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Major depressive disorder is a mental disorder characterized by a depressed mood for at least 2 weeks in nearly all situations. Common symptoms include feeling sad or worthless, losing interest in activities, having changes in appetite and sleep, lacking concentration, and having suicidal thoughts. Potential causes include stress, family upbringing, loss, relationship problems, and genetic risk factors. Treatment options include medication, psychotherapy, and electroconvulsive therapy for severe cases.






