1) In the mid-19th century, there were major advances in medicine including the first accurate description of the human body by Andreas Vesalius and the introduction of stitches instead of cauterization for wound closure.
2) Anesthesia was introduced, first with ether in 1842, which revolutionized surgery by reducing pain.
3) Dentistry lacked modern techniques like anesthesia, drills and fillings caused extreme pain.
4) Women faced barriers in medicine, with Elizabeth Blackwell becoming the first woman to earn a medical degree in 1849.