Metabolic antagonist and incompatibilities in mixed feed

1. Metabolic Antagonistic and
incompatibilities in mixed feed
• Muhammad Nauman Rafique
• Roll No. 01
• Bzu, Multan

2. What is antagonism?
Antagonism is a process in which a specific interaction between
two components occurs , in this interaction one component
counters the effect of other ( e.g two different amino acid
opposes the effect of each other ).This type of relationship is
called as antagonism.

3. Lysine – Arginine antagonism
• In lysine – arginine interaction in which
excess dietary lysine increases the
requirement for arginine.
• Lysine-arginine antagonism occurs readily in
poultry and it appears desirable to maintain
the ratio of arginine to lysine at 1.0 or more.

4. Excess of
lysine
Growth
Depressed
Improve by
addition of
arginine

5. Methionine , glycine and arginine :
In this interaction excess arginine and glycine
increase the requirement for the methionine

6. Increase
level of
Arginine
Increase
requirement
for
methionine
Increase
level of
Glycine

7. Leucine and caseine antagonism
• If a diet contain extra leucine in the diet ,this leucine
markedly reduces the growth.
• If the basal diet contain casein then no such growth
depression resulted from extra leucine.

8. Leucine
If a diet contain
3 percent extra
leucine.
Effect
It results in
decline in
growth by 10 to
12 percent.
Antagonism
If 18 percent of
caseine is added
in basal diet then
no such growth
depressions
occurs.

9. Vitamin-E and Vitamin-K antagonism
• Vitamin E has been shown to inhibit vitamin K function
with a lowering of vitamin K-dependent carboxylase
product.
• High dietary levels of vitamin E lead to high vitamin E
concentrations in liver which is where vitamin K and
vitamin K-dependent carboxylase are found and
function.

10. Hydrogen
of
(hydroquie)
form of
vitamin K
Quinone
form of
vitamin
-E
Hydrogen
High levels of vitamin E lead to lowered vitamin K-dependent carboxylase products

11. Some Other Examples antagonistic
interactions
A B
Zinc Calcium
Potassium Vitamin B 12
Selenium Zinc
Calcium Magnesium
Calcium Vitamin D

12. Incompatibilities in mixed feed
Topic : 02

13. 1. Water and fats incompatibility:
Liquid water is held together by hydrogen bonds.
Oils and fats not have any polar part and so for them to dissolve
in water they would have to break some of water's hydrogen bonds.
Water will not do this so the oil is forced to stay separate from
the water.

14. 2. Carbohydrates and Protein
incompatibilities
Another is that carbs are digested in an alkaline
environment while proteins are digested in an acidic
environment. Either way, the story goes, if you give chicken
a these foods in combination, they will “cancel each other
out” and not be digested
Source : www.settletime.com

15. FIN.