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Evidence-Based Guideline for Management 
of High Blood Pressure in Adults 
Report From the Panel Members Appointed to the 
Eighth Joint National Committee (JNC 8) 
Dr Arun kochar 
MD;DM;DNB 
Senior interventional cardiologist 
Fortis Hospital, Mohali
JNC 8 is not just JNC 7 “Renovated”…. 
but 911ed and Reconstructed
Historical Comments about Hypertension 
“The greatest danger to 
a man with 
high blood pressure 
lies in its discovery……. 
because then some fool is certain to try 
his hand and reduce it.” 
Hay, Brit Med J,
Let us take a early dinner… 
 Treat to 150/90 mm Hg in patients over age 60 and 
140/90 for everybody else. 
 Any of 4 classes of drugs could be chosen. 
 Destination is important and not the journey. 
 No stages please. 
 In blacks C and D. 
THANK YOU
Introduction 
 Hypertension remains one of the most important 
preventable contributors to disease and death. 
 Clinical guidelines are at the intersection between 
research evidence and clinical actions that can 
improve patient outcomes. 
 This report highlights the Evidence-Based Guideline 
for the Management of High Blood Pressure in 
Adults.
Introduction 
 The panel members appointed to the JNC 8 used 
evidence-based methods, developing Evidence 
Statements and recommendations for blood 
pressure treatment. 
 Recommendations are based on a systematic review 
of the literature to meet needs of the primary care 
clinician. 
 This is an Executive summary of the evidence and is 
provides clear recommendations for all clinicians.
From: 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the 
Panel Members Appointed to the Eighth Joint National Committee (JNC 8) 
Figure Legend: 
Date of download: 12/21/2013 
Copyright © 2012 American Medical 
Association. All rights reserved. 
JAMA. 2013;():. doi:10.1001/jama.2013.284427 
Comparison of Current Recommendations With JNC 7 Guidelines
Questions Guiding the Evidence Review 
 Guideline focuses on the panel’s most debated 
questions related to high BP management. 
 These questions address: 
 Thresholds and goals for treatment of hypertension. 
 Whether particular antihypertensive drugs have a bearing 
health outcomes.
Questions Guiding the Evidence Review 
1. In adults with hypertension, does initiating 
antihypertensive pharmacologic therapy at specific BP 
thresholds improve health outcomes? Goals 
2. In adults with hypertension, does treatment with 
antihypertensive pharmacologic therapy to a specified 
BP goal lead to improvement in health outcomes? 
Targets 
3. In adults with hypertension, do various 
antihypertensive drugs or drug classes differ in 
comparative benefits and harms on specific health 
outcomes? Impact of drugs
Recommendations
Concerning thresholds and goals. 
Recommendations 1 -5
Recommendation 1 
 General population aged 60 years or older 
SBP ≥150 mmHg 
Or 
DBP ≥ 90mmHg 
Goal of Treatment : 
SBP <150 mmHg 
OR 
DBP of < 90mmHg. 
Initiate Treatment at :
Recommendation 2 
 General population < 60 years 
Initiate Treatment at : DBP ≥ 90mmHg 
Goal of Treatment : DBP of < 90mmHg.
Recommendation 3 
 General population < 60 years 
SBP ≥ 140 mmHg 
Initiate Treatment at : 
Goal of Treatment : SBP of < 140 mmHg.
Recommendation 4 
 Population aged 18 years or older with CKD 
Initiate Treatment at: 
SBP ≥ 140 mmHg 
Or 
DBP ≥ 90 mmHg 
Goal of Treatment : 
SBP < 140 mmHg 
Or 
DBP < 90 mmHg
Recommendation 5 
 Population aged 18 years or older with 
diabetes 
Initiate Treatment at: 
SBP ≥ 140 mmHg 
Or 
DBP ≥ 90 mmHg 
Goal of Treatment : 
SBP < 140 mmHg 
Or 
DBP < 90 mmHg
Concerning selection of 
antihypertensive drugs. 
Recommendations6,7,8
Recommendation 6 
 In General nonblack population, including those 
with diabetes 
 Initial antihypertensive treatment should include any 
of the following: 
 A thiazide-type diuretic 
 Calcium channel blocker (CCB) 
 Angiotensin-converting enzyme inhibitor (ACEI) or 
 Angiotensin receptor blocker (ARB).
Recommendation 7 
 In general black population, including those 
with diabetes: 
 Initial antihypertensive treatment should 
include : 
 Thiazide-type diuretic 
 CCB.
Recommendation 8 
 Population aged 18 years or older with CKD 
and hypertension 
 Initial (or add-on) antihypertensive treatment 
should include an ACEI or ARB to improve 
kidney outcomes. 
 This applies to all CKD patients with 
hypertension regardless of race or diabetes 
status.
Recommendation 9 
 The main objective of hypertension treatment is to 
attain and maintain goal BP. 
 If goal BP is not reached within a month of 
treatment: 
 increase the dose of the initial drug OR 
 Add a second drug from one of the classes in 
recommendation 6 (thiazide-type diuretic, CCB, ACEI, or 
ARB). 
 The clinician should continue to assess BP and 
adjust the treatment regimen until goal BP is 
reached.
Opinion for starting & adding drugs 
. 
Recommendation 9
Recommendation 9 
 If goal BP cannot be reached with 2 drugs: 
 Add and titrate a third drug from the list provided. 
 Do not use an ACEI and an ARB together in the 
same patient. 
 If goal BP cannot be reached using the drugs in 
recommendation 6 because of a contraindication or 
the need to use more than 3 drugs to reach goal BP: 
antihypertensive drugs from other classes can be 
used.
From: 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the 
Panel Members Appointed to the Eighth Joint National Committee (JNC 8) 
Date of download: 12/21/2013 
Copyright © 2012 American Medical 
Association. All rights reserved. 
JAMA. 2013;():. doi:10.1001/jama.2013.284427 
Strategies to Dose Antihypertensive Drugs 
Figure Legend:
Recommendation 9 
 For patients in whom goal BP cannot be attained 
using the above strategy OR 
 The management of complicated patients for 
whom additional clinical consultation is needed. 
 Referral to a hypertension specialist may be 
indicated
JNC-8 ASH/ISH AHA/ACC 
Published on 18th Dec 2013 19th Dec 2013 21st Nov 2013 
Target goal 
For general 
patients 
including 
DM/CKD 
<140/90 <140/90 <140/90 
Lower targets may 
be appropriate for 
LVD, LVH, DM, 
CKD 
For Elderly 
people 
150/90(≥60 yrs) 150/90(≥80 yrs) 
Lower targets for 
the Elderly 
Treatment preference 
General <60 yrs 
Initiate Thiazide-type 
Diuretic or 
ACEI or ARB or 
CCB 
For uptitration, 
any possible 
combination from 
above (avoid 
ACEI+ARB) 
Stage 1 HT: 
ACEI or ARB 
(If needed, add 
CCB or Thiazide-type 
Diuretic) 
Stage 1 HT: 
Thiazide for most 
patients or 
ACEI, ARB, CCB, 
(or combination, if 
uncontrolled) 
Stage 2 HT: 
ACEI or ARB 
+ 
CCB or Thiazide-type 
Diuretic 
Stage 2 HT: 
Thiazide with 
ACEI / ARB/ CCB, 
or 
ACEI with CCB 
General ≥60 yrs Same as above 
Stage 1: CCB or 
Thiazide (If 
needed, add ACEI 
or ARB) 
Same as Above 
Hypertension 
with Diabetes 
Same as above 
ACEI or ARB 
If needed add CCB 
or thiazide-type 
diuretic 
ACEI or ARB, 
thiazide, BB, 
calcium channel 
blocker 
Hypertension 
with CKD 
ACEI or ARB alone 
Or in combination 
with other 
ACEI or ARB 
If needed add CCB 
or thiazide-type 
diuretic 
ACEI or ARB
Comparison..(cont.) 
Hypertension 
with CAD 
--- 
β-Blocker plus ARB 
or ACE inhibitor 
If needed add CCB 
or thiazide-type 
diuretic 
β-Blocker, ACEI 
Hypertension 
with stroke 
--- 
ACE inhibitor or 
ARB 
If needed add CCB 
or thiazide-type 
diuretic 
Thiazide, ACEI. 
Hypertension 
with HF 
--- 
ARB or ACE 
inhibitor+ β - 
blocker+ diuretic+ 
spironolactone 
regardless of blood 
pressure 
ACEI or 
angiotensin-receptor 
blocker 
(ARB), BB, 
aldosterone 
antagonist, 
thiazide;
Conclusion 
 Guidelines Offer clinicians an analysis of what is known 
and not known about BP treatment thresholds, goals, and 
drug treatment strategies 
 Provides evidence-based recommendations for the 
management of high BP 
 Should meet the clinical needs of most patients. 
 However, these recommendations are not a substitute for 
clinical judgment, and decisions must carefully consider 
and incorporate the clinical characteristics of each 
individual.
Thank you for your patience

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  • 1. Evidence-Based Guideline for Management of High Blood Pressure in Adults Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8) Dr Arun kochar MD;DM;DNB Senior interventional cardiologist Fortis Hospital, Mohali
  • 2. JNC 8 is not just JNC 7 “Renovated”…. but 911ed and Reconstructed
  • 3. Historical Comments about Hypertension “The greatest danger to a man with high blood pressure lies in its discovery……. because then some fool is certain to try his hand and reduce it.” Hay, Brit Med J,
  • 4. Let us take a early dinner…  Treat to 150/90 mm Hg in patients over age 60 and 140/90 for everybody else.  Any of 4 classes of drugs could be chosen.  Destination is important and not the journey.  No stages please.  In blacks C and D. THANK YOU
  • 5. Introduction  Hypertension remains one of the most important preventable contributors to disease and death.  Clinical guidelines are at the intersection between research evidence and clinical actions that can improve patient outcomes.  This report highlights the Evidence-Based Guideline for the Management of High Blood Pressure in Adults.
  • 6. Introduction  The panel members appointed to the JNC 8 used evidence-based methods, developing Evidence Statements and recommendations for blood pressure treatment.  Recommendations are based on a systematic review of the literature to meet needs of the primary care clinician.  This is an Executive summary of the evidence and is provides clear recommendations for all clinicians.
  • 7. From: 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8) Figure Legend: Date of download: 12/21/2013 Copyright © 2012 American Medical Association. All rights reserved. JAMA. 2013;():. doi:10.1001/jama.2013.284427 Comparison of Current Recommendations With JNC 7 Guidelines
  • 8. Questions Guiding the Evidence Review  Guideline focuses on the panel’s most debated questions related to high BP management.  These questions address:  Thresholds and goals for treatment of hypertension.  Whether particular antihypertensive drugs have a bearing health outcomes.
  • 9. Questions Guiding the Evidence Review 1. In adults with hypertension, does initiating antihypertensive pharmacologic therapy at specific BP thresholds improve health outcomes? Goals 2. In adults with hypertension, does treatment with antihypertensive pharmacologic therapy to a specified BP goal lead to improvement in health outcomes? Targets 3. In adults with hypertension, do various antihypertensive drugs or drug classes differ in comparative benefits and harms on specific health outcomes? Impact of drugs
  • 11. Concerning thresholds and goals. Recommendations 1 -5
  • 12. Recommendation 1  General population aged 60 years or older SBP ≥150 mmHg Or DBP ≥ 90mmHg Goal of Treatment : SBP <150 mmHg OR DBP of < 90mmHg. Initiate Treatment at :
  • 13. Recommendation 2  General population < 60 years Initiate Treatment at : DBP ≥ 90mmHg Goal of Treatment : DBP of < 90mmHg.
  • 14. Recommendation 3  General population < 60 years SBP ≥ 140 mmHg Initiate Treatment at : Goal of Treatment : SBP of < 140 mmHg.
  • 15. Recommendation 4  Population aged 18 years or older with CKD Initiate Treatment at: SBP ≥ 140 mmHg Or DBP ≥ 90 mmHg Goal of Treatment : SBP < 140 mmHg Or DBP < 90 mmHg
  • 16. Recommendation 5  Population aged 18 years or older with diabetes Initiate Treatment at: SBP ≥ 140 mmHg Or DBP ≥ 90 mmHg Goal of Treatment : SBP < 140 mmHg Or DBP < 90 mmHg
  • 17. Concerning selection of antihypertensive drugs. Recommendations6,7,8
  • 18. Recommendation 6  In General nonblack population, including those with diabetes  Initial antihypertensive treatment should include any of the following:  A thiazide-type diuretic  Calcium channel blocker (CCB)  Angiotensin-converting enzyme inhibitor (ACEI) or  Angiotensin receptor blocker (ARB).
  • 19. Recommendation 7  In general black population, including those with diabetes:  Initial antihypertensive treatment should include :  Thiazide-type diuretic  CCB.
  • 20. Recommendation 8  Population aged 18 years or older with CKD and hypertension  Initial (or add-on) antihypertensive treatment should include an ACEI or ARB to improve kidney outcomes.  This applies to all CKD patients with hypertension regardless of race or diabetes status.
  • 21. Recommendation 9  The main objective of hypertension treatment is to attain and maintain goal BP.  If goal BP is not reached within a month of treatment:  increase the dose of the initial drug OR  Add a second drug from one of the classes in recommendation 6 (thiazide-type diuretic, CCB, ACEI, or ARB).  The clinician should continue to assess BP and adjust the treatment regimen until goal BP is reached.
  • 22. Opinion for starting & adding drugs . Recommendation 9
  • 23. Recommendation 9  If goal BP cannot be reached with 2 drugs:  Add and titrate a third drug from the list provided.  Do not use an ACEI and an ARB together in the same patient.  If goal BP cannot be reached using the drugs in recommendation 6 because of a contraindication or the need to use more than 3 drugs to reach goal BP: antihypertensive drugs from other classes can be used.
  • 24. From: 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8) Date of download: 12/21/2013 Copyright © 2012 American Medical Association. All rights reserved. JAMA. 2013;():. doi:10.1001/jama.2013.284427 Strategies to Dose Antihypertensive Drugs Figure Legend:
  • 25. Recommendation 9  For patients in whom goal BP cannot be attained using the above strategy OR  The management of complicated patients for whom additional clinical consultation is needed.  Referral to a hypertension specialist may be indicated
  • 26. JNC-8 ASH/ISH AHA/ACC Published on 18th Dec 2013 19th Dec 2013 21st Nov 2013 Target goal For general patients including DM/CKD <140/90 <140/90 <140/90 Lower targets may be appropriate for LVD, LVH, DM, CKD For Elderly people 150/90(≥60 yrs) 150/90(≥80 yrs) Lower targets for the Elderly Treatment preference General <60 yrs Initiate Thiazide-type Diuretic or ACEI or ARB or CCB For uptitration, any possible combination from above (avoid ACEI+ARB) Stage 1 HT: ACEI or ARB (If needed, add CCB or Thiazide-type Diuretic) Stage 1 HT: Thiazide for most patients or ACEI, ARB, CCB, (or combination, if uncontrolled) Stage 2 HT: ACEI or ARB + CCB or Thiazide-type Diuretic Stage 2 HT: Thiazide with ACEI / ARB/ CCB, or ACEI with CCB General ≥60 yrs Same as above Stage 1: CCB or Thiazide (If needed, add ACEI or ARB) Same as Above Hypertension with Diabetes Same as above ACEI or ARB If needed add CCB or thiazide-type diuretic ACEI or ARB, thiazide, BB, calcium channel blocker Hypertension with CKD ACEI or ARB alone Or in combination with other ACEI or ARB If needed add CCB or thiazide-type diuretic ACEI or ARB
  • 27. Comparison..(cont.) Hypertension with CAD --- β-Blocker plus ARB or ACE inhibitor If needed add CCB or thiazide-type diuretic β-Blocker, ACEI Hypertension with stroke --- ACE inhibitor or ARB If needed add CCB or thiazide-type diuretic Thiazide, ACEI. Hypertension with HF --- ARB or ACE inhibitor+ β - blocker+ diuretic+ spironolactone regardless of blood pressure ACEI or angiotensin-receptor blocker (ARB), BB, aldosterone antagonist, thiazide;
  • 28. Conclusion  Guidelines Offer clinicians an analysis of what is known and not known about BP treatment thresholds, goals, and drug treatment strategies  Provides evidence-based recommendations for the management of high BP  Should meet the clinical needs of most patients.  However, these recommendations are not a substitute for clinical judgment, and decisions must carefully consider and incorporate the clinical characteristics of each individual.
  • 29. Thank you for your patience

Editor's Notes

  1. Eighth Joint National Committee JNC 8
  2. This evidence-based hypertension guideline focuses on the panel’s3highest- ranked questions related to high BP management.
  3. Nine recommendations are made reflecting these questions. Recommendations 1 -5 address questions 1 & 2 concerning thresholds and goals for BP treatment. Recommendations 6, 7, 8 address question concerning selection of antihypertensive drugs. Recommendation 9 is a summary of strategies based on expert opinion for starting and adding antihypertensive drugs
  4. In patients aged ≥60 years, initiate pharmacologic treatment if systolic BP ≥150mmHg or diastolic BP ≥90mmHg and treat to a goal systolic BP <150mmHg and goal diastolic BP <90mmHg.  (Strong Recommendation–Grade A)
  5. In the general population younger than 60 years, initiate pharmacologic treatment to lower BP at DBP of 90 mm Hg or higher and treat to a goal DBP of lower than 90mmHg.
  6. In the general population younger than 60 years, initiate pharmacologic treatment to lower BP at SBP of 140 mm Hg or higher and treat to a goal SBP of lower than 140mmHg.
  7. initiate pharmacologic treatment to lower BP at SBP of 140mmHg or higher or DBP of 90mmHg or higher and treat to goal SBP of lower than 140mm Hg and goal DBP lower than 90mmHg.
  8. the population aged 18 years or older with diabetes, initiate pharmacologic treatment to lower BP at SBP of 140mmHg or higher or DBP of 90 mm Hg or higher and treat to a goal SBP of lower than 140mmHg and goal DBP lower than 90mmHg.
  9. Nine recommendations are made reflecting these questions. Recommendations 1 -5 address questions 1 & 2 concerning thresholds and goals for BP treatment. Recommendations 6, 7, 8 address question concerning selection of antihypertensive drugs. Recommendation 9 is a summary of strategies based on expert opinion for starting and adding antihypertensive drugs