The document discusses metered dose inhalers (MDIs), which are devices that deliver a specific amount of medication to the lungs via a short burst of aerosolized medicine. MDIs are commonly used to treat asthma, COPD, and other respiratory diseases. The key components of an MDI are the container, actuator, propellant, and metered valve. When the metered valve is opened, the payload is forced out as an aerosol mist under pressure from the propellant. MDIs have advantages like delivering a low dose of medication in a portable and fixed amount, but also have disadvantages such as requiring coordination of inhalation and complex hand movements.

1. MANARAT INTERNATIONAL UNIVERSITY
Department of Pharmacy
Group Presentation

2. Metered Dose
Inhaler
Products in which the active drug along with propellant is
packed under pressure which is released upon application.

3. Metered Dose Inhaler
A metered-dose inhaler is a device that delivers a specific
amount of medication to the lungs,in this form of a short
burst of aerosolized medicine that is usually self-
administered bythe patient via inhalation.
It is the most commonly used delivery system for treating
asthma,chronic obstructive pulmonary disease and other
respiratory diseases.
Dute to metered valve exact amount of drug is delivered.
Mainly for asthma,COPD & heart diseases.

4. Mechanism of MDI:
 A dispensing system which
creates an aerosol mist of liquid
particles is used with a can or
bottle that contains a payload and
propellant under pressure.
When the container's metered
valve is opened, the payload is
forced out of a small hole and
emerges as an aerosol or mist.

5. Mechanism of MDI
A mask may be used for the
therapeutic administration of a
nebulized solution, humidity, or
high airflow with oxygen
enrichment.
It has a large-bore inlet and an
exhalation port.

6. CONTENTS OF THE METERED DOSE
INHALERS
MDI
Container
Actuator
Propellent
Metaered
valve

7. CONTAINERS
Aluminum is used as material
for preparing containers.
Internally coated with epoxy
resin.
Having 20mm opening at the
tip to receive metered valve.
These are seamless.

8. METERED VALVE

9. ACTUATOR
It is useful for the easy removal
of the drug from the container.
Used for applying drug on a
particular site which we
desired.

10. PROPELLENT
Propellants in MDIs are liquefied compressed
gases that are in the gaseous phase at
atmospheric pressure,but form liquids when
compressed.
Commonly used propellants.
Damage to ozone layer.

12. ADVANTAGES & DISADVANTAGES
Low dose
Cheap
Portable
Fixed dose
Efficient drug delivery
Short treatment time
Advantages:

13. Disadvantages
Complex hand-breathing coordination
Can not change drug concentration
Whether the canister is used up is difficult to
determine accurately
Some patients may have reactions to the
propellants
If an accessory is not used, high orophyaryngeal
impaction can be high and the drug is wasted