A 60-year-old woman presented with lesions on her hands that had been present for 20 years. A skin biopsy showed mild thickening of the epidermis, thickening and scaling of the skin surface, and inflammatory cells in the dermis surrounding blood vessels. The diagnosis was seborrheic keratosis based on the histological examination findings.

1. Lesions on the hands
What is you diagnosis?
www.dermatoblog.com
F. Peral Rubio, M.D.
Department of Dermatology
Hospital Universitario Virgen Macarena
Seville, Spain

2. Lesions on the hands
A 60 -years-old woman.
 The patient was referred to us for the
assessment of lesions on the hands 20
years previously.

11. Lesions on the hands
 Skin biopsy was performed and
histological examination showed:
• Mild acanthosis with slight papillomatosis.
• There was also hyperkeratosis, most marked
at the edges of the lesion, with moderate
hypergranulosis and a thin layer of
orthokeratosis.
• The dermis was infiltrated with a few
inflammatory cells surrounding the vessels

12. Lesions on the hands
What is you diagnosis?
www.dermatoblog.com
F. Peral Rubio, M.D.
Department of Dermatology
Hospital Universitario Virgen Macarena
Seville, Spain