The document provides information on the topic of Kustha (skin disorders) in Ayurveda. It begins with objectives of the presentation and then defines Kustha based on nirukti. It describes various nidanas (causes), samprapti (pathogenesis), poorvarupa (premonitory symptoms), classification into 7 mahakusthas and 11 kshudrakusthas. It then provides detailed lakshanas (symptoms) of each of the 7 mahakusthas. The document aims to educate students on the key concepts of Kustha according to Ayurvedic principles.
shotha nidana, poorva roopa, roopa, upashaya, samprapthi, chikitsa according to charaka, sushrutha, ashtanga hridaya, ashtanga sangaraha
you can get detail description on shotha from this presentation.
this is an ppt presentation by dr.b.arun kumar, who is working as a lecturer in MNR ayurvedic medical college, sangareddy, near hyderabad. in this presentation i given all details of virechana karma.
shotha nidana, poorva roopa, roopa, upashaya, samprapthi, chikitsa according to charaka, sushrutha, ashtanga hridaya, ashtanga sangaraha
you can get detail description on shotha from this presentation.
this is an ppt presentation by dr.b.arun kumar, who is working as a lecturer in MNR ayurvedic medical college, sangareddy, near hyderabad. in this presentation i given all details of virechana karma.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
4. Objectives
At the end of the presentation the students must be able to---
1. Quote Nirukti of Kushta
2. State Nidana of Kushta
3. Describe Samprapti of Kushta
4. List Poorvarupa of Kushta
5. Classify Kushta
6. Enumerate Lakshana of Mahakusta
7. Enumerate Lakshana of Kshudra kushta
8. Quote Sadhyasadhyata of Kushta
02/05/2020 KUSHTA (Dr Akshay Shetty) 4
8. • Viruddha annapana, excessive intake of drava, snigdha and guru
dravyas; restraining natural urges like vomiting etc; exercising or
coming in contact of excessive heat after eating excessive quantity of
food.
• Indulging in habits such as, taking shita quality food etc. followed
by ushna quality or either fasting followed by heavy meals.
• Having cold water immediately after exposure to scorching sun,
exertion and fear, eating uncooked or raw foods or having meals
although previously taken meals have not been digested.
• Indulging in food and other habits which have been restricted during
the phase of Panchakarma.
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9. • Consuming new grains, curds, fish, excessive salty and sour food
items.
• Black grams, radish, food prepared from flour paste, sesame, milk and
jaggery products.
• Indulging in sexual activity even if the food is not well digested (sexual
intercourse immediately after taking food), sleeping during day time,
• Insulting peers like brahmin / guru and other respected personal and
doing sinful acts are the etiological and risk factors of kushta
02/05/2020 KUSHTA (Dr Akshay Shetty) 9
10. Samprapti of Kushta
िािादयस्म्रयो दुष्टास्म्त्िग्रक्तिं मांसमतबु च|
दूषयन्ति स क
ु ष्ठानां सप्िको द्रव्यसङ्ग्रहिः||९||
अििः क
ु ष्ठातन जायतिे सप्ि चैकादशैि च|
न चैकदोषजं ककन्ञ्चि् क
ु ष्ठं समुपलभ्यिे||१०|| Ca. Ch 7
02/05/2020 KUSHTA (Dr Akshay Shetty) 10
11. • The vitiated three doshas- vata, pitta, kapha along with
impaired tvak, rakta, mamsa and ambu together constitute seven
essential entities which play role in pathogenesis of kushtha.
• Kushtha can be classified into seven mahakushtha (major skin
disorders) and eleven kshudrakushtha (eleven minor skin disorders).
• Single dosha cannot cause kushtha on its own i.e. kushtha is not
an nanatmaja
02/05/2020 KUSHTA (Dr Akshay Shetty) 11
14. • Decreased touch sensation, excessive sweating or absence of
sweating (which may be localized or generalized), change in color
(discoloration), papules on skin, horripilation, pruritus, pricking pain,
physical exhaustion, mental fatigue, severe pain in ulcerated area,
sudden appearance and chronic the ulcers, burning sensation,
numbness are the premonitory symptoms of skin disease
02/05/2020 KUSHTA (Dr Akshay Shetty) 14
19. Lakshana of Mahakusta
कृ ष्णारुणकपालाभं यद्रूिं परुषं िनु|
कापालं िोदबहुलं ित्क
ु ष्ठं विषमं स्म्मृिम ्||१४||
• The clinical presentation of kapala kushtha is as follows:
• Color –- kr̥ṣṇa (blackish), aruṇa (reddish)
• Nature – kapāla (similar to broken piece of earthen pot)
• Touch – rūkṣa (dry), paruṣa (rough), tanu (thin)
• Associated symptoms – severe pain
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20. Udumbara kushtha
दाहकर्ण्डूरुजारागपरीिं लोमवपञ्जरम ्|
उदुतबरफलाभासं क
ु ष्ठमौदुतबरं विदुिः||१५||
• The clinical presentation of udumbara kushtha is as follows:
• Color – Similar to udumbara fruit
• Nature – rāgaparīta (redness), lōmapiñjara (hair on the patch
become brown)
• Associated symptoms – burning sensation, pruritus and pain
02/05/2020 KUSHTA (Dr Akshay Shetty) 20
21. Mandala Kushtha
श्िेिं रक्तिं न्स्म्िरं स्म्त्यानं न्स्म्नग्धमुत्सतनमर्ण्डलम ्|
कृ च्छ्रमतयोतयसंसक्तिं क
ु ष्ठं मर्ण्डलमुच्छ्यिे||१६||
• The clinical features of mandala kushtha are as follows:
• Color – white and red
• Nature – sthira (slow
progress), styāna/ghana (compact), snigdha, elevated round patches
• Associated symptoms – patches are matted
• Sadhyasadhyata – Difficult to cure
02/05/2020 KUSHTA (Dr Akshay Shetty) 21
22. Rishyajivha Kushtha
कक
व शं रक्तिपयवतिमतििः श्यािं सिेदनम ्|
यदृष्यन्जह्िासंस्म्िानमृष्यन्जह्िं िदुच्छ्यिे||१७||
• The clinical features of rishyajivha kushtha are as follows:
• Color – Rakta paryanta anta śyāvaṁ (red in edges and brown inside)
• Nature – karkaśa (rough), it resembles the tongue of rṣya (a type of
deer ,Chakrapani)
• Associated symptoms – pain
02/05/2020 KUSHTA (Dr Akshay Shetty) 22
23. Pundarika Kushtha
सश्िेिं रक्तिपयवतिं पुर्ण्डरीकदलोपमम ्|
सोत्सेधं च सदाहं च पुर्ण्डरीक
ं िदुच्छ्यिे||१८||
• The clinical features of pundarika kushtha are as follows:
• Color – White with red edges
• Nature – resembles lotus petals, elevated patches
• Associated symptoms – burning sensation
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24. Sidhma Kushtha
श्िेिं िाम्रं िनु च यद्रजो [१] घृष्टं विमुञ्चति|
अलाबूपुष्पिणं िि ् शसध्मं प्रायेण चोरशस||१९||
• The clinical features of sidhma kushtha are as follows:
• Color – white coppery, color resembles flower of alabu (lagenaria
siceraria)
• Nature – thin
• Associated symptom – particles resembling dust are observed, it is
located mostly on chest [due to dominance of kapha on ura
pradesh Ca.Ci.7/19 Chakrapani].
02/05/2020 KUSHTA (Dr Akshay Shetty) 24
25. Kakanaka Kushtha
यि ् काकणन्तिकािणवमपाक
ं िीव्रिेदनम ्|
त्ररदोषशलङ्गं िि ् क
ु ष्ठं काकणं नैि शसध्यति||२०||
• The clinical features of Kākaṇaka kuṣṭha are as follows:
• Color – resemble gunjā (abrus precatorious) i.e. red in color
• Nature – does not get suppurated
• Associated symptoms – Pain and incurable, all the three doshas are
present
02/05/2020 KUSHTA (Dr Akshay Shetty) 25
30. • If all the symptoms are simultaneously observed, in weak patient,
suffering from morbid thirst, burning sensation, loss of digestive
power and presence of maggots then the intelligent person should
avoid treatment (as it is incurable).
• Further vata kapha predominated kushtha and
single dosha predominated kushtha are not so difficult to treat.
• Whereas kapha pitta and vata pitta dominated kushtha are krichchra
sadhya.
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31. Summary
• Sadhyasadhyat
a
• Lakshana of
Mahakushta
• Poorvarupa
• Nidhana
Nirukti Samprapti
Lakshana of
Kshudra
Kushta
Classification
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