The document discusses the Kyoto Encyclopedia of Genes and Genomes (KEGG), which is an online database that contains information on genomes, enzymatic pathways, and biological chemicals. KEGG aims to computerize current biological knowledge and provide consistent annotations. It maintains six main databases: KEGG Pathway, KEGG Genes, KEGG Genome, KEGG Ligand, KEGG BRITE, and KEGG Cancer. These databases contain information on metabolic pathways, gene catalogs, genome sequences, chemical reactions, functional hierarchies, and cancer pathways respectively. KEGG can be used to detect enzyme clusters, compare gene clusters across genomes, and model and simulate biological systems.

1. SARFARAZ NASRI GC UNIVERSITY FAISALABAD
SARFRAZ1412@GMAIL.COM

2. Presented to:
Dr. Rizwan
Department of Bioinformatics & Biotechnology
Gcuf

3. INTRODUCTION:
Kyoto Encyclopedia of Genes and Genomes(KEGG):
“It is a collection of online databases dealing with genomes,
enzymatic pathways, and biological chemicals.”
• Pathway database
• Record networks of molecule interaction

4. • Computerize current knowledge of biological systems & provide
consistent annotations.
• Maintain gene catalogs for sequenced genomes.
• Maintain catalogs of chemical reactions in living cells by
LIGAND.
• Provide new informatics technologies toward predicting
biological systems and designing further expriments.
OBJECTIVES:

5. DATABASE OF KEGG
KEGG maintain 6 main databases:
 KEGG Pathway(Atlas)
 KEGG Genes
 KEGG Genome
 KEGG Ligand
 KEGG BRITE
 KEGG Cancer

6. KEGG PATHWAY
“KEGG PATHWAY is a collection of manually drawn pathway
maps representing our knowledge on the molecular
interaction and reaction networks for:”
 Metabolism
 Genetic Information Processing
 Environmental Information Processing
 Cellular Processes
 Organismal Systems
 Human Diseases
 Drug Development

7. KEGG: METABOLIC
PATHWAY

8. KEGG GENES:
Collection of gene
catalogs for all complete
genomes
Four types:
 MGENES (Meta
Genomes)
 VGENES (Viral
Genome)
 DGENES (Draft
Genome)
 EGENES (EST datasets)

9. KEGG GENOME
Collection of KEGG
organisms which are
the organisms with
known complete
genome sequence.

10. KEGG LIGAND:

11. KEGG BRITE:
Collection of manually
created hierarchical text files
capturing functional
hierarchies of various of
biological objects, especially
those represented as kegg
object.

12. KEGG CANCER:

13. Applications:
 Use to detect functionally related enzyme clusters.
 Automatic detection of conserved gene clusters in
multiple genomes by graph comparison.
 Modeling & Stimulation
 Browsing and retrieval of data

14. CONCLUSION:
The Kyoto Encyclopedia of Genes and Genomes is a
vast library of information gathered from fully
sequenced genomes, genes, proteins, pathways, and
chemical compounds pertaining to over a hundred
different species of both prokaryotes and eukaryotes.