The Savvy Online Student Affairs ProfessionalPaul Brown
Originally presented at University of Binghamton to graduate students in the higher education program in February of 2017. This presentation provides basics and suggestions on safeguarding and building a digital reputation and engaging online.
My PLN Action Plan for UMBC’s EDUC 689 “ISD For Informal Learning.” A class assignment but something that will continue to shape my professional development and career.
An Overview of Digitized Student DevelopmentPaul Brown
Originally presented at the 2016 conference of the Association of Intermountain Housing Officers (AIMHO). This session provides an overview of developmental issues students in college face while online.
The Savvy Online Student Affairs ProfessionalPaul Brown
Originally presented at University of Binghamton to graduate students in the higher education program in February of 2017. This presentation provides basics and suggestions on safeguarding and building a digital reputation and engaging online.
My PLN Action Plan for UMBC’s EDUC 689 “ISD For Informal Learning.” A class assignment but something that will continue to shape my professional development and career.
An Overview of Digitized Student DevelopmentPaul Brown
Originally presented at the 2016 conference of the Association of Intermountain Housing Officers (AIMHO). This session provides an overview of developmental issues students in college face while online.
Become A Google+ Wizard - Tots & Technology 2015Diana Benner
Google+ is a great tool for connecting with other educators and like-minded individuals. Get plugged into an amazing circle of some of the best educators around the world. Learn how Google+ can be a magical place.
Activism Labs - Background and Brainstorm (at PNW Drupal Summit)auzigog
http://activismlabs.org
Activism Labs is a vision of a set of tools for small teams of activists to manage their projects: Dates, tasks, google groups, google docs, meeting notes, etc.
At PNW Drupal Summit in Vancouver BC.
Become A Google+ Wizard - Tots & Technology 2015Diana Benner
Google+ is a great tool for connecting with other educators and like-minded individuals. Get plugged into an amazing circle of some of the best educators around the world. Learn how Google+ can be a magical place.
Activism Labs - Background and Brainstorm (at PNW Drupal Summit)auzigog
http://activismlabs.org
Activism Labs is a vision of a set of tools for small teams of activists to manage their projects: Dates, tasks, google groups, google docs, meeting notes, etc.
At PNW Drupal Summit in Vancouver BC.
Despite the global quest for work-life balance, many people still regularly work over the weekend and don't use all of their vacation days. So if you dream about a 25th hour in the day to be fully productive and dedicate some time for yourself, we've got something for you! Since having an extra hour in the day is still impossible, we decided to give you some tips on how to work on things smarter. Here's a neat presentation with tips for saving heaps of time for leisure! www.wrike.com/
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Changing the Story - Using Social Media in Library Customer ServicesRob Wannerton
A short presentation on the ways Brunel University Library is using social media channels in delivering customer service and CRM, including Pinterest & Storify.
Presented at "Professionalism & Engagement in Customer Service: M25 Customer Service Group Conference, November 7th 2013", Kings College, London.
I gave a talk to students in the EHS 688: Topics in Environmental Health Sciences and Nutrition Class last week. Here are the slides! Working on getting the links to work. Check out the homework I made for the class before the talk! http://joyceisplayingontheinter.net/andexploringsm4ph.html
Cultural Historical Activity Theory (CHAT) has its origins in Lev Vygotsky’s pioneering work in the 1920s. More recently, education scholars have used CHAT to study learning behavior through the creation of activity systems analysis. When we view sales and marketing or even Lean as a knowledge building exercise this thought process brings an alternative way for learning about human behavior. It is not an exercise for the light-hearted. However the Business901 podcast, CHAT in Activity Theory Thinking, with Dr. Lisa Yamagata-Lynch serves as an introduction. This is a transcription of the podcast.
Presentation of Jeroen de Vos, Media Anthropologist at the MIT conference Public Media / Private Media. 3rd / 5th may of 2013 in Boston, Massachusetts.
Presentation on Social Media in Learning Development given at the National Conference of the Association of Learning Advisors of New Zealand / Aotearoa in Napier, New Zealand on November 29th, 2013
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Leaders and followers ann grand - open university - easst 2014
1. Dr Ann Grand, Institute of Educational Technology
Dr Anne Adams, Institute of Educational Technology
Dr Richard Holliman, Faculty of Science
Leaders and followers:
communities of practice in digitally-engaged
research
2. Engaged research
• Survey of Open University researchers
– 2013 Vitae Careers in Research (CROS) and the Principal Investigators and
Research Leaders (PIRLS) online surveys (www.vitae.ac.uk)
– CROS (n=57); PIRLS (n=114)
• How would you define ‘public engagement with research’?
• Describe an activity involving PER
• What publics have connections with your research?
3. Public engagement with research
• How would you define
‘public engagement with
research’?
• Describe an activity involving
PER
• What publics have
connections with your
research?
Dissemination
51%
Functional
Useful
11%
Collaboration
17%
Dialogue
13%
6%
Negative
2%
Personal
“I enjoy giving public lectures”
Utilitarian
“I’m paid to do it”
Philosophical
“as in Habermas’s conception of the
public sphere”
4. Public engagement with research
• Define ‘public engagement
with research’
• Describe an activity
involving PER
• What publics have
connections with your
research?
Presenting
29%
Partnerships
20%
None
11%
Not possible
Not possible
Writing
4%
2%
Schools
10%
Schools
10%
Activities
10%
Digital
4%
2%
Unclassifiable
10%
Presenting
29%
Partnerships
20%
None
11%
Activities
10%
Digital
4%
Writing
4%
Unclassifiable
10%
6. Levels of engagement
• “That means for each of the different … engagement levels … you have to
cater for the people that are very active, they want tools that support them in
producing stuff, getting out their blogs, editing. The people that casually do
something, they … probably have more questions than answers, they want to
raise awareness about the things they do, and so on. I think that, in general,
applies to any sort of research community; that once you go out of the core of
people that are really specialised on exactly this, and open up to the public, the
ways you communicate have to change as well.”
Interviewee 14
7. The fully-wired
“a number of us have personal blogs,
that we blog about our work and use our
social networks … a combination of
Twitter, LinkedIn, Facebook, to tell the
wider community about the work that
we’re doing … [X] uses his blog as his
research journal but also as a way to
disseminate what he’s found out and get
people interested. Similarly, I have a blog
that tries to capture both my research
and teaching interests and combine
them…” Interviewee 6
8. The experimenter
“I have a Twitter account but I’m not an
avid Twitter user. I’ve tried to use it more
and I’ve got slightly better but I wouldn’t
say it’s made any impression on the
outside world, really. I have a Facebook
account, but that’s just for keeping in
touch with my research students; it
doesn’t make any impact externally.
A colleague and I made some videos with
a little hand-held camera of the work we
did in [country] and they’re on YouTube,
where they’ve got not very many hits.
So we’ve done that, the sorts of things
we’ve been asked to do by the university
but to my knowledge, we haven’t gone
viral!”
Interviewee 13
9. The dabbler
“We have our individual profiles on the
Internet and our research centre has a
webpage but … … what I find difficult is
to keep them up to date myself. I learn
how to change the webpage or
something like that and a year later I
have forgotten, so it becomes ‘I’ll do it
another time’. For example wikis and
things like that, we are not so digitally
savvy, in our group.”
Interviewee 2
10. The unconvinced
“My priority is to get on with the research,
deliver publications, further knowledge,
rather than spend all the time packaging
up a small amount of work for general
consumption.”
Interviewee 4
“People have a Twitter account,
Facebook accounts, blogs – these are
not properly monitored; there is hardly
any quality control.”
Interviewee 15
11. Muddling through
[Name] and I muddled our way
through; it wasn’t actually that
difficult. I’m a bit of a novice at
social media, I’ve always kept my
head down out of fear of the
workload that it could generate, but
it is part of my remit in this job, I’ve
got to engage with it so I’m very
glad that [Name] is much more au
fait with that side of things than I
am. He can help me out!
(Researcher 3)
highly-wired
dabbler
experimenter
I’m new!
unconvinced
12. A muddling community?
Co-PI: We need
a digital
engagement plan
PI: We need to
engage with
everyone – let’s try
Co-PI: Scientific
publications are the
important thing
Co-PI: How about
x tweets, y blogs
per partner?
RA: Social media
shouldn’t have
rules; it’s about
freedom to express
RA: Well, I just
won’t use social
media
Project Manager: Other projects
are doing it – we should just do it!
Co-PI: I’ve just tweeted a photo of
us talking in this room!
RA: So have I
Original graphic by Dr Anne Adams
14. Engaged research
• Definition of ‘engaged research’
• Project seed funding
• Engaged Research Awards
• Changes to promotion criteria
15. Engaging Research blog
http://www.open.ac.uk/blogs/per/?p=4654
Ann Grand
ann.grand@open.ac.uk
Institute of Educational Technology
The Open University
Walton Hall
Milton Keynes
MK7 6AA
www.open.ac.uk