Okay, let me get started on the pedigree and urine testing. I'll be back with the results and an explanation of how alcaptonuria is inherited in this family.
Admixture lesions in congenital cyanotic heart diseaseRamachandra Barik
Admixture lesions in congenital cyanotic heart disease
Jaganmohan A Tharakan
Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India
A coronary bifurcation consists of a flow divider (carina) and three vessel segments:
The proximal main vessel (PMV)
The distal main vessel (DMV) and
The side branch (SB).
A bifurcation lesion is a major epicardial coronary artery stenosis next to and/or including the ostium of a significant side branch
A significant SB is a branch whose severe narrowing or acute occlusion before or during intervention can cause considerable ischemia or a new infarction area that will worsen the clinical course of a particular patient.
Other important elements to consider that are not inherent in the bifurcation classifications include:
Extent of disease on the SB (limited to the ostium or involving the vessel beyond the ostium)
Its size (over 2.5mm in reference diameter)
Bifurcation angle, and
Disease distribution
Summary of Pedigree Chart symbols.
How to use pedigree charts to analyse genetic conditions
Please note: this resource found on a fileserver on the internet. Author unknown.
Presenting the probability in genetics; Product law, Sum law, Binomial Theorem and Chi-square. Also brief explanation on pedigree analysis and genetic disorders of autosomal dominant and recessive.
Admixture lesions in congenital cyanotic heart diseaseRamachandra Barik
Admixture lesions in congenital cyanotic heart disease
Jaganmohan A Tharakan
Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India
A coronary bifurcation consists of a flow divider (carina) and three vessel segments:
The proximal main vessel (PMV)
The distal main vessel (DMV) and
The side branch (SB).
A bifurcation lesion is a major epicardial coronary artery stenosis next to and/or including the ostium of a significant side branch
A significant SB is a branch whose severe narrowing or acute occlusion before or during intervention can cause considerable ischemia or a new infarction area that will worsen the clinical course of a particular patient.
Other important elements to consider that are not inherent in the bifurcation classifications include:
Extent of disease on the SB (limited to the ostium or involving the vessel beyond the ostium)
Its size (over 2.5mm in reference diameter)
Bifurcation angle, and
Disease distribution
Summary of Pedigree Chart symbols.
How to use pedigree charts to analyse genetic conditions
Please note: this resource found on a fileserver on the internet. Author unknown.
Presenting the probability in genetics; Product law, Sum law, Binomial Theorem and Chi-square. Also brief explanation on pedigree analysis and genetic disorders of autosomal dominant and recessive.
This is an interactive teacher's resource for IB Biology. It illustrates the concepts of hydrolysis and condensation reactions using jmol images of molecules?
KEY CONCEPTS
14.1 Mendel used the scientific approach to identify two laws of inheritance
14.2 Probability laws govern Mendelian inheritance
14.3 Inheritance patterns are often more complex than predicted by simple Mendelian genetics
14.4 Many human traits follow Mendelian patterns of
inheritance
Genetics is the study of genes.
Inheritance is how traits, or characteristics, are passed on from generation to generation.
Chromosomes are made up of genes, which are made up of DNA.
Genetic material (genes,chromosomes, DNA) is found inside the nucleus of a cell.
Gregor Mendel is considered “The Father of Genetics"
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The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
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Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
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Antifertility, Toxicity studies as per OECD guidelines
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
2. 2. A chart used to follow
genetic traits in a family
2. Can be used to determine
who a trait is inherited from
2. Can be used to determine if
a trait is dominant,
1. Pedigree recessive, X linked or some
other mode of inheritance.
4. 1. Constructing a Pedigree
2. Males
represented by
squares
2. Females are
represented by
circles
2. A marriage is a
line between 2
shapes
2. Offspring are
shown using a line
from a marriage
5. 2. Shaded shapes show
people that have a
trait
2. Unshaded shapes do
not show the trait
2. Sometimes a
heterozygous person
is half-shaded
6. Practice – Write the answers to these
questions on a piece of paper.
1. In this pedigree, which numbers
are females?
2. Which numbers are male?
3. How many brothers does # 11
have?
4. Who is # 9 married to?
5. How many children does couple
1 and 2 have?
6. Which are married?
7. Which show the trait for which
the pedigree was constructed?
8. Guess: do you think this trait is
inherited as a dominant allele or
a recessive allele? WHY?
7. Practice – Write the answers to these questions
on a piece of paper. Use the numbers to show
which people are the answers to each question
1. In this pedigree, which numbers
are females?
1,4,7,8,10,11,13,15,16,17,18,19
2. Which numbers are male?
2,3,5,6,9,12,14,20
3. How many brothers does # 11
have? 1 (#12)
4. Who is # 9 married to? 8
5. How many children does couple
1 and 2 have? 3
6. Which are married? # 4 and #6
7. Which show the trait for which
the pedigree was constructed?
2,6,9,11,16,20
8. Guess: do you think this trait is
inherited as a dominant allele or
a recessive allele? WHY?
8. Try using a pedigree to determine
genotypes…..
• If this pedigree follows a
trait that is coded for by a
recessive allele….
• What is the genotype of
parent 1? A = dominant allele
a= recessive allele
• Parent 2?
• The daughter?
• The son?
9. Try using a pedigree to determine
genotypes…..
• If this pedigree follows a
trait that is coded for by a
recessive allele….
• What is the genotype of
parent 1? Aa
A = dominant allele
• Parent 2? Aa a= recessive allele
• The daughter? aa
• The son? A__ (we can’t
know the second allele yet)
10. Figure out if the trait is
dominant or recessive……
• Do you think this pedigree
shows a dominant trait or a
recessive trait?
• Explain why and draw a
punnett square to support
your answer.
11. • In this pedigree, the trait must be dominant,
and the parents must both be heterozygous
A a
A AA Aa
a
Aa aa
12. Summarize……
• List several types of information
that pedigrees can be used for.
• Explain how a pedigree is
constructed
• Explain whether the pedigree here
shows a dominant trait or a
recessive trait and explain why you
think so using a punnett square.
13. Try making a pedigree!
• The gene which results in Achondroplasia is dominant. Use
the numbers to make a pedigree which follows the genotypes
of each person in this picture. You can use the numbers to
show who is who on the pedigree.
3
4
5 6
1 2
14. Albinism is inherited as a recessive allele. In the figure above, assuming
that persons from the general population are not heterozygous for
albinism (Aa), what are the genotypes of all persons whose genotypes
are known?
15. Case Study
• Learn about a disorder called Alcaptonuria (click here).
• Read the fact sheet and determine the following :
• What are the SYMPTOMS of alcaptonuria?
• What are the CAUSES of alcaptonuria?
• What test determines whether a patient has
alcaptonuria?
• What are some effective treatments for
alcaptonuria?
16. The Story
A new baby is born into the family!! Baby Jenna appears
health and strong, but nurses notice that her diaper has
turned a disturbing brown/black color.
After testing, the doctor diagnoses the child with
alcaptonuria.
The family now needs to know more about the disease, so you
are called in to help.
Your goals:
1. Determine who in the family has the disease
2. Design a pedigree to help the family see how the trait
has moved through the family.
3. Explain how the trait is inherited in a way that the family
understands.
17. Start your research
• 1. Test the urine of the family.
Request urine samples of family members
Add the test solution to the tube
Record the results.
• 2. Design a pedigree and indicate who is
affected and who is not (hint: you may benefit from designing
the pedigree before the test and then shading in the affected family members
later. )
• 3. Fill in the genotypes of each of the family
members on the pedigree.
18. • The family: John and Lucy are the parents of
baby Jenna
• John has 1 sister named Suzanne
• John’s parents are Steven and Martha
• Lucy’s parents are David and Ann
• Lucy has a brother, Randy and a sister Lynne
