Intro to biomolecules

1. PHYSIOLOGY-A
PHARM 313
Lecture No. 2: Chemical composition of the body
BASIC CELL FUNCTIONS
Dr. Sadia Rehman
RIPS Sahiwal

2. RIPS Sahiwal Physiology 2
PART : 2

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LEARNING OBJECTIVES
 Molecules
 Polar molecules
 Free radicals
 Solutions and its types
 Water as universal solvent

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 If the two or more atoms of different elements are joined, the result is a
molecule.
 A molecule is the smallest unit of a compound that retains the
properties of that compound.
Molecules

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 Atoms whose shells are incomplete,
tend to interact with other atoms and
gain, lose, or share electrons. These
interactions form chemical bonds
 Types of chemical bonds:
 Ionic bond
 Covalent bond
 Hydrogen bond
Chemical Bonds

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 An attraction between ions of opposite charge
results in Ionic Bond.
 An ionic bond is formed when electrons are
transferred from one atom to another.
 Ionic bonds are most often formed between
atoms that have fewer than two electrons in
their outer electron shells.
 For example,
Sodium and chloride ions
 Bond to form sodium chloride, (table salt).
Ionic Bond
NaCl

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A covalent bond is formed when atoms share
electrons.
Single covalent bond one electron is shared
Double covalent bond two electrons are
shared
Triple covalent bond three electrons are
shared
Covalent Bonds

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Hydrogen Bonding
 They are mostly formed
between the molecules.

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Polar Molecules

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 A free radical is simply an atom with one or more unpaired
electrons in its outer orbit.
 Electron pairing in the outermost orbit indicates stability of the
atom. To maintain stability each electron in the outer orbit must be
paired with another electron.
 Probably the most well-known free radical, oxygen is the basis for
development of most free radicals in the body. Inherently, oxygen
is an unstable molecules.
Free Radicals
Outer orbit has two unpaired
electrons

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Characteristics of Free Radicals
How do they generate?
Uses
 free radical diagnostic techniques
such as, NMR.
 biomarkers
They are produced either from normal
cell metabolisms in situ or from external
sources (pollution, cigarette smoke,
radiation, medication).

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Characteristics of Free Radicals
 Free radicals are unstable molecules in the body that can damage
DNA in cells. In turn, this can increase your risk for disease,
including cancer.
 The body naturally makes some free radicals as a by product of the
processes it normally does, but you can also get more free radicals by
exposure to certain toxic substances.
 Antioxidants, like those found naturally in fruits and vegetables, are a
key way to "fight" free radicals and the oxidative stress they cause in
your body.

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Solutions
A solution is a homogeneous
mixture of one or more solutes
dissolved in a solvent.
A solute is dissolved in a solvent.
Solute is the substance being dissolved
Solvent is the liquid in which the solute
is dissolved
An aqueous solution has water as
solvent

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Solutions
Solutions can have varying amount of solute dissolved in varying amounts of solvent.
 Concentration is the measurement of the amount of solute dissolved in fixed
amount of solvent
 2% salt solution = 2g of salt in 100 ml of water
 Dilute solution contains relatively small quantity of solute as compared to the
amount of solvent.
 Concentrated solution contains large amount of solute in the solution than that in
dilute solution
 Un-saturated solution is a solution in which more solute can be dissolved at given
temperature
 A saturated solution is one where the concentration is maximum and no more
solute is able to dissolved at given temperature
 Super-saturated solution contains relatively larger amount of solute than that
required for saturation (it is prepared by heating).

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Types of Solutions: Based on physical states of solute and solvent

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 Water is the solvent of life
 Water has several unique properties that make it
one of the most important compound found in
living tissue
 Most reactions in living things occur in water
solutions
 The polar nature of water molecules causes water
molecules to be attracted to one another
 Polar or charged solutes dissolved when water
molecules sourrounds them forming aqueous
solutions
Water

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 Because of its hydrogen bonds, water has a high heat capacity, which means that
water can absorb or release large amounts of energy in the form of heat with only a
slight change in its temperature.
 During a hot day, water can absorb heat (hydrogen bonds break) and cool the air, at
night the water cools (hydrogen bonds reform) and releases heat into air.
 Earth’s oceans stabilize global temperatures enough for life to exist.
 Hydrogen bonds in water exert an attractive force strong enough that water
“sticks” to itself and other substances
 Cohesion- surface tension
 Adhesion- capillarity action
Water-Hydrogen bonding

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Molecular Solubility

20. REFERENCES
20
 Human Physiology An Integrated Approach. Dee Unglaub Silverthorn.
 Vander’s Human Physiology The mechanisms of the body function.
Physiology

21. Physiology in Quran
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Physiology