Zeine 2011 LinkedIn Use of Information Technology for Global Professional Networking
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Information Technology infrastructure for global networking of higher education professionals and scholars.
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![[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Holmes (8-2010). LinkedIn’s Data Infrastructure. Beyond Search. Retrieved from http://arnoldit.com/wordpress/2010/08/17/linkedins-data-infrastructure PROFESSIONAL E-NETWORK](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
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The document discusses the concepts of linked data, how it can be created and deployed from various data sources, and how it can be exploited. Linked data allows accessing data on the web by reference using HTTP-based URIs and RDF, forming a giant global graph. It can be generated from existing web pages, services, databases and content, and deployed using a linked data server. Exploiting linked data allows discovery, integration and conceptual interaction across silos of heterogeneous data on the web and in enterprises.
What do we want computers to do for us?
This slide deck has been prepared for a workshop on Linked Data Publishing and Semantic Processing using the Redlink platform (http://redlink.co). The workshop delivered at the Department of Information Engineering, Computer Science and Mathematics at Università degli Studi dell'Aquila aimed at providing a general understanding of Semantic Web Technologies and how these can be used in real world use cases such as Salzburgerland Tourismus.
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(PROJEKTURA) open data big data @tgg osijek
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Data Infrastructure at LinkedIn
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Research institutions, governments and sometimes even the industry are promoting a way to publish data that conforms to principles of openness such as being Findable, Accessible, Interoperable and Reusable.
These principles can be adhered to in a multitude of ways: Linked Open Data is one of them; it is favoured by scientific communities, but its adoption is not limited to research contexts. In this talk I will provide an account of how my research projects enjoyed the benefits of being on either side of the FAIR data supply chain.
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The Use of Diagnostic Interventions to Improve AgilityZeine et al. Considerate Leadership in Medical and Higher Education 2014
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This document discusses challenges faced by women in medicine and academia. It provides statistics showing fewer women reach higher ranks like full professor compared to men. A study of over 4,500 faculty found women reported lower sense of belonging, self-efficacy for career advancement, and perception of gender equity and family-friendly culture. Another study identified personal factors like marital status and work environment factors like incentives and research partnerships as affecting women's research productivity in academia.
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Analysis of Mission Articulation and Customer Service Focus as Measures of Organizational Effectiveness in Higher Education InstitutionsZeine et al. Considerate Leadership in HEd., Oxford 2014
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Zeine et al. 2011 Organizational Culture in Higher Education, in Kazeroony, H...Rana ZEINE, MD, PhD, MBA
The organizational culture of higher education institutions was analyzed using a survey. The results showed that behavioral norms associated with passive/defensive and aggressive/defensive cultures were overrepresented, while constructive norms were underrepresented compared to an ideal profile. This indicates a focus on tasks over people and lower-order needs over higher-order needs. Gaps between current and ideal profiles were identified to help target areas for cultural change in higher education institutions.Zeine 2011 Changing Organizational Culture in Higher Education Institutions
Recommendations to enhance constructive organizational cultural styles in Higher Educationa Institutions.
Su, Lin, Zeine et. al. Am J OBGYN 2009
This study investigated the role of estrogen receptor-beta (ESR2) in regulating cyclooxygenase-2 (COX-2) expression and prostanoid levels in human placental villous endothelial cells. The researchers found that knocking down ESR2 led to decreased COX-2 mRNA and protein levels as well as diminished prostacyclin and thromboxane concentrations in the cells, both in the presence and absence of estradiol. This suggests that ESR2 mediates COX-2 expression and prostanoid levels in a ligand-independent manner, playing a role in fetoplacental vascular function. Further investigation of ESR2 regulation of prostanoid biosynthesis and its effects on the fetop
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World Cancer Congress 2010
Presence of Cancer-Associated Fibroblasts correlates with Microvascular Proliferation which is a Poor Prognostic Factor in Neuroblastoma Tumors Zeine et al. Modern Pathology 2009
This study analyzed cancer-associated fibroblasts in 60 primary neuroblastoma tumors and a neuroblastoma xenograft model. Cancer-associated fibroblasts were characterized by expression of α-smooth muscle actin but not high-molecular weight caldesmon. High numbers of cancer-associated fibroblasts were associated with Schwannian stroma-poor histology and microvascular proliferation in human tumors. In xenografts with infiltrating Schwann cells, cancer-associated fibroblasts were approximately sevenfold less than controls without Schwann cells, suggesting Schwann cells may prevent fibroblast activation.
Peddinti, Zeine et al. Clinical Cancer Research 2007
This study examined microvascular proliferation (MVP) in neuroblastoma tumors to determine its clinical significance. MVP, including glomeruloid MVP, was significantly associated with poor prognosis in two independent cohorts of neuroblastoma patients. MVP was also significantly associated with the clinically aggressive Schwannian stroma-poor histology of neuroblastomas. These findings provide further evidence that angiogenesis plays an important role in neuroblastoma pathogenesis and behavior, and suggest angiogenesis is regulated differently depending on the amount of Schwannian stroma in the tumor.
Yang et al. Cancer Research 2007
This research article examines the combination of ABT-510, a peptide derivative of the natural angiogenic inhibitor thrombospondin-1, and valproic acid (VPA), a histone deacetylase inhibitor, as a potential antiangiogenic treatment strategy for high-risk neuroblastoma in children. In vitro, only VPA was able to inhibit neuroblastoma cell proliferation and induce apoptosis, but both ABT-510 and VPA significantly suppressed the growth of neuroblastoma xenografts in mice. Combination therapy more effectively inhibited tumor growth than single agents and achieved total cessation of tumor growth in some mice with large xenografts. The microvascular density and number of abnormal vessels in
Zeine & Owens, J. Neuroimmunology 1992
This study directly analyzed the infiltration of the central nervous system (CNS) by PKH2-labeled, myelin basic protein (MBP)-reactive CD4+ T cells in mice with experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. The researchers found that about 45% of CD4+ T cells in the CNS at disease onset were PKH2-labeled cells that had infiltrated from the periphery. Nearly all of these cells in the CNS exhibited a memory/effector phenotype of being CD44high and CD45RBlow and responded to MBP in vitro, indicating antigen recognition promoted their retention in the CNS. In contrast, few PK
Zeine & Owens, J. Neuroimmunology 1993
1) The study examined CD4+ T cells in the central nervous system (CNS) of mice during experimental allergic encephalomyelitis (EAE), both during active disease and remission.
2) Flow cytometry analysis revealed a 30-fold reduction in the number of CD4+ T cells in the CNS of mice in remission compared to those with active EAE.
3) However, the CD4+ T cells that remained in the CNS during remission maintained an activated memory/effector phenotype, suggesting remission is not due to downregulation of T cell function.
Zeine et al. J. Neuroimmunology 1993
This document describes a study examining the effects of T cell vaccination on the immune response in mice protected against experimental allergic encephalomyelitis (EAE). The researchers found that vaccination with myelin basic protein (MBP)-reactive T cell lines protected SJL/J mice against EAE induced by rat spinal cord homogenate. Lymph node cells from vaccinated mice showed enhanced proliferative responses to MBP and an encephalitogenic peptide from proteolipid protein, compared to untreated mice. The augmentation of responses was not antigen-specific and also occurred for ovalbumin. This suggests vaccination led to non-specific enhancement of immune activation in peripheral lymphoid tissues.
Zeine et al. J. Neuroscience Research 2001
This study examined the effects of perforin, a pore-forming protein, on oligodendrocytes cultured from SJL mice. Oligodendrocytes were exposed to perforin for up to 2.5 hours and examined using microscopy. The results showed that the majority of oligodendrocytes were killed within 60-90 minutes via pore expansion and membrane disruption. Structural features included cell body swelling, fenestration and fragmentation of membranes and processes, cytoplasmic vacuolation, and breakdown of the nuclear envelope. These patterns of damage resembled those seen in multiple sclerosis lesions. The findings suggest that perforin may play an important role in demyelination in multiple sclerosis.
Zeine et al. J. Neuroimmunology 1998
1. The study examines the mechanism by which gd T cells induce cytotoxicity of human oligodendrocytes, which are relevant to multiple sclerosis.
2. The results show that gd T cells from MS patients utilize both the Fas-mediated and perforin-based pathways to exert cytotoxic effects on oligodendrocytes.
3. Blocking perforin release completely inhibited killing of targets expressing high levels of heat shock proteins, but additional blocking of Fas ligand was required to fully inhibit killing of Fas-expressing targets and fresh oligodendrocytes.
Zeine et al. Poster 2007 Cancer Associated Fibroblasts in Neuroblastoma
This document summarizes a study examining the presence of cancer-associated fibroblasts (CAFs) in different subtypes of neuroblastoma tumors. The study found that CAFs, identified by alpha-smooth muscle actin expression, were abundant in schwannian stroma-poor neuroblastoma regions and associated with microvascular proliferation, but were less prevalent in schwannian stroma-rich regions. This suggests CAFs may promote angiogenesis in aggressive, schwannian stroma-poor neuroblastomas.
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