The Michelson-Morley experiment aimed to detect the motion of the Earth through the hypothesized luminiferous ether by measuring fringe shifts in an interferometer when the apparatus was rotated. However, the experiment yielded a null result, finding no difference in the speed of light in different directions. This contradicted the ether theory and provided early experimental evidence for Einstein's theory of relativity by showing there was no ether drag. The null result meant the Earth's speed could not be measured relative to the ether, disproving its existence and revolutionizing our understanding of space and time.
This PPT cover the con taints special theory of relativity,Michelon Morley experiment,variations in length ,mass and Time dilation,Einstein mass energy relation
Information theory and statistical mechanicsChandanShah35
Focused on basic terminology used in Statistical Mechanics, Relation ship between Information Theory and Statistical Mechanics and few terms related to quantum mechanics
This is an introduction to modern quantum mechanics – albeit for those already familiar with vector calculus and modern physics – based on my personal understanding of the subject that emphasizes the concepts from first principles. Nothing of this is new or even developed first hand but the content (or maybe its clarity) is original in the fact that it displays an abridged yet concise and straightforward mathematical development that provides for a solid foundation in the tools and techniques to better understand and have a good appreciation for the physics involved in quantum theory and in an atom!
It should be helpful, special thanks to our teacher (whose name is in the power point and the one who made it) from whom I asked his permission to post it here.
introduction to electrodynamics contains:
chapter 1: vectors
vector analysis
vector operations
vector transform
Divergence theorem
stock theorem
chapter 2 :electrostatics
Coulomb law
Electric field
Gauss law
Maxwell equations (1,2)
Potential energy
work done
Chapter3: Dipole
Electric field due to dipole
Potential energy due to dipole
Polarization
electric dipole moment
electric displacement
This PPT cover the con taints special theory of relativity,Michelon Morley experiment,variations in length ,mass and Time dilation,Einstein mass energy relation
Information theory and statistical mechanicsChandanShah35
Focused on basic terminology used in Statistical Mechanics, Relation ship between Information Theory and Statistical Mechanics and few terms related to quantum mechanics
This is an introduction to modern quantum mechanics – albeit for those already familiar with vector calculus and modern physics – based on my personal understanding of the subject that emphasizes the concepts from first principles. Nothing of this is new or even developed first hand but the content (or maybe its clarity) is original in the fact that it displays an abridged yet concise and straightforward mathematical development that provides for a solid foundation in the tools and techniques to better understand and have a good appreciation for the physics involved in quantum theory and in an atom!
It should be helpful, special thanks to our teacher (whose name is in the power point and the one who made it) from whom I asked his permission to post it here.
introduction to electrodynamics contains:
chapter 1: vectors
vector analysis
vector operations
vector transform
Divergence theorem
stock theorem
chapter 2 :electrostatics
Coulomb law
Electric field
Gauss law
Maxwell equations (1,2)
Potential energy
work done
Chapter3: Dipole
Electric field due to dipole
Potential energy due to dipole
Polarization
electric dipole moment
electric displacement
Successful search for ether drift in a modified michelson morley experiment u...Võ Hồng Quý
Ether drift resulting from the rotation of the Earth has been detected. This was accomplished using GPS technology in a modified Michelson-Morley experiment. The original Michelson-Morley experiment searched for ether drift by observing round-trip light travel time differences using interference fringe shifts. This method is limited by length contraction effects that significantly reduce any fringe shifts. In the modified approach elapsed time for one-way light transmission is directly determined using GPS clocks. The method yields travel time differences for light transmission in the East-West direction but not in the North-South direction consistent with rotationally-induced ether drift.
The nonmagnetic nucleus_of_comet_67_p_churyumov_gerasimenkoSérgio Sacani
Artigo descreve como a sonda Rosetta e o módulo Philae descobriram que o cometa Churyumov-Gerasimenko não é magnetizado, contrariando uma teoria da formação do Sistema Solar.
O centro da nossa Via Láctea é um lugar misterioso. Não somente está a milhares de anos-luz de distância, mas está também escondido sob grande quantidade de poeira de modo que a maior parte das estrelas em seu interior são invisíveis. Pesquisadores de Harvard, estão propondo uma nova maneira de limpar a neblina e registrar as estrelas ali escondidas. Eles sugerem observar os comprimentos de onda de rádio provenientes das estrelas supersônicas.
“Existem muitas, nós não sabemos sobre o centro galáctico, e nós queremos aprender muito”, disse o principal autor do estudo Idan Ginsburg do Harvard-Smithsonian Center for Astrophysics (CfA). “Usando essa técnica, nós podemos encontrar estrelas que ninguém observou antes”.
A grande trajetória do centro da nossa galáxia para a Terra é repleta de tanta poeira que até mesmo dos trilhões de fótons de luz visível que veem em nossa direção, somente um fóton atingirá nossos telescópios. Ondas de rádio, de uma diferente parte do espectro eletromagnético, possui energia mais baixa e comprimentos de onda maiores. Elas podem passar pela poeira de forma ilesa.
Why Does the Atmosphere Rotate? Trajectory of a desorbed moleculeJames Smith
As a step toward understanding why the Earth's atmosphere "rotates" with the Earth, we use using Geometric (Clifford) Algebra to investigate the trajectory of a single molecule that desorbs vertically upward from the Equator, then falls back to Earth without colliding with any other molecules. Sample calculations are presented for a molecule whose vertical velocity is equal to the surface velocity of the Earth at the Equator (463 m/s) and for one with a vertical velocity three times as high. The latter velocity is sufficient for the molecule to reach the Kármán Line (100,000 m). We find that both molecules fall to Earth behind the point from which they desorbed: by 0.25 degrees of latitude for the higher vertical velocity, but by only 0.001 degrees for the lower.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
1. Special Theory of Relativity-Lecture– 2
B.Sc Physics - First Year - First Semester
Topic: Michelson-Morley Experiment
2. Michelson-Morley Experiment
Michelson – Morley
experiment is aimed to
determine the velocity of the
earth with respect to ether
frame that means, to detect the
real existence of ether, which
was proposed by Huygens.
Source: wikipedia
3. Michelson and Morley conducted this experiment by using Michelson interferometer.
Michelson-Morley Experiments laid the experimental foundations of theory of relativity.
Source: wikipedia
4. The principle of the experiments lies finding the shift in
fringes in the Michelson interferometer due to difference in
time taken by light to travel along and opposite to the
direction of motion of the earth.
The time taken by a beam of light to travel along the
direction of motion of the earth is greater than that to travel
distance opposite to the direction of motion of the earth.
5. d
S
V
1
M
2
M
G
1
A
A
D
B B
d
GB
GA
2
T T
G
Experimental Arrangement:
The experimental
arrangement of Michelson –
Morley is shown in figure. S is
a monochromatic light source.
The monochromatic light from
S is incident on a semi silvered
glass plate G, which is kept at
an inclined angle of 450 with
the light. The light falls on the
semi silvered glass plate and
split into two rays, they are
reflected and transmitted rays.
6. The reflected ray (ray1)
towards the plane mirror M1,
which is at a distance of d from
the glass plate G. The
transmitted ray (ray2) travels
towards plane mirror M2, which
is also at a distance of d from
glass plate G.
The two rays are
incident normally on the
mirrors M1 and M2 respectively
and they are reflected back
along their original paths and
meet at the surface of the semi
silvered glass plate G.
d
S
V
1
M
2
M
G
1
A
A
D
B B
d
GB
GA
2
T T
As these rays(ray1 &ray2) satisfy the interference
conditions, hence an interference pattern can be
observed by the telescope T.
G
7. d
S
V
1
M
2
M
G
1
A
A
D
B B
d
GB
GA
2
T T
If the experimental setup at
rest in ether, then the two
reflected rays take equal time to
reach Glass plate G. But the
whole setup is moving along with
the earth.
Consider the direction of
motion of earth is in the direction
of the initial beam.
Due to the motion of the
earth, the optical paths travelled
by the two rays are not the same.
Then the reflections at the
mirrors and do not take
place at A and B, but take place at
A’ and B’ respectively.
So, the time taken by the two rays to travel to
the mirrors and back to G is different.
1
M 2
M
8. d
S
V
1
M
2
M
G
1
A
A
D
B B
d
GB
GA
2
T T
Let the velocities of the
light and the apparatus (earth)
are c and v respectively. it is
obvious from fig. that the
reflected ray 1 from glass plate G
will move along GA’ and strikes
the mirror M1 at A’ instead of A
due to the motion of the earth.
After reflection the total
path taken by the ray is GA'Gˈ
G
From the ∆GA’D, we have
(GA')2 = (GD)2 + (A'D)2 But, GD = AA’
∴ (GA')2 = (AA')2 + (A'D)2 ----(1)
9. d
S
V
1
M
2
M
G
1
A
A
D
B B
d
GB
GA
2
T T
G
If t is the time taken by the ray
to move from G to A’, then eq.(1)
becomes
(ct)2 = (vt)2 + (d)2
⇒ t2(c2-v2) = d2
2
2
v
c
d
t
If is the time taken by the ray1 to
travel whole path GA’G’, then
1
t
10. d
S
V
1
M
2
M
G
1
A
A
D
B B
d
GB
GA
2
T T
G
)
2
(
2
1
c
2d
t
1
c
2d
1
2
c
2d
2
2
2
1
2
1
2
2
2
2
2
2
1
c
v
c
v
c
v
c
d
v
t
t
11. d
S
V
1
M
2
M
G
1
A
A
D
B B
d
GB
GA
2
T T
G
Let the experimental setup is
moving with earth velocity v in the
direction of incident light. Then the
transmitted light ray 2 is travelling
with a velocity (c - v) from glass
plate G to plane mirror M2 with
respect to interferometer.
Similarly, it is reflected from M2
with a velocity of (c + v) and falls
on G. The distance between G and
M2 is d.
Then t2 is time taken by ray 2 to
reach G’, then
12. d
S
V
1
M
2
M
G
1
A
A
D
B B
d
GB
GA
2
T T
G
v
c
v
c
v
c
v
c
d
v
c
d
v
c
d
t
)
(
2
2
2
2
2
2
1
2
c
2dc
c
v
c
dc
v
1
2
2
1
2
c
v
c
d
)
3
(
1
2
2
2
2
c
v
c
d
t
13. Therefore, the difference in the times of intervals of ray1 and ray2 is
Δt = t1 – t2
2
2
2
2
2
1
2
1
2
1
c
2
c
v
c
d
c
v
d
t
t
t
2
2
2
2
2
1
1
2
c
v
c
v
c
d
)
4
(
2
2
3
2
2
2
c
dv
c
v
c
d
t
14. The Optical path difference between two rays is given by
Optical path difference = velocity x ∆ t
2
2
3
2
c
dv
c
x
c
dv
If the wave length of the light is 𝜆, then the path difference in
terms of wave length =
2
2
c
v
d
.
15. The path difference gives the fringe shift. When the apparatus is
rotated to 90°, hence the mirrors M1 and M2 exchange their positions.
It means initially if a ray travels lesser distance by rotating, it travels
longer distance. Hence, the path difference becomes negative. By
rotating the apparatus the resultant path difference results the fringe
shift to equal to
2
2
2
c
v
d
16. In the above experiment,
cm
-5
10
X
5
.
5
cm/sec
10
X
3 6
v
Therefore, theoretically it was expected a shift in fringes was less than
half a fringe. But, Michelson and Morley could observe a shift about
0.01 of fringe. This shift is within the limits of the error of observation.
cm
10
10 3
m
d
sec
/
m
10
3X 10
c
0.4
)
10
X
3
(
X
10
X
5
.
5
)
10
X
3
(
X
10
X
2
n
shift
Fringe 2
10
5
-
2
6
3
17. They have repeated the experiment at different places on the earth and
at different seasons of the year, but they could not find any shift. This is
known as null result.
The null result gives that it is impossible to measure the speed of the
earth relative to ether, i.e., there is no relative motion between earth and
ether. Experimentally it is proved that, there is no ether drag and this leads
to the total rejection of ether hypothesis.
To explain this, Albert Einstein has proposed Special Theory of
Relativity.