This study examined the systematic integration of MATLAB into undergraduate mathematics teaching at two UK institutions: University College London (UCL) and Manchester Metropolitan University (MMU). The objectives were to identify best practices for effective implementation of computer algebra systems like MATLAB. Both schools redesigned their mathematics curriculum to embed MATLAB in lectures, tutorials, and assessments. Lessons learned included introducing MATLAB in context, providing in-class and out-of-class support, and ensuring questions were at an appropriate technical level for students. The implementation was most successful when it was part of an overall program redesign, students and academics saw the benefits, and there was adequate institutional support.