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1. By
J.MUNI KRISHNA
Lecturer

2. Neural Activity

3. The Neuron
• Dendrites receive
signals.
• The cell body integrates
signals.
• The axon transmits
action potential. The
myelin sheath makes the
signal travel faster.
• Synaptic terminals
transmit signals.

4. Resting potential
• Using active
transport, the
neuron moves Na+
ions to the outside
of the cell and K+
ions to the inside of
the cell.
• Large molecules in
the cell maintain a
negative charge.

5. Action potential
• On receiving a
stimulus, sodium
gates and potassium
channels open briefly,
allowing these ions to
diffuse.
• The gates close, and
active transport
restores the resting
potential.

6. Synapse
• Neurons usually do
not connect directly
to one another. A
gap called a
synapse controls
the transmission of
signals.
• Neurotransmitters
cross the synapse
and stimulate the
next neuron.

7. Web Address
http://outreach.mcb.harvard.edu/animations/actionpotential.swf

8. Some Neurotransmitters
Neurotransmitter Location Some Functions
Acetylcholine Neuron-to-muscle synapse Activates muscles
Dopamine Mid-brain Control of movement
Epinephrine Sympathetic system Stress response
Serotonin Midbrain, pons, medulla Mood, sleep
Endorphins Brain, spine Mood, pain reduction
Nitric Oxide Brain Memory storage

9. Information Processing

10. Four basic operations
• Determine type of stimulus
• Signal the intensity of a stimulus
• Integrate responses from many sources
• Initiate and direct operations

11. Type of stimulus
• Wiring patterns in the brain determine
the type of stimulus.
• Areas of the brain dedicated to specific
sensory signals are connected to nerves
that connect to specific sensory organs.
• “Cross-sensory” effects: a poke in the eye
produces stimulates the optic nerve,
producing visual effects.

12. Intensity of stimulus
• Intensity = frequency of
action potentials

13. Integration of stimuli
• Convergence = Many signals arrive
through many neurons, but several may
pass their signal to a single connecting
neuron.
• Such cells may be “decision-making”
cells that may determine an appropriate
output.

14. Directing operations
• Neural pathways consist of:
• Sensory neurons
• Association neurons, which receive
signals from many sources
• Motor neurons
• Effectors: muscles, glands

15. Reflexes
• The simplest neural pathway is the reflex arc.
• This involves one or more sensory neurons,
association neurons in the spine, and motor
neurons, which carry out the reflex entirely
before the brain is aware of the response.

16. Reflex Arc

17. Why a Brain?
• Brains are the result of
selection for centralization of
the nervous system.
• Neurons control movement.
The brain (or spine) interprets
sensory signals and
determines the appropriate
movements (that is, behavior).
• Appropriate movement is
critical to the survival of most
animal species.

18. Organization

19. Neural Organization

20. Central Nervous System
• Consists of brain and spine
• Functions:
• Receives sensory signals and
determines appropriate response
• Stores memory
• Carries out thought

21. Spine: structure
• The spinal cord is
protected by the
vertebrae.
• Gray matter contains
cell bodies; white
matter contains
myelinated fibers.
• PNS nerves extend
outside of the
vertebrae.

22. Brain: Structure
• Hindbrain
carries out
the most
basic
functions.
• Midbrain
coordinates
signals.
• Forebrain
processes
signals,
stores
memories,
creates
thought.

23. Peripheral Nervous System
• Nerves, neurons, and sensory organs
outside the central nervous system
• Functions:
• Sends signals to the CNS
• Receives and transmits motor signals
from the CNS
• Stimulates effectors

24. Somatic Nervous System
• Motor neurons that control voluntary
movements by activating skeletal
muscles.
• Also involved in what we perceive as
involuntary movements, such as reflexes
(though voluntary control of the muscles
involved, such as tensing them, can
reduce the response).

25. Autonomic Nervous
System
• Motor neurons that control involuntary
responses involving the organs, glands,
and smooth muscles.
• Some voluntary control over the
responses can come from relaxation,
meditation, etc., which reduce
perceptions of stress and in turn reduce
the stress response.

26. Sympathetic Division
• Portion of the autonomic nervous system
that produces the “fight or flight”
response:
• Dilation of pupils
• Increased heart and breathing rates
• Constriction of blood vessels
• Inhibits digestion

27. Parasympathetic Division
• Portion of the autonomic nervous system
that produces the “rest and ruminate”
response:
• Constricts pupils
• Dilates blood vessels
• Reduces heart and breathing rates.
• Stimulates digestion.

28. Brain and Mind

29. The Complex Brain
• The mammalian brain is highly complex,
containing many specialized regions that
carry out specific functions.
• Generally, the brain is divided into
hindbrain, midbrain, and forebrain.

30. Hindbrain
• Medulla: controls
autonomic fuctions.
• Pons: controls sleep
stages.
• Cerebellum:
coordinates
movement, stores
some motor memory.

31. Midbrain
• Reticular formation:
the “traffic cops” of the
brain.
• Filters sensory input,
which allows us to
concentrate.
• Filtering can be
affected by higher
thoughts.

32. Try this:
• Stop and think: What have you been
paying attention to for the last ten
minutes?
• Pay attention to the feel of your shirt on
your arms. Had you been noticing it
during the last ten minutes? That’s the
reticular formation in action.
• What else have you not been paying
attention to?

33. Forebrain
• Thalamus: relay
station channeling
sensory information.
• Limbic system: basic
emotions, drives, and
behaviors.
• Cortex: higher thought

34. Limbic system
• Hypothalamus: master
controller of the
endocrine system.
• Amygdala: sensations of
pleasure or fear,
recognition of fear in
others.
• Hippocampus:
formation of memories.

35. Cortex
• Various areas control
sensory processing,
motor control,
thought, memory.
• Wiring is plastic:
people blind from
birth, for example,
use parts of the
visual cortex to
process auditory
signals.

36. Left brain, right brain?
• While there is some specialization to each
hemisphere, the idea has been oversimplified.
• The left brain controls the right half of the body;
the right brain controls the left half of the body.
• However, “right brain” or “left brain” functions
such as math, language, etc. produce activity on
both sides of the brain, and processing of these
may be different in different people (males vs.
females, novices vs. experts, etc.).

37. Brain “maps”?
While hemispheric research shows some specialization between
hemispheres, most “brain maps” like this are nonsense.

38. Memory
• How humans form memories is poorly
understood.
• “Working memory” appears to be
distinct from long-term memory. There
may be short-term memory as well,
things remembered for a few days. Is this
because the memory disappears, or
because it cannot be retrieved?

39. Models of Memory

40. Models of Memory
Craik & Lockhart, 1972

41. What is mind?
• Many traditions, including psychology, separate
“brain” from “mind.”
• What we perceive as “mind” (thought, will, self-
perception) does produce evidence of brain activity in
brain scans.
• That “brain” influences “mind” is well-established;
but some evidence shows “mind” can influence
“brain”; as cognitive therapy for depression can
physically change the brain.
• Neurology is a very young science, and there is still
much to learn about the brain-mind connection.

42. Senses

43. Sensory receptors
• Receptors are found in the sense organs.
They receive stimuli from the
environment and transmit stimuli to
neurons.
• Primary humans senses: photoreception,
chemoreception, mechanoreception,
thermoreception.

44. Thermoreception
• Free nerve endings
in the skin sense
changes in
temperature
(differences rather
than absolutes).
• These are directly
transmitted through
the PNS.

45. Mechanoreception
• Hearing is a form of
mechanoreception.
• Ears gather sound waves
from the environment.
• The inner ear bones
amplify sounds.
• Sounds are transmitted
to the cochlea.

46. Sound transmission
• Within the cochlea,
hair cells on the basilar
membrane vibrate to
certain frequencies,
and send signals down
the auditory nerve.
• Loud sounds can
damage these sensitive
hairs permanently.

47. Photoreception
• Sight is photoreception.
• Light enters the eye
through the cornea and
pupil.
• Light is focused by the
lens.
• Light strikes the retina,
and stimulates
receptors.

48. Photoreceptors
• Light breaks
pigments in the
receptor cells,
releasing energy that
stimulates neurons
connecting to the
optic nerve.
• Rod cells detect
amount of light, cone
cells distinguish
colors.

49. Chemoreceptioin
• Taste is one form of
chemoreception.
• Taste buds detect
certain ions
dissolved in saliva.
• Tastes: salty, sweet,
sour, bitter,
“umami.”

50. Chemoreception
• Smell is another
form of
chemoreception.
• Receptors in the
olfactory patch in
the human nose
can distinguish
between about
1000 different
chemicals in the
air.

51. “Flavor”
• What we sense as the “flavor” of food is
not taste alone. Smell and taste together
create the sensation of “flavor.”
• This is why things don’t “taste” good
when we have a cold; we lose the sense
of “flavor.”

52. Chemoreception
• The sense of pain is
another form of
chemoreception.
• Injured tissues release
chemicals as a
response. These
chemicals stimulate
free nerve endings in
the skin and the
stimulation is
perceived as pain.

53. Synesthesia
• The cause of synesthesia is unknown. Some
speculate that all infants are synesthetic, and
neural “pruning” during early years separates
the senses. In some individuals, the pruning
may not be complete. The evidence on this is
mixed.
• The experiences are unique to each individual
(i.e. there is no universal association between a
certain letter or a certain color), are not made up
or learned, and usually remain the same
throughout life.