This document summarizes liver function tests (LFTs), their uses, limitations, and interpretation. It discusses that LFTs can help screen and detect hepatic dysfunction, recognize disease patterns, and assess disease severity. However, they also have limitations like lack of sensitivity and specificity. The document categorizes LFTs into tests that assess transport/metabolism, detect hepatocyte injury, and measure biosynthetic capacity. It provides examples like bilirubin and aminotransferases. While single tests are not comprehensive, a battery of LFTs provides a sensitive screening tool when interpreting in the clinical context.
Liver Function Tests - An Approach for Primary CareJarrod Lee
This presentation is aimed at primary care physicians. It covers the fundamentals of liver function tests, including the basic principles of interpretation, and the key patterns of abnormalities. The focus is on how to approach liver function tests in a primary care setting.
SYSTEMATIC APPROACH TO LIVER FUNCTION TEST
BY Dr. Navas Shareef. P.P (MBBS)
THIS PRESENTATION IS MADE IN A SIMPLIFIED FORM SO THAT EVERYONE COULD UNDERSTAND ABOUT A LIVER FUNCTION TEST EASILY
Chronic Liver Disease in pediatric: a case presentation and discussionDr Abdalla M. Gamal
A presentation from a tutorial about an interesting case that came to the Pediatric Department of Sebha Medical Center and was imaged by the Radiology Department.
The tutorial was a joint effort between Dr Zeinab Salem Ali (from Pediatric Department) and me (from Radiology Department). In her slides, Dr Zeinab presented the case history, examination, investigations, differential diagnosis and discussed the clinical presentation, investigations and management for chronic liver diseases in pediatric patients.In my slides, I discussed the definition, etiology, natural history of this condition and explained the role of imaging in its diagnosis.
These are my slides after some modifications. I added an aknowlegement page to illustrate Dr Zeinab effort and to thank Dr Khaled Aljasem from Pediatric Department for his effort in revising the original presentations and the constructive feedback he provided which improved the quality of the presented material. Then I added a summary for the parts Dr Zeinab has presented to make this powerpoint presentation complete.
This presentation was presented by Dr Zeinab Salem (from Pediatric Department) and me in a joint tutorial between Pediatric Department and Radiology Department of Sebha Medical Center.
Total Bile Acids - The Importance of Fifth Generation TestsRandox Reagents
Measuring total bile acid (TBA) levels may prove useful for the detection of liver diseases such as viral hepatitis, mild liver injury through drug use and for further evaluation of patients with chronic hepatitis who were previously treated successfully. TBA levels may rise up to 100 times the normal concentration in patients with liver disease due to impairment of hepatic synthesis and extraction of bile acids.
Intrahepatic cholestasis of pregnancy (ICP) or obstetric cholestasis is a pregnancy-specific liver disorder. It can be indicated by pruritus, jaundice, elevated TBA levels and/or serum transaminases and usually affects women during the second and third trimester of pregnancy.
Newer methods such as the enzyme cycling method or fifth generation methods offer many advantages including greater sensitivity, liquid reagents, small sample volumes and reduced instrument contamination from formazan dye. Additionally, the fifth generation assay does not suffer from interference from lipaemic or haemolytic samples. Both lipaemia and haemolysis are common in new-borns and pregnant women.
Dear Clinicians,
We are happy to launch our first edition of quarterly newsletter bringing to your exotic clinical cases with unusual symptoms and/or diagnostic findings, or cases involving rare diseases. We will also share with you our recent achievements, the future roadmap and new test launches in the field of rare disorder diagnosis. We hope that you will find this information quite valuable as it may assist you to derive even better patient management.
Thanks for reading!
Team Sandor
Liver Function Tests - An Approach for Primary CareJarrod Lee
This presentation is aimed at primary care physicians. It covers the fundamentals of liver function tests, including the basic principles of interpretation, and the key patterns of abnormalities. The focus is on how to approach liver function tests in a primary care setting.
SYSTEMATIC APPROACH TO LIVER FUNCTION TEST
BY Dr. Navas Shareef. P.P (MBBS)
THIS PRESENTATION IS MADE IN A SIMPLIFIED FORM SO THAT EVERYONE COULD UNDERSTAND ABOUT A LIVER FUNCTION TEST EASILY
Chronic Liver Disease in pediatric: a case presentation and discussionDr Abdalla M. Gamal
A presentation from a tutorial about an interesting case that came to the Pediatric Department of Sebha Medical Center and was imaged by the Radiology Department.
The tutorial was a joint effort between Dr Zeinab Salem Ali (from Pediatric Department) and me (from Radiology Department). In her slides, Dr Zeinab presented the case history, examination, investigations, differential diagnosis and discussed the clinical presentation, investigations and management for chronic liver diseases in pediatric patients.In my slides, I discussed the definition, etiology, natural history of this condition and explained the role of imaging in its diagnosis.
These are my slides after some modifications. I added an aknowlegement page to illustrate Dr Zeinab effort and to thank Dr Khaled Aljasem from Pediatric Department for his effort in revising the original presentations and the constructive feedback he provided which improved the quality of the presented material. Then I added a summary for the parts Dr Zeinab has presented to make this powerpoint presentation complete.
This presentation was presented by Dr Zeinab Salem (from Pediatric Department) and me in a joint tutorial between Pediatric Department and Radiology Department of Sebha Medical Center.
Total Bile Acids - The Importance of Fifth Generation TestsRandox Reagents
Measuring total bile acid (TBA) levels may prove useful for the detection of liver diseases such as viral hepatitis, mild liver injury through drug use and for further evaluation of patients with chronic hepatitis who were previously treated successfully. TBA levels may rise up to 100 times the normal concentration in patients with liver disease due to impairment of hepatic synthesis and extraction of bile acids.
Intrahepatic cholestasis of pregnancy (ICP) or obstetric cholestasis is a pregnancy-specific liver disorder. It can be indicated by pruritus, jaundice, elevated TBA levels and/or serum transaminases and usually affects women during the second and third trimester of pregnancy.
Newer methods such as the enzyme cycling method or fifth generation methods offer many advantages including greater sensitivity, liquid reagents, small sample volumes and reduced instrument contamination from formazan dye. Additionally, the fifth generation assay does not suffer from interference from lipaemic or haemolytic samples. Both lipaemia and haemolysis are common in new-borns and pregnant women.
Dear Clinicians,
We are happy to launch our first edition of quarterly newsletter bringing to your exotic clinical cases with unusual symptoms and/or diagnostic findings, or cases involving rare diseases. We will also share with you our recent achievements, the future roadmap and new test launches in the field of rare disorder diagnosis. We hope that you will find this information quite valuable as it may assist you to derive even better patient management.
Thanks for reading!
Team Sandor
Dear Clinicians,
We are happy to launch our first edition of quarterly newsletter bringing to your exotic clinical cases with unusual symptoms and/or diagnostic findings, or cases involving rare diseases. We will also share with you our recent achievements, the future roadmap and new test launches in the field of rare disorder diagnosis. We hope that you will find this information quite valuable as it may assist you to derive even better patient management.
Thanks for reading!
Team Sandor
Liver function tests (LFT’s) are groups of laboratory blood assays designed to give information about the state of patients liver
They include
Liver enzymes (SGOT, SGPT, ALP, GGT etc.,)
Bilirubin(Direct and indirect)
Albumin
Prothrombin time / INR
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Liver Function Tests and their Interpretation
B.R. Thapa, Anuj Walia
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Post Graduate Institute of Medical Education and Research,
Chandigarh
ABSTRACT
Liver function tests (LFT) are a helpful screening tool, which are an effective modality to detect hepatic dysfunction.
Since the liver performs a variety of functions so no single test is sufficient to provide complete estimate of function
of liver. Often clinicians are faced with reports that do not tally with the clinical condition of the patient and they
face difficulty in interpreting the LFT. An attempt is being made to study and understand the LFT and simplify their
interpretation with algorithms.
Key words : LFT; Alkaline phosphatase; Albumin; Prothrombin time; Aminotransferases (ALT & AST)
I. INTRODUCTION
Liver has to perform different kinds of biochemical, synthetic and excretory functions, so no single biochemical test
can detect the global functions of liver. All laboratories usually employ a battery of tests for initial detection and
management of liver diseases and these tests are frequently termed “Liver function tests”, although they are of little
value in assessing the liver function per se. In spite of receiving a lot of criticism for this terminology, the phrase
‘Liver function tests’ is firmly entrenched in the medical lexicon. It might be argued that ‘Liver injury tests’ would
be a more appropriate terminology. Moreover, the clinical history and physical examination play important role to
interpret the functions. The role of specific disease markers, radiological imaging and liver biopsy can not be
underestimated.
II. USES
The various uses of Liver function tests include: Screening : They are a non-invasive yet sensitive screening
modality for liver dysfunction. Pattern of disease : They are helpful to recognize the pattern of liver disease. Like
being helpful in differentiating between acute viral hepatitis and various cholestatic disorders and chronic liver
disease. (CLD). Assess severity : They are helpful to assess the severity and predict the outcome of certain diseases
like primary biliary cirrhosis. Follow up : They are helpful in the follow up of certain liver diseases and also helpful
in evaluating response to therapy like autoimmune hepatitis.
LIMITATIONS
Lack sensitivity: The LFT may be normal in certain liver diseases like cirrhosis, non cirrhotic portal fibrosis,
congenital hepatic fibrosis, etc. Lack specificity : They lack specificity and are not specific for any particular
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disease. Serum albumin may be decreased in chronic disease and also in nephrotic syndrome. Aminotransferases
may be raised in cardiac diseases and hepatic diseases. Except for serum bile acids the LFT are not specific for liver
diseases and all the parameters may be elevated for pathological processes outside the liver.1,3 Thus, we see that
LFT have certain advantages as well as limitations at the same time. Thus, it is important to view them keeping the
clinical profile of the patient in mind.
III. CLASSIFICATION OF LIVER FUNCTION TESTS A.
Tests of the liver’s capacity to transport organic anions and to metabolize drugs- Serum bilirubin, urine bilirubin,
urobilinogen etc.
B. Tests that detect injury to hepatocytes (serum enzyme tests) – Aminotransferases, alkaline phosphatase, ã
glutamyl transpeptidase, 5 nucleotidase, leucine aminopeptidase etc
C. Tests of the Liver’s biosynthetic capacity- Serum proteins, albumin, prealbumin, serum ceruloplasmin,
procollagen III peptide, a 1 antitrypsin, a feto protein, prothrombin time etc. The clinical significance of LFT is
given in Table 1 A. Tests of the liver’s capacity to transport organic anions and to metabolize drugs.
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IV. URINE BILIRUBIN
The presence of urine bilirubin indicates hepatobiliary disease. Unconjugated bilirubin is tightly bound to albumin
and not filtered by the glomerulus and thus not present in urine. Measurable amounts of conjugated bilirubin in
serum are found only in hepatobiliary disease.1 Because the renal threshold for conjugated bilirubin is low and the
laboratory methods can detect low levels of bilirubin in urine so conjugated bilirubin may be found in urine when
the serum bilirubin levels are normal. This is the case in early acute viral hepatitis.1, 6 Tests strips impregnated with
diazo reagent are easy to use and detect as little as 1-2µ mol bilirubin/L
V. UROBILINOGEN
An increase in the urobilinogen in urine is a sensitive indicator of hepatocellular dysfunction. It is a good indication
of alcoholic liver damage, well compensated cirrhosis or malignant disease of the liver. In viral hepatitis it appears
early in urine. It is markedly increased in hemolysis.3, 5 In cholestatic jaundice urobilinogen disappears from urine.
VI. CONCLUSION
A single liver function test is of little value in screening for liver disease as many serious liver diseases may be
associated with normal levels and abnormal levels might be found in asymptomatic healthy individuals. The use of
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battery of liver function tests, however constitutes a highly sensitive procedure. The number of false negatives must
be reduced by this technique. The use of battery of liver tests is also associated with high specificity especially when
more than one test is abnormal. The pattern of enzyme abnormality, interpreted inthe context of the patient’s
characteristics, can aid in directing the subsequent diagnostic work-up. Awareness of the prevalence of determined
liver disease in specific populations and of possible hepatic involvement during systemic illnesses or drug therapies
may help the clinician identify the cause of alterations efficiently.
REFERENCES
1. Daniel SP, Marshall MK. Evaluation of the liver: laboratory tests. Schiff’s diseases of the liver, 8th edn. USA; JB
Lippincott publications, 1999; 205-239.
2. Rosen HR, Keefe EB. Evaluation of abnormal liver enzymes, use of liver tests and the serology of viral hepatitis:
Liver disease, diagnosis and management. 1st ed. New York; Churchill livingstone publishers, 2000; 24-35.
3. Sherlock S. Assessment of liver function Disease of liver and biliary system: Sheila Sherlock, 10th edn, London;
Blackwell science ltd, 1997; 17-32.
4. Friedman SF, Martin P, Munoz JS. Laboratory evaluation of the patient with liver disease. Hepatology, a textbook
of liver disease. Philedelphia; Saunders publication, 2003; 1 : 661-709.
5. Rosalki SB, Mcintyre N. Biochemical investigations in the management of liver disease. Oxford textbook of
clinical hepatology, 2nd ed. New York; Oxford university press, 1999; 503-521.
6. American Gastroenterological association. American gastroenterological association medical position statement:
Evaluation of liver chemistry tests. Gastroenterology 2002; 123: 1364-1366.
7. Green RM, Flamm S. AGA techinal review of evaluation of liver chemistry tests. Gastroenterology 2002; 123:
1367-1384.
8. Boyde TRC, Latner AL. Starch gel electrophoresis of transaminases in human tissues extracts and serum.
Biochem J 1961; 82 : 52-57.
9. Nalpus B, Vassault A, Charpin S et al. Serum mitochondrial aspartate amonitransferase as a marker of chronic
alcoholism: diagnostic value and interpretation in a liver unit. Hepatology 1986; 6: 608-613.
10. Rej R. Measurement of aminotransferases,aspartate aminotransferases. CRC Crit Rev Clin Lab Sci 1985; 21 : 99-
103.
11. Dunn M et al the disappearance rate of glutamic oxaloacetic transaminase from the circulation and its
distri utio i the ody’s fluid o part e ts a d se retio s. J La Cli Med 1958; 51; 259.
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12. Frankl HD, Merrit JH. Enzyme activity in the serum and common bile duct. Am J Gastroenterol 1959;
31 : 166-169.
13. Katkov WN, Friedman LS Cody H et al. Elevated serum alanine aminotransferases levels in blood
donors; the contribution of hepatitis C virus. Ann Intern Med 1991; 115 : 882-887.
14. Park GJH, Lin BPC, Ngu MC et al. Aspartate aminotransferases: alanine aminotransferases ratio in
chronic hepatitis C infection : is it a predictor of cirrhosis? 2000; 15 : 386-389.