouse CD1 Ventral Spinal Cord-derived Neurons Primary Cell
NCL-21P6-056 Mouse CD1 Dorsal Spinal Cord-derived Neurons Primary Cell
NCL-21P6-057 Mouse C57 Dorsal Spinal Cord-derived Neurons Primary Cell
NCL-21P6-058 Mouse CD1 Spinal Cord-derived Neurons Primary Cell
NCL-21P6-05- Mouse C57 Spinal Cord-derived Neurons Primary Cell
NCL-2108P2- Mouse Hippocampal Neuron Cells (HT-22), Immortalized Immortalized Cell
NCL-2105-P20--AM Mouse Hypothalamic Neurons - SV40T, Immortalized Immortalized Cell
NCL-2105-P212-AM Mouse Neuronal Cells (M4b), Immortalized Immortalized Cell
NCL-2105-P213-AM Mouse Trisomy 16 Neuronal Cells (MTh), Immortalized Immortalized Cell
Cutting Edge Tools for Neuroscience Research
Astrocytes are highly heterogeneous neuroglial cells with distinct functional and morphological characteristics in different parts
of the brain. They are responsible for maintaining a number of complex processes needed for a healthy central nervous system
(CNS).
Creative Biolabs' astrocyte precursor and mature cells are derived from neural stem cells differentiated from fully
characterized, normal karyotype human induced pluripotent stem cells (hiPSCs), using proprietary induction protocols that
produce high purity astrocytes, and using xeno-free and integration-free derivation and culturing.
• >-0% GFAP+ cells; <1% Tuj1+ cells with typical astrocyte morphology
• Characterized using immunocytochemistry and whole genome profiling
• Suitable for co-culturing with neurons for complex tissue modeling
• Limited proliferative potential and long-term viability
Human Astrocytes
Cat. Product Name Cell Type
NCL-21P6-00- Human iPSC-derived Cortical Astrocytes Primary Cell
NCL-21P6-010 Human iPSC-derived Spinal Astrocytes Primary Cell
NCL-21P6-032 Human Cerebral Cortex-derived Astrocytes Primary Cell
NCL-21P6-033 Human Cerebellum-derived Astrocytes Primary Cell
NCL-21P6-034 Human Spinal Cord-derived Astrocytes Primary Cell
NCL-21P6-035 Human Hippocampus-derived Astrocytes Primary Cell
NCL-21P6-036 Human Brain Stem-derived Astrocytes Primary Cell
NCL-21P6-037 Human Midbrain-derived Astrocytes Primary Cell
NCL-21P6-038 Human Retinal-derived Astrocytes Primary Cell
NCL2110P1-5 Human Mesencephalic-derived Astrocytes Primary Cell
NCL-21P6-14- Human Brain Astrocytes-GFP Primary Cell
NCL-21P6-150 Human Brain Astrocyte-RFP Primary Cell
NCL-2103-P01 Human Astrocytes (HA), Cryopreserved, Fetal Primary Cell
NCL-2103-P03 Human Astrocytes (HA), Cryopreserved, Adult Primary Cell
NCL-2105-P180-AM Human Astrocytes, Fetal - hTERT, Immortalized Immortalized Cell
NCL-2105-P182-AM Human Astrocytes, Fetal - SV40, Immortalized Immortalized Cell
NCL-2105-P336-AM Human Brain Astrocytes-GFP, Immortalized Immortalized Cell
NCL-2105-P340-AM Human Brain Astrocyte-RFP, Immortalized Immortalized Cell
NCL2110P065 Human Astrocyte Cell Line SVG P12, Immortalized Immortalized Cell
Mouse Astrocytes
Cat. Product Name Cell Type
NCL-21P6-064 Mouse Astrocytes from CD1 Primary Cell
NCL-21P6-065 Mouse Astrocytes from C57BL/6 Primary Cell
NCL-21P6-066 Mouse Brain Cerebellar Cortex-derived Astrocytes-from CD1 Primary Cell
NCL-21P6-067 Mouse Brain Cerebellar Cortex-derived Astrocytes-from C57BL/6 Primary Cell
NCL-21P6-071 Mouse Spinal Cord-derived Astrocytes-from CD1 Primary Cell
NCL-21P6-072 Mouse Spinal Cord-derived Astrocytes-from C57BL/6 Primary Cell
NCL-21P6-073 Mouse Brain Stem-derived Astrocytes-from CD1 Primary Cell
NCL-2105-P154-IX Mouse Midbrain-derived Astrocytes Primary Cell
NCL-2105-P155-IX Mouse Brain Hippocampus-derived Astrocytes Primary Cell
NCL-2105-P156-IX Neonatal Mouse Spinal Cord-derived Astrocytes Primary Cell
NCL-2105-P153-IX Neonatal Mouse Brain Cerebellar Cortex-derived Astrocytes Primary Cell
NCL-2105-P1---AM Mouse Astrocytes - SV40T (IMA2.1), Immortalized Immortalized Cell
Rat Astrocytes
Cat. Product Name Cell Type
NCL-21P6-076 Rat Cerebellum-derived Astrocytes Primary Cell
NCL-21P6-077 Rat Hippocampus-derived Astrocytes Primary Cell
NCL-21P6-078 Adult Rat Brain-derived Astrocytes Primary Cell
NCL-21P6-07- Rat Retinal-derived Astrocytes Primary Cell
NCC20--PZ61 Rat Brain Striatum-derived Astrocytes Primary Cell
NCC20--PZ4- Rat Brain Cortex-derived Astrocytes Primary Cell
NCL-2103-P26 Rat Cerebellar Astrocytes, Cryopreserved, Neonatal Primary Cell
NCL-2103-P11 Rat Astrocytes, Cryopreserved, Neonatal Primary Cell
NCL-2105-P173-AM Adult Rat Hippocampal Astrocytes - SV40, Immortalized Immortalized Cell
Astrocytes
Selected Astrocytes
Cutting Edge Tools for Neuroscience Research
Microglia are commonly described as the immune cells of the brain, with key roles in brain development, neurogenesis,
synaptic plasticity and homeostatic maintenance.
Creative Biolabs' Human iPSC-derived Microglia provide a reproducible, physiologically-relevant model in an easy-to-use, assay-
ready format for investigating neuroglia involvement in neurodegeneration and neurodevelopment. Our iPSC-derived Microglia
deliver the advantage that they provide an almost infinite source of microglia from a single donor with a normal karyotype. Our
iPSC-derived Microglia also express the microglia-specific marker TMEM11- along with myeloid markers TREM2 and IBA-1.
These phenotypes make iPSC-derived Microglia suitable models for investigating neuroinflammation in Alzheimer’s disease,
multiple sclerosis and Parkinson’s disease. We also offer a fully optimized serum-free Microglia Maintenance Medium to
promote and support the maintenance of microglia.
Human Microglia
Cat. Product Name Cell Type
NCL-7P018 iNeu™ Human iPSC-derived Microglia Primary Cell
NCL-7P016 iNeu™ Human iPSC-derived Microglia, Isogenic Control Primary Cell
NCL-2108P38 Human Microglia Cell Line HMC3, Immortalized Immortalized Cell
NCL-2105-P337-AM Human Microglia-GFP, Immortalized Immortalized Cell
NCL-2105-P341-AM Human Microglia-RFP, Immortalized Immortalized Cell
NCL-7P014 iNeu™ Microglia AD TREM2 HO, Disease Model Disease Model
NCL-7P015 iNeu™ Microglia AD TREM2 HZ, Disease Model Disease Model
NCL-7P036 iNeu™ Microglia AD APOE E4/E4, 11--5, Disease Model Disease Model
NCL-7P037 iNeu™ Microglia AD APOE E4/E4, 11--3, Disease Model Disease Model
NCL-7P038 iNeu™ Microglia AD APOE E4/E4, 12037, Disease Model Disease Model
NCL-7P03- iNeu™ Microglia AD APOE E4/E4, 12061, Disease Model Disease Model
NCL-7P040 iNeu™ Microglia AD APOE E2/E4, 11-68, Disease Model Disease Model
NCL-7P050 iNeu™ Microglia TREM2 R47H, 11-6-, Disease Model Disease Model
NCL-7P051 iNeu™ Microglia ABCA7 G1527A, 12000, Disease Model Disease Model
NCL-7P020 iNeu™ Microglia Rett Syndrome MECP2, Disease Model Disease Model
Mouse Microglia
Cat. Product Name Cell Type
NCL-21P6-081 Mouse Microglia from CD1 Primary Cell
NCL-21P6-082 Mouse Microglia from C57BL/6 Primary Cell
NCL-2103-P28 Mouse Microglia, Cryopreserved Primary Cell
NCL-2105-P210-AM Mouse Microglia SIM-A-, Immortalized Immortalized Cell
NCL-2108P32 Mouse Microglia BV-2, Immortalized Immortalized Cell
Rat Microglia
Cat. Product Name Cell Type
NCL-2105-P35--AM Rat Primary Microglia Primary Cell
NCL-2103-P1- Rat Primary Microglia, Neonatal Primary Cell
NCL2110P015 Rat Hippocampal Microglia Primary Cell
NCL-2106-S7- Rat Cochlear Microglial Cell Line Primary Cell
NCL2110P037 Rat Microglia Cell Line HAPI, Immortalized Immortalized Cell
NCL-21P6-222 Rat Cochlear Microglial Cell Line, Immortalized Immortalized Cell
Microglial Cells
Selected Microglial Cells
Cutting Edge Tools for Neuroscience Research
Oligodendrocytes are a type of large glial cell found in the central nervous system. Oligodendrocytes produce the myelin sheath
insulating neuronal axons (analogous to Schwann cells in the peripheral nervous system), although some oligodendrocytes
(called satellite oligodendrocytes) are not involved in myelination.
Creative Biolabs' Human Oligodendrocyte Differentiation Kit contains Human Oligodendrocyte Progenitor Cells (OPCs) along
with optimized media for their expansion and spontaneous differentiation into mature oligodendrocytes. Human OPCs can be
used for a variety of research applications including studies of neurotoxicity, co-culture applications and screening for
molecules that induce or inhibit preferential differentiation to mature oligodendrocytes.
Human Oligodendrocyte Kit
Cat. Product Name
NCL200506ZP Human Oligodendrocyte Progenitors (OPCs)
NCC200524ZP Human Oligodendrocyte Differentiation Kit
NCC200527ZP Human Oligodendrocyte Characterization Kit
Rat Oligodendrocyte
Cat. Product Name
NCL-21P6-0-4 Rat Oligodendrocyte Progenitor Cells
Oligodendrocytes
Selected Oligodendrocytes
Cutting Edge Tools for Neuroscience Research
Oligodendrocytes are a type of large glial cell found in the central nervous system. Oligodendrocytes produce the myelin
sheath insulating neuronal axons (analogous to Schwann cells in the peripheral nervous system), although some
oligodendrocytes (called satellite oligodendrocytes) are not involved in myelination.
Creative Biolabs' Human Oligodendrocyte Differentiation Kit contains Human Oligodendrocyte Progenitor Cells (OPCs) along
with optimized media for their expansion and spontaneous differentiation into mature oligodendrocytes. Human OPCs can be
used for a variety of research applications including studies of neurotoxicity, co-culture applications and screening for
molecules that induce or inhibit preferential differentiation to mature oligodendrocytes.
Human Schwann Cells
Cat. Product Name Cell Type
NCL-2103-P106 Human Schwann Cells Primary Cell
NCL2110P107 Human Schwann Cell, Immortalized Immortalized Cell
Mouse Schwann Cells
Cat. Product Name Cell Type
NCL-21P6-060 Mouse Schwann Cells from CD1 Primary Cell
NCL-21P6-061 Mouse Schwann Cells from C57BL/6 Primary Cell
NCL-2105-P167-IX Mouse Schwann Cells Primary Cell
NCL-2105-P223-AM Mouse Schwann Cells, Immortalized Immortalized Cell
NCL-2105-P168-AM Mouse Schwann Cells from C57BL/6, Immortalized Immortalized Cell
NCL-2105-P1-8-AM Mouse alpha-GalA-/o Schwann Cells, Immortalized Immortalized Cell
NCL-2105-P207-AM Mouse Hexb-/- Schwann Cells (1113C1), Immortalized Immortalized Cell
NCL-2105-P214-AM Mouse NPCNIH Schwann Cells (573C10), Immortalized Immortalized Cell
NCL-2108P158 Mouse Schwann Cell (1-70C3), Immortalized Immortalized Cell
NCL-2105-P224-AM Mouse Schwann Cells (IMS32), Immortalized Immortalized Cell
NCL-2105-P225-AM Mouse Schwann Cells (IKARS1), Immortalized Immortalized Cell
NCL-2105-P226-AM Mouse Schwann Cells (IWARS1), Immortalized Immortalized Cell
NCL-2108P24 Mouse Schwann Cell Line SW10, Immortalized Immortalized Cell
Rat Schwann Cells
Cat. Product Name Cell Type
NCL-21P6-0-5 Rat Schwann Cells Primary Cell
NCL-2108P05 Rat Schwann Cells RSC-6, GFP, Immortalized Immortalized Cell
NCL-2108P21 Rat Schwann Cells RSC-6, Immortalized Immortalized Cell
NCL-2105-P244-AM Rat Schwann Cells (IFRS1), Immortalized Immortalized Cell
Schwann Cells
Selected Schwann Cells
Cutting Edge Tools for Neuroscience Research
Translation from in vitro models & assays into animal models are critical to understanding the progression of neurological
disease while providing a complete interactive physiology to understand the pharmacokinetics and pharmacodynamics of a
candidate. We have developed robust and reproducible in vitro models and in vivo pharmacology studies that are validated for
multiple assay platforms and reliable tools to screen small molecules to biologics.
Applications of Cell-Based Models:
DISEASE MODELING. Generate patient-specific human "disease-in-a-dish" models.
DRUG DISCOVERY. Screen drug candidates on physiologically relevant human cell types, including diseased cells.
TOXICITY SCREENING. Evaluate neurotoxicity on differentiated human neural cell types.
CELL THERAPY VALIDATION. Generate human neural cell types for pre-clinical validation of potential cell therapy applications.
Selected Neurological Disease Cell Models
Gene-edited Disease Model
Cat. Product Name Disease Cell Type
NCL-7P001 iNeu Motor Neurons ALS TDP43 Q331K, Disease Model Amyotrophic Lateral Sclerosis Gene-edited Disease Model
NCL-7P002 iNeu Motor Neurons ALS TDP43 M337V, Disease Model Amyotrophic Lateral Sclerosis Gene-edited Disease Model
NCL-7P004 iNeu Motor Neurons ALS TDP43 Q331K Kit, Disease Model Amyotrophic Lateral Sclerosis Gene-edited Disease Model
NCL-7P005 iNeu Motor Neurons ALS TDP43 M337V Kit, Disease Model Amyotrophic Lateral Sclerosis Gene-edited Disease Model
NCL-2105-P133-IX iNeu Motor Neurons (SOD1 mutant, A4V, HOM) Amyotrophic Lateral Sclerosis Gene-edited Disease Model
NCL-7P012 iNeu Microglia AD TREM2 HO Kit, Disease Model Alzheimer’s Disease Gene-edited Disease Model
NCL-7P013 iNeu Microglia AD TREM2 HZ Kit, Disease Model Alzheimer’s Disease Gene-edited Disease Model
NCL-7P014 iNeu Microglia AD TREM2 HO, Disease Model Alzheimer’s Disease Gene-edited Disease Model
NCL-7P015 iNeu Microglia AD TREM2 HZ, Disease Model Alzheimer’s Disease Gene-edited Disease Model
NCL-7P031 iNeu Microglia AD APOE E4/E4 Kit, 11--3, Disease Model Alzheimer’s Disease Gene-edited Disease Model
NCL-7P032 iNeu Microglia AD APOE E4/E4 Kit, 11--5, Disease Model Alzheimer’s Disease Gene-edited Disease Model
NCL-7P033 iNeu Microglia AD APOE E4/E4 Kit, 12037, Disease Model Alzheimer’s Disease Gene-edited Disease Model
NCL-7P034 iNeu Microglia AD APOE E4/E4 Kit, 12061, Disease Model Alzheimer’s Disease Gene-edited Disease Model
NCL-7P035 iNeu Microglia AD APOE E2/E4 Kit, 11-68, Disease Model Alzheimer’s Disease Gene-edited Disease Model
NCL-7P036 iNeu Microglia AD APOE E4/E4, 11--5, Disease Model Alzheimer’s Disease Gene-edited Disease Model
NCL-7P037 iNeu Microglia AD APOE E4/E4, 11--3, Disease Model Alzheimer’s Disease Gene-edited Disease Model
NCL-7P038 iNeu Microglia AD APOE E4/E4, 12037, Disease Model Alzheimer’s Disease Gene-edited Disease Model
NCL-7P03- iNeu Microglia AD APOE E4/E4, 12061, Disease Model Alzheimer’s Disease Gene-edited Disease Model
NCL-7P040 iNeu Microglia AD APOE E2/E4, 11-68, Disease Model Alzheimer’s Disease Gene-edited Disease Model
NCL-7P026 iNeu DopaNeurons PD SNCA A53T HZ Kit, Disease Model Parkinson’s Disease Gene-edited Disease Model
NCL-7P027 iNeu DopaNeurons PD SNCA A53T HZ, Disease Model Parkinson’s Disease Gene-edited Disease Model
NCL-7P020 iNeu Microglia Rett Syndrome MECP2, Disease Model Rett Syndrome Gene-edited Disease Model
NCL-2101-ZP06 iNeu Neural Stem Cells - AD Patient (APOE4 HOM) Alzheimer’s Disease Gene-edited Disease Model
NCL-2101-ZP07 iNeu Neural Stem Cells - AD Patient (PSEN1 L286V) Alzheimer’s Disease Gene-edited Disease Model
NCL-2101-ZP08 iNeu Neural Stem Cells - AD Patient (PSEN1 M146L) Alzheimer’s Disease Gene-edited Disease Model
NCL-2101-ZP0- iNeu Neural Stem Cells - AD Patient (PSEN1 A246E) Alzheimer’s Disease Gene-edited Disease Model
Neurological Disease Cell Models
Cutting Edge Tools for Neuroscience Research
Donor-derived Disease Model
Cat. Product Name Disease Cell Type
NRZP-0622-P28 iNeu™ Human Neural Stem Cells - Alzheimer’s Disease Patient, Donor 1 Alzheimer’s Disease Donor-derived Disease Model
NRZP-0622-P31
iNeu™ Human Neural Stem Cells - Frontotemporal Dementia (FTD) Patient,
Donor 4
Frontotemporal Dementia (FTD) Donor-derived Disease Model
NRZP-0622-P33
iNeu™ Human Neural Stem Cells - Frontotemporal Dementia (FTD), Paget’s
Disease Patient, Donor 6
Frontotemporal Dementia (FTD),
Paget’s Disease
Donor-derived Disease Model
NRZP-0622-P35
iNeu™ Human Neural Stem Cells - Frontotemporal Dementia, ALS Patient,
Donor 8
Frontotemporal Dementia,
Amyotrophic Lateral Sclerosis
Donor-derived Disease Model
NRZP-0622-P37
iNeu™ Human Neural Stem Cells - Behavioural Variant Frontotemporal
Dementia (bvFTD) Patient, Donor 10
Behavioural Variant
Frontotemporal Dementia (bvFTD)
Donor-derived Disease Model
NRZP-0622-P41 iNeu™ Human Neural Stem Cells - Mucolipidosis IV (ML4) Patient, Donor 14 Mucolipidosis IV (ML4) Donor-derived Disease Model
NRZP-0622-P45 iNeu™ Human Neural Stem Cells - Nasu-Hakola Disease Patient, Donor 18 Nasu-Hakola Disease Donor-derived Disease Model
NRZP-0622-P47
iNeu™ Human Neural Stem Cells - Nasu-Hakola Disease (familial control)
Patient, Donor 20
Nasu-Hakola Disease (familial
control)
Donor-derived Disease Model
NRZP-0622-P48 iNeu™ Human Neural Stem Cells - Parkinson’s Disease Patient, Donor 21 Parkinson’s Disease Donor-derived Disease Model
NRZP-0622-P5-
iNeu™ Human Neural Stem Cells - Parkinsonism/Machado-Joseph Disease
(SCA3) Patient, Donor 32
Parkinsonism/MachAlzheimer’s
Diseaseo-Joseph Disease (SCA3)
Donor-derived Disease Model
NRZP-0622-P63
iNeu™ Human Neural Stem Cells - Amyotrophic Lateral Sclerosis (ALS) Patient,
Donor 36
Amyotrophic Lateral Sclerosis
(Amyotrophic Lateral Sclerosis)
Donor-derived Disease Model
NRZP-0622-P65
iNeu™ Human Neural Stem Cells - Amyotrophic Lateral Sclerosis (ALS)
(unaffected) Patient, Donor 38
Amyotrophic Lateral Sclerosis
(Amyotrophic Lateral Sclerosis)
(unaffected)
Donor-derived Disease Model
NRZP-0622-P66
iNeu™ Human Neural Stem Cells - Charcot-Marie-Tooth Disease, Type 4J
(CMT4J) Patient, Donor 3-
Charcot-Marie-Tooth Disease,
Type 4J (CMT4J)
Donor-derived Disease Model
NRZP-0622-P67
iNeu™ Human Neural Stem Cells - Dentatorubral-Pallidoluysian Atrophy (DRPLA)
Patient, Donor 40
Dentatorubral-Pallidoluysian
Atrophy (DRPLA)
Donor-derived Disease Model
NRZP-0622-P71 iNeu™ Human Neural Stem Cells - Friedreich’s Ataxia Patient, Donor 44 Friedreich’s Ataxia Donor-derived Disease Model
NRZP-0622-P75
iNeu™ Human Neural Stem Cells - Friedreich’s Ataxia (control) Patient, Donor
48
Friedreich’s Ataxia (control) Donor-derived Disease Model
NRZP-0622-P76
iNeu™ Human Neural Stem Cells - Friedreich’s Ataxia (familial control) Patient,
Donor 4-
Friedreich’s Ataxia (familial control) Donor-derived Disease Model
NRZP-0622-P77 iNeu™ Human Neural Stem Cells - Huntington’s Disease Patient, Donor 50 Huntington’s Disease Donor-derived Disease Model
NRZP-0622-P80
iNeu™ Human Neural Stem Cells - Huntington’s Disease RCi004-B Patient,
Donor 53
Huntington’s Disease RCi004-B Donor-derived Disease Model
NRZP-0622-P82
iNeu™ Human Neural Stem Cells - Spinal and Bulbar Muscular Atrophy (SBMA)
Patient, Donor 55
Spinal and Bulbar Muscular
Atrophy (SBMA)
Donor-derived Disease Model
NRZP-0622-P83
iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 2 (SCA2) Patient,
Donor 56
Spinocerebellar Ataxia Type 2
(SCA2)
Donor-derived Disease Model
NRZP-0622-P8-
iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 7 (SCA7) Patient,
Donor 62
Spinocerebellar Ataxia Type 7
(SCA7)
Donor-derived Disease Model
NRZP-0622-P-0
iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 6 (SCA6) Patient,
Donor 63
Spinocerebellar Ataxia Type 6
(SCA6)
Donor-derived Disease Model
NRZP-0622-P-1
iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 3 (SCA3) Patient,
Donor 64
Spinocerebellar Ataxia Type 3
(SCA3)
Donor-derived Disease Model
NCL-2105-P130-IX iNeu Human Motor Neurons - ALS Patient, Sporadic Amyotrophic Lateral Sclerosis Donor-derived Disease Model
NCL-2101-ZP11 iNeu Human Neural Stem Cells - Epilepsy Patient Epilepsy Donor-derived Disease Model
NCL-2101-ZP12 iNeu Human Neural Stem Cells - Trisomy X Patient Trisomy X Donor-derived Disease Model
NCL-2108-P007 iNeu Human Neural Progenitor Cell Line, AD Patient Alzheimer’s Disease Donor-derived Disease Model
Neurological Disease Cell Models
Cutting Edge Tools for Neuroscience Research
Assay Cell Line Models
Cat. Product Name Cell Type
NCL2110P230 APP Processing Assay Cell Line [Alzheimer’s Disease (AD) Model] Assay Model
NCL2110P231 FUS/TLS Stress Granules Assay Cell Line [Amyotrophic Lateral Sclerosis (ALS) Model] Assay Model
NCL2110P232 Gamma Secretase Activity Assay Cell Line [Alzheimer’s Disease (AD) Model] Assay Model
NCL2110P234 Parkin Mitochondrial Recruitment Assay Cell Line [Parkinson’s Disease (PD) Model] Assay Model
NCL2110P235 Tau Phosphorylation Assay Cell Line [Alzheimer’s Disease (AD) Model] Assay Model
NCL2110P236 TDP-43 Stress Granules Assay Cell Line [Amyotrophic Lateral Sclerosis (ALS) Model] Assay Model
NCL2110P337 Parkinsonism Cell Line, Disease Model Assay Model
Extensive Neural Tissue Biorepository from Healthy and Diseased Donors !
Creative Biolabs offers a comprehensive repository of neural tissue samples, covering multiple regions of the brain and spinal
cord from many species and tissue types. Certified tissues are available as OCT frozen blocks & snap-frozen samples, FFPE
blocks, FFPE tissue arrays, frozen tissue arrays, frozen tissue sections, FFPE tissue sections, FFPE tissue panels, as well as
fresh tissue. We have a wide range of donors and provide both healthy and diseased tissue.
Also available: Total RNA– cDNA– Genomic DNA– Total Protein
Human Tissue
- Adult and Fetal Normal
- Tumour and Adjacent Tissue
- Diseased tissues including Alzheimer's Disease, Parkinson's Disease and Dementia
Multiple Species Available
Tissue Dissociation:
Creative Biolabs has developed Neural Tissue Dissociation Kits used for the gentle and efficient generation of single-cell
suspensions from neural tissues. The Neural Tissue Dissociation Kit - Postnatal Neurons has been optimized for the special
needs of sensitive postnatal neurons during dissociation. We also offers highly purified collagenase free of any animal-based
components. For research applications, non-GMP grade Collagenase NB4 Standard Grade and Collagenase NB 5 Sterile Grade
are economical alternatives with comparable enzymatic properties to Collagenase NB 6 GMP Grade.
Ordering Information:
- Mouse
- Rhesus Monkey
- Cynomolgus Monkey
- Marmoset
- Guinea Pig
- Cat
- Chicken
- Dog
- Horse
- Bovine
- Rat
- Rabbit
- Hamster
- Nude Mouse
- Mini Pig
- Pig
Cat. Product Name
NRZP-0622-ZP15 Neural Tissue Dissociation Kit (P) – Postnatal Neurons
NRZP-0622-ZP16 Neural Tissue Dissociation Kit (T) – Postnatal Neurons
NRZP-0622-ZP17 Brain Tumor Dissociation Kit (P), Human and Mouse
NRZP-0622-ZP14 Adult Brain Dissociation Kit, Mouse and Rat
NRZP-0622-ZP390 Collagenase NB 4 Standard Grade
NRZP-0622-ZP389 Collagenase NB 5 Sterile Grade
NRZP-0622-ZP394 Collagenase NB 6 GMP Grade
NRZP-0622-ZP396 Neutral Protease NB GMP Grade
Neural Tissues
Cutting Edge Tools for Neuroscience Research
We supply neural cell culture medium optimized to support undifferentiated growth both as adherent cultures or neurosphere
suspensions. We also provide medium, supplements and growth factors to differentiate neural stem cells and to maintain long-
term cultures of differentiated cells. In addition to culture mediums, Creative Biolabs also supplies all supporting reagents to
characterize neural stem cells including nestin antibodies as well as differentiated neurons using βIII-tubulin antibodies,
oligodendrocytes using O3 antibodies and astrocytes using GFAP antibodies.
Ordering Information:
Growth Medium
Cat. Product Name
CAT#: NCC20-9PZ02 Astrocyte Growth Medium
NCL-21P6-226 Microglial Cell Growth Medium
NCC-2101-ZP14 Striatal Neuron Growth Medium
NRZP-0522-ZP1151 Oligodendrocyte Growth Media
NCL-21P6-105 Oligodendrocyte Precursor Cell Growth Medium
NCC20-9PZ10 Primary Neuron Growth Medium
NCC2009PZ17 Retinal Pigment Epithelial Cell Growth Medium Kit
NCC20-9PZ26 Endothelial Cell Growth Medium
NCC-2103-P65 Schwann Growth Medium
NCL-2105-P140-IX Human Neural Stem Cell Growth Medium
Maintenance Medium
Cat. Product Name
NCC200631ZP StemTes™ A Maintenance Medium
NCC-2101-ZP26 Microglia Maintenance Medium
NCC-2101-ZP15 Sensory Neuron Maintenance Medium
NCC-2101-ZP24 Motor Neuron Maintenance Medium
NCC-2101-ZP25 Astrocyte Maintenance Medium
NCL-2105-P119-IX Cortical Neuron Maintenance Medium
Differentiation Medium
Cat. Product Name
NCL-21P6-106 Oligodendrocyte Precursor Cell Differentiation Medium
NCC200538ZP ES/iPS Neuronal Differentiation Medium
Neural Supplements
Cat. Product Name
NCL-7P062 Nervous System Supplement
NCL-21P6-124 Astrocyte Growth Supplement
NCL-21P6-118 Epithelial Cell Growth Supplement
NCL-21P6-116 Fibroblast Growth Supplement
NCL-21P6-114 Endothelial Cell Growth Supplement
NCC200512ZP NeuroInduc™ Neural Stem and Progenitor Cells Differentiation Supplement
NCC200600ZP NeuroInduc™ N2 Supplement-A
NCC200605ZP NeuroInduc™ N2 Supplement-B
NRZP-0622-ZP403 GS21 Neural Supplement
NCC-2101-ZP17 Human/Murine/Rat BDNF [CAT#:]
NCC-2101-ZP19 Human beta-NGF
NCC-2101-ZP20 Human NT-3
Neural Cell Culture Media and Supplements
Cutting Edge Tools for Neuroscience Research
Laminin for Neural Cell Attachment
Laminins (heterotrimers composed of α, β, and γ chains), are
multifunctional glycoproteins present in basement membranes. Laminin
has long been an important mainstay of neural cell culture as coating
substrates and is also used as a supplement of culture medium to
enhance growth of human neural stem cells. We provide a range of high
quality laminin products that are ideally suited as tools for neural cell
culture to allow you to select the most suitable version for your research.
Cat. Product Name
NRZP-0622-ZP398 Mouse Laminin I
NRZP-0622-ZP399 Antibiotic-Free Mouse Laminin I
NRZP-0622-ZP400 Stem Cell Qualified Mouse Laminin I
NRZP-0622-ZP401 3D Culture Matrix Laminin I
NRZP-0622-ZP402 Poly-D-Lysine & Laminin Coating Solution
Extracellular Matrix for Neurosphere Formation
Neurospheres demonstrated the first unequivocal evidence that cells derived
from adult brain can have stem cell properties and remain a useful tool for
the in vitro study of neural stem cells. Applications include analysis of
selfrenewal capacity, potency, neural development and neurogenesis. We
provide an optimized spheroid formation matrix to help with consistent
generation of neurospheres for use in your research.
Ordering Information:
Cat. Product Name
NRZP-0622-ZP397 Neurosphere Formation Matrix
Neural Cell Culture Matrices
Ordering Information:
Optimized transfection reagents tailored for neural cells!
Physiologically relevant models, such as primary neurons and small animal models, increase the need for new nucleic acid
delivery tools. One of the greatest challenges is the ability to manipulate the desired cell models that are traditionally difficult to
transfect, including primary neurons and neural stem cells. Methods typically used have not met these needs—reagent-
mediated DNA transfection is inefficient for nuclear entry; electroporation requires cell disruption and special instrumentation,
and is expensive; and virus-mediated transduction can be very time-consuming. To facilitate the use of more relevant cell
models, we have developed NeuroIn™ Transfection Reagent, which we recommend as the primary gene delivery solution (Fig.1).
Figure 1. Recommended transfection methods, by cell type.
Cat. Product Name
NRZP-0622-ZP377 NeuroIN™ mRNA Transfection Reagent
NRZP-0622-ZP378 NeuroIN™ DNA Transfection Reagent, Lipo 3000
NRZP-0622-ZP37- NeuroIN™ DNA Transfection Reagent, Lipo 2000
NRZP-0622-ZP380 NeuroIN™ Invivo Brain Transfection Reagent, 3.0
NRZP-0622-ZP381 NeuroIN™ RNAi Transfection Reagent
Product Nucleic acid type Cell model Performance Cell viability Ease of use
NeuroIN™ mRNA Transfection Reagent mRNA
Primary cells, stem cells, and difficult-to-
transfect cells
+++ ++++ ++++
NeuroIN™ DNA Transfection Reagent, Lipo 3000 DNA
Easy- and difficult-to-transfect immortalized
cell lines, viral delivery
++ ++++ ++++
NeuroIN™ DNA Transfection Reagent, Lipo 2000 DNA Easy-to-transfect cells, primary neurons + ++++ ++++
NeuroIN™ Invivo Brain Transfection Reagent, 3.0 siRNA, mRNA In vivo directbraininjection ++ ++ ++
NeuroIN™ RNAi Transfection Reagent siRNA All neuronal cell models (gene knockdown) ++++ ++++ ++++
Neural Cell Transfection
Ordering information:
Product selection guide
We offer a variety of other gene delivery options based on your research needs, including lentiviral delivery and physical
methods such as electroporation. However, there are advantages and limitations for each method based on the cell models
being used and the end goal of the experiment: gene expression or gene knockdown. An overview of our most effective
delivery solutions for neurobiology research is shown in Table 1.
Table 1. Gene delivery products for neurobiology research by nucleic acid type.
Cutting Edge Tools for Neuroscience Research
Keeping your cells safe with the CELLBANKER Series!
There are numerous protocols available for cryopreserving neural stem cells (NSCs) derived from human embryonic stem cells;
the primary objective of these methods are the recovery of the cells post-thaw and the retention of their multipotent properties.
Creative Biolabs supplies cutting edge cryopreservation reagents to meet the demands of your neural cell research. Our high
performance and quality assured CELLBANKER cryopreservation solutions ensure stable long-term storage of cells.
CELLBANKER is a series of easy-to-use cell freezing media with defined formulations, available in serum and serum-free
formulations to successfully cryopreserve the most sensitive mammalian cells.
Figure 1. Recommended transfection methods, by cell type.
Product selection guide
- CELL-BANKER 1 was launched in 1--2 and now has a significant history of reliable, consistent
and high viability recoveries post-cryopreservation. Contains serum, DMSO, glucose, salts and buffer.
- CELLBANKER 2 is a chemically defined serum-free cell freezing medium that allows cell cryopreservation
directly at -80˚C without requiring a rate controlled freezer. Contains no animal derived products and is
guaranteed sterile.
- STEM-CELLBANKER is a chemically defined xeno-free freezing medium optimized for stem cells and iPS
cells storage as well as other valuable cells. It is free of serum and animal derived components and contains
only European or US Pharmacopoeia graded ingredients. Use STEM-CELLBANKER to achieve consistently high
cell viability post-thaw, even over extended long-term storage, while maintaining cell pluripotency, normal
karyotype and proliferation ability.
Ordering information:
Cat. Product Name
NRZP-0622-ZP382 CELLBANKER 1 (100ml)
NRZP-0622-ZP383 CELLBANKER 2 (100ml)
NRZP-0622-ZP384 STEM-CELLBANKER - GMP Grade (20ml)
Neural Cell Cryopreservation
Cutting Edge Tools for Neuroscience Research
SUITE 203, 17 Ramsey Road, Shirley, NY 11-67, USA
Tel: 1-631-357-2254
Fax: 1-631-207-8356
Email: info@creative-biolabs.com
167-16-Great Portland Street, 5th Floor, London, W1W 5PF
Tel: 44-207-0-7-1828
Email: info@creative-biolabs.com
USA UK

More Related Content

Similar to Neuros Cell Line Products-Creative Biolabs

poster BrainPlotting
poster BrainPlottingposter BrainPlotting
poster BrainPlotting
Nicolas Perriere
 
Neuroscience research services
Neuroscience research servicesNeuroscience research services
Neuroscience research services
cailynnjohnson
 
brain chemoarchitecture
brain chemoarchitecturebrain chemoarchitecture
brain chemoarchitecture
James Ikpa Onah
 
Potential Therapeutic Application Of Stem Cell
Potential Therapeutic Application Of Stem CellPotential Therapeutic Application Of Stem Cell
Potential Therapeutic Application Of Stem Cell
Stefanus Nofa
 
Bioinformatics final
Bioinformatics finalBioinformatics final
Bioinformatics final
Rainu Rajeev
 
Detecting Nuclei from Microscopy Images with Deep Learning
Detecting Nuclei from Microscopy Images with Deep LearningDetecting Nuclei from Microscopy Images with Deep Learning
Detecting Nuclei from Microscopy Images with Deep Learning
Dmytro Fishman
 
Cell reports best of 2019
Cell reports best of 2019Cell reports best of 2019
Cell reports best of 2019
maria202415
 
NIFSTD: A Comprehensive Ontology for Neuroscience
NIFSTD: A Comprehensive Ontology for NeuroscienceNIFSTD: A Comprehensive Ontology for Neuroscience
NIFSTD: A Comprehensive Ontology for Neuroscience
Neuroscience Information Framework
 
Poster BrainPlotting SEISC 2017 "Prediction of Human PK data based on innovat...
Poster BrainPlotting SEISC 2017 "Prediction of Human PK data based on innovat...Poster BrainPlotting SEISC 2017 "Prediction of Human PK data based on innovat...
Poster BrainPlotting SEISC 2017 "Prediction of Human PK data based on innovat...
Nicolas Perriere
 
Introductionto biotechnology
Introductionto biotechnologyIntroductionto biotechnology
Introductionto biotechnology
ADELABU Olusesan Adeyemi
 
Cell Therapy Industry News Round-Up - September 13, 2022 [BioInformant]
Cell Therapy Industry News Round-Up - September 13, 2022 [BioInformant]Cell Therapy Industry News Round-Up - September 13, 2022 [BioInformant]
Cell Therapy Industry News Round-Up - September 13, 2022 [BioInformant]
BioInformant
 
Cell based assays presentation v3_03_2012
Cell based assays presentation v3_03_2012Cell based assays presentation v3_03_2012
Cell based assays presentation v3_03_2012
Pete Shuster
 
Cell based assays presentation V2_03_2012
Cell based assays presentation V2_03_2012Cell based assays presentation V2_03_2012
Cell based assays presentation V2_03_2012
Pete Shuster
 
126 micro array study for gene expression
126 micro array study for gene expression126 micro array study for gene expression
126 micro array study for gene expression
SHAPE Society
 
Neuromics presentation november 2021
Neuromics presentation november 2021Neuromics presentation november 2021
Neuromics presentation november 2021
Pete Shuster
 
Blue brain technology
Blue brain technologyBlue brain technology
Blue brain technology
TabassumSaifi2
 
Differentiation of neural_cells_in_human_embryonic_stem
Differentiation of neural_cells_in_human_embryonic_stemDifferentiation of neural_cells_in_human_embryonic_stem
Differentiation of neural_cells_in_human_embryonic_stem
Honey Cheng
 
PPT Differentiation_of_neural_cells_in_human_embryonic_stem
PPT Differentiation_of_neural_cells_in_human_embryonic_stemPPT Differentiation_of_neural_cells_in_human_embryonic_stem
PPT Differentiation_of_neural_cells_in_human_embryonic_stem
Cheng Han-Ni
 
126 micro array study for gene expression
126 micro array study for gene expression126 micro array study for gene expression
126 micro array study for gene expression
Society for Heart Attack Prevention and Eradication
 
1-International.pdf
1-International.pdf1-International.pdf
1-International.pdf
MaigaAyubHussein
 

Similar to Neuros Cell Line Products-Creative Biolabs (20)

poster BrainPlotting
poster BrainPlottingposter BrainPlotting
poster BrainPlotting
 
Neuroscience research services
Neuroscience research servicesNeuroscience research services
Neuroscience research services
 
brain chemoarchitecture
brain chemoarchitecturebrain chemoarchitecture
brain chemoarchitecture
 
Potential Therapeutic Application Of Stem Cell
Potential Therapeutic Application Of Stem CellPotential Therapeutic Application Of Stem Cell
Potential Therapeutic Application Of Stem Cell
 
Bioinformatics final
Bioinformatics finalBioinformatics final
Bioinformatics final
 
Detecting Nuclei from Microscopy Images with Deep Learning
Detecting Nuclei from Microscopy Images with Deep LearningDetecting Nuclei from Microscopy Images with Deep Learning
Detecting Nuclei from Microscopy Images with Deep Learning
 
Cell reports best of 2019
Cell reports best of 2019Cell reports best of 2019
Cell reports best of 2019
 
NIFSTD: A Comprehensive Ontology for Neuroscience
NIFSTD: A Comprehensive Ontology for NeuroscienceNIFSTD: A Comprehensive Ontology for Neuroscience
NIFSTD: A Comprehensive Ontology for Neuroscience
 
Poster BrainPlotting SEISC 2017 "Prediction of Human PK data based on innovat...
Poster BrainPlotting SEISC 2017 "Prediction of Human PK data based on innovat...Poster BrainPlotting SEISC 2017 "Prediction of Human PK data based on innovat...
Poster BrainPlotting SEISC 2017 "Prediction of Human PK data based on innovat...
 
Introductionto biotechnology
Introductionto biotechnologyIntroductionto biotechnology
Introductionto biotechnology
 
Cell Therapy Industry News Round-Up - September 13, 2022 [BioInformant]
Cell Therapy Industry News Round-Up - September 13, 2022 [BioInformant]Cell Therapy Industry News Round-Up - September 13, 2022 [BioInformant]
Cell Therapy Industry News Round-Up - September 13, 2022 [BioInformant]
 
Cell based assays presentation v3_03_2012
Cell based assays presentation v3_03_2012Cell based assays presentation v3_03_2012
Cell based assays presentation v3_03_2012
 
Cell based assays presentation V2_03_2012
Cell based assays presentation V2_03_2012Cell based assays presentation V2_03_2012
Cell based assays presentation V2_03_2012
 
126 micro array study for gene expression
126 micro array study for gene expression126 micro array study for gene expression
126 micro array study for gene expression
 
Neuromics presentation november 2021
Neuromics presentation november 2021Neuromics presentation november 2021
Neuromics presentation november 2021
 
Blue brain technology
Blue brain technologyBlue brain technology
Blue brain technology
 
Differentiation of neural_cells_in_human_embryonic_stem
Differentiation of neural_cells_in_human_embryonic_stemDifferentiation of neural_cells_in_human_embryonic_stem
Differentiation of neural_cells_in_human_embryonic_stem
 
PPT Differentiation_of_neural_cells_in_human_embryonic_stem
PPT Differentiation_of_neural_cells_in_human_embryonic_stemPPT Differentiation_of_neural_cells_in_human_embryonic_stem
PPT Differentiation_of_neural_cells_in_human_embryonic_stem
 
126 micro array study for gene expression
126 micro array study for gene expression126 micro array study for gene expression
126 micro array study for gene expression
 
1-International.pdf
1-International.pdf1-International.pdf
1-International.pdf
 

More from cailynnjohnson

Complement Testing Services
Complement Testing ServicesComplement Testing Services
Complement Testing Services
cailynnjohnson
 
AI-augmented Drug Discovery.pdf
AI-augmented Drug Discovery.pdfAI-augmented Drug Discovery.pdf
AI-augmented Drug Discovery.pdf
cailynnjohnson
 
Cellular Neuroscience Products
Cellular Neuroscience ProductsCellular Neuroscience Products
Cellular Neuroscience Products
cailynnjohnson
 
synuclein
synucleinsynuclein
synuclein
cailynnjohnson
 
In Vitro BBB Models
In Vitro BBB ModelsIn Vitro BBB Models
In Vitro BBB Models
cailynnjohnson
 
LDH Cytotoxicity Test.pdf
LDH Cytotoxicity Test.pdfLDH Cytotoxicity Test.pdf
LDH Cytotoxicity Test.pdf
cailynnjohnson
 
gamma delta T cell receptor.pdf
gamma delta T cell receptor.pdfgamma delta T cell receptor.pdf
gamma delta T cell receptor.pdf
cailynnjohnson
 
alpha beta T cells.pdf
alpha beta T cells.pdfalpha beta T cells.pdf
alpha beta T cells.pdf
cailynnjohnson
 
Calcium Assay Service.pdf
Calcium Assay Service.pdfCalcium Assay Service.pdf
Calcium Assay Service.pdf
cailynnjohnson
 

More from cailynnjohnson (9)

Complement Testing Services
Complement Testing ServicesComplement Testing Services
Complement Testing Services
 
AI-augmented Drug Discovery.pdf
AI-augmented Drug Discovery.pdfAI-augmented Drug Discovery.pdf
AI-augmented Drug Discovery.pdf
 
Cellular Neuroscience Products
Cellular Neuroscience ProductsCellular Neuroscience Products
Cellular Neuroscience Products
 
synuclein
synucleinsynuclein
synuclein
 
In Vitro BBB Models
In Vitro BBB ModelsIn Vitro BBB Models
In Vitro BBB Models
 
LDH Cytotoxicity Test.pdf
LDH Cytotoxicity Test.pdfLDH Cytotoxicity Test.pdf
LDH Cytotoxicity Test.pdf
 
gamma delta T cell receptor.pdf
gamma delta T cell receptor.pdfgamma delta T cell receptor.pdf
gamma delta T cell receptor.pdf
 
alpha beta T cells.pdf
alpha beta T cells.pdfalpha beta T cells.pdf
alpha beta T cells.pdf
 
Calcium Assay Service.pdf
Calcium Assay Service.pdfCalcium Assay Service.pdf
Calcium Assay Service.pdf
 

Recently uploaded

Journal Article Review on Rasamanikya
Journal Article Review on RasamanikyaJournal Article Review on Rasamanikya
Journal Article Review on Rasamanikya
Dr. Jyothirmai Paindla
 
Efficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in AyurvedaEfficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in Ayurveda
Dr. Jyothirmai Paindla
 
Abortion PG Seminar Power point presentation
Abortion PG Seminar Power point presentationAbortion PG Seminar Power point presentation
Abortion PG Seminar Power point presentation
AksshayaRajanbabu
 
Cardiac Assessment for B.sc Nursing Student.pdf
Cardiac Assessment for B.sc Nursing Student.pdfCardiac Assessment for B.sc Nursing Student.pdf
Cardiac Assessment for B.sc Nursing Student.pdf
shivalingatalekar1
 
Netter's Atlas of Human Anatomy 7.ed.pdf
Netter's Atlas of Human Anatomy 7.ed.pdfNetter's Atlas of Human Anatomy 7.ed.pdf
Netter's Atlas of Human Anatomy 7.ed.pdf
BrissaOrtiz3
 
A Classical Text Review on Basavarajeeyam
A Classical Text Review on BasavarajeeyamA Classical Text Review on Basavarajeeyam
A Classical Text Review on Basavarajeeyam
Dr. Jyothirmai Paindla
 
Ketone bodies and metabolism-biochemistry
Ketone bodies and metabolism-biochemistryKetone bodies and metabolism-biochemistry
Ketone bodies and metabolism-biochemistry
Dhayanithi C
 
Role of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of HyperthyroidismRole of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of Hyperthyroidism
Dr. Jyothirmai Paindla
 
The Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in IndiaThe Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in India
Swastik Ayurveda
 
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
Donc Test
 
Best Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and IndigestionBest Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and Indigestion
Swastik Ayurveda
 
Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)
Josep Vidal-Alaball
 
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...
rightmanforbloodline
 
THERAPEUTIC ANTISENSE MOLECULES .pptx
THERAPEUTIC ANTISENSE MOLECULES    .pptxTHERAPEUTIC ANTISENSE MOLECULES    .pptx
THERAPEUTIC ANTISENSE MOLECULES .pptx
70KRISHPATEL
 
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptxREGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
LaniyaNasrink
 
Complementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLSComplementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLS
chiranthgowda16
 
OCT Training Course for clinical practice Part 1
OCT Training Course for clinical practice Part 1OCT Training Course for clinical practice Part 1
OCT Training Course for clinical practice Part 1
KafrELShiekh University
 
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
bkling
 
Chapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptxChapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptx
Earlene McNair
 
Post-Menstrual Smell- When to Suspect Vaginitis.pptx
Post-Menstrual Smell- When to Suspect Vaginitis.pptxPost-Menstrual Smell- When to Suspect Vaginitis.pptx
Post-Menstrual Smell- When to Suspect Vaginitis.pptx
FFragrant
 

Recently uploaded (20)

Journal Article Review on Rasamanikya
Journal Article Review on RasamanikyaJournal Article Review on Rasamanikya
Journal Article Review on Rasamanikya
 
Efficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in AyurvedaEfficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in Ayurveda
 
Abortion PG Seminar Power point presentation
Abortion PG Seminar Power point presentationAbortion PG Seminar Power point presentation
Abortion PG Seminar Power point presentation
 
Cardiac Assessment for B.sc Nursing Student.pdf
Cardiac Assessment for B.sc Nursing Student.pdfCardiac Assessment for B.sc Nursing Student.pdf
Cardiac Assessment for B.sc Nursing Student.pdf
 
Netter's Atlas of Human Anatomy 7.ed.pdf
Netter's Atlas of Human Anatomy 7.ed.pdfNetter's Atlas of Human Anatomy 7.ed.pdf
Netter's Atlas of Human Anatomy 7.ed.pdf
 
A Classical Text Review on Basavarajeeyam
A Classical Text Review on BasavarajeeyamA Classical Text Review on Basavarajeeyam
A Classical Text Review on Basavarajeeyam
 
Ketone bodies and metabolism-biochemistry
Ketone bodies and metabolism-biochemistryKetone bodies and metabolism-biochemistry
Ketone bodies and metabolism-biochemistry
 
Role of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of HyperthyroidismRole of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of Hyperthyroidism
 
The Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in IndiaThe Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in India
 
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
 
Best Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and IndigestionBest Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and Indigestion
 
Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)
 
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...
 
THERAPEUTIC ANTISENSE MOLECULES .pptx
THERAPEUTIC ANTISENSE MOLECULES    .pptxTHERAPEUTIC ANTISENSE MOLECULES    .pptx
THERAPEUTIC ANTISENSE MOLECULES .pptx
 
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptxREGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
 
Complementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLSComplementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLS
 
OCT Training Course for clinical practice Part 1
OCT Training Course for clinical practice Part 1OCT Training Course for clinical practice Part 1
OCT Training Course for clinical practice Part 1
 
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
 
Chapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptxChapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptx
 
Post-Menstrual Smell- When to Suspect Vaginitis.pptx
Post-Menstrual Smell- When to Suspect Vaginitis.pptxPost-Menstrual Smell- When to Suspect Vaginitis.pptx
Post-Menstrual Smell- When to Suspect Vaginitis.pptx
 

Neuros Cell Line Products-Creative Biolabs

  • 1. Neural Cell Lines TEL: 1-631-357-2254 E-mail: info@creative-biolabs.com SUITE 203, 17 Ramsey Road, Shirley, NY 11967, USA neuros.creative-biolabs.com
  • 2. Cutting Edge Tools for Neuroscience Research In 2005, Creative Biolabs opened its doors offering neuroscience research antibodies with the goal of putting customers first. From day one, our vision has been to provide products you can trust. We stand behind our products—leading us to create our policy of replacing or refunding reagents or cells that do not meet expectations. As our number of loyal and satisfied customers grow, so do our offerings. Our selection of antibodies has expanded, along with other products, including human cells, specialized media, sera, and cell models. We continue to assess the needs of the neuroscience research field and add new resources to our neuroscience range to add to our cutting edge technologies. Currently, Creative Biolabs offers a range of specific tools & reagents to allow you stay at the forefront of your field. Creative Biolabs is your source for neural cells, media and supplements including iPSC-derived cells. Our large range of substrates and matrices including natural extracellular matrices and artificial scaffolds gives you numerous options to develop your in vitro system. We also offer innovative neural tracers and customized technical services that help researchers explore questions about genes, neurons, circuitry structure, function of brain network, mechanism and treatment of diseases. We also have an extensive biorepository with neural tissue from numerous species. We will always offer proven reagents for results you can trust and understand. Cutting Edge Tools for Neuroscience Research
  • 3. Neural Cell Lines Neural Stem Cells Neural Progenitor Cells Neurons Astrocytes Microglial Cells Oligodendrocytes Schwann Cells Neurological Disease Cell Models Neural Tissues Neural Cell Culture Media and Supplements Neural Cell Culture Matrices Neural Cell Transfection Neural Cell Cryopreservation Cutting Edge Tools for Neuroscience Research Table of Contents
  • 4. Cellular models are highly important tools for numerous applications in neuroscience, for example the study of neurodegeneration, neurogenesis and developmental diseases. There is also a growing sense of the importance of studying the behaviour of neurons, glial cells and neural stem cells within a physiologically relevant context. Creative Biolabs offers a range of cryopreserved human, mouse and rat neural cells and neurological disease models to allow you stay at the forefront of your field. With years of experience in primary neural cell isolation, Creative Biolabs offers ready-to use, high quality primary neural cells for your research. Extensive testing and optimization provides quality and performance of our neural cells with every batch produced. Creative Biolabs' portfolio also includes reliable neural media products (see page 16 ) that are optimized and tested specifically with our neural cells. Creative Biolabs guarantees the performance of its cells when cultured with the recommended medium and following the protocol. Neuron Microglia Astrocyte Oligodendrocyte Neural Stem Cell Neural Progenitor Cell Neural Cell Lines Cutting Edge Tools for Neuroscience Research
  • 5. Neural stem cells are undifferentiated cells found within the brain. They were first described in the subventricular zone (SVZ) by Sally Temple in 1-8- but were not isolated until 1--2 from adult striatal tissue by Brent Reynolds. Like mesenchymal stem cells, neural stem cells have the capacity to undergo extensive cell divisions in vitro and are multipotent in nature. Human iPSC-derived Neural Stem Cells from Healthy Donors Cat. Product Name Starting Material Quantity NCL-2101-ZP01 Human iPSC-Derived Neural Stem Cells (Male), Source Cord Blood CD34+ Cells Cord Blood CD34+ Cells 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP02 Human iPSC-Derived Neural Stem Cells (Male), Source Cord Blood CD34+ Cells, Validated Cord Blood CD34+ Cells 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP03 Human iPSC-Derived Neural Stem Cells (Female), Source Cord Blood CD34+ Cells Cord Blood CD34+ Cells 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP04 Human iPSC-Derived Neural Stem Cells (Male), Source Fibroblasts (74 Yr Donor), Validated Fibroblasts (74 Yr Donor) 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP05 Human iPSC-Derived Neural Stem Cells (Female), Source Fibroblasts (64 Yr Donor) Fibroblasts (64 Yr Donor) 1.5 million cells & Neural Plating-XF Medium Human iPSC-derived Neural Stem Cells from Patient Donors Cat. Product Name Starting Material Quantity NCL-2101-ZP06 Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (APOE4 HOM) Fibroblasts (87 Yr Female) 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP07 Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 L286V) Fibroblasts (38 Yr Female) 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP08 Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 M146L) Fibroblasts (53 Yr Male) 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP0- Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 A246E) Fibroblasts (31 Yr Female) 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP10 Human iPSC-Derived Neural Stem Cells - Huntington's Disease Patient Fibroblasts (48 Yr Female) 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP11 Human iPSC-Derived Neural Stem Cells - Epilepsy Patient Fibroblasts (5 Mo Female) 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP12 Human iPSC-Derived Neural Stem Cells - Trisomy X Patient Fibroblasts (74 Yr Female) 1.5 million cells & Neural Plating-XF Medium CRIGEM™ Genetically Edited Human iPSC-derived Neural Stem Cells Cat. Product Name Starting Material Quantity NCL-2101-ZP05 Human iPSC-Derived Neural Stem Cells (Female), Source Fibroblasts (64 Yr Donor) Fibroblasts (64 Yr Donor) 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP14 CRIGEM™ iPSC-Derived Neural Stem Cells LRRK2 G201-S HOM Fibroblasts (64 Yr Donor) 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP15 CRIGEM™ iPSC-Derived Neural Stem Cells LRRK2 G201-S HET Fibroblasts (64 Yr Donor) 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP16 CRIGEM™ iPSC-Derived Neural Stem Cells MAPT R406W HET Fibroblasts (64 Yr Donor) 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP17 CRIGEM™ iPSC-Derived Neural Stem Cells MAPT V337M HOM Fibroblasts (64 Yr Donor) 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP18 CRIGEM™ iPSC-Derived Neural Stem Cells MAPT V337M HET Fibroblasts (64 Yr Donor) 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP1- CRIGEM™ iPSC-Derived Neural Stem Cells MAPT P301L HOM Fibroblasts (64 Yr Donor) 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP20 CRIGEM™ iPSC-Derived Neural Stem Cells MAPT P301L HET Fibroblasts (64 Yr Donor) 1.5 million cells & Neural Plating-XF Medium Cat. Product Name Cell Type NCL-2105-P205-AM Mouse Embryo Neural Stem Cells, Immortalized Immortalized Cell NCL-2108P23 Mouse Neural Stem Cells Ne-4C Immortalized Cell NCL-2108P25 Mouse Neural Stem Cells C17.2 Immortalized Cell NCL-2105-C356 Mouse Neural Stem Cells, Adult Primary Cell NCL-2105-F356 Mouse Neural Stem Cells, Fetal Primary Cell NCL-2108-P016 Mouse Cortical Neural Stem Cells Primary Cell NCL-2108-P017 Mouse Spinal Cord Neural Stem Cells Primary Cell NCL-2105-P242-AM Rat Neural Stem Cells (1464R), Immortalized Immortalized Cell NCL-2108-P01- Rat Neural Stem Cells, Adult Primary Cell NCL-2108-F01- Rat Neural Stem Cells, Fetal Primary Cell NCL-2108-C001 Rat Neural Stem Cells Fetal (E14 cortex) Primary Cell Neural Cell Lines Mouse/Rat Neural Stem Cells Cutting Edge Tools for Neuroscience Research Human iPSC-Derived Neural Stem Cells
  • 6. Since the discovery that neural progenitor cells (NPCs) from induced pluripotent stem cells (iPSCs) can proliferate or differentiate into neurons, oligodendrocytes, or astrocytes, NPCs are becoming an attractive in vitro model to study neurological development and neurotoxicity and to model diseases. Creative Biolabs’ NPCs are derived from a collection of well-characterized, integration-free reprogrammed iPSCs. For investigators looking to reduce the time from initial culture to experiment readout, our NPCs can eliminate the 4 to 8 weeks for iPSCs to differentiate into NPCs. Creative Biolabs provides a complete system of NPC solutions for investigating development, degeneration and regeneration, neurogenetics, neural excitability, nervous system disorders, neurotransmitters, and screening therapeutics. • Normal and neurological disease iPSC-derived NPCs • Gene-edited, lineage-specific reporter NPCs • Expansion and differentiation media kits • Validated growth and differentiation protocols Cat. Product Name Cell Type NCL-2108-P001 Human Neural Progenitor Cells, Fully Validated Primary Cell NCL-21P6-17- Human Neural Progenitor Cell Line, Cortical Derived Primary Cell NCL-2105-P11-HP NeuCell™ Human GABAergic Neural Progenitor Cells (GPC), 1M Primary Cell NCL-2105-P17-HP NeuCell™ Human Motor Neural Progenitor Cells (MPC), 1M Primary Cell NCL-2105-P2--HP NeuCell™ Human Dopaminergic Neural Progenitor Cells (DPC), 1M Primary Cell NCL-2105-P33-HP NeuCell™ Human Glutamatergic Neural Progenitor Cells (GPC), 1M Primary Cell NCL200506ZP Human Oligodendrocyte Progenitor Cells Primary Cell NCL-2105-P187-AM Human Cranial Suture Progenitor Cells (iSuPs), Immortalized Immortalized Cell NCL-2108P147 Human Neuron Progenitor Cells (Neu41), Immortalized Immortalized Cell NCL200501ZP Human Neural Progenitor Cell Line, Cortical Derived, Immortalized Immortalized Cell NCL-21P6-212 Human Neural Progenitor Cell Line, Ventral Mesencephalon Derived, Immortalized Immortalized Cell NCL-2108-P002 NeuCELL™ VM Human Neural Progenitor Cell Line, Immortalized Immortalized Cell NCL-2108-P003 NeuCELL™ CX Human Neural Progenitor Cell Line, Immortalized Immortalized Cell NCL-2105-P211-AM Mouse Neural Progenitor Cells, Immortalized Immortalized Cell NCL-2105-P276-AM Mouse Pituitary Progenitor Cells (αT1-1), Immortalized Immortalized Cell NCL-2105-P247-AM Rat Sympathoadrenal Progenitor Cells (MAH-A3), Immortalized Immortalized Cell NCL-2108-P007 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone A4H1 Disease Model NCL-2108-P008 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone D4 Disease Model NCL-2108-P00- Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone B2 Disease Model NCL-2108-P010 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone 3C1 Disease Model NCL-2108-P011 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone A5 Disease Model NCL-2108-P012 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone E6F4 Disease Model NCL-2108-P013 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone H10 Disease Model Neural Progenitor Cells Selected Neural Progenitor Cell Lines Cutting Edge Tools for Neuroscience Research
  • 7. Neurons (also called neurones or nerve cells) are the fundamental units of the brain and nervous system, the cells responsible for receiving sensory input from the external world, for sending motor commands to our muscles, and for transforming and relaying the electrical signals at every step in between. Creative Biolabs supplies a number of high viability cryopreserved and live primary neurons which are ideal for studying mechanisms of developmental neurobiology, disease progression, neurotoxicology and other areas of neuroscience. Human Neurons Cat. Product Name Cell Type NCL-2103-P71 iNeu™ Human iPSC-derived Motor Neurons Primary Cell NCL-2103-P77 iNeu™ Human iPSC-derived Dopaminergic Neurons Primary Cell NCL-2103-P78 iNeu™ Human iPSC-derived Cortical Neurons Primary Cell NCL-2103-P62 iNeu™ Human iPSC-derived Sensory Neurons Primary Cell NCL-21P6-001 iNeu™ Human iPSC-derived Spinal Motor Neurons Primary Cell NCL-21P6-002 iNeu™ Human iPSC-derived Layer V Glutamatergic Neurons Primary Cell NCL-21P6-003 iNeu™ Human iPSC-derived Midbrain Dopaminergic Neurons Primary Cell NCL-21P6-004 iNeu™ Human iPSC-derived Cortical GABAergic Neurons Primary Cell NCL-21P6-005 iNeu™ Human iPSC-derived Cortical Glutamatergic Neurons Primary Cell NCL-21P6-007 iNeu™ Human iPSC-derived Mixed Cortical Neurons Primary Cell NCL-21P6-008 iNeu™ Human iPSC-derived Medium Spiny Neurons Primary Cell NCL-21P6-025 Human Hippocampus-derived Neurons Primary Cell NCL-21P6-172 Human Midbrain-derived Neurons Primary Cell NCL-21P6-027 Human Brain Stem-derived Neurons Primary Cell NCL2110P18- Human Cortical-derived Neurons Primary Cell NCL-2105-P130-IX Human iPSC-derived Motor Neurons (Amyotrophic Lateral Sclerosis Patient, Sporadic) Disease Model NCL-2105-P133-IX Human iPSC-derived Motor Neurons (SOD1 mutant, A4V, HOM) Disease Model NCL-2105-P134-IX Human iPSC-derived Motor Neurons (TDP-43 mutation, M337V, HET) Disease Model NCL-2105-P135-IX Human iPSC-derived Motor Neurons (TDP-43 mutation, Q331K, HET) Disease Model NCL-2105-P136-IX Human iPSC-derived Motor Neurons (TDP-43 mutation, M337V, HOM) Disease Model NCL-2105-P137-IX Human iPSC-derived Motor Neurons (TDP-43 mutation, Q331K, HOM) Disease Model NCL-2105-P138-IX Human iPSC-derived Motor Neurons (TDP43 mutation, N352S, HET) Disease Model Neurons Selected Neurons Cutting Edge Tools for Neuroscience Research
  • 8. Neurons Rat Neurons Cat. Product Name Cell Type NCL-21P6-08- Rat Substantia Nigra-derived Neurons Primary Cell NCL-21P6-0-1 Rat Ventral Spinal Cord-derived Neurons Primary Cell NCL-21P6-0-2 Rat Dorsal Spinal Cord-derived Neurons Primary Cell NCL-21P6-0-3 Rat Spinal Cord-derived Neurons Primary Cell NCL-2103-P15 Rat Cortical Neurons (RCoN) Primary Cell NCL-2103-P16 Rat Dorsal Root Ganglion Neurons (DRG) Primary Cell NCL-2103-P17 Rat Hindbrain Neurons (RHbN) Primary Cell NCL-2103-P18 Rat Hippocampal Neurons (RHiN) Primary Cell NCL-2103-P21 Rat Midbrain Neurons Primary Cell NCC20--PZ15 Rat Dorsal Root Ganglion (DRG) Neurons, Neonatal Primary Cell NCC20--PZ20 Rat Embryonic Dorsal Root Ganglion (eDRG) Neurons Primary Cell NCC20--PZ5- Rat Brain Striatum Neurons Primary Cell NCC20--PZ60 Rat Cerebellar Granular Neurons Primary Cell Live Ready-To-use Neurons Cat. Product Name Cell Type N100200-AM E18 Hippocampal Neurons 1 M cells/vial N200200-AM E18 Cortical Neurons 1 M cells/vial N300200-AM P8 Cerebellar Neurons 4 Pairs N400200-AM E18 Hypothalamus Neurons 1 Pair N500200-AM E18 Striatal Neurons 1 Pair N600200-AM E18 Spinal Cord Neurons 1 Cord N700200-AM E18 Midbrain Cells 1 Midbrain Mouse Neurons Cat. Product Name Cell Type NCL-21P6-051 Mouse C57 Brain Hippocampus Neurons Primary Cell NCC20--PZ47 Mouse CD1 Brain Hippocampus Neurons Primary Cell NCC20--PZ48 Mouse C57 Brain Cortex Neurons Primary Cell NCC20--PZ52 Mouse CD1 Brain Cortex Neurons Primary Cell NCC20--PZ53 Mouse C57 Brain Striatum Neurons Primary Cell NCC20--PZ56 Mouse CD1 Brain Striatum Neurons Primary Cell NCL-21P6-044 Mouse CD1 Brain Raphe-derived Neurons Primary Cell NCL-21P6-045 Mouse C57 Brain Raphe-derived Neurons Primary Cell NCL-21P6-052 Mouse CD1 Substantia Nigra-derived Neurons Primary Cell NCL-21P6-053 Mouse C57 Substantia Nigra-derived Neurons Primary Cell NCL-21P6-055 Mouse CD1 Ventral Spinal Cord-derived Neurons Primary Cell NCL-21P6-056 Mouse CD1 Dorsal Spinal Cord-derived Neurons Primary Cell NCL-21P6-057 Mouse C57 Dorsal Spinal Cord-derived Neurons Primary Cell NCL-21P6-058 Mouse CD1 Spinal Cord-derived Neurons Primary Cell NCL-21P6-05- Mouse C57 Spinal Cord-derived Neurons Primary Cell NCL-2108P2- Mouse Hippocampal Neuron Cells (HT-22), Immortalized Immortalized Cell NCL-2105-P20--AM Mouse Hypothalamic Neurons - SV40T, Immortalized Immortalized Cell NCL-2105-P212-AM Mouse Neuronal Cells (M4b), Immortalized Immortalized Cell NCL-2105-P213-AM Mouse Trisomy 16 Neuronal Cells (MTh), Immortalized Immortalized Cell Cutting Edge Tools for Neuroscience Research
  • 9. Astrocytes are highly heterogeneous neuroglial cells with distinct functional and morphological characteristics in different parts of the brain. They are responsible for maintaining a number of complex processes needed for a healthy central nervous system (CNS). Creative Biolabs' astrocyte precursor and mature cells are derived from neural stem cells differentiated from fully characterized, normal karyotype human induced pluripotent stem cells (hiPSCs), using proprietary induction protocols that produce high purity astrocytes, and using xeno-free and integration-free derivation and culturing. • >-0% GFAP+ cells; <1% Tuj1+ cells with typical astrocyte morphology • Characterized using immunocytochemistry and whole genome profiling • Suitable for co-culturing with neurons for complex tissue modeling • Limited proliferative potential and long-term viability Human Astrocytes Cat. Product Name Cell Type NCL-21P6-00- Human iPSC-derived Cortical Astrocytes Primary Cell NCL-21P6-010 Human iPSC-derived Spinal Astrocytes Primary Cell NCL-21P6-032 Human Cerebral Cortex-derived Astrocytes Primary Cell NCL-21P6-033 Human Cerebellum-derived Astrocytes Primary Cell NCL-21P6-034 Human Spinal Cord-derived Astrocytes Primary Cell NCL-21P6-035 Human Hippocampus-derived Astrocytes Primary Cell NCL-21P6-036 Human Brain Stem-derived Astrocytes Primary Cell NCL-21P6-037 Human Midbrain-derived Astrocytes Primary Cell NCL-21P6-038 Human Retinal-derived Astrocytes Primary Cell NCL2110P1-5 Human Mesencephalic-derived Astrocytes Primary Cell NCL-21P6-14- Human Brain Astrocytes-GFP Primary Cell NCL-21P6-150 Human Brain Astrocyte-RFP Primary Cell NCL-2103-P01 Human Astrocytes (HA), Cryopreserved, Fetal Primary Cell NCL-2103-P03 Human Astrocytes (HA), Cryopreserved, Adult Primary Cell NCL-2105-P180-AM Human Astrocytes, Fetal - hTERT, Immortalized Immortalized Cell NCL-2105-P182-AM Human Astrocytes, Fetal - SV40, Immortalized Immortalized Cell NCL-2105-P336-AM Human Brain Astrocytes-GFP, Immortalized Immortalized Cell NCL-2105-P340-AM Human Brain Astrocyte-RFP, Immortalized Immortalized Cell NCL2110P065 Human Astrocyte Cell Line SVG P12, Immortalized Immortalized Cell Mouse Astrocytes Cat. Product Name Cell Type NCL-21P6-064 Mouse Astrocytes from CD1 Primary Cell NCL-21P6-065 Mouse Astrocytes from C57BL/6 Primary Cell NCL-21P6-066 Mouse Brain Cerebellar Cortex-derived Astrocytes-from CD1 Primary Cell NCL-21P6-067 Mouse Brain Cerebellar Cortex-derived Astrocytes-from C57BL/6 Primary Cell NCL-21P6-071 Mouse Spinal Cord-derived Astrocytes-from CD1 Primary Cell NCL-21P6-072 Mouse Spinal Cord-derived Astrocytes-from C57BL/6 Primary Cell NCL-21P6-073 Mouse Brain Stem-derived Astrocytes-from CD1 Primary Cell NCL-2105-P154-IX Mouse Midbrain-derived Astrocytes Primary Cell NCL-2105-P155-IX Mouse Brain Hippocampus-derived Astrocytes Primary Cell NCL-2105-P156-IX Neonatal Mouse Spinal Cord-derived Astrocytes Primary Cell NCL-2105-P153-IX Neonatal Mouse Brain Cerebellar Cortex-derived Astrocytes Primary Cell NCL-2105-P1---AM Mouse Astrocytes - SV40T (IMA2.1), Immortalized Immortalized Cell Rat Astrocytes Cat. Product Name Cell Type NCL-21P6-076 Rat Cerebellum-derived Astrocytes Primary Cell NCL-21P6-077 Rat Hippocampus-derived Astrocytes Primary Cell NCL-21P6-078 Adult Rat Brain-derived Astrocytes Primary Cell NCL-21P6-07- Rat Retinal-derived Astrocytes Primary Cell NCC20--PZ61 Rat Brain Striatum-derived Astrocytes Primary Cell NCC20--PZ4- Rat Brain Cortex-derived Astrocytes Primary Cell NCL-2103-P26 Rat Cerebellar Astrocytes, Cryopreserved, Neonatal Primary Cell NCL-2103-P11 Rat Astrocytes, Cryopreserved, Neonatal Primary Cell NCL-2105-P173-AM Adult Rat Hippocampal Astrocytes - SV40, Immortalized Immortalized Cell Astrocytes Selected Astrocytes Cutting Edge Tools for Neuroscience Research
  • 10. Microglia are commonly described as the immune cells of the brain, with key roles in brain development, neurogenesis, synaptic plasticity and homeostatic maintenance. Creative Biolabs' Human iPSC-derived Microglia provide a reproducible, physiologically-relevant model in an easy-to-use, assay- ready format for investigating neuroglia involvement in neurodegeneration and neurodevelopment. Our iPSC-derived Microglia deliver the advantage that they provide an almost infinite source of microglia from a single donor with a normal karyotype. Our iPSC-derived Microglia also express the microglia-specific marker TMEM11- along with myeloid markers TREM2 and IBA-1. These phenotypes make iPSC-derived Microglia suitable models for investigating neuroinflammation in Alzheimer’s disease, multiple sclerosis and Parkinson’s disease. We also offer a fully optimized serum-free Microglia Maintenance Medium to promote and support the maintenance of microglia. Human Microglia Cat. Product Name Cell Type NCL-7P018 iNeu™ Human iPSC-derived Microglia Primary Cell NCL-7P016 iNeu™ Human iPSC-derived Microglia, Isogenic Control Primary Cell NCL-2108P38 Human Microglia Cell Line HMC3, Immortalized Immortalized Cell NCL-2105-P337-AM Human Microglia-GFP, Immortalized Immortalized Cell NCL-2105-P341-AM Human Microglia-RFP, Immortalized Immortalized Cell NCL-7P014 iNeu™ Microglia AD TREM2 HO, Disease Model Disease Model NCL-7P015 iNeu™ Microglia AD TREM2 HZ, Disease Model Disease Model NCL-7P036 iNeu™ Microglia AD APOE E4/E4, 11--5, Disease Model Disease Model NCL-7P037 iNeu™ Microglia AD APOE E4/E4, 11--3, Disease Model Disease Model NCL-7P038 iNeu™ Microglia AD APOE E4/E4, 12037, Disease Model Disease Model NCL-7P03- iNeu™ Microglia AD APOE E4/E4, 12061, Disease Model Disease Model NCL-7P040 iNeu™ Microglia AD APOE E2/E4, 11-68, Disease Model Disease Model NCL-7P050 iNeu™ Microglia TREM2 R47H, 11-6-, Disease Model Disease Model NCL-7P051 iNeu™ Microglia ABCA7 G1527A, 12000, Disease Model Disease Model NCL-7P020 iNeu™ Microglia Rett Syndrome MECP2, Disease Model Disease Model Mouse Microglia Cat. Product Name Cell Type NCL-21P6-081 Mouse Microglia from CD1 Primary Cell NCL-21P6-082 Mouse Microglia from C57BL/6 Primary Cell NCL-2103-P28 Mouse Microglia, Cryopreserved Primary Cell NCL-2105-P210-AM Mouse Microglia SIM-A-, Immortalized Immortalized Cell NCL-2108P32 Mouse Microglia BV-2, Immortalized Immortalized Cell Rat Microglia Cat. Product Name Cell Type NCL-2105-P35--AM Rat Primary Microglia Primary Cell NCL-2103-P1- Rat Primary Microglia, Neonatal Primary Cell NCL2110P015 Rat Hippocampal Microglia Primary Cell NCL-2106-S7- Rat Cochlear Microglial Cell Line Primary Cell NCL2110P037 Rat Microglia Cell Line HAPI, Immortalized Immortalized Cell NCL-21P6-222 Rat Cochlear Microglial Cell Line, Immortalized Immortalized Cell Microglial Cells Selected Microglial Cells Cutting Edge Tools for Neuroscience Research
  • 11. Oligodendrocytes are a type of large glial cell found in the central nervous system. Oligodendrocytes produce the myelin sheath insulating neuronal axons (analogous to Schwann cells in the peripheral nervous system), although some oligodendrocytes (called satellite oligodendrocytes) are not involved in myelination. Creative Biolabs' Human Oligodendrocyte Differentiation Kit contains Human Oligodendrocyte Progenitor Cells (OPCs) along with optimized media for their expansion and spontaneous differentiation into mature oligodendrocytes. Human OPCs can be used for a variety of research applications including studies of neurotoxicity, co-culture applications and screening for molecules that induce or inhibit preferential differentiation to mature oligodendrocytes. Human Oligodendrocyte Kit Cat. Product Name NCL200506ZP Human Oligodendrocyte Progenitors (OPCs) NCC200524ZP Human Oligodendrocyte Differentiation Kit NCC200527ZP Human Oligodendrocyte Characterization Kit Rat Oligodendrocyte Cat. Product Name NCL-21P6-0-4 Rat Oligodendrocyte Progenitor Cells Oligodendrocytes Selected Oligodendrocytes Cutting Edge Tools for Neuroscience Research
  • 12. Oligodendrocytes are a type of large glial cell found in the central nervous system. Oligodendrocytes produce the myelin sheath insulating neuronal axons (analogous to Schwann cells in the peripheral nervous system), although some oligodendrocytes (called satellite oligodendrocytes) are not involved in myelination. Creative Biolabs' Human Oligodendrocyte Differentiation Kit contains Human Oligodendrocyte Progenitor Cells (OPCs) along with optimized media for their expansion and spontaneous differentiation into mature oligodendrocytes. Human OPCs can be used for a variety of research applications including studies of neurotoxicity, co-culture applications and screening for molecules that induce or inhibit preferential differentiation to mature oligodendrocytes. Human Schwann Cells Cat. Product Name Cell Type NCL-2103-P106 Human Schwann Cells Primary Cell NCL2110P107 Human Schwann Cell, Immortalized Immortalized Cell Mouse Schwann Cells Cat. Product Name Cell Type NCL-21P6-060 Mouse Schwann Cells from CD1 Primary Cell NCL-21P6-061 Mouse Schwann Cells from C57BL/6 Primary Cell NCL-2105-P167-IX Mouse Schwann Cells Primary Cell NCL-2105-P223-AM Mouse Schwann Cells, Immortalized Immortalized Cell NCL-2105-P168-AM Mouse Schwann Cells from C57BL/6, Immortalized Immortalized Cell NCL-2105-P1-8-AM Mouse alpha-GalA-/o Schwann Cells, Immortalized Immortalized Cell NCL-2105-P207-AM Mouse Hexb-/- Schwann Cells (1113C1), Immortalized Immortalized Cell NCL-2105-P214-AM Mouse NPCNIH Schwann Cells (573C10), Immortalized Immortalized Cell NCL-2108P158 Mouse Schwann Cell (1-70C3), Immortalized Immortalized Cell NCL-2105-P224-AM Mouse Schwann Cells (IMS32), Immortalized Immortalized Cell NCL-2105-P225-AM Mouse Schwann Cells (IKARS1), Immortalized Immortalized Cell NCL-2105-P226-AM Mouse Schwann Cells (IWARS1), Immortalized Immortalized Cell NCL-2108P24 Mouse Schwann Cell Line SW10, Immortalized Immortalized Cell Rat Schwann Cells Cat. Product Name Cell Type NCL-21P6-0-5 Rat Schwann Cells Primary Cell NCL-2108P05 Rat Schwann Cells RSC-6, GFP, Immortalized Immortalized Cell NCL-2108P21 Rat Schwann Cells RSC-6, Immortalized Immortalized Cell NCL-2105-P244-AM Rat Schwann Cells (IFRS1), Immortalized Immortalized Cell Schwann Cells Selected Schwann Cells Cutting Edge Tools for Neuroscience Research
  • 13. Translation from in vitro models & assays into animal models are critical to understanding the progression of neurological disease while providing a complete interactive physiology to understand the pharmacokinetics and pharmacodynamics of a candidate. We have developed robust and reproducible in vitro models and in vivo pharmacology studies that are validated for multiple assay platforms and reliable tools to screen small molecules to biologics. Applications of Cell-Based Models: DISEASE MODELING. Generate patient-specific human "disease-in-a-dish" models. DRUG DISCOVERY. Screen drug candidates on physiologically relevant human cell types, including diseased cells. TOXICITY SCREENING. Evaluate neurotoxicity on differentiated human neural cell types. CELL THERAPY VALIDATION. Generate human neural cell types for pre-clinical validation of potential cell therapy applications. Selected Neurological Disease Cell Models Gene-edited Disease Model Cat. Product Name Disease Cell Type NCL-7P001 iNeu Motor Neurons ALS TDP43 Q331K, Disease Model Amyotrophic Lateral Sclerosis Gene-edited Disease Model NCL-7P002 iNeu Motor Neurons ALS TDP43 M337V, Disease Model Amyotrophic Lateral Sclerosis Gene-edited Disease Model NCL-7P004 iNeu Motor Neurons ALS TDP43 Q331K Kit, Disease Model Amyotrophic Lateral Sclerosis Gene-edited Disease Model NCL-7P005 iNeu Motor Neurons ALS TDP43 M337V Kit, Disease Model Amyotrophic Lateral Sclerosis Gene-edited Disease Model NCL-2105-P133-IX iNeu Motor Neurons (SOD1 mutant, A4V, HOM) Amyotrophic Lateral Sclerosis Gene-edited Disease Model NCL-7P012 iNeu Microglia AD TREM2 HO Kit, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P013 iNeu Microglia AD TREM2 HZ Kit, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P014 iNeu Microglia AD TREM2 HO, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P015 iNeu Microglia AD TREM2 HZ, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P031 iNeu Microglia AD APOE E4/E4 Kit, 11--3, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P032 iNeu Microglia AD APOE E4/E4 Kit, 11--5, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P033 iNeu Microglia AD APOE E4/E4 Kit, 12037, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P034 iNeu Microglia AD APOE E4/E4 Kit, 12061, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P035 iNeu Microglia AD APOE E2/E4 Kit, 11-68, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P036 iNeu Microglia AD APOE E4/E4, 11--5, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P037 iNeu Microglia AD APOE E4/E4, 11--3, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P038 iNeu Microglia AD APOE E4/E4, 12037, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P03- iNeu Microglia AD APOE E4/E4, 12061, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P040 iNeu Microglia AD APOE E2/E4, 11-68, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P026 iNeu DopaNeurons PD SNCA A53T HZ Kit, Disease Model Parkinson’s Disease Gene-edited Disease Model NCL-7P027 iNeu DopaNeurons PD SNCA A53T HZ, Disease Model Parkinson’s Disease Gene-edited Disease Model NCL-7P020 iNeu Microglia Rett Syndrome MECP2, Disease Model Rett Syndrome Gene-edited Disease Model NCL-2101-ZP06 iNeu Neural Stem Cells - AD Patient (APOE4 HOM) Alzheimer’s Disease Gene-edited Disease Model NCL-2101-ZP07 iNeu Neural Stem Cells - AD Patient (PSEN1 L286V) Alzheimer’s Disease Gene-edited Disease Model NCL-2101-ZP08 iNeu Neural Stem Cells - AD Patient (PSEN1 M146L) Alzheimer’s Disease Gene-edited Disease Model NCL-2101-ZP0- iNeu Neural Stem Cells - AD Patient (PSEN1 A246E) Alzheimer’s Disease Gene-edited Disease Model Neurological Disease Cell Models Cutting Edge Tools for Neuroscience Research
  • 14. Donor-derived Disease Model Cat. Product Name Disease Cell Type NRZP-0622-P28 iNeu™ Human Neural Stem Cells - Alzheimer’s Disease Patient, Donor 1 Alzheimer’s Disease Donor-derived Disease Model NRZP-0622-P31 iNeu™ Human Neural Stem Cells - Frontotemporal Dementia (FTD) Patient, Donor 4 Frontotemporal Dementia (FTD) Donor-derived Disease Model NRZP-0622-P33 iNeu™ Human Neural Stem Cells - Frontotemporal Dementia (FTD), Paget’s Disease Patient, Donor 6 Frontotemporal Dementia (FTD), Paget’s Disease Donor-derived Disease Model NRZP-0622-P35 iNeu™ Human Neural Stem Cells - Frontotemporal Dementia, ALS Patient, Donor 8 Frontotemporal Dementia, Amyotrophic Lateral Sclerosis Donor-derived Disease Model NRZP-0622-P37 iNeu™ Human Neural Stem Cells - Behavioural Variant Frontotemporal Dementia (bvFTD) Patient, Donor 10 Behavioural Variant Frontotemporal Dementia (bvFTD) Donor-derived Disease Model NRZP-0622-P41 iNeu™ Human Neural Stem Cells - Mucolipidosis IV (ML4) Patient, Donor 14 Mucolipidosis IV (ML4) Donor-derived Disease Model NRZP-0622-P45 iNeu™ Human Neural Stem Cells - Nasu-Hakola Disease Patient, Donor 18 Nasu-Hakola Disease Donor-derived Disease Model NRZP-0622-P47 iNeu™ Human Neural Stem Cells - Nasu-Hakola Disease (familial control) Patient, Donor 20 Nasu-Hakola Disease (familial control) Donor-derived Disease Model NRZP-0622-P48 iNeu™ Human Neural Stem Cells - Parkinson’s Disease Patient, Donor 21 Parkinson’s Disease Donor-derived Disease Model NRZP-0622-P5- iNeu™ Human Neural Stem Cells - Parkinsonism/Machado-Joseph Disease (SCA3) Patient, Donor 32 Parkinsonism/MachAlzheimer’s Diseaseo-Joseph Disease (SCA3) Donor-derived Disease Model NRZP-0622-P63 iNeu™ Human Neural Stem Cells - Amyotrophic Lateral Sclerosis (ALS) Patient, Donor 36 Amyotrophic Lateral Sclerosis (Amyotrophic Lateral Sclerosis) Donor-derived Disease Model NRZP-0622-P65 iNeu™ Human Neural Stem Cells - Amyotrophic Lateral Sclerosis (ALS) (unaffected) Patient, Donor 38 Amyotrophic Lateral Sclerosis (Amyotrophic Lateral Sclerosis) (unaffected) Donor-derived Disease Model NRZP-0622-P66 iNeu™ Human Neural Stem Cells - Charcot-Marie-Tooth Disease, Type 4J (CMT4J) Patient, Donor 3- Charcot-Marie-Tooth Disease, Type 4J (CMT4J) Donor-derived Disease Model NRZP-0622-P67 iNeu™ Human Neural Stem Cells - Dentatorubral-Pallidoluysian Atrophy (DRPLA) Patient, Donor 40 Dentatorubral-Pallidoluysian Atrophy (DRPLA) Donor-derived Disease Model NRZP-0622-P71 iNeu™ Human Neural Stem Cells - Friedreich’s Ataxia Patient, Donor 44 Friedreich’s Ataxia Donor-derived Disease Model NRZP-0622-P75 iNeu™ Human Neural Stem Cells - Friedreich’s Ataxia (control) Patient, Donor 48 Friedreich’s Ataxia (control) Donor-derived Disease Model NRZP-0622-P76 iNeu™ Human Neural Stem Cells - Friedreich’s Ataxia (familial control) Patient, Donor 4- Friedreich’s Ataxia (familial control) Donor-derived Disease Model NRZP-0622-P77 iNeu™ Human Neural Stem Cells - Huntington’s Disease Patient, Donor 50 Huntington’s Disease Donor-derived Disease Model NRZP-0622-P80 iNeu™ Human Neural Stem Cells - Huntington’s Disease RCi004-B Patient, Donor 53 Huntington’s Disease RCi004-B Donor-derived Disease Model NRZP-0622-P82 iNeu™ Human Neural Stem Cells - Spinal and Bulbar Muscular Atrophy (SBMA) Patient, Donor 55 Spinal and Bulbar Muscular Atrophy (SBMA) Donor-derived Disease Model NRZP-0622-P83 iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 2 (SCA2) Patient, Donor 56 Spinocerebellar Ataxia Type 2 (SCA2) Donor-derived Disease Model NRZP-0622-P8- iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 7 (SCA7) Patient, Donor 62 Spinocerebellar Ataxia Type 7 (SCA7) Donor-derived Disease Model NRZP-0622-P-0 iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 6 (SCA6) Patient, Donor 63 Spinocerebellar Ataxia Type 6 (SCA6) Donor-derived Disease Model NRZP-0622-P-1 iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 3 (SCA3) Patient, Donor 64 Spinocerebellar Ataxia Type 3 (SCA3) Donor-derived Disease Model NCL-2105-P130-IX iNeu Human Motor Neurons - ALS Patient, Sporadic Amyotrophic Lateral Sclerosis Donor-derived Disease Model NCL-2101-ZP11 iNeu Human Neural Stem Cells - Epilepsy Patient Epilepsy Donor-derived Disease Model NCL-2101-ZP12 iNeu Human Neural Stem Cells - Trisomy X Patient Trisomy X Donor-derived Disease Model NCL-2108-P007 iNeu Human Neural Progenitor Cell Line, AD Patient Alzheimer’s Disease Donor-derived Disease Model Neurological Disease Cell Models Cutting Edge Tools for Neuroscience Research Assay Cell Line Models Cat. Product Name Cell Type NCL2110P230 APP Processing Assay Cell Line [Alzheimer’s Disease (AD) Model] Assay Model NCL2110P231 FUS/TLS Stress Granules Assay Cell Line [Amyotrophic Lateral Sclerosis (ALS) Model] Assay Model NCL2110P232 Gamma Secretase Activity Assay Cell Line [Alzheimer’s Disease (AD) Model] Assay Model NCL2110P234 Parkin Mitochondrial Recruitment Assay Cell Line [Parkinson’s Disease (PD) Model] Assay Model NCL2110P235 Tau Phosphorylation Assay Cell Line [Alzheimer’s Disease (AD) Model] Assay Model NCL2110P236 TDP-43 Stress Granules Assay Cell Line [Amyotrophic Lateral Sclerosis (ALS) Model] Assay Model NCL2110P337 Parkinsonism Cell Line, Disease Model Assay Model
  • 15. Extensive Neural Tissue Biorepository from Healthy and Diseased Donors ! Creative Biolabs offers a comprehensive repository of neural tissue samples, covering multiple regions of the brain and spinal cord from many species and tissue types. Certified tissues are available as OCT frozen blocks & snap-frozen samples, FFPE blocks, FFPE tissue arrays, frozen tissue arrays, frozen tissue sections, FFPE tissue sections, FFPE tissue panels, as well as fresh tissue. We have a wide range of donors and provide both healthy and diseased tissue. Also available: Total RNA– cDNA– Genomic DNA– Total Protein Human Tissue - Adult and Fetal Normal - Tumour and Adjacent Tissue - Diseased tissues including Alzheimer's Disease, Parkinson's Disease and Dementia Multiple Species Available Tissue Dissociation: Creative Biolabs has developed Neural Tissue Dissociation Kits used for the gentle and efficient generation of single-cell suspensions from neural tissues. The Neural Tissue Dissociation Kit - Postnatal Neurons has been optimized for the special needs of sensitive postnatal neurons during dissociation. We also offers highly purified collagenase free of any animal-based components. For research applications, non-GMP grade Collagenase NB4 Standard Grade and Collagenase NB 5 Sterile Grade are economical alternatives with comparable enzymatic properties to Collagenase NB 6 GMP Grade. Ordering Information: - Mouse - Rhesus Monkey - Cynomolgus Monkey - Marmoset - Guinea Pig - Cat - Chicken - Dog - Horse - Bovine - Rat - Rabbit - Hamster - Nude Mouse - Mini Pig - Pig Cat. Product Name NRZP-0622-ZP15 Neural Tissue Dissociation Kit (P) – Postnatal Neurons NRZP-0622-ZP16 Neural Tissue Dissociation Kit (T) – Postnatal Neurons NRZP-0622-ZP17 Brain Tumor Dissociation Kit (P), Human and Mouse NRZP-0622-ZP14 Adult Brain Dissociation Kit, Mouse and Rat NRZP-0622-ZP390 Collagenase NB 4 Standard Grade NRZP-0622-ZP389 Collagenase NB 5 Sterile Grade NRZP-0622-ZP394 Collagenase NB 6 GMP Grade NRZP-0622-ZP396 Neutral Protease NB GMP Grade Neural Tissues Cutting Edge Tools for Neuroscience Research
  • 16. We supply neural cell culture medium optimized to support undifferentiated growth both as adherent cultures or neurosphere suspensions. We also provide medium, supplements and growth factors to differentiate neural stem cells and to maintain long- term cultures of differentiated cells. In addition to culture mediums, Creative Biolabs also supplies all supporting reagents to characterize neural stem cells including nestin antibodies as well as differentiated neurons using βIII-tubulin antibodies, oligodendrocytes using O3 antibodies and astrocytes using GFAP antibodies. Ordering Information: Growth Medium Cat. Product Name CAT#: NCC20-9PZ02 Astrocyte Growth Medium NCL-21P6-226 Microglial Cell Growth Medium NCC-2101-ZP14 Striatal Neuron Growth Medium NRZP-0522-ZP1151 Oligodendrocyte Growth Media NCL-21P6-105 Oligodendrocyte Precursor Cell Growth Medium NCC20-9PZ10 Primary Neuron Growth Medium NCC2009PZ17 Retinal Pigment Epithelial Cell Growth Medium Kit NCC20-9PZ26 Endothelial Cell Growth Medium NCC-2103-P65 Schwann Growth Medium NCL-2105-P140-IX Human Neural Stem Cell Growth Medium Maintenance Medium Cat. Product Name NCC200631ZP StemTes™ A Maintenance Medium NCC-2101-ZP26 Microglia Maintenance Medium NCC-2101-ZP15 Sensory Neuron Maintenance Medium NCC-2101-ZP24 Motor Neuron Maintenance Medium NCC-2101-ZP25 Astrocyte Maintenance Medium NCL-2105-P119-IX Cortical Neuron Maintenance Medium Differentiation Medium Cat. Product Name NCL-21P6-106 Oligodendrocyte Precursor Cell Differentiation Medium NCC200538ZP ES/iPS Neuronal Differentiation Medium Neural Supplements Cat. Product Name NCL-7P062 Nervous System Supplement NCL-21P6-124 Astrocyte Growth Supplement NCL-21P6-118 Epithelial Cell Growth Supplement NCL-21P6-116 Fibroblast Growth Supplement NCL-21P6-114 Endothelial Cell Growth Supplement NCC200512ZP NeuroInduc™ Neural Stem and Progenitor Cells Differentiation Supplement NCC200600ZP NeuroInduc™ N2 Supplement-A NCC200605ZP NeuroInduc™ N2 Supplement-B NRZP-0622-ZP403 GS21 Neural Supplement NCC-2101-ZP17 Human/Murine/Rat BDNF [CAT#:] NCC-2101-ZP19 Human beta-NGF NCC-2101-ZP20 Human NT-3 Neural Cell Culture Media and Supplements Cutting Edge Tools for Neuroscience Research
  • 17. Laminin for Neural Cell Attachment Laminins (heterotrimers composed of α, β, and γ chains), are multifunctional glycoproteins present in basement membranes. Laminin has long been an important mainstay of neural cell culture as coating substrates and is also used as a supplement of culture medium to enhance growth of human neural stem cells. We provide a range of high quality laminin products that are ideally suited as tools for neural cell culture to allow you to select the most suitable version for your research. Cat. Product Name NRZP-0622-ZP398 Mouse Laminin I NRZP-0622-ZP399 Antibiotic-Free Mouse Laminin I NRZP-0622-ZP400 Stem Cell Qualified Mouse Laminin I NRZP-0622-ZP401 3D Culture Matrix Laminin I NRZP-0622-ZP402 Poly-D-Lysine & Laminin Coating Solution Extracellular Matrix for Neurosphere Formation Neurospheres demonstrated the first unequivocal evidence that cells derived from adult brain can have stem cell properties and remain a useful tool for the in vitro study of neural stem cells. Applications include analysis of selfrenewal capacity, potency, neural development and neurogenesis. We provide an optimized spheroid formation matrix to help with consistent generation of neurospheres for use in your research. Ordering Information: Cat. Product Name NRZP-0622-ZP397 Neurosphere Formation Matrix Neural Cell Culture Matrices Ordering Information:
  • 18. Optimized transfection reagents tailored for neural cells! Physiologically relevant models, such as primary neurons and small animal models, increase the need for new nucleic acid delivery tools. One of the greatest challenges is the ability to manipulate the desired cell models that are traditionally difficult to transfect, including primary neurons and neural stem cells. Methods typically used have not met these needs—reagent- mediated DNA transfection is inefficient for nuclear entry; electroporation requires cell disruption and special instrumentation, and is expensive; and virus-mediated transduction can be very time-consuming. To facilitate the use of more relevant cell models, we have developed NeuroIn™ Transfection Reagent, which we recommend as the primary gene delivery solution (Fig.1). Figure 1. Recommended transfection methods, by cell type. Cat. Product Name NRZP-0622-ZP377 NeuroIN™ mRNA Transfection Reagent NRZP-0622-ZP378 NeuroIN™ DNA Transfection Reagent, Lipo 3000 NRZP-0622-ZP37- NeuroIN™ DNA Transfection Reagent, Lipo 2000 NRZP-0622-ZP380 NeuroIN™ Invivo Brain Transfection Reagent, 3.0 NRZP-0622-ZP381 NeuroIN™ RNAi Transfection Reagent Product Nucleic acid type Cell model Performance Cell viability Ease of use NeuroIN™ mRNA Transfection Reagent mRNA Primary cells, stem cells, and difficult-to- transfect cells +++ ++++ ++++ NeuroIN™ DNA Transfection Reagent, Lipo 3000 DNA Easy- and difficult-to-transfect immortalized cell lines, viral delivery ++ ++++ ++++ NeuroIN™ DNA Transfection Reagent, Lipo 2000 DNA Easy-to-transfect cells, primary neurons + ++++ ++++ NeuroIN™ Invivo Brain Transfection Reagent, 3.0 siRNA, mRNA In vivo directbraininjection ++ ++ ++ NeuroIN™ RNAi Transfection Reagent siRNA All neuronal cell models (gene knockdown) ++++ ++++ ++++ Neural Cell Transfection Ordering information: Product selection guide We offer a variety of other gene delivery options based on your research needs, including lentiviral delivery and physical methods such as electroporation. However, there are advantages and limitations for each method based on the cell models being used and the end goal of the experiment: gene expression or gene knockdown. An overview of our most effective delivery solutions for neurobiology research is shown in Table 1. Table 1. Gene delivery products for neurobiology research by nucleic acid type. Cutting Edge Tools for Neuroscience Research
  • 19. Keeping your cells safe with the CELLBANKER Series! There are numerous protocols available for cryopreserving neural stem cells (NSCs) derived from human embryonic stem cells; the primary objective of these methods are the recovery of the cells post-thaw and the retention of their multipotent properties. Creative Biolabs supplies cutting edge cryopreservation reagents to meet the demands of your neural cell research. Our high performance and quality assured CELLBANKER cryopreservation solutions ensure stable long-term storage of cells. CELLBANKER is a series of easy-to-use cell freezing media with defined formulations, available in serum and serum-free formulations to successfully cryopreserve the most sensitive mammalian cells. Figure 1. Recommended transfection methods, by cell type. Product selection guide - CELL-BANKER 1 was launched in 1--2 and now has a significant history of reliable, consistent and high viability recoveries post-cryopreservation. Contains serum, DMSO, glucose, salts and buffer. - CELLBANKER 2 is a chemically defined serum-free cell freezing medium that allows cell cryopreservation directly at -80˚C without requiring a rate controlled freezer. Contains no animal derived products and is guaranteed sterile. - STEM-CELLBANKER is a chemically defined xeno-free freezing medium optimized for stem cells and iPS cells storage as well as other valuable cells. It is free of serum and animal derived components and contains only European or US Pharmacopoeia graded ingredients. Use STEM-CELLBANKER to achieve consistently high cell viability post-thaw, even over extended long-term storage, while maintaining cell pluripotency, normal karyotype and proliferation ability. Ordering information: Cat. Product Name NRZP-0622-ZP382 CELLBANKER 1 (100ml) NRZP-0622-ZP383 CELLBANKER 2 (100ml) NRZP-0622-ZP384 STEM-CELLBANKER - GMP Grade (20ml) Neural Cell Cryopreservation Cutting Edge Tools for Neuroscience Research
  • 20. SUITE 203, 17 Ramsey Road, Shirley, NY 11-67, USA Tel: 1-631-357-2254 Fax: 1-631-207-8356 Email: info@creative-biolabs.com 167-16-Great Portland Street, 5th Floor, London, W1W 5PF Tel: 44-207-0-7-1828 Email: info@creative-biolabs.com USA UK