Unexplained weight loss can be a symptom of serious illness and lead to emaciation or cachexia. Karshya in Ayurveda refers to weight loss and wasting of muscles. It is caused by excess purification treatments or inadequate nutrition. Symptoms include visible bones and vessels, intolerance to activity, and susceptibility to disease. Treatment focuses on nourishment and building tissues through easy to digest substances like meat, herbs like ashwagandha and shatavari, and formulations like rasayana and kashayas. Panchakarma treatments like abhyanga and vasti may also be used. The key is to identify and address the underlying cause while strengthening the body.