Multi-modality intraoperative neurophysiological monitoring (IONM) refers to the assessment of neural structures through electrophysiological means during surgery. The document presents 5 case studies demonstrating the use of IONM: Case 1 showed a gradual increase in right Wave V latency during trigeminal nerve decompression, identifying pressure on the VIII nerve. Case 2 showed transient degradation of median SSEPs during insertion of a spinal shunt, but spontaneous return without intervention. Case 3 demonstrated changes in upper extremity MEPs and median SSEPs during cervical laminectomy and shunt placement for C5 tetraplegia. Case 4 assessed sensory and motor function and SSEPs/MEPs before and after