This document defines microsystems as small clinical units composed of healthcare professionals and staff who work together to care for a specific patient population. Microsystems have distinct clinical and operational processes, a shared information environment, and aim to improve both patient care and staff experience. The benefits of the microsystem approach include enhanced patient safety, involvement of all staff in improvement efforts, and alignment of frontline work with organizational goals. Key aspects of effective microsystems are strong leadership, interdisciplinary teamwork, staff education, performance measurement, and process improvement focused on patient-centered care.