This document summarizes the treatment of neuropathic pain. It discusses the various causes of neuropathic pain including diabetes, shingles, and spinal cord injuries. It then describes common neuropathic pain conditions and symptoms. The document outlines the pathophysiology of neuropathic pain in both the peripheral and central nervous systems. It provides details on different drug classes used to manage neuropathic pain such as antidepressants, antiepileptics, opioids, topical agents, and other possibilities. The summary notes that neuropathic pain has no single highly effective treatment and often requires a trial-and-error process to determine the appropriate polypharmacy regimen for each patient.