A 66-year-old woman with risk factors for cardiovascular disease underwent a PET/CT stress test which showed strongly positive results. The test revealed a large, totally reversible perfusion defect in the anterior wall, apex, and septum consistent with moderate-severe ischemia in the LAD territory. Left ventricular function was normal at rest but dropped significantly with stress, and myocardial flow reserve was reduced globally with evidence of steal phenomenon in the LAD territory. Coronary calcium scoring and other PET/CT findings were indicative of high cardiac risk. The patient was found to have severe coronary artery disease on subsequent cardiac catheterization.