This document discusses common complications that can arise from diabetes. It covers complications that can affect the heart, kidneys, eyes, nerves, skin, and feet. Maintaining good control of blood sugar, blood pressure, and cholesterol is important for preventing or delaying diabetes complications like heart disease, kidney disease, and eye problems. Taking good care of feet by daily examination and wearing proper footwear can help prevent foot complications like ulcers, infections, and possible amputation.
Diabetic muscle infarction (DMI) is the muscle tissue damage due to diabetes. It is a medical condition in which tissue dies because its blood supply is cut off. It is a rare complication in patients with advanced diabetes mellitus (DM). Patients having diabetic nephropathy are prone to develop diabetic muscle infarction.
It is caused by infarcted (tissue death due to inadequate blood supply to the affected area) muscle tissue, most commonly in the thigh. Nearly one-fourth of Diabetic muscle infarction patients receive renal replacement treatment.
Because its symptoms can be easy to miss, DMI is often not noticed or treated as quickly as it should be. Anyone who has diabetes should be aware of the possibility of developing DMI. If you suspect that you might have DMI, then you should seek immediate medical attention.
I have tried to create awareness about causes, types and symptoms of diabetes. As millions of people are sufferings from this disease, so this article will be helpful to control the sugar level.
Minimal change disease is a kidney disorder that can lead to nephrotic syndrome. A nephrotic syndrome is a group of symptoms that include protein in the urine, low blood protein levels in the blood, high cholesterol levels, high triglyceride levels, and swelling.
10 common diseases relate to the skin complications of diabetesmisurali
Diabetes can cause a lot of complications that affect most parts of your body. In which, it is estimated that one out of three people with diabetes will have a person appear to have skin problems. Also, these complications can occur quite early in the period before the disease is diagnosed. Luckily, most skin problems can be prevented or easily treated if they are detected early. So, the content in the below article will give you a more general look at how to identify some skin disorders of diabetes and how to handle them in each specific case.
10 common diseases relate to the skin complications of diabetes
Diabetic muscle infarction (DMI) is the muscle tissue damage due to diabetes. It is a medical condition in which tissue dies because its blood supply is cut off. It is a rare complication in patients with advanced diabetes mellitus (DM). Patients having diabetic nephropathy are prone to develop diabetic muscle infarction.
It is caused by infarcted (tissue death due to inadequate blood supply to the affected area) muscle tissue, most commonly in the thigh. Nearly one-fourth of Diabetic muscle infarction patients receive renal replacement treatment.
Because its symptoms can be easy to miss, DMI is often not noticed or treated as quickly as it should be. Anyone who has diabetes should be aware of the possibility of developing DMI. If you suspect that you might have DMI, then you should seek immediate medical attention.
I have tried to create awareness about causes, types and symptoms of diabetes. As millions of people are sufferings from this disease, so this article will be helpful to control the sugar level.
Minimal change disease is a kidney disorder that can lead to nephrotic syndrome. A nephrotic syndrome is a group of symptoms that include protein in the urine, low blood protein levels in the blood, high cholesterol levels, high triglyceride levels, and swelling.
10 common diseases relate to the skin complications of diabetesmisurali
Diabetes can cause a lot of complications that affect most parts of your body. In which, it is estimated that one out of three people with diabetes will have a person appear to have skin problems. Also, these complications can occur quite early in the period before the disease is diagnosed. Luckily, most skin problems can be prevented or easily treated if they are detected early. So, the content in the below article will give you a more general look at how to identify some skin disorders of diabetes and how to handle them in each specific case.
10 common diseases relate to the skin complications of diabetes
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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Heart Disease
Kidney Disease/Kidney
Transplantation
Eye Complications
Diabetic Neuropathy and Nerve
Damage
Foot Complications
Skin Complications
Gastroparesis and Diabetes
Depression
Common Potential Complications of
Diabetes
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Heart Disease
Caused by a narrowing or
blocking of the blood vessels to
your heart.
The vessels carry oxygen and
nutrients to your heart.
Vessels can become partially or
totally blocked by fatty
deposits.
A heart attack - when the blood
supply to your heart is reduced
or cut off.
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Diabetes increases the risk for
coronary artery disease, a heart
attack or stroke.
Take preventive steps now.
Keep your ABCs of diabetes on
target.
Heart Disease and Diabetes
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“A” is for A1C A1C is the blood glucose check “with a memory” over the past 2 to 3
months.
“B” is for blood
pressure
The ADA recommends a blood pressure below 130/80.
“C” is for
cholesterol
HDL protects your heart.
LDL can clog your blood vessels, leading to heart disease.
Triglycerides can increase your risk for heart disease.
“The ABCs”
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Kidney Function
Kidneys act as filters.
Kidneys remove waste products from the
blood.
We create waste products from digestion.
Normally, waste products are eliminated in
urine from the body.
Protein and red blood cells are too big to pass
through the filter and remain in the blood.
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Kidney Disease
High levels of blood sugar can put extra stress on
the kidneys.
After years of damage, the kidneys start to leak.
Useful proteins are lost in the urine.
Get a condition known as microalbuminuria.
There are several treatments at this point that may
keep the kidney disease from getting worse.
When kidney disease is diagnosed later, during
macroalbuminuria, end-stage renal disease (ESRD)
usually follows.
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Kidney Disease
Kidneys lose their filtering ability.
Waste products begin to build up in the
blood.
Finally, the kidneys fail.
ESRD
kidney transplant or
regular visits to a dialysis clinic.
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Who Gets Kidney Disease?
Factors that influence kidney disease development
include:
Genetics
Blood pressure
Blood sugar control
Controlling blood sugar and blood pressure are very
important in reducing the chances of developing kidney
disease.
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Facts About Diabetes and
Kidney Disease
Nephropathy - 10-21% of diabetes cases.
~ 43% of new cases of ESRD are attributed to
diabetes.
12 times higher in people with type 1 diabetes
4 times higher in African Americans,
4 to 6 times higher in Mexican Americans
6 times higher in Native Americans
than in the general population of diabetes patients.
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---Eye Complications---
Higher risk of blindness.
Many have minor eye disorders.
Early treatments critical.
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Glaucoma
Pressure build-up in the eye.
Pinches the blood vessels.
Damages nerves.
Vision is gradually lost.
40% more likely to suffer from
glaucoma.
Risk increases with age and
duration of diabetes.
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Cataracts
The eye’s clear lens clouds,
blocking light.
Wear sunglasses
Use glare-control lenses in
eyeglasses.
Damaged lens –
remove.
transplant.
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Individuals with diabetes are:
60% more likely to develop cataracts
at a younger age
faster progression
have problems if removal of the lens is necessary
due to the beginning stages of glaucoma
Cataracts
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Retinopathy
Diabetic retinopathy is a general term
for all disorders of the retina caused
by diabetes.
There are 2 major types of
retinopathy:
Nonproliferative: This is the common, mild
form.
Proliferative: This form is much more
serious.
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There are several factors that
influence whether you get
retinopathy:
Blood sugar control
Blood pressure levels
How long you have had diabetes
Genetics
Almost everyone with type 1
diabetes will eventually develop
nonproliferative retinopathy.
Retinopathy
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Diabetic Neuropathy & Nerve Damage
~50% have some form of nerve damage.
It’s more common in those who have had the
disease for many years.
Blood glucose control can help prevent or
delay nerve damage.
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2 Common Types of Nerve Damage
Sensorimotor neuropathy:
Also known as “peripheral neuropathy”
Can cause tingling, pain, numbness, or weakness in
hands and feet.
Autonomic neuropathy: Can lead to
Digestive problems such as feeling full, nausea
Vomiting, diarrhea, or constipation
Problems with how well the bladder works
Problems having sex
Dizziness or faintness
Loss of the typical warning signs of a heart attack
Loss of warning signs of low blood glucose
Increased or decreased sweating
Changes in how your eyes react to light and dark
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Keep Your Blood Glucose Levels in
Your Target Range
It is important to:
Report all possible signs of diabetic
neuropathy
Get treatment right away if you have
problems.
Take good care of your feet, checking them
every day.
Protect your feet. Wear shoes and socks that
fit well and wear them all the time.
Purchase special shoes, if they are needed.
Be careful with exercising. Some activities are
not safe for individuals with neuropathy.
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Skin Changes and Calluses
Skin Changes:
Dry skin and feet.
Seal remaining moisture in with plain petroleum jelly,
unscented hand cream, or a similar product.
It is important not to put oils or creams between toes.
Calluses
Occur more often and build up faster.
May need therapeutic shoes and inserts.
Calluses can lead to ulcers (open sores).
Never try to cut calluses yourself– this can lead to
infection.
Let your healthcare provider cut them.
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Foot Ulcers and Poor Circulation
Foot Ulcers
Every ulcer should be seen by your health care provider
immediately.
Can result in infections, potentially leading to loss of a limb.
It is important to keep off of your feet.
Poor Circulation
Can lead to infection and delay healing.
To improve poor circulation:
Stop smoking and keep blood pressure and cholesterol
in check
Exercise improves circulation. It increases blood flow. Exercise
is a good idea for individuals who currently do not have any
open sores on the foot. Proper shoes are essential.
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Amputation
Highly likely in diabetes.
Due to artery disease, which
reduces blood flow to the feet and
nerve damage, which reduces
sensation.
These can lead to ulcers and
infections that may lead to
amputation.
Amputations are preventable.
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Amputation - Prevention
Take good care of your
feet.
Always follow your health
care provider’s advice
when caring for foot
problems.
Stop smoking!
Smoking decreases blood
flow to the feet.
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Bacterial and Fungal Infections
Bacterial infections
Many kinds.
Styes.
Boils.
Carbuncles.
Inflamed tissues are usually hot,
swollen, red, and painful.
Treated by antibiotics.
Fungal infections
Candida albicans is a yeast-like
fungus.
Leads to common fungal infections.
Can be treated by medication.
Stye
Athlete’s foot
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Itching and Diabetic Dermopathy
Itching
Localized.
Can be caused by a yeast infection, dry skin, or poor circulation.
Occurs often in the lower parts of the legs.
Use mild soap with moisturizer, and apply skin cream after bathing to
help resolve the issue.
Diabetic Dermopathy
Changes in the small blood vessels.
Looks like light brown, scaly patches.
The disorder most often occurs on the front of both legs.
The patches do not hurt, open up, or itch.
Dermopathy is harmless and does not require treatment.
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Atherosclerosis and Allergic Reactions
Atherosclerosis
Thickening of the arteries
Occurs at younger ages.
Can lead to skin changes.
Skin becomes hairless, thin, cool, and shiny.
Affected legs heal slowly when the skin is injured.
Allergic Reactions
In response to medications, such as insulin or diabetes pills.
If you think you are having a reaction to a medication, contact
your doctor immediately.
Report any rashes, depressions, or bumps around the insulin
injection sites immediately.
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Diabetic Blisters and
Eruptive Xanthomatosis
Diabetic Blisters
Occurs rarely in individuals with diabetes
They can occur on the backs of fingers, hands, toes, feet, and on legs or
forearms.
They are sometimes large and resemble burn blisters.
Painless and with no redness around them, they often heal themselves within
3 weeks.
The only treatment is to bring blood sugar levels under control.
Eruptive Xanthomatosis
This is a condition caused by diabetes that is out of control.
Consists of firm, yellow, pea-like enlargements in the skin.
The disorder usually occurs in young men with type 1 diabetes.
Like diabetic blisters, these bumps disappear when diabetes control
is restored.
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Digital Sclerosis and
Disseminated Granuloma Annulare
Digital Sclerosis
Consists of tight, thick, waxy skin on the back of the hands.
The finger joints become stiff and can no longer move the way they should.
Rarely, knees, ankles, or elbows also get stiff.
Happens to about 1/3 of people with type 1 diabetes
The only treatment is to bring blood sugar levels under control.
Disseminated Granuloma Annulare
Consists of sharply defined ring-shaped or arc-shaped raised areas on the
skin.
Rashes most often occur on parts of the body far from the trunk
(i.e., ears or fingers), but sometimes the raised areas occur on the trunk.
Contact your doctor when rash appears.
Certain drugs can help clear up the condition.
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Acanthosis Nigricans
Acanthosis Nigricans
This is a condition in which tan or brown raised
areas appear on the sides of the neck, armpits, and groin.
Usually strikes people who are overweight.
The best treatment is to lose weight.
Some creams can help the spots look better.
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Gastroparesis and Diabetes
Due to nerve damage that control the stomach.
Leads to poor muscle control of the stomach and intestines. Movement of
food is slowed or stopped.
Signs and symptoms:
Heartburn
Nausea
Vomiting of undigested food
An early feeling of fullness when eating
Weight loss
Abdominal bloating
Erratic blood glucose (sugar) levels
Lack of appetite
Gastroesophageal reflux
Spasms of the stomach wall
*These symptoms may be mild
or severe, depending on the
person.*
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Complications of Gastroparesis
Gastroparesis makes it harder to manage
blood glucose.
Slower digestion can result in:
Bacterial overgrowth due to fermentation
Food can harden into solid masses called
bezoars that may cause nausea, vomiting, and
obstruction of the stomach
Bezoars can be dangerous if they block the
passage of food into the small intestine.
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Treatment of Gastroparesis
The most important
treatment goal for
diabetes-related
gastroparesis is to
manage your blood
glucose levels as well
through the usage of:
Insulin May need to adjust schedule.
Medication May need drugs to treat
gastroparesis.
Meal and
food
changes
Refer to your physician or a
dietitian for more information.
Feeding
tube
May be used in severe cases.
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Depression
Consult your doctor to eliminate any physical cause for your
depression.
Poorly controlled diabetes can cause depression like symptoms:
High or low blood sugar during the day can make you feel tired or anxious
Low blood sugar levels can also lead to hunger and eating too much
Low blood sugar n the night could disturb sleep
High blood sugar in the night can lead to frequent urinating and then feeling
tired throughout the next day
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Conclusions
There are many potential complications of diabetes.
Complications can be minimized with good blood glucose control.
Discuss any developments with the physician immediately.
37. PBRC 2009 37
Division of Education
Reviewed by:
Beth Kalicki
Edited : 10/ 2009
Division of Education
Phillip Brantley, PhD, Director
Pennington Biomedical Research Center
Claude Bouchard, PhD, Executive Director
Heli J. Roy, PhD, RD
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The Pennington Biomedical Research Center is a world-renowned nutrition research center.
Mission:
To promote healthier lives through research and education in nutrition and preventive medicine.
The Pennington Center has several research areas, including:
Clinical Obesity Research
Experimental Obesity
Functional Foods
Health and Performance Enhancement
Nutrition and Chronic Diseases
Nutrition and the Brain
Dementia, Alzheimer’s and healthy aging
Diet, exercise, weight loss and weight loss maintenance
The research fostered in these areas can have a profound impact on healthy living and on the prevention
of common chronic diseases, such as heart disease, cancer, diabetes, hypertension and osteoporosis.
The Division of Education provides education and information to the scientific community and the public
about research findings, training programs and research areas, and coordinates educational events for the
public on various health issues.
We invite people of all ages and backgrounds to participate in the exciting research studies being
conducted at the Pennington Center in Baton Rouge, Louisiana. If you would like to take part, visit the
clinical trials web page at www.pbrc.edu or call (225) 763-3000.
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References
All information used was obtained from:
American Diabetes Association
http://www.diabetes.org
Copyright, 2009
PBRC # PPT29