Depression is a psychological disorder characterized by persistent sadness and lack of interest in activities that were once enjoyable. Main symptoms include feelings of sadness, hopelessness, irritability, lack of energy, changes in sleep and appetite. Depression can be mild, affecting daily tasks, or major, affecting personal and social activities. While there is no single cause, depression is more common when genetic, biological, environmental, and psychological factors increase predisposition. It can occur at any life stage but signs differ for children, teenagers, and pregnant women. All types of depression should be properly diagnosed and treated.