2. (Cha. Su. 21/9, M.N.)
Definition of Medoroga
• Excess growth of Meda and Mamsa dhatu
• Chala Sphik Udara Sthana - Pendulous movement of Buttock,
Abdomen and Breast
• Ayatha Upachaya – Altered Configuration
• Anutsaha (A-Utsaha) – Lack of enthusiasm
16. Definition of Obesity
Obesity may be defined as an abnormal growth of
adipose tissue due to
• Enlargement of fat cell size (Hypertrophic obesity) or
• Increase in fat cell number (Hyper plastic obesity) or
• Combination of the above two. (Perk)
The W.H.O. definition
• BMI ≥ 25 is overweight
• BMI ≥ 30 is obesity.
Whatever may be the definition, it is due to fat deposition in the
body results from the discrepancy between energy consume and
expenditure.
17. Etiopathogenesis of Obesity
Obesity doesn't occur overnight. It develops gradually over
time when there is discrepancy between energy consume and
expenditure.
• Genetic factors
Genetics may play a role in conversion of food into energy
and how body burns calories during exercise.
Genes may affect the amount of fat storage and distribution
of fat in body.
A few rare single gene disorders have been identified
Melanocortin-4 receptor (MC4R)
Prader-Will Syndrome
Mutations in the Leptin gene.
18. • Family history
Obesity frequently runs in families, not just because of
genetics but family members tend to share similar eating
and activity habits.
Children’s choices, diet and physical activity habits are
influenced by their surrounding environment.
• Unhealthy diet
Diet rich in calories (fast foods)
High calorie beverages
Oversized portions
Bad eating habits (eating between meals, preference to
sweets, refined foods and fats)
Diet lacking with fruits and vegetables
19.
20. • Sedentary life style
Due to Sedentary occupation and inactive recreation more
calories are stored in the body every day than used
through exercise.
If there is any associated medical problems such as
arthritis can lead to decreased activity; that contributes to
more weight gain.
• Emotional / Psychosocial factors
For some people, eating habits are influenced by emotions
such as sadness, stress, boredom or anger and they react
by eating excessively.
Excessively obese individuals are usually withdrawn, self-
conscious, lonely and secret eaters.
21. • Age
Obesity can occur at any age, even in young children.
About one third of obese adult have been so since
childhood.
As age increases, muscle mass tends to decrease and
some hormonal changes also occur; these factors along
with less active lifestyle increase the risk of obesity in later
age.
• Sex
Men were found to gain most weight between the ages of
29 -35 years while women most between 45-49 years of
age.
Men have more muscle mass and use more calories (even
at rest) than women.
22. • Giving up Smoking
Quitting smoking is often associated with weight gain
(average weight gain of 2.8 kg in males and 3.8 kg in females).
However, smoking is a serious health risk, and quitting is
more important than possible weight gain.
• Alcohol consumption
Alcohol consumption promotes weight gain by providing
substantial energy (7 kcal per gram).
It can also stimulate appetite and loosen restraint.
• Sleep
Not having enough sleep or getting too much sleep can
cause changes in hormones that may increase appetite
and craving for foods high in calories and carbohydrates,
which can contribute to weight gain.
23. • Pregnancy
Woman may develop adiposity increasing the body weight
to about 4 - 5 kg and this may go on increasing in
subsequent pregnancies.
This may be due to female sex hormone especially the
estrogen.
• Medicines
Some drugs when taken over a long period can result in
unwanted weight gain. Example –
Corticosteroids
Oral contraceptive pills (some agents)
Antipsychotics (Phenothiazines, Butyrophenones)
Antidepressants
Antiepileptics (Sodium valporate, Carbamazepine)
Insulin and some oral hypoglycemics (Sulphonylurea)
24. • Environment
Lack of neighborhood sidewalks, parks, and safe places for
recreation prevents people to be physically active.
People working with long work hours and time spent
commuting don’t have enough time to be physically active.
Lack of access to healthy foods such as fresh fruits and
vegetables, or, for some people these healthy foods are too
costly.
Lack of awareness about healthy diet and healthy cooking
practices.
Food advertisements for high-calorie, high-fat snacks and
sugary drinks promote people to buy them.
Rich man consume lots of protein, fat and carbohydrate in
their diets.
25. • Health conditions (Obesity due to endocrinal causes)
Some medical conditions may cause obesity because of
hormonal disturbances
Hypothyroidism - Lack of thyroid hormone slows down
the metabolism and causes weight gain. Excess weight
is actually edema, which is lost with replacement of
thyroid hormone.
Cushing’s syndrome – In this, increased production of
cortisol hormone from adrenal glands occurs. Here fat is
accumulated on the trunk, in the supra-clavicular fossa
and over the dorsal-posterior cervical region. The arms
and legs usually are spared.
PCOS - It is a condition that affects women of child
bearing age. It is often associated with obesity due to
high levels of androgens.
26. Insulinoma - Insulin promotes the synthesis of fat. The
post-prandial unparallel rise in blood insulin level to
that of glucose is particularly responsible for the
synthesis of excess fat, which is deposited in the fat
depots leading to obesity.
Hypothalamic Syndrome - Lesions in the
hypothalamus i.e. hypothalamic tumors or injury etc
may give rise to polyphagia and subsequent obesity.
27. Increased food intake
Hypothalamic Lesions
Adipose Cell hyperplasia
Hyper Lipogenesis
Decreased Lipolytic
hormones
Defective Adipose Cells
Abnormality in
autonomous innervations
Hyper Lipogenesis
Aging
Defective Lipid
Oxidation
Defective
thermogenesis
Increased Lipid
Deposition
Diminished
Utilization
Diminished Lipid
Mobilization
O B E S I T Y
ETIMOPATHOGENESIS OF OBESITY (Schematic Diagram)
28. Clinical features of Obesity
Weight gain (usually occurs over time)
Breathlessness
Increased sweating
Snoring
Back and joint pains
Feeling tired even with routine activities
Inability to cope with sudden physical activity
Psychological problems such as low self –
esteem, low confidence level
29.
30. Assessment of obesity
Body weight according to Body frame
Body mass index (B.M.I.)
Ponderal index
Brocca index
Lorentz formula
Corpulence index
Other measurements (associated with obesity hazards)
Skin fold thickness
Waist – Hip Ratio (W.H.R.)
Waist Circumference
31. Standard Height and Weight for Indian Men & Women
Height (Feet & Metres) Men Weight (kgs) Women Weight (kgs)
5'-0" (1.523 m) 50.8 - 54.4 50.8 - 54.4
5'-1" (1.548 m) 51.7 - 55.3 51.7 - 55.3
5'-2" (1.574 m) 56.3 - 60.3 53.1 - 56.7
5'-3" (1.599 m) 57.6 - 61.7 54.4 - 58.1
5'-4" (1.624 m) 58.9 - 63.5 56.3 - 59.9
5'-5" (1.650 m) 60.8 - 65.3 57.6 - 61.2
5'-6" (1.675 m) 61.6 - 66.7 58.9 - 63.5
5'-7" (1.700 m) 64.0 - 68.5 60.8 - 65.3
5'-8" (1.726 m) 65.8 - 70.8 62.2 - 66.7
5'-9" (1.751 m) 67.6 - 72.6 64.0 - 68.5
5'-10" (1.777 m) 69.4 - 74.4 65.8 - 70.3
5'-11" (1.802 m) 71.2 - 76.2 67.1 - 71.7
6'-0" (1.827 m) 73.0 - 78.5 68.5 - 73.9
6'-1" (1.853 m) 73.3 - 80.7 73.3 - 80.7
6'-2" (1.878 m) 77.6 - 83.5 77.6 - 83.5
6'-3" (1.904 m) 79.8 - 85.9 79.8 - 85.9
Body weight, though
not an accurate
measure of excess
fat, is a widely used
index.
33. Category Small Frame Medium Frame Large Frame
Male < 8 inches 8 - 9.25 inches > 9.25 inches
Female < 7.5 inches 7.5 - 8.75 inches > 8.75 inches
Body weight according to Body Frame
• Body Frame is of three types.
Small Frame
Medium Frame
Large Frame
• It is calculated from ankle girth.
• Take the ankle girth at the smallest point above the ankle with
the tape as tight as possible.
• Weight is different according to frame with a same height.
34. Men
Height
Small
frame
Medium
frame
Large
frame
Ft. in Cm Kg Kg Kg
5’2” 157.5
50.8 –
54.4
53.8 –
58.5
57.2 –
64.0
5’3” 160.0
52.2 –
55.8
54.9 –
60.3
58.5 –
65.3
5’4” 162.6
53.5 –
57.2
56.2 –
61.7
59.9 –
67.1
5’5” 165.1
54.9 –
58.5
57.6 –
63.0
61.2 –
68.9
5’6” 167.6
56.2 –
60.3
59.0 –
64.9
62.8 –
70.8
5’7” 170.2
58.1 –
62.1
60.8 –
66.7
64.4 –
73.0
5’8” 172.7
59.9 –
64.0
62.6 –
68.9
66.7 –
75.3
5” 9” 175.3
61.7 –
65.8
64.4 –
70.8
68.5 –
77.1
5’10” 177.8
63.5 –
68.0
66.2 –
72.6
70.3 –
78.9
Women
Height
Small
frame
Medium
frame
Large
frame
Ft. in Cm Kg Kg Kg
4’10” 147.3
41.7 –
44.5
43.5 – 48.5
47.2 –
54.0
4’11” 149.9
42.6 –
45.8
44.5 – 49.9
48.1 –
55.3
5’0” 152.4
43.5 –
47.2
45.8 – 51.3
49.4 –
56.7
5’1” 154.9
44.9 –
48.5
47.2 – 52.8
50.8 –
58.1
5’2” 157.5
46.3 –
49.9
48.5 – 54.9
52.2 –
59.4
5’3” 160.0
47.6 –
51.3
49.9 – 55.3
53.5 –
60.8
5’4” 162.6
49.0 –
52.6
51.3 – 57.2
54.9 –
62.6
5”5” 160.1
50.3 –
54.0
52.6 – 59.0
56.7 –
64.0
5’6” 167.6
51.7 –
55.8
54.4 – 61.2
59.5 –
66.2
This was first developed by life insurance companies in 1980 to determine insurance rates
based on how long people were expected to live.
Body weight according to Body frame
35. BODY MASS INDEX (BMI) {Quetelet’s index}
• Body Mass Index (BMI) is a number tool for indicating nutritional
status in adults, based on both height and weight.
• It is defined as
(Weight in kilograms divided by the square of the height in meters)
• BMI UNIT - kg/m2
• For example
Height - 1.77 m , Weight - 80 kg
then BMI = 70 / (1.77)2
= 80 / 3.1329 = 25.54 kg/m2
36. Body Mass Index (B.M.I.)
(W.H.O. classification)
< 16.00 Thinness Grade – 3
16.0 – 16.99 Thinness Grade – 2
17.0 – 18.49 Thinness Grade – 1
18.5 – 24.99 NORMAL
25.0-29.99 Overweight
30.0-34.99 Obesity Grade -1
35 - 39.99 Obesity Grade -2
≥ 40.00 Obesity Grade -3 (Morbid obesity)
BMI is also not 100% perfect as some people like athletes may measure a
high BMI but more muscle than fat.
37. The guidelines have been revised lately for Asians, considering the
fact that Asians (esp. South East Asians including Indians) are
more susceptible to metabolic syndrome.
38. 1. Relative Weight (RW) =
2. Ponderal Index =
3. Broca Index = Height (cm) minus 100 (Ht - 100)
4. Lorenz’s Formula =
5. Corpulence Index = Actual weight / Desirable weight.
(It should not exceeds 1.2)
3 )
(
)
(
Kg
Weight
Body
cm
Height
)
(
4
)
(
2
150
)
(
100
)
(
men
or
women
cm
Ht
cm
Ht
Weight
Desirable
Weight
Actual
RW > 120 % Obese
RW > 200 % Morbid obese
39. Skin fold thickness (S.F.T.)
• It is a rapid and ‘non invasive’ method for assessing body fat.
• Several varieties of calipers used for this (e.g. Harpender skin calipers).
• The measurement may be taken at all the four sites
Mid-triceps
Mid-biceps
Sub-scapular
Supra-iliac regions
• The sum of the measurement should be less than 40 mm in boys and 50
mm in girls.
• Unfortunately standards for subcutaneous fat do not exist for comparison. The main
drawback of skin fold measurement is their poor repeatability.
41. • Waist – Hip Ratio (W.H.R.)
This is the Waist circumstance divided by Hip circumstance (in cm).
Waist circumstance is measured half way between the superior iliac
crest and the rib cage in the mid axillary line measured in the
horizontal plane, with the subject standing.
Hip circumstance is measured one third of the distance between the
superior iliac spine and the patella.
The average value
W.H.O. (in cm) NIDDK
MALE < 0.90 < 1.0
FEMALE < 0.85 < 0.8
National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK)
42. • Waist Circumference
Waist is measured at mid point of
lower border of rib cage and iliac crest (at the
level of umbilicus).
Co-Morbidity risk with Waist circumference
normal Increased risk Substantial risk.
Men < 90cm (≈36’’) > 94 cm (≈37”) >102 cm (≈40”)
Women <80cm (≈32’’) > 80 cm (≈32’’) > 88 cm (≈35”)
NHLBI – National heart, Lung and Blood institute (United states)
43. Arthritis – OA, RA
Cancers
Cardiovascular Disease (CVD)
Deep Vein Thrombosis (DVT)
Diabetes (Type 2)
End Stage Renal Disease (ESRD)
Hypertension
Infertility
Low Back Pain
Gout
Heat Disorders
Impaired Immune Response
Impaired Respiratory Function
Infections Following Wounds
Liver Disease
Birth Defects
Carpal Tunnel Syndrome (CTS)
Chronic Venous Insufficiency (CVI)
Daytime Sleepiness
Gallbladder Disease
Obstetric and Gynecologic
Complications
Pain
Pancreatitis
Sleep Apnea
Stroke
Surgical Complications
Urinary Stress Incontinence
And many more
Complications
44.
45. Investigations
• Routine evaluation of co-morbidity such as diabetes, hypertension,
dyslipidaemia.
• A cardiovascular examination is needed for those older than 40
years or persons having history of heart disease.
• Various laboratory tests may be performed to assess co- morbid
conditions-
Fasting lipid profile
Liver function tests
Thyroid function tests
Fasting glucose and haemoglobin A1c(HBA1c)
46. “Most obese people
won’t enter treatment,
most who do, won’t
lose weight and most
who lose weight,
regain it” ~ Stukardz
48. LIFESTYLE CHANGE
• The safest and most effective way to lose weight is setting
goals with life style changes through
Dietary Modifications
Physical activity
Behavior modification
• If lifestyle changes are not enough then only medicines and
weight loss surgery are options.
49. Dietary Modification
• Food weight (Calorie):
A kilocalorie deficit of 500/day, in order to facilitate sustained
weight loss of 5 to 10 % of body weight at a rate of 0.5 to 1
kg/week.
Eat foods that are lower in calories, contain high fiber and
low fat.
Whole-grain foods (whole-wheat bread and chapati, oatmeal and brown
rice)
Legumes and nuts
Fat-free and low-fat dairy products, such as low-fat yogurt, cheese
and milk
Avoiding whole milk, whole-milk cheese, cream, butter, and ice
cream, solid fats (vanaspati ghee, lard, coconut, and palm oils), fried
fast foods
Limiting use of ground beef, sausage and processed meats
50. • Food portion size
Use a smaller plate, bowl etc.
Avoid oversized portions is a good way to eat fewer calories.
• Low calorie diet (LCD)
Diets consisting of between 800 and 1200 kcal/d are classified as
LCDs.
LCD is a low fat diet
• Very low calorie diet (VLCD)
VLCDs provide 200 to 800 kcal per day, with a substantial number
of calories coming from protein in order to preserve lean body
mass.
Though these diets can lead to rapid weight loss, but Cutting
calories drastically may lead to serious health problems. So they
Normally the recommended daily calories are 2,500 for men and 2,000 for women.
51.
52.
53. Regular physical exercise is essential to increase energy
expenditure.
Exercise is very effective in preventing long term weight regain.
At least, doing exercise 3 times / week for 45 minute Or doing
20 minute exercise each day.
Start physical activity slowly and increase intensity and duration
gradually with time.
Start activity with doing more everyday activities, such as taking
the stairs instead of elevators and doing house hold chores.
Physical Activity
54. Changing behaviors or habits related to food and physical
activity is important for losing weight such as:
Change the habits promoting weight gain such as
watching television for long hours.
Keep a record of weight loss.
Ask for help or encouragement from friends, family and
health care provider.
Reward the success for meeting weight-loss goals.
Behavioral changes
55. PHARMACOTHERAPY: (DRUGS)
• Anti-obesity drugs can be useful adjuncts to diet and exercise
for obese adults who have failed to achieve weight loss with
diet and exercise.
• Drugs are only prescribed when BMI is ≥ 28 kg/m 2 with other
weight related conditions or BMI ≥ 30 kg/m 2 .
• Anti-obesity drugs work by
• Inhibiting intestinal fat absorption (Orlistat)
• Suppressing food intake by act on CNS to suppress
appetite (Phentermine)
• Increasing energy consumption and thermogenesis
56. Medication Dose How It Works
• Orlistat
60 - 120
mg/day TID
• Works in gut to reduce fat absorbtion from
the food
• Phentermine-
Topiramate
3.75 mg/23
mg to 7.5
mg/46 mg
OD
• Phentermine lessens appetite
• Topiramate (seizures or migraine),
• Make less hungry or feel full sooner.
• Naltrexone -
Bupropion
8 mg / 90 mg
OD
• Naltrexone (alcohol and drug
dependence)
• Bupropion (depression or to quit
smoking)
• Make feel less hungry or full sooner
• Liraglutide
0.6 mg SC
Inj, OD
• Mimics like glucagon-like peptide-1 (GLP-
1) that targets areas of the brain that
regulate appetite and food intake
57. Medication Dose How It Works
• Semaglutide
(Weekly by injection)
0.25 mg SC
weekly
Mimics a hormone called glucagon-
like peptide-1 (GLP-1) that targets
areas of the brain that regulate
appetite and food intake
• Setmelanotide • 2 mg SC, OD
Reduce appetite and increase feeling
of fullness, increase resting
metabolism
• Sibutramine
(Banned)
• 5 – 15 mg OD • Appetite suppressant
• Other medications
that curb desire to eat
Phentermine
Benzphetamin
e
Increases chemicals in brain to
increase feeling of fullness,
58. WEIGHT - LOSS SURGERY (Bariatric Surgery)
• Used to treat people who are severely obese
(For BMI of 35 kg/m2 with co-morbidity or BMI over 40
kg/m 2).
• Common weight-loss surgeries include:
Laparoscopic adjustable gastric banding (LAGB)
Gastric bypass surgery
Gastric sleeve
Biliopancreatic diversion with duodenal switch
(BPD/DS)
59. An inflatable silicone device placed around the top portion of the stomach,
intended to slow consumption of food and thus the amount of food consumed
reduced.
Bariatric Surgery
60. Roux- en- Y Gastric Bypass Procedure -
First divides the stomach into a small
upper pouch and a much larger lower
"remnant" pouch and then re-arranges
the small intestine to connect to both.
Sleeve Gastrectomy -
Removal of a portion of
the stomach.
61. BPD/DS is a complex procedure
1. First, a sleeve gastrectomy is
performed.
2. The small intestine (first part or
duodenum) is then divided. A
very short length of the last part
of the small intestine is brought
up and attached to it
(duodenum). This is the duodenal
switch.
3. The part of the small intestine
that has been separated is
reconnected to the last part of
the small intestine. This is the
biliopancreatic diversion.
62. • It involves implanting a device under the skin of the abdomen
that sends intermittent electrical pulses to the abdominal vagus
nerve, which tells the brain when the stomach feels empty or
full.
Vagal nerve blockade
63. Intragastric Balloon (Gastric Balloon)
• Placing a deflated balloon into the stomach, and then filling it to
decrease the amount of gastric space.
70. Sample Prescription slip
1. Navaka Guggulu - 500 mg BD after food with Gomutra arka
2. Lauhasavam - 25ml BD after food with equal water
3. Vidangadi Lauha (Medohara) – 250 mg BD after food with water
4. Triphala Churna – 5 gm OD at night with lukewarm water
5. Cap Vrikshamla – 1 Cap BD after food with water
6. Panchakarma therapy
• Ruksha udvartan with Kolakulatthadi Churna
• Lekhana Vasti
Advice for
• Nidana
Parivarjanam
• Pathyapathya
72. THANK U
• Medications don’t replace physical activity or
healthy eating habits as a way to lose weight.
• Studies show that weight management
medications work best when combined with a
lifestyle program.