A 35-year-old woman was referred to a dermatologist for evaluation of a lesion on her right leg that had been present for 3 years. Based on the limited information provided, the dermatologist cannot make a definitive diagnosis about the lesion.
This presentation deals with the basics of Genetics, a little about the Human Genome Project and just a touch on Genodermatosis & Chromosomal Disorders
This presentation deals with the basics of Genetics, a little about the Human Genome Project and just a touch on Genodermatosis & Chromosomal Disorders
Pengertian seborrhea
Adalah suatu peradangan pada kulit bagian atas, yang menyebabkan timbulnya sisik pada kulit kepala, wajah dan kadang pada bagian tubuh lainnya. Biasanya, proses pergantian sel-sel pada kulit kepala terjadi secara perlahan-lahan dan tidak terlihat oleh mata. Proses pergantian tersebut terjadi setiap bulan. Jika proses ini menjadi lebih cepat, maka akan timbul gangguan pada kulit kepala yang kita sebut ketombe. Gangguan yang lebih parah yaitu dermatitis seboroik, berupa serpihan berwarna kuning berminyak yang melekat pada kulit kepala.
Etiologi
Faktor hereditas, yaitu disebabkan karena adanya faktor keturunan orang tua :
Intake makanan berlemak dan berkalori tinggi
Asupan minuman beralkohol
Adanya gangguan emosi
Kelenjar minyak pada bayi biasanya bekerja terlalu aktif akibat tingginya kadar hormon ibu yang mengalir didalam tubuh bayi
Pengaruh hormon ibu biasanya hanya berlangsung pada bulan-bulan pertama kehidupan sikecil.
Pemeriksaan penunjang
Pemeriksaan yang dapat dilakukan pada pasien dermatitis seboroik adalah pemeriksaan histopatologi walaupun gambarannya kadang juga ditemukan pada penyakit lain, seperti pada dermatitis atopik atau psoriasis. Gambaran histopatologi tergantung dari stadium penyakit.
Diagnosis banding
Diagnosis banding dermatitis seboroik tergantung pada lokasi dari kelainan dan umur dari pasien. Pada anak, diferensial diagnosisnya adalah :
Psoriasis VulgarisPsoriasis vulgaris meskipun jarang pada bayi, memiliki ciri yang mirip dengan dermatitis seboroik.
2. Pitiriasis Rosea
Pitiriasis rosea ialah penyakit kulit yang belum diketahui penyebabnya, dimulai dengan lesi inisial berbentuk eritema dan skuama halus.
3. Tinea kapitis
Tinea kapitis adalah kelainan pada kulit dan rambut kepala yang disebabkan oleh spesies dermatofit dan biasanya menyerang anak–anak. Kelainan pada tinea kapitis dapat ditandai dengan lesi bersisik, kemerahan.
Pencegahan diagnosis
Diagnosis dapat ditegakkan berdasarkan :
Anamnesa
Pemeriksaan fisik
Riwayat penyakit
gambaran klinis maupun hasil dari pemeriksaan penunjang
Dari riwayat didapatkan bahwa dermatitis ini terjadi pada bayi terutama yang berusia 1 bulan, tampak sebagai peradangan yang mengenai kulit kepala dan lipatan-lipatan intertriginosa yang disertai skuama berminyak dan krusta.
Penatalaksanaan seborrhea
Penatalaksanaan seborrhea tergantung kepada usia penderita.
1. Anak-anak
Untuk ruam bersisik tebal di kulit kepala, bisa dioleskan minyak mineral yang mengandung asam salisilat secara perlahan dengan menggunakan sikat gigi yang lembut pada malam hari.
2. Bayi
Kulit kepala dicuci dengan sampo bayi yang lembut dan diolesi dengan krim hydrocortisone. Selama ada sisik, kulit kepala dicuci setiap hari dengan sampo yang lembut. setelah sisik menghilang cukup dicuci 2 kali/minggu.
Pencegahan seborrhea
Pencegahan dapat dilakukan dengan cara sebagai berikut:
Hindari rangsangan gesek, lebih berhati-hati menggunakan sabun
Cysts with a lining of stratified squamous epithelium: Epidermoid cyst
Milium
Trichilemmal cyst
Vellus hair cyst
Steatocystoma
Dermoid cyst
Cysts lined with non-stratified squamous epithelium: Hidrocystoma, Eccrine or Apocrine
Cysts without an epithelial lining: Mucocele
Digital mucous cyst
Ganglion
They are a heterogenous group of inherited disorders of epidermal differentiation featuring excessive scaling, Ichthyosis vulgaris,
X-linked recessive ichthyosis,
Lamellar ichthyosis,
Non-bullous ichthyosiform erythroderma,
Bullous ichthyosiform erythroderma,
Ichthyosis bullosa of Siemens,
Harlequin ichthyosis
Pengertian seborrhea
Adalah suatu peradangan pada kulit bagian atas, yang menyebabkan timbulnya sisik pada kulit kepala, wajah dan kadang pada bagian tubuh lainnya. Biasanya, proses pergantian sel-sel pada kulit kepala terjadi secara perlahan-lahan dan tidak terlihat oleh mata. Proses pergantian tersebut terjadi setiap bulan. Jika proses ini menjadi lebih cepat, maka akan timbul gangguan pada kulit kepala yang kita sebut ketombe. Gangguan yang lebih parah yaitu dermatitis seboroik, berupa serpihan berwarna kuning berminyak yang melekat pada kulit kepala.
Etiologi
Faktor hereditas, yaitu disebabkan karena adanya faktor keturunan orang tua :
Intake makanan berlemak dan berkalori tinggi
Asupan minuman beralkohol
Adanya gangguan emosi
Kelenjar minyak pada bayi biasanya bekerja terlalu aktif akibat tingginya kadar hormon ibu yang mengalir didalam tubuh bayi
Pengaruh hormon ibu biasanya hanya berlangsung pada bulan-bulan pertama kehidupan sikecil.
Pemeriksaan penunjang
Pemeriksaan yang dapat dilakukan pada pasien dermatitis seboroik adalah pemeriksaan histopatologi walaupun gambarannya kadang juga ditemukan pada penyakit lain, seperti pada dermatitis atopik atau psoriasis. Gambaran histopatologi tergantung dari stadium penyakit.
Diagnosis banding
Diagnosis banding dermatitis seboroik tergantung pada lokasi dari kelainan dan umur dari pasien. Pada anak, diferensial diagnosisnya adalah :
Psoriasis VulgarisPsoriasis vulgaris meskipun jarang pada bayi, memiliki ciri yang mirip dengan dermatitis seboroik.
2. Pitiriasis Rosea
Pitiriasis rosea ialah penyakit kulit yang belum diketahui penyebabnya, dimulai dengan lesi inisial berbentuk eritema dan skuama halus.
3. Tinea kapitis
Tinea kapitis adalah kelainan pada kulit dan rambut kepala yang disebabkan oleh spesies dermatofit dan biasanya menyerang anak–anak. Kelainan pada tinea kapitis dapat ditandai dengan lesi bersisik, kemerahan.
Pencegahan diagnosis
Diagnosis dapat ditegakkan berdasarkan :
Anamnesa
Pemeriksaan fisik
Riwayat penyakit
gambaran klinis maupun hasil dari pemeriksaan penunjang
Dari riwayat didapatkan bahwa dermatitis ini terjadi pada bayi terutama yang berusia 1 bulan, tampak sebagai peradangan yang mengenai kulit kepala dan lipatan-lipatan intertriginosa yang disertai skuama berminyak dan krusta.
Penatalaksanaan seborrhea
Penatalaksanaan seborrhea tergantung kepada usia penderita.
1. Anak-anak
Untuk ruam bersisik tebal di kulit kepala, bisa dioleskan minyak mineral yang mengandung asam salisilat secara perlahan dengan menggunakan sikat gigi yang lembut pada malam hari.
2. Bayi
Kulit kepala dicuci dengan sampo bayi yang lembut dan diolesi dengan krim hydrocortisone. Selama ada sisik, kulit kepala dicuci setiap hari dengan sampo yang lembut. setelah sisik menghilang cukup dicuci 2 kali/minggu.
Pencegahan seborrhea
Pencegahan dapat dilakukan dengan cara sebagai berikut:
Hindari rangsangan gesek, lebih berhati-hati menggunakan sabun
Cysts with a lining of stratified squamous epithelium: Epidermoid cyst
Milium
Trichilemmal cyst
Vellus hair cyst
Steatocystoma
Dermoid cyst
Cysts lined with non-stratified squamous epithelium: Hidrocystoma, Eccrine or Apocrine
Cysts without an epithelial lining: Mucocele
Digital mucous cyst
Ganglion
They are a heterogenous group of inherited disorders of epidermal differentiation featuring excessive scaling, Ichthyosis vulgaris,
X-linked recessive ichthyosis,
Lamellar ichthyosis,
Non-bullous ichthyosiform erythroderma,
Bullous ichthyosiform erythroderma,
Ichthyosis bullosa of Siemens,
Harlequin ichthyosis
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
1. Lesion on the leg.
What is you diagnosis?
F. Peral Rubio, M.D.
Department of Dermatology
Hospital Universitario Virgen Macarena
Seville, Spain
2. What is you diagnosis?
Lesion on the leg.
A 35-years-old women.
The patient was referred to us for the
assessment of a lesion on the right
leg 3 years
3.
4.
5.
6. Lesion on the leg.
What is you diagnosis?
F. Peral Rubio, M.D.
Department of Dermatology
Hospital Universitario Virgen Macarena
Seville, Spain