Origin and Evolution of Life by Ratnodip SahaRatnodip Saha
Here I've discussed, how life originated on earth and how it evolved to today's form.
Contents:
What is life? What is life cycle?
Abiogenesis or Origin of life: chemogeny & biogeny
Steps of Abiogenesis
What is Hot dilute soup theory?
Protocells: coacervates & microspheres
What is evolution?
What is variation?
Differences between variation and Mutation
Delivered this as talk series on Evolution to some of my colleagues interested in systems thinking. It was a great learning for me and will incorporate it into a sequel later.
Updates:
1. Version 2013.11.23 - Reorganized some slides, added images and credits
2. Version 2013.11.25 - Reorganized presentation around three aspects. Added better intro.
3. Version 2013.11.26 - Updated implications aspect for global warming and behavioral sink.
4. Version 2013.11.27 - Updated taxonomy discussion.
5. V 2013.12.05 - Updated natural selection, convergent evolution and punctuated equilibrium. Reorg of slides.
6. V 2013.12.16 - Added chaos and self-organization slides.
7. V 2013.12.21 - Added extinctions and explosions.
8. V2013.12.23 - Added more chaos explanation and Wikipedia logo.
9. V2014.05.05 - Corrected spelling mistakes and cleaned up slides.
Origin and Evolution of Life by Ratnodip SahaRatnodip Saha
Here I've discussed, how life originated on earth and how it evolved to today's form.
Contents:
What is life? What is life cycle?
Abiogenesis or Origin of life: chemogeny & biogeny
Steps of Abiogenesis
What is Hot dilute soup theory?
Protocells: coacervates & microspheres
What is evolution?
What is variation?
Differences between variation and Mutation
Delivered this as talk series on Evolution to some of my colleagues interested in systems thinking. It was a great learning for me and will incorporate it into a sequel later.
Updates:
1. Version 2013.11.23 - Reorganized some slides, added images and credits
2. Version 2013.11.25 - Reorganized presentation around three aspects. Added better intro.
3. Version 2013.11.26 - Updated implications aspect for global warming and behavioral sink.
4. Version 2013.11.27 - Updated taxonomy discussion.
5. V 2013.12.05 - Updated natural selection, convergent evolution and punctuated equilibrium. Reorg of slides.
6. V 2013.12.16 - Added chaos and self-organization slides.
7. V 2013.12.21 - Added extinctions and explosions.
8. V2013.12.23 - Added more chaos explanation and Wikipedia logo.
9. V2014.05.05 - Corrected spelling mistakes and cleaned up slides.
Chapter 17
Evoution of Life
The Origin of Life
Did Life on Earth Originate on Mars?
Early Life on Earth
Charles Darwin and The Origin of Species
How Natural Selection Works
Adaptation
Staying Warm and Keeping Cool
Evolution and Genetics
How Species Form
Evidence of Evolution
Fossils: Earth's Tangible Evidence of Evolution
The Evolution of Humans
History of Science: The Peppered Moth
Science and Society: Antibiotic-Resistant Bacteria
Chapter 17
Evoution of Life
The Origin of Life
Did Life on Earth Originate on Mars?
Early Life on Earth
Charles Darwin and The Origin of Species
How Natural Selection Works
Adaptation
Staying Warm and Keeping Cool
Evolution and Genetics
How Species Form
Evidence of Evolution
Fossils: Earth's Tangible Evidence of Evolution
The Evolution of Humans
History of Science: The Peppered Moth
Science and Society: Antibiotic-Resistant Bacteria
If you look around you will see a large variety of living organisms, be itpotted plants, insects, birds, your pets or other animals and plants. Thereare also several organisms that you cannot see with your naked eye butthey are all around you.
Protozoa (also protozoan, plural protozoans) is an informal term for a group of single-celled eukaryotes, either free-living or parasitic, which feed on organic matter such as other microorganisms or organic tissues and debris.
IT IS A LIST OF
WONDERS OF NATURE SERIES OF BOOKS PUBLISHED BY ME ON WEEBLY.COM .
SOME OF THESE BOOKS ARE ON SCRIBD.COM AND SOME ON SLIDE SHARE .NET AS WELL;
ALL COVER SCIENTIFIC TOPICS; 2 BOOKS ARE IN ENGLISH AND REST IN BILINGUAL ( ENGLISH/HINDI ) FORMAT ;
ALL IN SEMI POETIC STYLE
MANY ARCHAEA ARE EXTREMOPHILES SOME ARE HALOPHILIC, BUT SOME ARE HYPERHALOPHILIC ,SOME ARE ALKALOPHILIC SOME HYPER ALKALOPHILIC BUT SOME ARE DOUBLE EXTREMOPHILES BEING HYPER HALO ALKALIPHILIC LIKE NATRIALBA -A FACULTATIVE ANAEROBE WHICH IS EXOELECTROGEN AS WELL AND CAN PRODUCE ELECTRICITY IN SUNLIGHT AS WELL AS MFC .
MANY ARCHAEA & BACTERIA ARE EXTREMOPHILES BUT SOME ARCHAEA ARE HYPER THERMOPHILES LIKE SULFOLOBALES DISCOVERED FIRST IN SOLFATANA VOLCANO ITALY AND LATER IN MANY HOT SPRINGS AND HOT MUD POOLS
THEY HAVE SPECIAL STRUCTURE AND METABOLISM TO BE ABLE TO SURVIVE AT 70-85 C MAIN THING IS THEY CAN GENERATE ELECTRICITY EVEN AT 80 C IN MFC
INTERESTINGLY THEY HAVE BEEN SELECTED FOR SPACE TRIPS BY NASA .
CHLAMYDOMONAS IS A WONDERFUL ORGANISM KNOWN FOR ITS MANY FEATURES AND QUALITIES ;BUT THESE DAYS IT IS IN NEWS MAINLY FOR ITS ABILITY TO CONVERT LIGHT INTO ELECTRICITY DIRECTLY IN ITS
' EYE ' AND IN MFC ;HERE WE HAVE FOCUSED ON TRANSFER OF ELECTRONS OBTAINED FROM PHOTOSYNTHETIC REACTIONS TO ANODES INMFC
EXOELECTROGENS ARE ELECTROACTIVE ORGANISMS CAPABLE OF TRANSFERING ELECTRONS OUTSIDE THEIR CELLS
PYROCOCCUS IS ONE SUCH MICROORGANISM -A HYPERTHERMOPHILE CAPABLE OF TRANSFERING ELECTRONS TO ANODES AND PRODUCE ELECTRICITY EVEN AT 90C IT IS A UNIQUE ORGANISM IN MANY RESPECTS
EXOELECTROGENS ARE CAPABLE OF EXPORTING ELECTRONS OUT OF THEIR CELLS AND HAVE GREAT AFFINITY WITH ELECTRODES;HENCE THEY TRANSFER EXCESS ELECTRONS PRODUCED DURING PHOTOSYNTHESIS OR RESPIRATION .MANY BACTERIA AND ALGAE ARE ELECTRO ACTIVE AND MACRO ALGAE ARE ONE OF THEM AND HAVE BEEN FOUND TO BEMORE EFFICIENT THAN BACTERIA AS EVIDENT FROM THE EXPERIMENTS BY SHLODBERG ON ULVA.
EXO ELECTROGENIC SPECIES ARE FOUND IN MANY GENERA OF EUKARYOTIC AS WELL AS PROKARYOTIC ORGANISMS ;BUT BACTERIA ,PARTICULARLY CYANOBACTERIA AND PHOTOSYNTHETIC EUKAROTES LIKE ALGAE AREIN THE FOREFRONT - BOTH MICRO AMD MACRO ALGAE ARE BEING UTILISED WITH OR WITHOUT BACTERIA IN MFCs FOR TREARING POLLUTED WATER AND SIMULTANEOUS PRODUCTION OF ELECTRICITY -THE ADVANTAGE WITH ALGAE IS THEY SUCK IN CO2 AND GIVE OUT O2 AND ARE THUS
BETTER FOR ENVIRONMENT
NITZCHIA IS A LARGE GENUS OF DIATOMS WHICH INCLUDES BOTH FRESH WATER AND MARINE SPECIES -MANY TOXIC ALSO;BUT THEY ALSO SERVES AS GOOD BIOSENSORS MAINLY DUE TO THEIR BIOLUMINESCENT POROUS SILICON FRISTULE
DIATOMS LIKE NITZSCIA ARE ALSO PREFERRED DUE TO THEIR OIL PRODUCTION AND OTHER USES OF THEIR FRISTULE
EXOELECTROGENS ARE ORGANISMS
WHICH CAN RECEIVE ELECTRONS FROM DONARS AND CAN EXPORT
ELECTRONS OUTSIDE THE CELL OR CELLS
THE ELECTRONS PRODUCED DURING PHOTOSYNTHESIS OR RESPIRATION AVAILABLE TO THEM CAN BE PASSED ON TO ELCTRON ACCEPTORS VIA ELECTRODES AND DURING THE PROCESS ELECTRICITY GETS GENERATED IN THE CIRCUIT .
THE CHALLENGE IS TO EXTRACT ELECTRONS AND USE THEM FOR POWER GENERATION AS WELL AS SIMULTANEOUSLY CLEAN POLLUTED WATER AND PRODUCE HYDROGEN ETC AND OTHER BY PRODUCTS .
CYANOBACTERIA ARE ONE MOST OF THE MOST FAMOUS BACTERIA -KNOWN FROM PRECAMBIAN DAYS AND DISTINGUISHED AS MULTITASK MASTERS -EARLIER CONSIDERED RESPONSIBLE FOR OXYGENATED ATMOSPHERE WHERE AEROBICS FLOURISHED AND FOR NITROGEN FIXING ABILITIES BUT KNOW VALUED EQUALLY FOR THEIR CONVERTINF LIGHT ENERGY INTO ELECTRICAL ENERGY ;AND ALSO FOR CAPABILITY TO PRODUCE HYDROGEN AND ORGANICS LIKE ETHANOL ETC
SHEWANELLA - VERSATILE EXOELECTROGENIC FACULTATIVE ANAEROBE CAPABLE OF GENERATING ELECTRICITY BY REDUCING MANY METALS WHILE RESPIRING AND TRANSFERING ELECTRONS EXTRACELLULARLY
HENCE THEIR BIOFILMS AREUSED IN MFCs,MECs. ;KNOWN FOR THRIVING ON A VARIETY OF SUBSTRATES AND REDUCING MANY NOBLE METALS LIKE GOLD SILVER PLATINUM ETC ; ALSO CAPABLE OF PRODUCING HYDROGEN AND H2S; ALSO FAMOUS FOR BIOSYNTHESIS OF NANOPARICLES ;PRAISED FOR EFFICIENCY OF ITS NANOWIRES AND BIOFILMS ; CAN GENERATE ELECTRICITY FROM WASTE ALSO;HENCE SELECTED FOR DEEPSPACE RESEARCH -COULD SOLVE ASTRAUNOTS URINE DISPOSAL PROBLEM AS IT CAN MAKE IT REUSABLE WHILE PROVIDING POWER TO SATELLITE;IT IS ALSO INFAMOUS FOR SPOILING FOOD-FISH MEAT ETC AND CAUSING DISEASES IN HUMANS .
GEOBACTER IS ONE OF THE MOST FAMOUS EXOELECTROGENIC BACTERIA WHICH WAS THE FIRST BACTERIUM DISCOVERED WITH CAPABLITY OF OXIDISING ORGANIC COMPONDS AND METALS( INCLUDING RADIOACTIVE METALS AND PETROLEUM COMPOUNDS )INTO CO2 USING IRONOXIDE ETC AS ELECTRON ACCEPTOR AND PRODUCING ELECTRIC CURRENT. ITHAS BEEN USED IN VARY MANY EXPERIMENTS TO TEST THE WONDERFUL QUALITIES, ABILITIES AND CAPABILITIES OF VERSATILE EXOELECTROGENS AND THEIR USE FOR BIOREMEDIATION AND BIOFUEL PRODUCTION., THEY ARE ALSO CAPABLE OF RESPIRING ON GRAPHITE ELECTRODES
EXOELECTROGENS ARE VERSATILE HEROES CAPABLE OF SIMULTANEOUSLY DELIVERING MULTIPLE BENEFITS TO US INVARIOUS FIELDS RANGING FROM BIOREMEDIATION TO ENERGY,ENVIRONMENT, SENSORS, CLEAN BIO FUELS DESALINATION,Etc AND ARE POISED TO SOLVE OUR WASTE DISPOSAL PROBLEM EVEN IN SPACE.
ONE FEALS LIKE SALUTING THEM FOR THEIR MULTIPLE TALENTS.
THEY INCLUDE MAINLY BACTERIA BUT ALSO MICRO ALGAE, FUNGI,AND EVEN SOME ANGIOSPERMS .
EXOELECTROGENS ARE ORGANISMS WHICH ARE CAPABLE OF SENDING EXCESS ELECTRONS OUT OF THE CELL TO AN ULTIMATE ELECTRON ACCEPTOR . THE MOST FAMOUS EXOELECTROGENS INCLUDE GEOBACTER & SHEWANELLA BACTERIA. THEIR THESE QUALITIES ARE BEING USED IN MICROBIAL FUEL CELLS .
THEIR APPLICATION FOR PRODUCING ELECTRICITY FROM WASTEWATERS BIOREMEDIATION
CHAMPIONS OF THE PLANT KINGDOM - CONTENTS SNIP.docxSantoshBhatnagar1
HERE 'PLANT KINGDOM' HAS BEEN USED IN LARGER SENSE TO INCLUDE NOT ONLY PLANTAE BUT ALSO PROTISTA FUNGI BACTERIA AND LICHENS AND EXTENDED TO INCLUDE EVEN THE ENEMIES OF ALL LIVING BEINGS -THE VIRUSES .
CHAMPION FUNGI -PHELLINUS ELLIPSOIDEUS - LARGEST FRUITING BODY - SNIP PD.docxSantoshBhatnagar1
PHELLINUS ELLIPSOIDEUS PREFERS INFECTING DRYING OR DRY LOGS OF WOOD AND IS KNOWN FOR ITS UNUSUALLY LARGE FRUITING BODY WHICH HAS PROVED TO BE THE LARGEST IN THE WORLD
'AND IS CAPABLE OF RELEASING OR RATHER SHOWERING A TRILLION SPORES FROM MILLIONS OF PORES PER DAY.
VIRUSES ARE NOT CONSIDERED LIVING BEINGS BUT EVEN IF THEY WERE THEY WOULD NOT FIT IN ANY KINGDOM ;THEY ARE ACTUALLY ENEMIES OF ALL KINGDOMS OF LIVING BEINGS;
HENCE I WAS INITIALLY RELUCTENT TO INCLUDE THEM IN ABOOK ABOUT LIVING BEINGS BUT THEN I THOUGHT WITHOUT THEM THE STORY OF LIVING BEINGS IS NOT COMPLETE ;FURTHER THEY ARE NOT TREATED AS LIVING BY OUR DEFINITION OF LIFE AND LIVING BEINGS OTHERWISE THEY HAVE MANY CHARCTERISTICS OF BEINGS AND ARE WORTHY OF DUE CONSIDERATION AND FIT INTO OUR DEFINITION OF CHAMPIONS
AMONGST VIRUSES PITHO VIRUSESARE LARGEST AND MOST ANCIENT AND WITH MANY INTERESTING FEATURES .
IT IS A PRAYER INCORPORATING THANKS TO CHAMPION OFCHAMPIONS- LORD VISHVKARMA -GREAT GOD WHO CREATED THIS UNIVERSE AND SCOPE OF CHANPIONSHIP TO EACH CLASS AND CATEGORY OF LIVING BEINGS
IT IS INTERESTING TO KNOW THAT THERE ARE TWO CLAIMENTS FOR THE TITLE OF SMALLEST BACTERIA
AND BOTH ARE RIGHT IN THEIR OWN
WAY - MYCOPLASMA AS A PARASITE AND PELAGIBACTER AS A SELF SUFFICIENT ORGANISM .
BACTERIA ARE THEMSELVES MICROORGANISMS BUT THEY AREOF DIFFERENT SIZES AND MYCOPLASMA ARE SMALLEST PARASITIC BACTERIA;THEY ARE HOWEVER MORE KNOWN OR FEARED DUE TO THEIR PARASITIC NATURE.PARTICULARLY THEIR VARIETIES WHICH CAUSE SERIOUS DISEASES IN HUMANBEINGS.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Lateral Ventricles.pdf very easy good diagrams comprehensive
Life sustaining processes phenomenaJeev jagat ki Adharshila chapter 13 kingdoms english poem English
1. Jeev jagat Chapter 13 ki Adharshhila 1
Kingdoms of Life
Homosapiens & other species
Sons of Adam and Eve
day & night morning eve
have proudly proclaimed
from the top of every hill in sight
Right from the grand old time
when they started to cultivate ,
hunt ,capture or domesticate,
animals bigger than themselves
saying without thinking twice
that they are a superior race
Master of all the animal kind
better than all of them overall
They are intelligent, brilliant & bright
they know what is wrong or right
they can do what others can not
they perform what others do not
2. Jeev jagat 2
It is a boon to be born a Man
a privilege our own alone
obtained only by God’s grace
doing deeds which pleased the Gods
All this tempted me to try
to test this bragging about, the
‘ Uniqueness of Man in the Universe’
on the touchstone of science
And so I browsed through the
modern scientific literature
focusing on the qualities
which other species possess
And see and show ,in the
light of all this ,how far
this is true ,if at all;
How Man stands after all
in comparison with the species
of other domains or kingdoms
and various varieties of the
kingdom animalia in particular.
3. Jeev jagat 3
The first to breath on earth we know
Leeuwenhoek’s animalcule bacteria alone
whether Eu or Archae we do not know
but were extremophiles we are almost sure
They were the ones who
created the RNA world
of millions unicellular cells,
with ribosomes in cytosol gel!
They were the ones who knew
the trick of self assembly of
molecules,and the skill of
RNA replication somehow
Multiplication by cell division
also seems to be their invention
along with utilizing lipids & protein
for metabolism and membrane
They were the ones who began
hunter hunted line of food chain
and showed also that symbionts can
do, better than whatever each alone can
4. Jeev jagat 4
The Cyanobacteria of their tribe
did wonders no one can deny
causing first great extinction
filling with oxygen the whole sky
using the bacterial Chlorophyll
for trapping sun light and making
carbohydrates ensuring their supply
and in giving rise, to many a many
new varieties or forms of Life
which were dependent on
oxygen instead of methane,
in the universal survival game
They were the ones to start using
the DNA for heredity and variation
mastering conjugation transformation
and transduction also for reproduction
ultimately giving rise to eukaryotic
Protista the parent kingdom of
The fungi animalia & plantae
Via protophyta ,protozoa & protofungi
5. Jeev jagat 5
For the first 2 billion years
they ruled the world all alone
And then joined evolving domain
of eukaryotes in the struggle of existence
Harming them by causing diseases
helping them in various ways
inventing Nitrogen fixation techniques
they still sustain life in many ways
Perhaps protista’s greatest contribution
is broadening the canvas of life
with a wide range of forms,& nutrition
life cycles and modes of locomotion
Unicellular ,colonial , multicellular forms
of a variety of styles , designs and shapes
gliding , floating, swimming ,micro or macro
autotrophic or heterotrophic all crowded the seas
Intensification of struggle for life
is discernible and the modes of
offense & defense ,symbiosis as well as
parasitism reached new heights
6. Jeev jagat 6
Amongst protophyta the Algae
stole the show with great variety
of their forms, colours and styles
becoming founding fathers of Plantae
They are a polyphyletic popular grouping
of unrelated plant like organisms
apparently of bacterial parentage
with a question mark about their origins
Their pigments are said to be
a gift of their cyanobacterial friends
symbiosis with fungi ,corals ,sponges ,
gives them a remarkable stand
They contribute merrily to greenery
oxygen sugars oils & minerals
make corals look so beautiful
are capable of solving our problems !
Bioluminescence of some of them charms
but blooms of many are pretty dangerous
causing death and destruction all around
of uncountable living ones in their prime.
7. Jeev jagat 7
Fungi are no less wonderful
rulers of the underground world
invisible supporters of large jungles
forming their connecting channels as well
Acting as pioneers in association
with cyanobacteria or algae as lichens
are inventers of antibiotics which save life
but cause serious diseases which destroy life
Of protozoa enough to say
many of their modes of nutrition
locomotion and reproduction
have jolly well come to stay
Via inheritance from them
by succeeding kingdom animalia
Thankful for these grand pa’s inventions
we are merrily carrying on
with each phylum adding its own
special features and techniques
to the treasure house of the world’s
large living community over all
8. Jeev jagat 8
And we the men have learnt
a lot from our brotheren from
sister phyla and other classes
for it seems, envy has its own uses
Of Plantae ,what we can say for it is they
made earth inhabitable by us in a way
bequeathing greenery ,providing energy
and making it pleasant by its colourful ways
We must be indeed thankful
to the God ,if any ,and its Nature
for providing such a nice company
of plants ,animals and other creatures
And blessing us with mind and wisdom
capacity to learn and befriend them all
use them as best as we can in our struggle
and survive in their company so far so well .
NB : -----------
The only regret is that Virus blight
of uncertain origin and unknown tribe
still haunts us in our dreams
is still free to hurt us and jibe .