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Joe DiNardo – Toxicologist
May 17, 2018
Impact of
Chemical
Sunscreens on
the
Environment
and Us
Hanauma Bay – Honolulu,HI
Water Levels – Maui, Hi
2 Year Increase
213%
Water Levels – Maui, Hi
2 Year Increase
362%
Occurrence, distribution and ecological risk assessment of
multiple classes of UV filters in surface waters from different
countries – Tsui et al 2014
Compound Hong Kong
(n=60)
Tokyo
(n=8)
New York
(n=6)
Los Angeles
(n=4)
Shantou
(n=4)
Chaozhou
(n=3)
Bangkok
(n=2)
Arctic
(n=14)
4-Methylbenzlidene
Camphor
(4-MBC)
173 - 379 LOD LOD LOD LOD LOD LOD LOD
Avobenzone
(BMDM)
24 - 721 78 - 104 70 - 87 67 - 109 53 - 100 LOD 36 - 38 18 - 70
Oxybenzone
(Benzophenone-3)
39 - 5429 24 - 86 23 - 178 227 - 601 55 - 188 37 - 49 86 - 116 17 - 33
2,4-
Dihydroxybenzone
(Benzophenone-1)
82 - 135 52 - 95 <LOD - 74 100 - 117 22 - 58 LOD 127 - 166 2.5 - 5
Sulisobenzone
(Benzophenone-4)
54 - 389 71 - 136 89 - 574 LOD LOD <LOD - 49 80 - 95 LOD
Dioxybenzone
(Benzophenone-8)
64 - 117 76 - 96 72 - 92 29 - 96 LOD LOD 63 - 71 2 - 3.3
Octinoxate
(EHMC)
89 - 4043 46 - 95 89 - 150 91 - 138 52 - 78 <LOD - 79 88 - 95 25- 66
Octisalate
(EHS)
61 - 1030 71 - 95 LOD 53 - 120 LOD 121 - 128 28 - 56 LOD
Homosalate
(HMS)
66 - 2812 65 - 110 91 - 114 142 - 270 LOD LOD 29 - 59 LOD
Isoamyl p-
Methoxycinnamate
(IAMC)
63 - 173 LOD LOD LOD LOD LOD LOD LOD
Octocrylene
(OC)
103 - 6812 87 - 108 117 - 128 145 - 377 75 - 107 36 - 102 153 - 205 26 - 31
Octyl Dimethyl
PABA (ODPABA)
95 - 182 LOD LOD LOD LOD LOD LOD LOD
Concentrations (ng/L = ppt) and detection frequencies of 12 UV filters in surface water samples from different cities. Conc.: (median-maximum); DF:
detection frequencies (calculated by dividing the number of positive detections by the total number of samples from each location); LOD: limit of detection.
Chemicals Can
Kill in 14 Days
or Less, But Can
Hang Around
Up to 5 Years or
More
Photos courtesy of Dr. Phil Dustan
Florida Keys
1975 to 2014 Massive Coral Death
• BP3 = oxybenzone. BP1, 4HB, & 4DHB are metabolites of oxybenzone. OC =
octocrylene; EHMC = methoxycinnamate; ng/g = parts per billion
 This is the edible part of the fish
154
13/30
Bioaccumulation of UV filters in fish
Muscle analysis
Sources of Oxybenzone/Octinoxate
Plastic Bottles UV Coatings/Adhesives
Fish Based Live Stock Meal Fish Based Fertilizers
Plastic Bags Printing Inks
Pharmaceutical Agricultural
American Cancer Society – Siegel et al 2018
Trends in Incidence Rates for Selected Cancers by Sex, United States
Over the last 40 years, Melanoma cases have increased by 270% in men and 122% in women
Mineral Sunscreens

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Joe dinardo ppt.

  • 1. Joe DiNardo – Toxicologist May 17, 2018 Impact of Chemical Sunscreens on the Environment and Us
  • 2. Hanauma Bay – Honolulu,HI
  • 3. Water Levels – Maui, Hi 2 Year Increase 213%
  • 4. Water Levels – Maui, Hi 2 Year Increase 362%
  • 5. Occurrence, distribution and ecological risk assessment of multiple classes of UV filters in surface waters from different countries – Tsui et al 2014 Compound Hong Kong (n=60) Tokyo (n=8) New York (n=6) Los Angeles (n=4) Shantou (n=4) Chaozhou (n=3) Bangkok (n=2) Arctic (n=14) 4-Methylbenzlidene Camphor (4-MBC) 173 - 379 LOD LOD LOD LOD LOD LOD LOD Avobenzone (BMDM) 24 - 721 78 - 104 70 - 87 67 - 109 53 - 100 LOD 36 - 38 18 - 70 Oxybenzone (Benzophenone-3) 39 - 5429 24 - 86 23 - 178 227 - 601 55 - 188 37 - 49 86 - 116 17 - 33 2,4- Dihydroxybenzone (Benzophenone-1) 82 - 135 52 - 95 <LOD - 74 100 - 117 22 - 58 LOD 127 - 166 2.5 - 5 Sulisobenzone (Benzophenone-4) 54 - 389 71 - 136 89 - 574 LOD LOD <LOD - 49 80 - 95 LOD Dioxybenzone (Benzophenone-8) 64 - 117 76 - 96 72 - 92 29 - 96 LOD LOD 63 - 71 2 - 3.3 Octinoxate (EHMC) 89 - 4043 46 - 95 89 - 150 91 - 138 52 - 78 <LOD - 79 88 - 95 25- 66 Octisalate (EHS) 61 - 1030 71 - 95 LOD 53 - 120 LOD 121 - 128 28 - 56 LOD Homosalate (HMS) 66 - 2812 65 - 110 91 - 114 142 - 270 LOD LOD 29 - 59 LOD Isoamyl p- Methoxycinnamate (IAMC) 63 - 173 LOD LOD LOD LOD LOD LOD LOD Octocrylene (OC) 103 - 6812 87 - 108 117 - 128 145 - 377 75 - 107 36 - 102 153 - 205 26 - 31 Octyl Dimethyl PABA (ODPABA) 95 - 182 LOD LOD LOD LOD LOD LOD LOD Concentrations (ng/L = ppt) and detection frequencies of 12 UV filters in surface water samples from different cities. Conc.: (median-maximum); DF: detection frequencies (calculated by dividing the number of positive detections by the total number of samples from each location); LOD: limit of detection.
  • 6.
  • 7.
  • 8. Chemicals Can Kill in 14 Days or Less, But Can Hang Around Up to 5 Years or More
  • 9. Photos courtesy of Dr. Phil Dustan Florida Keys 1975 to 2014 Massive Coral Death
  • 10.
  • 11.
  • 12.
  • 13. • BP3 = oxybenzone. BP1, 4HB, & 4DHB are metabolites of oxybenzone. OC = octocrylene; EHMC = methoxycinnamate; ng/g = parts per billion  This is the edible part of the fish 154 13/30 Bioaccumulation of UV filters in fish Muscle analysis
  • 14.
  • 15.
  • 16. Sources of Oxybenzone/Octinoxate Plastic Bottles UV Coatings/Adhesives Fish Based Live Stock Meal Fish Based Fertilizers Plastic Bags Printing Inks Pharmaceutical Agricultural
  • 17.
  • 18.
  • 19. American Cancer Society – Siegel et al 2018 Trends in Incidence Rates for Selected Cancers by Sex, United States Over the last 40 years, Melanoma cases have increased by 270% in men and 122% in women