mTORC signaling in myfobroblast diferentiation
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role of the mechanistic target of rapamycin (mTOR) in regulating TGF-b1- induced myofibroblastic responses in human pterygium fibroblasts (HPFs)
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This document discusses how genetic polymorphisms can influence how individuals respond to drugs. It explains that genetics can account for 20-95% of variability in drug effects between people. Sequence variants in genes encoding drug-metabolizing enzymes, transporters, and targets can impact drug disposition and response. Specifically, it describes genetic polymorphisms that influence the cytochrome P450 enzyme CYP3A5 and the drug transporter P-glycoprotein, and how these affect the metabolism and transport of various medications. The document stresses that pharmacogenomic studies are helping to elucidate the inherited basis of differing drug responses.
gonadocorticoids: a potential treatment for parkinson's disease
estrogens are useful in the treatment of Parkinson's disease. the estrogen receptors and the mechanism behind their effect is shown in the ppt.
MicroRNA Profiling of Hepatocellular Carcinomas in B6C3F1 Mice Treated with G...
MicroRNA Profiling of Hepatocellular Carcinomas in B6C3F1 Mice Treated with Ginkgo biloba Extract by Gavage for 2 Years
MPHBS-2016-488-118
This study investigated the relationship between MMP-9 gene expression and sialic acid (NANA) in human glial cell lines. Researchers treated glial cell lines with varying concentrations of NANA and found that MMP-9 mRNA expression increased with treatment, indicating NANA may be involved in signaling pathways regulating MMP-9 expression. The results suggest determining how NANA influences MMP-9 and other inflammatory molecules could provide insight into neurodegenerative diseases involving inflammation.
MS Thesis Presentation on TPMT Gene Polymorphism
It is a thesis presentation on " Genotyping of Thiopurine S-methyltransferase (TPMT) for its Variant TPMT*3B (G460A) in a Bangladeshi Population".
Whole Genome Sequencing
Virilizer (Vir), first isolated from Drosophila melanogaster, plays a role in sex determination. In humans, its homologue and METTL3 are involved in N6-adenosine methylation (m6A) writing. As m6A of mRNA is an important process in most eukaryotes, it is very important to understand its role and the status of factors accompanying this modification. Whole genome sequencing enables genome-wide mutation profiling in the viral mutant of Arabidopsis. https://www.cd-genomics.com/whole-genome-sequencing.html https://www.cd-genomics.com/whole-genome-sequencing.html
4640-63316-1-PB
- The document examines the role of plasminogen activator inhibitor 1 (PAI-1) in the recruitment of mast cells (MCs) to glioma tumors.
- It finds that neutralizing PAI-1 attenuates the infiltration of MCs into glioma tumors. It also finds that MCs express the PAI-1 receptor LRP1, and blocking LRP1 also attenuates MC migration.
- Activation of the potential PAI-1/LRP1 axis in MCs by purified PAI-1 promotes increased phosphorylation of STAT3 and subsequent MC exocytosis. This indicates the PAI-1/LRP1 axis influences MC recruitment in glioma tumors.
StAR
This study investigated protein-DNA interactions within the cAMP-responsive region of the murine steroidogenic acute regulatory (StAR) protein gene. The researchers found that:
1) Steroidogenic factor 1 (SF-1) binds to an element at -95 bp (SF1-3) in the mouse StAR promoter and this site is required for full basal promoter activity.
2) SF-1 stabilizes protein-DNA interactions at the C/EBPβ/AP-1/nuclear receptor half-site (CAN) region located at -79 bp.
3) GATA-4 binds to the StAR promoter at -68 bp and contributes to approximately 20% of the cAMP-
Tesi baiula monica
The document discusses research into the regulation and role of the transcription factor REST in neuronal differentiation of SH-SY5Y human neuroblastoma cells exposed to IGF-I and PMA. The key findings are: 1) IGF-I and PMA increase nuclear REST levels early in treatment but REST declines with longer exposure as neurite outgrowth increases, 2) Downregulating REST with antisense oligonucleotides enhances the effects of IGF-I and PMA on neuronal markers and neurite growth, 3) REST degradation involves the ubiquitin-proteasome system and contributes to later stage neuronal differentiation. The document also analyzes the O-glycosylation pattern of REST protein in these cells.
Venters Molecular and Cellular Biology 2011 2253-2261
This study investigates the contributions of conserved regions of the essential yeast protein Mot1 to genome-wide gene regulation and transcription factor (TBP) recruitment. The researchers used a transient replacement strategy to delete conserved regions of Mot1 and analyzed the effects on gene expression and TBP occupancy. They found that the four conserved regions of Mot1 are generally required for all Mot1-regulated genes. Deletion of the ATPase region specifically altered transcriptional dependence for some genes and caused TBP to redistribute away from Mot1-inhibited genes and to other normally Mot1-independent genes. This suggests that Mot1 uses ATP hydrolysis to redistribute accessible TBP between sites of high and low intrinsic preference.
Seminar 1104
1) p53 activation through nutlin-3a treatment suppressed M2 macrophage polarization by downregulating M2 marker genes like c-MYC, IRF4 and FIZZ1.
2) Loss of p53 increased M2 macrophage polarization both in vitro and in vivo by increasing the expression of M2 marker genes.
3) p53 was found to suppress M2 macrophage polarization by directly binding to the promoter region of c-MYC gene, reducing its expression and influencing the expression of downstream M2 genes.
Similar to mTORC signaling in myfobroblast diferentiation (20)
Primary Human Cell Systems Analysis of Drug Mechanisms
Primary Human Cell Systems Analysis of Drug Mechanisms
Quantitative Analysis of IGF1R/AKT/mTOR Pathway using Multiplex-Immunoprecipi...
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From Nutrigenomics to nutritional systems biology of fatty acid sensing
From Nutrigenomics to nutritional systems biology of fatty acid sensing
gonadocorticoids: a potential treatment for parkinson's disease
gonadocorticoids: a potential treatment for parkinson's disease
MicroRNA Profiling of Hepatocellular Carcinomas in B6C3F1 Mice Treated with G...
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Venters Molecular and Cellular Biology 2011 2253-2261
Venters Molecular and Cellular Biology 2011 2253-2261
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Isolation of pure culture, its various method.
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Slides from:
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Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/Cytokines and their role in immune regulation.pptx
This presentation covers the content and information on "Cytokines " and their role in immune regulation .
Equivariant neural networks and representation theory
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
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https://ashpc.eu/
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The Petroleum System of the Çukurova Field - the Shallowest Oil Discovery of Türkiye, Adana
Nucleophilic Addition of carbonyl compounds.pptx
Nucleophilic addition is the most important reaction of carbonyls. Not just aldehydes and ketones, but also carboxylic acid derivatives in general.
Carbonyls undergo addition reactions with a large range of nucleophiles.
Comparing the relative basicity of the nucleophile and the product is extremely helpful in determining how reversible the addition reaction is. Reactions with Grignards and hydrides are irreversible. Reactions with weak bases like halides and carboxylates generally don’t happen.
Electronic effects (inductive effects, electron donation) have a large impact on reactivity.
Large groups adjacent to the carbonyl will slow the rate of reaction.
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The binding of cosmological structures by massless topological defects
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
Deep Software Variability and Frictionless Reproducibility
Deep Software Variability and Frictionless ReproducibilityUniversity of Rennes, INSA Rennes, Inria/IRISA, CNRS
The ability to recreate computational results with minimal effort and actionable metrics provides a solid foundation for scientific research and software development. When people can replicate an analysis at the touch of a button using open-source software, open data, and methods to assess and compare proposals, it significantly eases verification of results, engagement with a diverse range of contributors, and progress. However, we have yet to fully achieve this; there are still many sociotechnical frictions.
Inspired by David Donoho's vision, this talk aims to revisit the three crucial pillars of frictionless reproducibility (data sharing, code sharing, and competitive challenges) with the perspective of deep software variability.
Our observation is that multiple layers — hardware, operating systems, third-party libraries, software versions, input data, compile-time options, and parameters — are subject to variability that exacerbates frictions but is also essential for achieving robust, generalizable results and fostering innovation. I will first review the literature, providing evidence of how the complex variability interactions across these layers affect qualitative and quantitative software properties, thereby complicating the reproduction and replication of scientific studies in various fields.
I will then present some software engineering and AI techniques that can support the strategic exploration of variability spaces. These include the use of abstractions and models (e.g., feature models), sampling strategies (e.g., uniform, random), cost-effective measurements (e.g., incremental build of software configurations), and dimensionality reduction methods (e.g., transfer learning, feature selection, software debloating).
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Exposé invité Journées Nationales du GDR GPL 2024
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Plant breeding for disease resistance is a strategy to reduce crop losses caused by disease. Plants have an innate immune system that allows them to recognize pathogens and provide resistance. However, breeding for long-lasting resistance often involves combining multiple resistance genes
ESR spectroscopy in liquid food and beverages.pptx
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
Phenomics assisted breeding in crop improvement
As the population is increasing and will reach about 9 billion upto 2050. Also due to climate change, it is difficult to meet the food requirement of such a large population. Facing the challenges presented by resource shortages, climate
change, and increasing global population, crop yield and quality need to be improved in a sustainable way over the coming decades. Genetic improvement by breeding is the best way to increase crop productivity. With the rapid progression of functional
genomics, an increasing number of crop genomes have been sequenced and dozens of genes influencing key agronomic traits have been identified. However, current genome sequence information has not been adequately exploited for understanding
the complex characteristics of multiple gene, owing to a lack of crop phenotypic data. Efficient, automatic, and accurate technologies and platforms that can capture phenotypic data that can
be linked to genomics information for crop improvement at all growth stages have become as important as genotyping. Thus,
high-throughput phenotyping has become the major bottleneck restricting crop breeding. Plant phenomics has been defined as the high-throughput, accurate acquisition and analysis of multi-dimensional phenotypes
during crop growing stages at the organism level, including the cell, tissue, organ, individual plant, plot, and field levels. With the rapid development of novel sensors, imaging technology,
and analysis methods, numerous infrastructure platforms have been developed for phenotyping.
bordetella pertussis.................................ppt
Bordettela is a gram negative cocobacilli spread by air born drop let
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
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1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
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Travis Hills' Endeavors in Minnesota: Fostering Environmental and Economic Pr...
Travis Hills of Minnesota developed a method to convert waste into high-value dry fertilizer, significantly enriching soil quality. By providing farmers with a valuable resource derived from waste, Travis Hills helps enhance farm profitability while promoting environmental stewardship. Travis Hills' sustainable practices lead to cost savings and increased revenue for farmers by improving resource efficiency and reducing waste.
Recently uploaded (20)
8.Isolation of pure cultures and preservation of cultures.pdf
8.Isolation of pure cultures and preservation of cultures.pdf
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Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...
Cytokines and their role in immune regulation.pptx
Cytokines and their role in immune regulation.pptx
Equivariant neural networks and representation theory
Equivariant neural networks and representation theory
The binding of cosmological structures by massless topological defects
The binding of cosmological structures by massless topological defects
Deep Software Variability and Frictionless Reproducibility
Deep Software Variability and Frictionless Reproducibility
aziz sancar nobel prize winner: from mardin to nobel
aziz sancar nobel prize winner: from mardin to nobel
ESR spectroscopy in liquid food and beverages.pptx
ESR spectroscopy in liquid food and beverages.pptx
bordetella pertussis.................................ppt
bordetella pertussis.................................ppt
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
Travis Hills' Endeavors in Minnesota: Fostering Environmental and Economic Pr...
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mTORC signaling in myfobroblast diferentiation
- 1. ANA MARÍA OSPINA ZULETA Medicine Student-Third semester
- 2. mTOR : Mammalian target of rapamycin: ● Protein complex ● Sensor and regulator INTRODUCTION
- 3. TGF-B1: Transforming growth factor beta-1: ● Cytokine ● Growth, differentiation, proliferation INTRODUCTION
- 4. Investigate the role of the mechanistic target of rapamycin (mTOR) in regulating TGF-b1- induced myofibroblastic responses in human pterygium fibroblasts (HPFs) and elucidated the relative contributions of mTOR signaling components. GENERAL OBJECTIVE
- 5. METHODS- Western blot acid pH basic pH
- 6. METHODS- Interfering RNAs Gene silencing RNAm
- 7. METHODS- PCR
- 8. METHODS- Immunoassays Flow cytometry Immunofluorescence
- 9. mTORC1 mTORC2 Control RESULTS mTOR action Phosphorylation
- 11. RESULTS Presence of TGF-B1 Inhibition of mTOR
- 12. RESULTS
- 13. AUTHORS SENTENCE ARTICLE Zhao XR, Zhang MC, Xie HT, Ji N, Ma XQ Increased expression of mTOR in pterygium compared to normal conjunctiva and positive correlation between pS6K expression and clinical severity Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J The inhibitory activity of rapamycin is not sufficient to completely block mTORC1. Xie J, Wang X, P Kim YC, Guan KL New generation mTOR inhibitors have been developed and tested for many diseases, including cáncer DISCUSSION
- 14. CONCLUSION ● Torin2 is more effective inhibitor than rapamycin ● Importance of the different biomolecular techniques