1) A Lisfranc fracture is a fracture or dislocation of the tarsal bones where they meet the bases of the metatarsal bones in the midfoot.
2) It is usually caused by high-energy twisting injuries or axial loading with the foot fixed. Common mechanisms are falls from heights or motor vehicle accidents.
3) Diagnosis involves x-rays of the foot, and sometimes CT or MRI to further evaluate bone and ligament injuries. Operative treatment is usually needed for displaced fractures to restore the normal alignment of the bones.
Lisfranc injuries -surgical management , dr mohamed ashraf ,HOD orthopaedics,...drashraf369
lisfranc injuries are a group of very complex foot injuries.these injury is notorious for missed and mismanaged due to associated more lethal multisystem trauma.dr mohamed ashraf ,dept of orthopaedics,govt medical college,alleppey,kerala,india is doing the presentation with various examples to show how not to miss these injuries.
Lisfranc injuries -surgical management , dr mohamed ashraf ,HOD orthopaedics,...drashraf369
lisfranc injuries are a group of very complex foot injuries.these injury is notorious for missed and mismanaged due to associated more lethal multisystem trauma.dr mohamed ashraf ,dept of orthopaedics,govt medical college,alleppey,kerala,india is doing the presentation with various examples to show how not to miss these injuries.
paediatric injuries around the elbow
supracondylar elbow injuries
pulled elbow in paediatric age r
radiological signs around elbow in supracondylar fracture humerus
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
2. LISFRANC FRACTURE is basically known as fracture
dislocation of tarsal and metatarsal joint complex, which
includes tarsal bones articulate with cuneiform, cuboid and
lisfranc.
The metatarsals dislocate from their normal articulation with
the mid-tarsal bones
3. Jacques Lisfranc de St. Martin
(April 2, 1790 – May 13, 1847)
Lisfranc described an amputation involving the tarsometatarsal
joint due to a severe gangrene that developed when a soldier
fell from a horse with his foot caught in a stirrup.
4. INCIDENCE
Incidence is 1 in 55,000 people each year.
Most commonly involves the 1st and 2nd metatarsals and the
medial cuneiform.
Approximately 4% of professional football players sustain
Lisfranc injuries each year.
5. ANATOMY
Ap plane, the base of the
second metatarsal is recessed
between the medial and
lateral cunieforms.
This limits translation of the
metatarsals in the frontal
plane
6. Coronal plane, middle three metatarsal bases are trapezoidal
that forming a transverse arch that prevents plantar
displacement of metatarsal bases.
The second metatarsal base is the keystone in the transverse
arch of the foot.
The bony architecture is composed of 5 MTs and their
respective articulations with the cuneiforms medially and the
cuboid laterally.
The TMT joint complex represents the dividing line between
the midfoot and the forefoot
7. LIGAMENT:
Ligamentous support begins with the strong ligamentous
linking at the bases of the 2nd through 5th metatarsals.
Most important ligament is the lisfranc ligament that attaches
from the medial cuniform to the base of second metatarsal.
8. Ligamentous, bony and soft tissue support provides intrensic stability
across the plantar aspect of lisfranc joint.
Dorsal aspect is not reinforced like the plantar aspect.
There is no ligamentous connection between the 1st and 2nd
metatarsals.
Dorsalis pedis artery dives between the first and second metatarsals
at lisfranc joint, may be damaged during injury, approach, reduction.
Motion across tarsometatarsal joints, 10-20 degree of dorsal plantar
motion at the 5th metatarso cuboidal joint
20 degree of plantar flexion from neutral at the metatarsocuneiform .
10. MECHANISM OF INJURY
3 most common mechanisms :
# Twisting
# Axial loading of a fixed foot
# Crush injury
11. TWISTING:
Forcefull abduction of the forefoot on the tarsus results in
fracture of the second metatarsal and shear or crush fracture of
the cuboid.
Commonly seen in horse riders, equestrian accidents when
a rider fell from a horse with the foot engaged in the stirrup.
Nowadays seen most commonly in motor vehicle accidents.
12. AXIAL LOADING OF A FIXED
FOOT :
Two different plantar flexion
mechanisms lead to dorsal joint
failure.
The first occurs in ankle equinus
and metatarsophalangeal joint
plantar flexion, with the Lisfranc
joint engaged along an elongated
lever arm. The joint is “rolled
over” by the body
Placing the foot into extreme
plantar flexion with an axial load
13.
14. CRUSH INJURY:
Most common in industrial type of injuries to lisfranc joint,
often with sagital plane displacement, soft tissue compromise
and compartment syndrome.
16. QUENU AND KUSS
Commonly observed pattern of injury.
HOMOLATERAL: all five metatarsals displaced in
the same direction.
ISOLATED: one or two metatarsals displaced
from the others.
DIVERGENT: displacement of the metatarsals in
both the sagittal and coronal planes
17.
18. MYERSON
Based on commonly observed patterns of injury with regard to
treatment.
TOTAL INCONGRUITY: lateral and dorsoplantar
PARTIAL INCONGRUITY: medial and lateral
DIVERGENT: partial and total
19.
20. CLINICAL PRESENTATION
Midfoot pain with difficulty in weight bearing
Swelling across the dorsum of the foot
Deformity variable due to possible spontaneous reduction.
Plantar Ecchymosis is the pathognomonic for a lisfranc injury.
21. Careful neurovascular examination to elicit dorsalis pedis
artery injury, compartment syndrome must be ruled out and
monitoring for compartment syndrome is necessary.
PIANO KEY SIGN:
Stressing the second tarsometatarsal joint by elevating
and depressing the second metatarsal head relative to the first
metatarsal head elicits pain at the Lisfranc joint.
Cant be elicited in acute condition.
24. IN AP LOOK FOR
On the AP, the lateral border of the 1st metatarsal is aligned
with the Lateral border of the medial cuneiform.
On the AP the medial border of the 2nd metatarsal is in line
with the medial border of the intermediate cuneiform
26. IN OBLIQUE VIEW LOOK FOR
Medial and lateral borders of the lateral Cuneiform should
align with the medial and lateral borders of the 3rdmetatarsal.
Medial border of the cuboid should align with the medial
border of the 4th metatarsal
28. CT
CT plays an important role in looking at the widening of the
joint spaces
CT also can detect associated fractures
Help with confirming the diagnosis
Help to formulate the surgical
treatment plan
30. MRI
MRI has an advantage in identifying partial ligament injuries
and subtle ligament injuries.
Especially useful in low velocity injuries and in settings of
Normal radiographs.
MRI can be useful to evaluate the
soft tissue damage.
Looks at the Lisfranc ligament
Not routinely used
31.
32. Doppler ultrasound may be used to look at the dorsalis pedis
artery if it can not be felt by hand
33. FRACTURES ASSOCIATED WITH LISFRANC
DISLOCATIONS
Base of 2nd metatarsal
Cuboid
Fractures of the shafts of the metatarsals
Navicular
34. MANAGEMENT
The key to successful outcome in Lisfranc injuries is
anatomical alignment of the involved joints.
Non-operative
Operative
35. NON OPERATIVE:
Injuries that present with painful weight bearing, pain with
metatarsal motion, tenderness on palpation but fail to exhibit
instability should be considered sprain.
Patient with nondisplaced ligamentous injury with or without
small plantar avulsion fractures of the
metatarsal or tarsal bones should
be placed in a below knee cast
36. Injuries can be treated with a non–weight bearing cast for 6
weeks followed by a weight bearing cast for an additional 4 to
6 weeks.
Repeat x-rays are necessary once swelling decreases, to detect
osseous displacement
37. OPERATIVE:
Operative management should be considered when
displacement of the tarsometatarsal joint is > 2mm.
Fixation should be used to maintain the reduction.
Best results are obtained through anatomic reduction and stable
fixation.
38. Most common approach is
using two longitudinal
incisions.
39.
40. A dorsal 5 cm longitudinal incision was made just lateral to the EHL,
extending from the navicular to the first metatarsal space.
Sharp dissection with minimal soft tissue disruption was carried out.
The EHL was retracted medially and the dorsalis pedis artery and the deep
peroneal nerve were retracted laterally, use a vessel loop for retraction.
41. The capsule over the base of second metatarsal was incised and the
articular surface of the middle cuneiform was identi fied.
The first and second TMT joints were reduced checking for both rotational
and angular alignment.
Provisional stabilization was performed using the threaded guide wires.
42. A second incision was made from the cuboid to the third web space distally.
The superficial peroneal nerve was protected.
The lateral border of the third metatarsal was reduced to the lateral border of
the lateral cuneiform.
A guide wire was used to fix the lateral column going from the fourth
metatarsal to the cuboid.
• Reduction was checked
46. POST-OP MANAGEMENT
Foot is immobilized in a non-weight bearing cast for 6weeks.
Progressive weight bearing is then allowed after 6weeks.
Cast removal is done once pain free full weight bearing is
achieved.
Lat column stabilization is removed at 8 to 12 weeks.
Medial column stabilization should not be removed until 6
months, better leaving screws indefinitely unless symptomatic.
47. Complications
The major complications of this fracture complex are incomplete
reduction, loss of reduction or post-traumatic arthropathy
Post traumatic arthritis:
The x-ray appearance of degeneration of the joint is not
unusual with this injury and does not correlate well with
clinical symptoms.
Anatomic reduction of the joint complex with medial column
arthrodesis is the treatment of choice for symptomatic
arthropathy
48. Compartment syndrome:
A tense swollen foot may hide a serious compartment
syndrome that may result in ischaemic contrature.
Neurovascular injury
During trauma, approach.
Infections:
49. REFERENCE:
Lisfranc Open Reduction and Internal Fixation
- Robert Frangie
Campbell's Operative Orthopaedics. 12th edition, pg 4189
Apley’s system of orthopaedics and fracture 9th edition, pg 932