This document summarizes lessons learned from using the Most Significant Change (MSC) technique in evaluations conducted in five countries. The MSC technique involves collecting stories from participants about significant changes resulting from an intervention, analyzing the stories to identify themes, and sharing the stories with stakeholders. The document discusses strengths and limitations of MSC, provides examples of its application in different programs and countries, and identifies lessons learned. Key lessons are that MSC generates rich qualitative data but requires careful facilitation and training, and follow-up interviews can further strengthen learning from the approach.