This document provides an overview of the Most Significant Change (MSC) technique, which is used to monitor and evaluate social programs. It describes the MSC process in 10 steps: 1) starting and raising interest; 2) defining domains of change; 3) defining reporting periods; 4) collecting stories of significant change; 5) selecting the most significant stories; 6) feeding back results; 7) verifying stories; 8) quantifying results; 9) analyzing results and revising systems; and 10) revising the MSC system. The document also discusses how MSC fits within monitoring and evaluation frameworks and compares MSC to other approaches. It aims to provide guidance to organizations on implementing and using MSC.