Gastrointestinal-Pancreatic NET managementChandan K Das
1. The document discusses the management of neuroendocrine tumors (NETs), including their definition, classification, diagnostic evaluation, and treatment approaches.
2. NETs are defined and classified based on their histology, grade, and biomarkers like Ki-67 index. Higher grades (G2/G3) have worse survival outcomes than lower grades (G1).
3. Diagnostic evaluation involves biomarkers, imaging modalities, and pathology. Treatment focuses on controlling symptoms, tumor growth, and improving survival through surgery, liver-directed therapies, and somatostatin analogs like octreotide which has been shown to prolong time to progression in midgut NETs.