1. A new Schiff base ligand was synthesized by condensing amoxicillin and 4-(dimethylamino)benzaldehyde. Mixed ligand complexes were synthesized from reactions of the Schiff base ligand with metal salts such as Fe(II), Co(II), Ni(II), Cu(II), and Zn(II) along with nicotinamide.
2. The complexes were characterized using various techniques such as elemental analysis, FT-IR, UV-Vis, magnetic susceptibility measurements, and evaluating their conductivities. The data indicated the complexes had octahedral geometries and were non-electrolytes.
3. The antimicrobial activities of the complexes were evaluated against various bacteria and found to have
A new Schiff base 4-chlorophenyl)methanimine
(6R,7R)-3-methyl-8-oxo-7-(2-phenylpropanamido)-5-thia-1-
azabicyclo[4.2.0]oct-2-ene-2-carboxylate= (HL)= C23H20
ClN3O4S) has been synthesized from β-lactam antibiotic
(cephalexin mono hydrate(CephH)=(C16H19N3O5S.H2O) and 4-
chlorobenzaldehyde . Figure(1) Metal mixed ligand complexes
of the Schiff base were prepared from chloride salt of
Fe(II),Co(II),Ni(II),Cu(II),Zn(II) and Cd (II), in 50% (v/v)
ethanol –water medium (SacH ) .in aqueous ethanol(1:1)
containing and Saccharin(C7H5NO3S) = sodium hydroxide.
Several physical tools in particular; IR, CHN, 1H NMR, 13C
NMR for ligand and melting point molar conductance, magnetic
moment. and determination the percentage of the metal in the
complexes by flame(AAS). The ligands and there metal
complexes were screened for their antimicrobial activity against
four bacteria (gram + ve) and (gram -ve) {Escherichia coli,
Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus}.
The proposed structure of the complexes using program, Chem
office 3D(2006). The general formula have been given for the
prepared mixed ligand complexes Na2[M(Sac)3(L)], M(II) = Fe
(II), Co(II) , Ni(II), Cu (II), Zn(II) , and Cd(II).
HL= C29H24 ClN3O4S, L= C29H23 ClN3O4S -.
Bidentate Schiff base ligand 3-(3,4-Dihydroxy-phenyl)-2-[(4-dimethylamino-benzylidene)-amino]-2-methyl-propionic acid was prepared and characterized by spectroscopic techniques studies and elemental analysis. The Cd(II), Ni(II), Cu(II), Co(II), Cr(III),and Fe(III) of mixed-ligand complexes were structural explicate through moler conductance , [FT-IR, UV-Vis & AAS], chloride contents, , and magnetic susceptibility measurements. Octahedral geometries have been suggested for all complexes. The Schiff base and its complexes were tested against various bacterial species, two of {gram(G+) and gram(G-)} were shown weak to good activity against all bacteria.
Synthesis And Antibacterial Activity Of 3-[(3-Phenyl-5-Thioxo-1, 5-Dihydro-4h...inventionjournals
A series of 3-[(3-phenyl-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)imino]-1,3-dihydro-2Hindole-2-one derivatives were synthesised through the nucleophilic substitution at carbonyl carbon of Isatin. Structure of synthesized compounds were elucidated by using IR, 1H NMR & 13C NMR spectrometry. Synthesised compounds showed significant antibacterial activity against E.coli (ATCC 35218), S.aureus (ATCC 25323), E.faecalis (Clinical isolate), K. Pneumonia, P. aeruginosa (ATCC 27893) using agar well diffusion method.
Mixed Ligand, Palladium(II) and Platinum(II) Complexes of Tertiary Diphosphin...Karwan Omer
Palladium(II) and platinum(II) complexes containing the mixed ligands tertiary
diphosphinesdppm. dppp and dppf with Thioester ligand S-1H benzo[d] imidazole-2-yl benzothioate
(HSBIBT) have been prepared by the reaction of PdCl2 and PtCl2 with one equiv of tertiary
diphosphines ligands to form [Pd(k2-dppf)Cl2], [Pd(k2-dppp)Cl2] and [Pt(k2-dppmCl)Cl2] complexes
and then add the ligand HSBIBT to these complexes to form mixed ligand complexes. The prepared
complexes have been characterized by single-crystal X-ray diffraction, elemental analysis, magnetic
susceptibility, molar conductance, IR spectral data and UV-Visible. The results suggested that the
ligand HSBIBT bonded to the metal through N atom and square planner geometries were assigned
for the complexes.
Facial and Simple Synthesis of Some New (Pyrazole and Triazole) Coumarin Deri...IOSRJAC
2-oxo-2H-coumarin-3-carbohydrazide (2) which prepared from the reaction of ethyl-2-oxo-2Hcoumarin-3-carboxylate (1) with hydrazine hydrate in ethanol containing a catalytic amount of piperidine mixture consider a good and available starting intermediate for synthesis of series of functionalized coumarins. So, compound (2) was utilized as a key for the synthesis of some new (pyrazole, triazole)-2H- coumarin-2-one derivatives by the reaction with some selected reagents.
A series of novel 5-[2-(4-fluorobenzyl)-6-aryl-imidazo[2,1-b][1,3,4]thiadiazol-5-ylmethylene] thiazolidine-2,4-dione derivatives (4a-d) were synthesized. These final compounds (4a-d) were synthesized by Knoevenagel condensation of 2-(4-fluorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehydes (3a-d) with thiazolidine-2,4-dione. All the newly synthesized compounds were screened for their invivo hypoglycemic and hypolipidemic activity in male Wister rats. The Structures of all the newly synthesized compounds were established by analytical and spectral data.
A new Schiff base 4-chlorophenyl)methanimine
(6R,7R)-3-methyl-8-oxo-7-(2-phenylpropanamido)-5-thia-1-
azabicyclo[4.2.0]oct-2-ene-2-carboxylate= (HL)= C23H20
ClN3O4S) has been synthesized from β-lactam antibiotic
(cephalexin mono hydrate(CephH)=(C16H19N3O5S.H2O) and 4-
chlorobenzaldehyde . Figure(1) Metal mixed ligand complexes
of the Schiff base were prepared from chloride salt of
Fe(II),Co(II),Ni(II),Cu(II),Zn(II) and Cd (II), in 50% (v/v)
ethanol –water medium (SacH ) .in aqueous ethanol(1:1)
containing and Saccharin(C7H5NO3S) = sodium hydroxide.
Several physical tools in particular; IR, CHN, 1H NMR, 13C
NMR for ligand and melting point molar conductance, magnetic
moment. and determination the percentage of the metal in the
complexes by flame(AAS). The ligands and there metal
complexes were screened for their antimicrobial activity against
four bacteria (gram + ve) and (gram -ve) {Escherichia coli,
Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus}.
The proposed structure of the complexes using program, Chem
office 3D(2006). The general formula have been given for the
prepared mixed ligand complexes Na2[M(Sac)3(L)], M(II) = Fe
(II), Co(II) , Ni(II), Cu (II), Zn(II) , and Cd(II).
HL= C29H24 ClN3O4S, L= C29H23 ClN3O4S -.
Bidentate Schiff base ligand 3-(3,4-Dihydroxy-phenyl)-2-[(4-dimethylamino-benzylidene)-amino]-2-methyl-propionic acid was prepared and characterized by spectroscopic techniques studies and elemental analysis. The Cd(II), Ni(II), Cu(II), Co(II), Cr(III),and Fe(III) of mixed-ligand complexes were structural explicate through moler conductance , [FT-IR, UV-Vis & AAS], chloride contents, , and magnetic susceptibility measurements. Octahedral geometries have been suggested for all complexes. The Schiff base and its complexes were tested against various bacterial species, two of {gram(G+) and gram(G-)} were shown weak to good activity against all bacteria.
Synthesis And Antibacterial Activity Of 3-[(3-Phenyl-5-Thioxo-1, 5-Dihydro-4h...inventionjournals
A series of 3-[(3-phenyl-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)imino]-1,3-dihydro-2Hindole-2-one derivatives were synthesised through the nucleophilic substitution at carbonyl carbon of Isatin. Structure of synthesized compounds were elucidated by using IR, 1H NMR & 13C NMR spectrometry. Synthesised compounds showed significant antibacterial activity against E.coli (ATCC 35218), S.aureus (ATCC 25323), E.faecalis (Clinical isolate), K. Pneumonia, P. aeruginosa (ATCC 27893) using agar well diffusion method.
Mixed Ligand, Palladium(II) and Platinum(II) Complexes of Tertiary Diphosphin...Karwan Omer
Palladium(II) and platinum(II) complexes containing the mixed ligands tertiary
diphosphinesdppm. dppp and dppf with Thioester ligand S-1H benzo[d] imidazole-2-yl benzothioate
(HSBIBT) have been prepared by the reaction of PdCl2 and PtCl2 with one equiv of tertiary
diphosphines ligands to form [Pd(k2-dppf)Cl2], [Pd(k2-dppp)Cl2] and [Pt(k2-dppmCl)Cl2] complexes
and then add the ligand HSBIBT to these complexes to form mixed ligand complexes. The prepared
complexes have been characterized by single-crystal X-ray diffraction, elemental analysis, magnetic
susceptibility, molar conductance, IR spectral data and UV-Visible. The results suggested that the
ligand HSBIBT bonded to the metal through N atom and square planner geometries were assigned
for the complexes.
Facial and Simple Synthesis of Some New (Pyrazole and Triazole) Coumarin Deri...IOSRJAC
2-oxo-2H-coumarin-3-carbohydrazide (2) which prepared from the reaction of ethyl-2-oxo-2Hcoumarin-3-carboxylate (1) with hydrazine hydrate in ethanol containing a catalytic amount of piperidine mixture consider a good and available starting intermediate for synthesis of series of functionalized coumarins. So, compound (2) was utilized as a key for the synthesis of some new (pyrazole, triazole)-2H- coumarin-2-one derivatives by the reaction with some selected reagents.
A series of novel 5-[2-(4-fluorobenzyl)-6-aryl-imidazo[2,1-b][1,3,4]thiadiazol-5-ylmethylene] thiazolidine-2,4-dione derivatives (4a-d) were synthesized. These final compounds (4a-d) were synthesized by Knoevenagel condensation of 2-(4-fluorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehydes (3a-d) with thiazolidine-2,4-dione. All the newly synthesized compounds were screened for their invivo hypoglycemic and hypolipidemic activity in male Wister rats. The Structures of all the newly synthesized compounds were established by analytical and spectral data.
Simple Synthesis of Some Novel Polyfunctionally Derivatives of 2H-Coumarin-2-...IOSRJAC
Compound (2) was prepared from the reaction of ethyl-2-oxo-2H-coumarin-3-carboxylate (1) with ethylcyanoacetate in ethanol containing a catalytic amount of piperidine as catalyst. Compound (2) is the key intermediate for the synthesis of several series of new compounds such as ((pyrimidine, tetrazine, piperidine, oxazepine)-2H-coumarin-2-one derivatives by reaction with selected reagents such as urea, cyanoacetamide, cyanoacetohydrazide, orthoaminophenol and 5-aminotriazole.
Novel coumarin isoxazoline derivatives: Synthesis and study of antibacterial ...Ratnakaram Venkata Nadh
A highly efficient and mild protocol for the syntheses of ethyl-3-
[7-benzyloxy-4-methyl-2-oxo-2H-8-chromenyl]-5-aryl-4,5-dihydro-4-
isoxazole carboxylates and ethyl-3-[7-benzyloxy-3-chloro-4-methyl-2-
oxo-2H-8-chromenyl]-5-aryl-4,5-dihydro-4-isoxazole carboxylates in
good yields via [3 þ 2] cycloaddition of in situ–generated nitrile
oxides from 7-benzyloxy-4-methyl-coumarin hydroxymoylchlorides
and 7-benzyloxy-3-chloro-4-methyl-coumarin hydroxymoylchlorides
respectively with ethyl-3-aryl prop-2-enoate has been developed.
The new compounds are screened for antibacterial activity.
Design, Synthesis, Biological Evaluation, and In Silico ADMET Studies of 1,8-...BRNSS Publication Hub
In the present study, 1,8-naphthyridine-3-carboxylic acid derivatives (5a1, 5a2, 5b1, and 5b2) were
designed, synthesized, and screened for their in vitro H1-antihistaminic activity. H1R inhibitory activity
of the synthesized derivatives was calculated by the modified Van Arman technique, histamine-induced
bronchoconstriction in guinea pigs. A good bronchorelaxant effect of compounds was observed in
histamine-contracted guinea pig tracheal chain through H1-receptor antagonism. In addition, the
hypothetically resulted compounds are checked for their reliability on other in silico drug designing
online web services like SwissADME predictor. In silico ADMET analysis results show that all the
derivatives had negligible toxicity, good absorption, and solubility profile. These compounds may serve
as possible lead for establishing safe and effective antihistaminic agent(s).
Research Inventy : International Journal of Engineering and Scienceresearchinventy
Research Inventy : International Journal of Engineering and Science is published by the group of young academic and industrial researchers with 12 Issues per year. It is an online as well as print version open access journal that provides rapid publication (monthly) of articles in all areas of the subject such as: civil, mechanical, chemical, electronic and computer engineering as well as production and information technology. The Journal welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published by rapid process within 20 days after acceptance and peer review process takes only 7 days. All articles published in Research Inventy will be peer-reviewed.
Synthesis and Characterization of New Complexes of 2-(6-Methoxybenzo[d]thiazo...IOSR Journals
Abstract: The synthesis and characterization of manganese (ІІ), cobalt (ІІ), nickel (ІІ), copper (ІІ), zinc (ІІ), cadmium (ІІ) and mercury (ІІ) bidentate 2-(6-methoxybenzo[d]thiazol-2-ylamino)-2-phenyl acetonitrile ligand which was prepared from Benz aldehyde and 6-methoxybenzo[d]thiazol-2-amine in the presence of KCN and acidic medium. The complexes were synthesized by treating an ethanolic solution of the ligand with appropriate amount of metal salts [1:2] [M: L] ratio. The complexes were characterized by using metal and elemental chemical analysis, molar conductance, magnetic susceptibility measurements, FTIR , electronic spectral and mole ratio method. According to the obtained data the probable coordination geometries of manganese (ІІ), cobalt (ІІ), nickel (ІІ), copper (ІІ) zinc (ІІ), cadmium (ІІ) and mercury (ІІ) in these complexes are octahedral. All complexes were found to be non-electrolyte in absolute ethanol, and the complexes were formulated as [ML2Cl2] XH2O. Keywords: 2-(6-methoxybenzo[d]thiazol-2-ylamino)-2-phenyl acetonitrile, N2-donor, transition metals.
Some physicochemical properties such as density, refractive index, solubility, conductance, dissociation constant etc. have been studied for some newly synthesized chalcones in different solvents at 308.15 K.
Synthesis, Identification and Surface Active Properties of Some Nonionic Surf...IOSRJAC
This research includes synthesis of new heterocyclic derivatives of quinazolinone and studying the possibility for their application as surfactants. The preparation process started by the reaction of pentadecanoyl chloride with anthranilic acid gave 2-pentadecyl-4H-benzo[3,1]oxazin-4-one [1] which was used as starting material to synthesis some heterocyclic compounds by a reaction with nitrogen nucleophiles. Compound [1] as starting material reacted by three ways. The first way react Compound [1] with semicarbazide, thiosemicarbazide and phenylsemicarbazide in pyridine as solvent to obtained [1-(4-oxo-2- pentadecylquinazolin-3(4H)-yl) urea [2], thiourea [3], phenylthiourea [4] respectively]. The second way include the reaction of Compound [1] with 99% hydrazine hydrate to produce 3-amino-2-pentadecylquinazolin- 4(3H)-one [5], then converted to amino derivatives [6-8] by the reaction of Compound [5] with different halogenated compounds such as (benzoyl chloride, acetyl chloride and chloro acetyl chloride ) in DMF and pyridine as catalyst. The third way include the reaction of compound [1] with different substituted amine and amide compounds (thiourea, hydroxylamine hydrochloride, glycine, ammonium acetate and phenyl hydrazine) respectively to obtain derivatives of quinazoline [9-14]. The produced compounds [2,4,5,7 and 12] react with propylene oxide in different moles (n=3, 5 and7) to yield novel groups of nonionic compounds having a function as surface active agents. The surface active properties like surface tension and interfacial tension, wetting time, cloud point, emulsion stability, foam height and CMC of these compounds were measured and showed a pronounced surface activity, good emulsifying properties and highly foaming in some of these compounds. Newly synthesized compounds were identified via spectral methods; their [FTIR and some of them by 1HNMR, 13C-NMR] and measurements of some of its physical properties.
ABSTRACT- L-Ascorbic acid derivatives was synthesized on treatment with acetone and acetyl chloride afforded 5,6-acetal of L-ascorbic acid then benzylation of C-2 and C-3 hydroxyl groups of the lactone ring was accomplished using K2CO3 and benzyl bromide in DMF, then deblocking of the 5,6-O,O-protected derivative of L-Ascorbic acid with acetic acid and methanol gave 2,3-O,O-dibenzyl-L-Ascorbic acid. Subsequently mono-tosylation at 6 position of 2,3-O, O-dibenzyl-L-Ascorbic acid was carried out with addition of p-toluenetosylchloride (PTSC) in Pyridine and MDC solvent medium gave 2,3-O,O-dibenzyl-6-O-tosyl-L-Ascorbic acid. All the structures were characterized by 1H NMR, 13C NMR and Mass Spectroscopy.
Key-words- L-Ascorbic acid, 5,6-Acetal, Benzylation, Hydrolysis, Tosylation
Synthesis, Characterization, Spectral (FT-IR, 1H, 13C NMR, Mass and UV) and B...Dr. Pradeep mitharwal
Bio-potent ligands, 2-hydroxy-N-phenylbenzamide hydrazinecarbothioamide(HPHTSCZH2) and 2-hydroxy-N-phenylbenzamide hydrazine carbodithioic benzyl ester (HPHCBESH2) have been synthesized by the condensation of 2-hydroxy-N-phenylbenzamide with hydrazinecarbothioamide and hydrazine carbodithioic benzyl ester, respectively and reacted with hydrated lanthanide chlorides. The coordination moieties of the ligands have been confirmed by various spectral studies. - See more at: http://www.sciencedomain.org/abstract.php?iid=271&id=16&aid=2488#sthash.6v3aFQIi.dpuf
FEASIBILITY STUDY OF TREATMENT OF EFFLUENT FROM A BULK DRUG MANUFACTURING IND...Journal For Research
A study has been carried out on aerobic biological treatment of a bulk drug industrial effluent which is highly acidic in nature and shows high value of BOD5 (≈ 36000 mg/l), COD (≈ 84000 mg/l). Chemical treatment conducted for neutralizing the pH followed by biological treatment using a lab-scale reactor with acclimatized bacterial consortia isolated from natural soil has confirmed its feasibility for biological treatment. About 99% removal of COD from starting value of around 8000 mg/l has been achieved. The COD value in different hydraulic retention time (HRT) has been brought down to less than 100 mg/l in treated effluent, showing high removal of dissolved organics by aerobic biological treatment.
Simple Synthesis of Some Novel Polyfunctionally Derivatives of 2H-Coumarin-2-...IOSRJAC
Compound (2) was prepared from the reaction of ethyl-2-oxo-2H-coumarin-3-carboxylate (1) with ethylcyanoacetate in ethanol containing a catalytic amount of piperidine as catalyst. Compound (2) is the key intermediate for the synthesis of several series of new compounds such as ((pyrimidine, tetrazine, piperidine, oxazepine)-2H-coumarin-2-one derivatives by reaction with selected reagents such as urea, cyanoacetamide, cyanoacetohydrazide, orthoaminophenol and 5-aminotriazole.
Novel coumarin isoxazoline derivatives: Synthesis and study of antibacterial ...Ratnakaram Venkata Nadh
A highly efficient and mild protocol for the syntheses of ethyl-3-
[7-benzyloxy-4-methyl-2-oxo-2H-8-chromenyl]-5-aryl-4,5-dihydro-4-
isoxazole carboxylates and ethyl-3-[7-benzyloxy-3-chloro-4-methyl-2-
oxo-2H-8-chromenyl]-5-aryl-4,5-dihydro-4-isoxazole carboxylates in
good yields via [3 þ 2] cycloaddition of in situ–generated nitrile
oxides from 7-benzyloxy-4-methyl-coumarin hydroxymoylchlorides
and 7-benzyloxy-3-chloro-4-methyl-coumarin hydroxymoylchlorides
respectively with ethyl-3-aryl prop-2-enoate has been developed.
The new compounds are screened for antibacterial activity.
Design, Synthesis, Biological Evaluation, and In Silico ADMET Studies of 1,8-...BRNSS Publication Hub
In the present study, 1,8-naphthyridine-3-carboxylic acid derivatives (5a1, 5a2, 5b1, and 5b2) were
designed, synthesized, and screened for their in vitro H1-antihistaminic activity. H1R inhibitory activity
of the synthesized derivatives was calculated by the modified Van Arman technique, histamine-induced
bronchoconstriction in guinea pigs. A good bronchorelaxant effect of compounds was observed in
histamine-contracted guinea pig tracheal chain through H1-receptor antagonism. In addition, the
hypothetically resulted compounds are checked for their reliability on other in silico drug designing
online web services like SwissADME predictor. In silico ADMET analysis results show that all the
derivatives had negligible toxicity, good absorption, and solubility profile. These compounds may serve
as possible lead for establishing safe and effective antihistaminic agent(s).
Research Inventy : International Journal of Engineering and Scienceresearchinventy
Research Inventy : International Journal of Engineering and Science is published by the group of young academic and industrial researchers with 12 Issues per year. It is an online as well as print version open access journal that provides rapid publication (monthly) of articles in all areas of the subject such as: civil, mechanical, chemical, electronic and computer engineering as well as production and information technology. The Journal welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published by rapid process within 20 days after acceptance and peer review process takes only 7 days. All articles published in Research Inventy will be peer-reviewed.
Synthesis and Characterization of New Complexes of 2-(6-Methoxybenzo[d]thiazo...IOSR Journals
Abstract: The synthesis and characterization of manganese (ІІ), cobalt (ІІ), nickel (ІІ), copper (ІІ), zinc (ІІ), cadmium (ІІ) and mercury (ІІ) bidentate 2-(6-methoxybenzo[d]thiazol-2-ylamino)-2-phenyl acetonitrile ligand which was prepared from Benz aldehyde and 6-methoxybenzo[d]thiazol-2-amine in the presence of KCN and acidic medium. The complexes were synthesized by treating an ethanolic solution of the ligand with appropriate amount of metal salts [1:2] [M: L] ratio. The complexes were characterized by using metal and elemental chemical analysis, molar conductance, magnetic susceptibility measurements, FTIR , electronic spectral and mole ratio method. According to the obtained data the probable coordination geometries of manganese (ІІ), cobalt (ІІ), nickel (ІІ), copper (ІІ) zinc (ІІ), cadmium (ІІ) and mercury (ІІ) in these complexes are octahedral. All complexes were found to be non-electrolyte in absolute ethanol, and the complexes were formulated as [ML2Cl2] XH2O. Keywords: 2-(6-methoxybenzo[d]thiazol-2-ylamino)-2-phenyl acetonitrile, N2-donor, transition metals.
Some physicochemical properties such as density, refractive index, solubility, conductance, dissociation constant etc. have been studied for some newly synthesized chalcones in different solvents at 308.15 K.
Synthesis, Identification and Surface Active Properties of Some Nonionic Surf...IOSRJAC
This research includes synthesis of new heterocyclic derivatives of quinazolinone and studying the possibility for their application as surfactants. The preparation process started by the reaction of pentadecanoyl chloride with anthranilic acid gave 2-pentadecyl-4H-benzo[3,1]oxazin-4-one [1] which was used as starting material to synthesis some heterocyclic compounds by a reaction with nitrogen nucleophiles. Compound [1] as starting material reacted by three ways. The first way react Compound [1] with semicarbazide, thiosemicarbazide and phenylsemicarbazide in pyridine as solvent to obtained [1-(4-oxo-2- pentadecylquinazolin-3(4H)-yl) urea [2], thiourea [3], phenylthiourea [4] respectively]. The second way include the reaction of Compound [1] with 99% hydrazine hydrate to produce 3-amino-2-pentadecylquinazolin- 4(3H)-one [5], then converted to amino derivatives [6-8] by the reaction of Compound [5] with different halogenated compounds such as (benzoyl chloride, acetyl chloride and chloro acetyl chloride ) in DMF and pyridine as catalyst. The third way include the reaction of compound [1] with different substituted amine and amide compounds (thiourea, hydroxylamine hydrochloride, glycine, ammonium acetate and phenyl hydrazine) respectively to obtain derivatives of quinazoline [9-14]. The produced compounds [2,4,5,7 and 12] react with propylene oxide in different moles (n=3, 5 and7) to yield novel groups of nonionic compounds having a function as surface active agents. The surface active properties like surface tension and interfacial tension, wetting time, cloud point, emulsion stability, foam height and CMC of these compounds were measured and showed a pronounced surface activity, good emulsifying properties and highly foaming in some of these compounds. Newly synthesized compounds were identified via spectral methods; their [FTIR and some of them by 1HNMR, 13C-NMR] and measurements of some of its physical properties.
ABSTRACT- L-Ascorbic acid derivatives was synthesized on treatment with acetone and acetyl chloride afforded 5,6-acetal of L-ascorbic acid then benzylation of C-2 and C-3 hydroxyl groups of the lactone ring was accomplished using K2CO3 and benzyl bromide in DMF, then deblocking of the 5,6-O,O-protected derivative of L-Ascorbic acid with acetic acid and methanol gave 2,3-O,O-dibenzyl-L-Ascorbic acid. Subsequently mono-tosylation at 6 position of 2,3-O, O-dibenzyl-L-Ascorbic acid was carried out with addition of p-toluenetosylchloride (PTSC) in Pyridine and MDC solvent medium gave 2,3-O,O-dibenzyl-6-O-tosyl-L-Ascorbic acid. All the structures were characterized by 1H NMR, 13C NMR and Mass Spectroscopy.
Key-words- L-Ascorbic acid, 5,6-Acetal, Benzylation, Hydrolysis, Tosylation
Synthesis, Characterization, Spectral (FT-IR, 1H, 13C NMR, Mass and UV) and B...Dr. Pradeep mitharwal
Bio-potent ligands, 2-hydroxy-N-phenylbenzamide hydrazinecarbothioamide(HPHTSCZH2) and 2-hydroxy-N-phenylbenzamide hydrazine carbodithioic benzyl ester (HPHCBESH2) have been synthesized by the condensation of 2-hydroxy-N-phenylbenzamide with hydrazinecarbothioamide and hydrazine carbodithioic benzyl ester, respectively and reacted with hydrated lanthanide chlorides. The coordination moieties of the ligands have been confirmed by various spectral studies. - See more at: http://www.sciencedomain.org/abstract.php?iid=271&id=16&aid=2488#sthash.6v3aFQIi.dpuf
FEASIBILITY STUDY OF TREATMENT OF EFFLUENT FROM A BULK DRUG MANUFACTURING IND...Journal For Research
A study has been carried out on aerobic biological treatment of a bulk drug industrial effluent which is highly acidic in nature and shows high value of BOD5 (≈ 36000 mg/l), COD (≈ 84000 mg/l). Chemical treatment conducted for neutralizing the pH followed by biological treatment using a lab-scale reactor with acclimatized bacterial consortia isolated from natural soil has confirmed its feasibility for biological treatment. About 99% removal of COD from starting value of around 8000 mg/l has been achieved. The COD value in different hydraulic retention time (HRT) has been brought down to less than 100 mg/l in treated effluent, showing high removal of dissolved organics by aerobic biological treatment.
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New Schiff base ligand (E)-6-(2-(4-
(dimethylamino)benzylideneamino)-2-phenylacetamido)-3,3-
dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic
acid = (HL) Figure(1) was prepared via condensation of
Ampicillin and 4(dimethylamino)benzaldehyde in methanol
.Polydentate mixed ligand complexes were obtained from 1:1:2
molar ratio reactions with metal ions and HL, 2NA on reaction
with MCl2 .nH2O salt yields complexes corresponding to the
formulas [M(L)(NA)2Cl] ,where M =
Fe(II),Co(II),Ni(II),Cu(II),and Zn(II) and NA=nicotinamide.
The 1H-NMR, FT-IR, UV-Vis and elemental analysis
were used for the characterization of the ligand. The complexes
were structurally studied through AAS, FT-IR, UV-Vis,
chloride contents, conductance, and magnetic susceptibility
measurements. All complexes are non-electrolytes in DMSO
solution. Octahedral geometries have been suggested for each
of the complexes. The Schiff base ligands function as
tridentates and the deprotonated enolic form is preferred for
coordination. In order to evaluate the effect of the bactericidal
activity, these synthesized complexes, in comparison to the un
complexed Schiff base has been screened against bacterial
species, Staphy
METALLO - BIOACTIVE COMPOUNDS AS POTENTIAL NOVEL ANTICANCER THERAPYijac123
Mono and bi-organometallic complexes of Cu(II), Ni(II), Mn(II), Zn(II) and Ag(I) complexes with
oxaloamide ligand has much potential as therapeutic and diagnostic agents. The ligand allows the
thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for
functionalization. Specific examples involving the design of metal complexes as anticancer agents are
discussed. These complexes have been synthesized and characterized by (1H-NMR, mass, IR, UV-VIS,
ESR) spectra, magnetic moments and conductance measurements, elemental and thermal analyses. Molar
conductances in DMF solution indicates that, the complexes are non-electrolytes. The ESR spectra of solid
Cu(II) complexes (2-5) show an axial type indicating a d(X2-y2) ground state with a significant covalent
bond character. However, Mn(II) complex(9), shows an isotropic type indicating an octahedral geometry.
Cytotoxic evolution IC50 of the ligand and its complexes have been carried out. Cu(II) Complexes show
enhanced activity in comparison to the parent ligand or standard drug. Copper is enriched in various
human cancer tissues and is a co-factor essential for tumor angiogenesis processes. However, the use of
copper binding ligand to target tumor, copper could provide a novel strategy for cancer selective
treatment.
International Journal of Engineering and Science Invention (IJESI)inventionjournals
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Synthesis, Characterization, and Antibacterial Activity of Some Novel 5-Chlor...IJERA Editor
The development of potential antibacterial requires the synthesis of a new series of 5- Chloroisatin derivatives incorporating various aromatic aldehydes in the case 1,3-Dipolar Cycloaddition including Nitrile oxide, as well as the cycloaddition Alcyne-Azide Catalytic with Copper. The charcterization of the structure of the synthesized compounds was confirmed by means of their IR, 1H-NMR and 13C-NMR spectral data. In addition, the antibacterial properties in vitro were tested against certain microorganisms using the disk diffusion technique. A majority of compounds show better activity against several of the microorganisms.
A STUDY TO EVALUATE THE IN VITRO ANTIMICROBIAL ACTIVITY AND ANTIANDROGENIC E...Dr. Pradeep mitharwal
The present paper deals with synthesis and characterization
of some new chromium (III) Schiff base complexes using microwave irradiation
technique as well as conventional heating. The S∩N donor benzothiazolines, 1-
(2-furanyl) ethanone benzothiazoline (Bzt1N
∩
SH), 1-(2-thienyl) ethanone
benzothiazoline (Bzt2N
∩
SH) and 1-(2-pyridyl) ethanone benzothiazoline
(Bzt3N
∩
SH) were prepared by the condensation of ortho-aminothiophenol with
respective ketones in ethanol.
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
An efficient synthesis, characterization and antibacterial activity of novel ...iosrjce
IOSR Journal of Applied Chemistry (IOSR-JAC) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of applied chemistry and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Chemical Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Synthesis, characterization, antimicrobial, anticancer and antidiabetic activ...inventionjournals
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Synthesis, Characterization and Biological Evaluation of Substitutedthiazolid...paperpublications3
Abstract: A new series of substituted thiazolidin-4-ones were synthesized and evaluated for anticancer activity by means of MTT assay method for improved anticancer activity .The structures of these synthesized compounds were established by means of IR,H NMR analysis.All the compounds were evaluated for their anticancer activity .Compounds TH10 & TH19 were found most active due to presence of electron withdrawing groups at appropriate position.
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Chelation Trends and Antibacterial Activity of Some Mixed Ligand ChelatesTaghreed Al-Noor
Synthesis and investigation of new Co(II), Ni(II), Cu(II), Zn(II) and Cr(III)chelates of mixed ligands including
aSchiff base [(E)-2-(4-(dimethylamino)benzylideneamino)phenol] (C15H16N2O) derived from the condensation of 4-
dimethylaminobenzaldehyde with 2-aminophenol as main ligand (L1) and an amino acid; L-Histidine as co-ligand (L2)
were studied. The obtained Schiff base and the mixed ligand chelates were subjected to several physiochemical
techniques, in terms of CHN elemental analyses, molar conductivity, magnetic moment measurements, infrared,
electronic and mass spectroscopies. The CHN analytical data showed the formation of the Schiff base compound and the
mixed ligand chelates in 1:1:1[M:L1:L2] ratio. All the prepared mixed ligand chelates were non-electrolyte in nature.
The infrared spectral data exhibited that the used ligands behaving as bidentate ligands towards the metal ions. The
1HNMR spectra of the ligands and their Zn(II) mixed ligand chelate exhibited the effect of the activated groups of the
ligands by the metal ion. The electronic spectral results showed the existence of π→π* (phenyl ring) and n→π*(HC=N)
and suggested the geometrical structures of the chelates. Meanwhile, the mass spectral data revealed the fragmentations
of the Schiff base, Histidine and their Cu(II) mixed ligand chelate. The studies made on these chelates proposed a six
coordinated octahedral geometry for all these chelates. The antibacterial activities of the Schiff base, Histidine, metal
salts and mixed ligand chelates were screened. It is found that the mixed ligand chelates have the most biological activity
in comparison to the free ligands and salts.
Keywords: Schiff base; 4-dimethylaminobenzaldehyde; 2-aminophenol; Histidine; mixed ligand chelates;
Physiochemical techniques; Antibacterial activity.
Shanghai ranking's global ranking of academic subjects 2020 chemistry convertedTaghreed Al-Noor
Shanghai Ranking's Global Ranking of Academic Subjects 2020 – Chemistry
http://www.shanghairanking.com/Shanghairanking-Subject-Rankings/chemistry.html
2020 تصنيف شنغهاي للجامعات حسب الموضوع – الكيمياء
Shanghai Ranking's Global Ranking of Academic Subjects 2020 Chemistry
prof .Taghreed H Al-Noor أ. د تغريد هاشم النور
جامعة بغداد University of Baghdad
that causes COVID-19 is called SARS-CoV
2020 - www.compoundchem.com @
prof .Taghreed H Al-Noor أ.د تغريد هاشم النور
University of Baghdad,Chair ACS Iraq chapter
Virtual International Scientific Conference Curriculum The Role Of Higher Education And Scientific Research Formations And National Institutions In Confronting The Corona Pandemic Forensic DNA Center for Research and Training / Al-Nahrain University .American Chemical Society ACS and its role in confronting Corona pandemic )
Prof. Taghreed Hashim Al.Noor Chairman chapter Iraq of the American Chemical Society
Asian Journal of Biochemistry is an International peer-reviewed journal dedicated to publish the results of original research in form of original articles, reviews and short communications. Scope of the journal includes: Structure, function and regulation of biologically active molecules; gene structure and expression; biochemical mechanisms; protein biosynthesis; protein folding; membrane structure-function relationships; bioenergetics and immunochemistry. Asian Journal of Biochemistry now accepting new submissions. Submit your next paper via online submission system.
ACS Iraq chapter
Supported
45Mins5th International Turkic World
Conference on Chemical Sciences and
Technologies (ITWCCST 2019)” which will take place in Sakarya,
Turkey between 25-29 October 2019.
1SecondScientific Committee
Taghreed H AL-NOOR
University of Baghdad, Iraq chair ACS IRAQ member in
http://2019.itwccst.org/?page_id=149
Catalysis, chemical engineering 2019 taghreed al noorTaghreed Al-Noor
Synthesis, spectroscopic characterization, biological Activity and dye on
cotton fabric of mixed ligand metal complexes derived From curcumin and Lphenyl alanine, schiff Base and anthranilic acid
DFT, cytotoxicity and molecular docking studies of (E)-2((2- hydroxybenzylide...Taghreed Al-Noor
Kathmandu Symposia on Advanced Materials (KaSAM)-2018; October 26-29, 2018, Kathmandu, Nepal
DFT, cytotoxicity and molecular docking studies of (E)-2((2-
hydroxybenzylidene) amino-3-mercaptopropanoic acid and its Co(II),
Ni(II) and Cu(II) complexes
M.M. El-ajaily1*, S.S. Mahmoud2, R.N. El-daghare1, A.K. Sarangi3, R.K. Mohapatra3* and T.H.
Al-Noor4
1Chemistry Department, Faculty of Science, Benghazi University, Benghazi, Libya
2Chemistry department, Faculty of Science, Cairo University, Giza, Egypt
3Department of Chemistry, Government College of Engineering, Keonjhar, Odisha, India
4Chemistry Department, Ibn-Al-Haithem College of Education for Pure Science, Baghdad University,
Baghdad, Iraq
*E-mail: ranjank_mohapatra@yahoo.com
The cytotoxicity studies of a Schiff base; (E)-2((2-hydroxybenzylidene)amino-3-mercaptopropanoic acid
(HL) derived from the condensation of 2-hydroxybenzaldehyde and L-cysteine and its Co(II), Ni(II)
and Cu(II) complexes have been reported against four cancer cell lines. The evaluation of the growth
inhibitory on human cancer cells is studied for the chelates against HCT-116, MCF-7, HFB-4,
HepG-2 cell lines. The obtained results (Fig. 1) revealed that the compounds are active against human
hepatocellular carcinoma cell line (HepG-2).
Scimago journal & country rank taghreed al noorTaghreed Al-Noor
Scimago Journal & Country Rank
ترتيب الدول من ناحية نشر الباحثين في المجلات العالمية المصنفة و
H index جودة البحوث من خلال عدد الاقتباسات
حسب موقع
)SJR (Scimago Journal Rank الترتيب خاص بسنة 201
ACS GCCE Chemical Society ACS GCCE Chemical Society ACS GCCE Chemical Society ACS GCCE Chemical Society ACS GCCE Chemical Society ACS GCCE Chemical Society ACS GCCE Chemical Society ACS GCCE Chemical Society Capacity Building Workshop Capacity Building Workshop Capacity Building Workshop Capacity Building Workshop Capacity Building Workshop Capacity Building Workshop Capacity Building Workshop 14 -18 October, 2018 October, 2018October, 2018 October, 2018
•
Anthranillic acid and tributylphosphine4652 6725-1-pbTaghreed Al-Noor
Mixed ligand complexes of bivalent metal ions, viz; Co(II), Ni(II), Cu(II) and Zn(II) of the
composition [M(A)2((PBu3)2]in(1:2:2)(M:A:(PBu3). molar ratio, (where A- Anthranilate ion
,(PBu3)= tributylphosphine. M= Co(II),Ni(II),Cu(II) and Zn(II).
The prepared complexes were characterized using flame atomic absorption, by FT-IR,
UV/visible spectra methods as well as magnetic susceptibility and conductivity measurements. The
metal complexes were tested in vitro against three types of pathogenic bacteria microorganisms:
(Staphylococcus, Klebsiella SPP .and Bacillas)to assess their antimicrobial properties. Results. The
study shows that all complexes have octahedral geometry; in addition, it has high activity against
tested bacteria. Based on the reported results, it may be concluded that.The results showed that the
deprotonated ligand(nthranilc acid ) to anthranilate ion (A-) by using (KOH) coordinated to metal
ions as bidentate ligand through the oxygen atom of the carboxylate group (−COO−), and the
nitrogen atom of the amine group (-NH2), where the Tributylphosphine coordinated as a
3rd Internatioanl Medical Congress, will be hold in Kerbala, Iraq in 14-15 De...Taghreed Al-Noor
3rd Internatioanl Medical Congress, will be hold in Kerbala, Iraq in 14-15 December 2018 by Nab'a Al-Hayat Foundation for Medical Sciences and Health Care, and in collaboration with (University of Kerbala, University of Kufa, Directory of Research -Ministry of Health Oman, University of Sussex, University of Komar, University of Diyala, University of Qaddisya, University of Al-Anbar, University of Al-Mustansariya and Helal Iran Pharmaceutical Complex.
Facial Acne Therapy by Using Pumpkin Seed Oil with Its Physicochemical Proper...Taghreed Al-Noor
The herbal remedy individually or in combination with standard medicines has been used in diverse medical treatises for the cure of different diseases. Pumpkin seed oil is one of the recognized edible oil and has substantial medicinal properties due to the presence of unique natural edible substances. Inflammation is an adaptive response that is triggered by noxious stimuli and conditions, which involves interactions amongst many cell types and mediators, and underlies many pathological processes. Unsaturated fatty acids (UFAs) can influence inflammation through a variety of mechanisms, and have been indicated as alternative anti-inflammatory agents to treat several inflammatory skin disorders. Pumpkin seed oil is rich in (UFAs), that its topical anti-inflammatory properties have been investigated. For that reason, the goal of this article was to evaluate the effects of pumpkin seed oil on acute and chronic cutaneous inflammation experimental models. The extracted pumpkin seed oil had an acceptable initial quality, when it was extracted using soxhlet extraction method and was characterized using standard methods .The physicochemical parameters of purified oil were determined. The boiling point of pumpkin seed oil was (158.90 oC) that equal to the values obtained in literature for some oil seeds, but lower than the boiling point of the oils studied, plus the melting point of pumpkin seed oil was (15.39 oC) that lead to a characteristic in cold cream manufacture. The iodine value was (104 ± 0.03 mg of KOH/g) of oil, indicated a high degree of unsaturation. The saponification value was (181± 3.2 mg KOH/g), this value indicated the pumpkin seed oil had fatty acids with higher number of carbon atoms. As a final point, the acid value was
GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using Deplo...James Anderson
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
JMeter webinar - integration with InfluxDB and GrafanaRTTS
Watch this recorded webinar about real-time monitoring of application performance. See how to integrate Apache JMeter, the open-source leader in performance testing, with InfluxDB, the open-source time-series database, and Grafana, the open-source analytics and visualization application.
In this webinar, we will review the benefits of leveraging InfluxDB and Grafana when executing load tests and demonstrate how these tools are used to visualize performance metrics.
Length: 30 minutes
Session Overview
-------------------------------------------
During this webinar, we will cover the following topics while demonstrating the integrations of JMeter, InfluxDB and Grafana:
- What out-of-the-box solutions are available for real-time monitoring JMeter tests?
- What are the benefits of integrating InfluxDB and Grafana into the load testing stack?
- Which features are provided by Grafana?
- Demonstration of InfluxDB and Grafana using a practice web application
To view the webinar recording, go to:
https://www.rttsweb.com/jmeter-integration-webinar
Securing your Kubernetes cluster_ a step-by-step guide to success !KatiaHIMEUR1
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However, this ease of use means that the subject of security in Kubernetes is often left for later, or even neglected. This exposes companies to significant risks.
In this talk, I'll show you step-by-step how to secure your Kubernetes cluster for greater peace of mind and reliability.
Elevating Tactical DDD Patterns Through Object CalisthenicsDorra BARTAGUIZ
After immersing yourself in the blue book and its red counterpart, attending DDD-focused conferences, and applying tactical patterns, you're left with a crucial question: How do I ensure my design is effective? Tactical patterns within Domain-Driven Design (DDD) serve as guiding principles for creating clear and manageable domain models. However, achieving success with these patterns requires additional guidance. Interestingly, we've observed that a set of constraints initially designed for training purposes remarkably aligns with effective pattern implementation, offering a more ‘mechanical’ approach. Let's explore together how Object Calisthenics can elevate the design of your tactical DDD patterns, offering concrete help for those venturing into DDD for the first time!
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
Builder.ai Founder Sachin Dev Duggal's Strategic Approach to Create an Innova...Ramesh Iyer
In today's fast-changing business world, Companies that adapt and embrace new ideas often need help to keep up with the competition. However, fostering a culture of innovation takes much work. It takes vision, leadership and willingness to take risks in the right proportion. Sachin Dev Duggal, co-founder of Builder.ai, has perfected the art of this balance, creating a company culture where creativity and growth are nurtured at each stage.
Software Delivery At the Speed of AI: Inflectra Invests In AI-Powered QualityInflectra
In this insightful webinar, Inflectra explores how artificial intelligence (AI) is transforming software development and testing. Discover how AI-powered tools are revolutionizing every stage of the software development lifecycle (SDLC), from design and prototyping to testing, deployment, and monitoring.
Learn about:
• The Future of Testing: How AI is shifting testing towards verification, analysis, and higher-level skills, while reducing repetitive tasks.
• Test Automation: How AI-powered test case generation, optimization, and self-healing tests are making testing more efficient and effective.
• Visual Testing: Explore the emerging capabilities of AI in visual testing and how it's set to revolutionize UI verification.
• Inflectra's AI Solutions: See demonstrations of Inflectra's cutting-edge AI tools like the ChatGPT plugin and Azure Open AI platform, designed to streamline your testing process.
Whether you're a developer, tester, or QA professional, this webinar will give you valuable insights into how AI is shaping the future of software delivery.
Assuring Contact Center Experiences for Your Customers With ThousandEyes
Jcpr 2014-6-4-1225-1231
1. Available online www.jocpr.com
Journal of Chemical and Pharmaceutical Research, 2014, 6(4):1225-1231
Research Article
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CODEN(USA) : JCPRC5
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Synthesis, characterization and antimicrobial activities of [Fe(II), Co(II),
Ni(II),Cu(II) and Zn(II)] mixed ligand complexes schiff base derived from
amoxicillin drug and 4-(dimethylamino)benzaldehyde with nicotinamide
*Taghreed H. Al-Noor, Manhel Reemon Aziz and Ahmed T. AL- Jeboori
Department of Chemistry, Ibn -Al-Haithem College of Education for Pure Science, Baghdad University-Iraq
_____________________________________________________________________________________________
ABSTRACT
New Schiff base ligand (E)-6-(2-(4-(dimethylamino)benzylideneamino)-2-(4-hydroxyphenyl)acetamido)-3,3-
dimethyl-7-oxo-4-thia-1- azabicyclo[3.2.0]heptane-2-carboxylic acid = (HL) was synthesized via condensation of
Amoxicillin and 4(dimethylamino)benzaldehyde in methanol. Figure -1 Polydentate mixed ligand complexes were
obtained from 1:1:2 molar ratio reactions with metal ions and HL, 2NA on reaction with MCl2 .nH2O salt yields
complexes corresponding to the formulas [M(L)(NA)2Cl],where M=Fe(II),Co(II),Ni(II),Cu(II),and Zn(II),
A=nicotinamide .
Figure (1): The proposed molecular structure and 3D of (HL)
The 1
H-NMR, FT-IR, UV-Vis and elemental analysis were used for the characterization of the ligand. The complexes
were structurally studied through AAS, FT-IR, UV-Vis, chloride contents, conductance, and magnetic susceptibility
measurements. All complexes are non-electrolytes in DMSO solution. Octahedral geometries have been suggested
for each of the complexes. the Schiff base ligands function as tridentate and the deprotonated enolic form is
preferred for coordination. In order to evaluate the effect of the bactericidal activity, these synthesized complexes, in
comparison to the un complexed Schiff base has been screened against six bacterial species, Staphylococcus aureus,
Escherichia coli. Klebsiella pneumonia, Acinetobacter baumannii, Salmonella and Acinetobacter baumanni and the
results are reported.
Key words: Amoxicillin drug, Nicotinamide, mixed ligand) Complexes, Antibacterial activities, and spectral
studies.
_____________________________________________________________________________________________
INTRODUCTION
Amoxicillin, an acid stable, semi‐synthetic drug belongs to a class of antibiotics called the Penicillin (β‐lactam
antibiotics). It is shown to be effective against a wide range of infections caused by wide range of Gram ‐positive
and Gram‐ negative bacteria in both human and animals[1‐4]. It is a congener of ampicillin (a semi‐synthetic amino
penicillin) differing from the parent drug only by hydroxylation of the phenyl side chain. It has found a niche in the
treatment of ampicillin‐responsive infections after oral administration. Chemically amoxicillin is (2S, 5R, 6R) 6-
[[(2R)-2-Amino-2, 3, 3-dimethyl-7-oxo- 4-thia-1-azabicyclo[3.2.0]heptanes-2-carboxylic acid [1].
Compounds containing an azomethine group (imine) are a class of important compounds in medicinal and
pharmaceutical field. The biological applications of these compounds have attracted remarkable attention. Some
Schiff‐bases were exhibits antibiotic, antiviral and antitumor agents because of their specific structure. The wide use
of antibiotics resulted in the serious medical problem of drugs resistance and public health concern. The synthesis of
new derivatives of antibiotics has become an important task to cope with drug resistance problems. [1].
Due to the activities associated with amoxicillin and imines, an attempt was made to generate new derivatives
containing imine and amoxicillin in the same molecules. All the synthesized compounds were further characterized
2. Taghreed H. Al-Noor et al J. Chem. Pharm. Res., 2014, 6(4):1225-1231
______________________________________________________________________________
1226
and evaluated for antibacterial activities. There are many interesting studies on the Schiff bases compounds and their
complexes derived from antibiotics [2]. Naz and Iqbal [3] found that the Schiff base complexes derived from
amoxicillin having good antibacterial activity in good range when comparison to control (Amoxicillin).
In 2009 El-Said and co-workers [4], Synthesized Mixed ligand complexes of Zn(II) and Cd(II) containing
ceftriaxone (Naceftria) or cephradine (Hcefphr) antibiotics and other ligands have been prepared and characterized
by elemental analysis, spectral, biological and thermal studies. The complexes have the general formulas
[Cd2(cephr)(diamine)Cl3(H2O)].xH2O [Cd3(cephr)(µHL)Cl5(H2O)].2H2O where diamine=2,2'-bipyridyl or o-
phenanthroline; M= Cd(II) or Zn(II), L=glycine, proline or methionine and x=0-6.
In 2011Sunil, and co- workers [5], synthesis and characterized some new Schiff bases derived from Amoxicillin
trihydrate with Cinnamaldehyde and p-Chlorobenzaldehyde and their complexes with bivalent transition metal ions
viz. Co(II), Zn(II), Ni(II), and Mn(II), have been synthesized. The ligand and their metal complexes were
characterized on the basis of elemental analysis and micro analytical datas. Shift in the characteristic spectral
frequency of the metal complexes, confirms the coordination through metal ion with azomethine group. They were
screened for antibacterial activity against several bacterial strains namely E. coli(-), S. aureus(+) M. luteus(+) and B.
lichenformis(+) (ATCC), the metal complexes showed enhanced antibacterial activity compared to uncomplexed
ligand.
In 2013 Tghreed and co-workers [6], Synthesis a New Schiff base ligand (Z)-7-(2-(4-(dimethylamino)
benzylideneamino)-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid =
(HL)was prepared via condensation of Cephalexin and 4(dimethylamino)benzaldehyde in methanol. Polydentate
mixed ligand complexes were obtained from 1:1:2 molar ratio reactions with metal ions and HL, 2NA on reaction
with MCl2 .nH2O salt yields complexes corresponding to the formulas [M(L)(NA)2Cl], where M =
Fe(II),Co(II),Ni(II),Cu(II),and Zn(II) and NA= nicotinamide.
The work presented in this paper concerns the Preparation , Characterization and Antimicrobial activities of
Fe(II),Co(II),Ni(II),Cu(II), and Zn(II)}Mixed Ligand Complexes Schiff base derived from Amoxicillin drug and
4dimethylamino benzaldehyde with Nicotinamide in 1:1:2(M:L:2NA) ratio.
EXPERIMENTAL SECTION
1-Chemicals
All chemicals used were of reagent grade (supplied by either Merck or Fluka, and used as received, ethanol
methanol and dimethylforamaide, and KBr, from (B.D.H). amoxicillin tri hydrate powder) and 4-(dimethylamino)
benzaldehyde from Riedial-Dehaen DSM (Spain).
2-Instrumentation
UV-Vis spectra were recorded on a (Shimadzu UV- 160A) Ultra Violet-Visible Spectrophotometer. IR- spectra were
taken on a (Shimadzu, FTI R- 8400S) Fourier Transform Infrared Spectrophotometer (4000- 400) cm-1
with samples
prepared as KBr discs. Elemental micro analysis for the ligand was performed on a (C.H.N.S.O) Perkin Elemar
2400. While metal contents of the complexes were determined by atomic absorption(A.A) technique using a
Shimadzu AA 620G atomic absorption spectrophotometer. The Chloride contents of complexes were determined by
potentiometric titration method using (686-Titro processor-665. Dosimat Swiss) Molecular weight determined by
Rast Camphor method, confirming the monomeric nature of the compounds. Conductivities were measured for 10-
3
M of complexes in DMSO at 25оC using (conductivity meter, Jewnwary, model 4070). Magnetic measurements
were recorded on a Bruker BM6 instrument at 298°K following the Farady’s method .Nuclear magnetic resonance
spectrum 1
H NMR for ligand was recorded in DMSO-d6 using a Bruker 300 MHz instrument with a tetra methyl
silane (TMS) as an internal standard. The samples were recorded at Queen Mary, university of Al-Albeit, Jordon,
Amman. In addition melting points were obtained using (Stuart Melting Point Apparatus).The proposed molecular
structure of the complexes was drawing by using chem.office prog, 3DX (2006).
2.3- preparation of ligand (HL): [7]
A solution of (Amoxi) (0.419 gm, mmole) in methanol (5 ml) was added to a solution of (4DMAB) (0.149 gm, m
mole) in methanol (10 ml). The mixture was refluxed for (5 hours) with stirring. The resulting was an orange
solution allowed to cool and dried at room temperature, then re-crystallization to the precipitate with ethanol, orange
solid was obtained by evaporation of ethanol during (24 hours) Scheme (1), m. p (146-152º C). Anal. Calcd for
ligand ( HL), C = 60.47%, H = 5.68%, N = 11.28 %. = Found: C = 59.30%, H = 6.37%, N = 10.40%.
2.4- Synthesis of [Cu(L)(NA)2Cl] complex:[7]
A solution of (HL) (0.496gm, 1 mmole) in methanol (10 ml) and a solution of (NA) (0.244 gm, 2mmole) in
methanol (10ml), were added to a stirred solution of Cu (II) chloride dihydrate (0.17 gm, 1mmole) in methanol (5
ml).The resulting mixture was heated under reflux for (5 hours). Then the mixture was filtered and the precipitation
was washed with an excess of ethanol and dried at room temperature during (24 hours). A green solid was obtained,
m.p (260-266º C).
2.5-Synthesis of[Fe(L)(NA)2Cl], [Co(L)(NA)2Cl], [Ni(L)(NA)2Cl, and [Zn(L)(NA)2Cl] complexes
The method used to prepare these complexes was similar method to that mentioned in preparation of
[Cu(L)(NA)2Cl] complex in paragraph above.
2.6-Preparation of Microorganism suspension
A) The micro- organism suspension was prepared by taking 2–4 colonies from all the studied microorganism. Then
it was inserted in the physiological solution in 0.85% concentration and was compared with Macferr land tube
number 0.5 which is equal to 1.5×108 cell/mm. It is used for Petri dish preparation for the examination of biological
activity against the under studied chemical compound.
3. Taghreed H. Al-Noor et al J. Chem. Pharm. Res., 2014, 6(4):1225-1231
______________________________________________________________________________
1227
B) Inhibition Activity Selection for the complexes in studied Microorganism The agar well diffusion method was
used to see the effect of under studied chemical complexes on the microorganism growth. This is done by using 20–
25 ml from Nutrient agar medium for each Petri dish. The dish was incubated in incubator for 24 hours at (37°C) to
make sure that no contamination would occur in the dish .Bore was made on the cultured medium surface by using
cork borer. The chemical complexes were made as 100 m ml per bore and left the central bore containing only
DMF. The biological activity for the complexes was defined by measuring the diameter of the inhibition area
surrounding each bore in millimeters. [8]
C
C H 3
O
H
N
H 3C
3 H2ON
H
N
S
C H 3
H O
N H 2
O
H
C H 3
O
O
O H
M eOH
N H
H
O
C H 3
H 3C
C H 3
H C
N
O N
H
C H 3
O
OH
S
H O
N
.
+
amoxicilin
Reflux 5 hours
4-(dimethylamino)benzaldehyde
H L
Scheme (1): Schematic representation of synthesis of the ligand (HL)
RESULTS AND DISCUSSION
3. 1-Physical Properties
Ligand (HL) is soluble in( N,N-dimetylformamide (DMF), dimetylsulphoxide (DMSO), methanol (Me OH), ethanol
(EtOH), acetone (C3H6O), 2-propanol (C3H8O) and completely insoluble in water (H2O),carbon tetra chloride
(CCl4), benzene(C6H6), Petroleum ether and chloroform (CHCl3).
3. 2- Characterization of Metal Complexes:
Generally, the complexes were prepared by reacting the respective metal salts with the ligands using 1:1:2 mole
ratio, i.e. one mole of metal salt : one mole of HL and two moles of nicotinamide. The formula weights and melting
points are given in(Table 1 based on the physicochemical characteristics, it was found that all the complexes were
non-hygroscopic, stable at room temperature and appears as powders with high melting points. The solubility of the
complexes of ligands was studied in various solvents. They are not soluble in water .All complexes are soluble in
(DMF) and (DMSO) solvents. The complexes were analyzed for their metal by atomic absorption measurements and
chloride contents were determined by standard methods. (Table-1) for all complexes gave approximated values for
theoretical values. Molar conductance values of the soluble complexes in DMSO show values
(9.4-12.3 Ω-1
cm2
mol-1
) indicating that they are all non-electrolytic in nature [9].
FT-IR spectrum of the ligand (HL):
The (FT-IR) spectrum for the starting material amoxicillin , the band at (3456) cm-1
due to υ (N–H) primary amine
stretching vibration, and (3525) cm-1
for (-OH), and amoxicillin major peak absolved at (3176) cm-1
(amide N–H)
and phenol OH stretch). The band at (3039) cm-1
benzene ring υ (C–H) stretching vibration. The band at (1774) cm-
1
is due to υ (C=O) β-Lactam group, (1452) cm-1
υ (N–H) bend (CN) stretch combination and (NH3
+
) symmetric
deformation. The bands at (1585), and (1396) cm-1
were assigned to stretching vibration υ (COO-
) asymmetric and
symmetric stretching vibration, respectively.,υ (COO-
)asym- υ (COO-
)sym =189 cm-1
. The bands at (1519) cm-1
, (3039)
cm-1
, (1178) cm-1
, and (2970) cm-1
were assigned to υ(C=C) aromatic, υ(C–H) aromatic, υ(C–C) aliphatic, and υ(C–
C) stretching vibration respectively. The band at (1282) cm-1
is due to υ(C–N) cm-1
stretching vibration. The band at
(1249) cm-1
was assigned to υ(C–O) stretching vibration. The band at (557) cm-1
was assigned to υ(C–S) stretching
vibration.
The spectrum for the starting material 4(dimethylamino)benzaldehyde (DMBA) which exhibits a band due to υ (C–
N) were observed in the (1371) cm–1
.The bands at (1165) cm–1
and (2796) cm–1
were assigned to the υ(C–C) and
υ(C–H) aliphatic stretching vibration. The very strong bands due to carbonyl group υ(C=O) stretching of (DMBA)
were observed in the (1662 -1600) cm-1
regions, while the bands at (1548) cm–1
and (2819) cm–1
were assigned to
the υ(C=C) aromatic and υ(C–H) aromatic stretching vibration respectively.
The (FT-IR) spectrum for the ligand (HL),Figure (1),the band at (3298) cm-1
due to υ (N–H) secondary amine
stretching vibration and disappeared the band for the υ(N–H) primary amine stretching vibration. The spectrum
displays a new band at (1658) cm-1
is due to azomethine group υ(-HC=N-) stretching vibrations of the ligand. The
band at (1735) cm-1
is due to υ(C=O) cm-1
stretching vibration for (COOH).The band at (1658) cm-1
stretching
vibration is due to υ (C=O) for β-Lactam group overlapping with υ (-HC=N-) stretching vibrations. The bands at
4. Taghreed H. Al-Noor
______________________________________________________________________________
(1597) cm-1
, and (1377) cm
vibration, respectively. The bands at (1546) cm
aromatic, υ(C–H) aromatic, υ
is due to υ(C–N) cm-1
stretching vibration. The band at (1230) cm
The band at (555) cm-1
was assigned to
due to υ (–OH) hydroxyl group overlapping with
assignment of the characteristic bands for the starting materials, intermediate compounds and the ligand are
summarized in Table (2).
1
H NMR spectrum for the ligand (H
In 1H NMR spectrum of the ligand (HL) in DMSO
at (δ 3.031) ppm (2CH3) and (2CH
doublet due one proton of aromatic ring of phenyl. The signal obtained at (
one proton of -CH=N linkage in the ligand. This confirms the formations of imine ligand. This observation was also
supported by the FTIR data of the ligand discussed earlier. One group of four resonance signals attributed to (S
CH) on the dihydrothiazine ring was observed in the (
(CO–CH) and (N–CH) on the
respectively. single peak attributed to hydroxyl group appeared at (
FT-IR of spectral data for the Schiff base mixed ligands complexes
[Fe(L)(NA)2Cl](1),[Co(L)(NA)
The spectrum of the (HL) displays a new band at (1658) cm
stretching vibrations of the ligand [5,6],on complexation these band has been shifted to higher frequencies (1624),
(1624), (1624), (1630), and (1630) cm
compounds revealed the presence of wide strong bands between (3541
(O-H) and υ (N-H) in accord with the results in found it difficult to get reasonable resolution between bands due to
OH and NH, hence abroad band between (3500
(1597),and (1377) cm-1
were assigned to stretching vibration
vibration, respectively. on complexation these
(1604), (1604), and (1620) cm
(1363) cm-1
, for υ(-COO)sy
occurred through the oxygen atom of carboxylate ion. The overlap band at (1658) cm
υ (C=O) for β-Lactam group, these band has been shifted to higher frequency at (1670
showing that the coordination is through the Oxygen atom of
Noor et al J. Chem. Pharm. Res., 2014, 6(4):
______________________________________________________________________________
1228
, and (1377) cm-1
were assigned to stretching vibration (COOH) asymmetric and symmetric stretching
vibration, respectively. The bands at (1546) cm-1
,(2962) cm-1
, (1168) cm
H) aromatic, υ(C–C) aliphatic and υ(C–C) stretching vibration respectively. The band at (1315) cm
stretching vibration. The band at (1230) cm-1
was assigned to
was assigned to υ(C–S) stretching vibration. The band at (3298)
OH) hydroxyl group overlapping with υ (N–H) secondary amine stretching vibration [9
assignment of the characteristic bands for the starting materials, intermediate compounds and the ligand are
H NMR spectrum for the ligand (HL):
In 1H NMR spectrum of the ligand (HL) in DMSO-d6 Figure (2), single peaks attributed to methyl groups appeared
) and (2CH3) (δ 1.56) ppm. The signal obtained in range (
doublet due one proton of aromatic ring of phenyl. The signal obtained at (
CH=N linkage in the ligand. This confirms the formations of imine ligand. This observation was also
ted by the FTIR data of the ligand discussed earlier. One group of four resonance signals attributed to (S
CH) on the dihydrothiazine ring was observed in the (δ 3.421 - 3.660) ppm, Three groups of double peaks given by
CH) on the β-lactam ring and (NH sec.) amide appeared at (
respectively. single peak attributed to hydroxyl group appeared at (δ 9.67) ppm (17).
Figure (2): 1H NMR spectrum of the ligand (HL) in DMSO
Figure (3): FT-IR spectrum of (HL)
IR of spectral data for the Schiff base mixed ligands complexes
Cl](1),[Co(L)(NA)2Cl](2),[Ni(L)(NA)2Cl](3),[Cu(L)(NA)
The spectrum of the (HL) displays a new band at (1658) cm-1
is due to
stretching vibrations of the ligand [5,6],on complexation these band has been shifted to higher frequencies (1624),
(1624), (1624), (1630), and (1630) cm-1
for complexes (1), (2), (3), (4),(5).Infra red spectra
compounds revealed the presence of wide strong bands between (3541
H) in accord with the results in found it difficult to get reasonable resolution between bands due to
NH, hence abroad band between (3500 - 2500) cm-1
is definitely due to OH and NH stretching. The bands at
were assigned to stretching vibration (COOH) asymmetric and symmetric stretching
vibration, respectively. on complexation these bands have been shifted to higher frequencies [(1599), (1600),
(1604), (1604), and (1620) cm-1
for υ(-COO)asy], and lower frequencies [(1363), (1366), (1366), (1367), and
sy] for the compounds (1) , (2) , (3) ,(4) , and (5), that
occurred through the oxygen atom of carboxylate ion. The overlap band at (1658) cm
Lactam group, these band has been shifted to higher frequency at (1670
showing that the coordination is through the Oxygen atom of β
J. Chem. Pharm. Res., 2014, 6(4):1225-1231
______________________________________________________________________________
(COOH) asymmetric and symmetric stretching
, (1168) cm-1
, and (2823) cm-1
were assigned to υ(C=C)
etching vibration respectively. The band at (1315) cm-1
was assigned to υ(C–O) stretching vibration.
S) stretching vibration. The band at (3298) cm-1
stretching vibration is
H) secondary amine stretching vibration [9-14]. The
assignment of the characteristic bands for the starting materials, intermediate compounds and the ligand are
d6 Figure (2), single peaks attributed to methyl groups appeared
1.56) ppm. The signal obtained in range (δ 6.71-7.70) ppm was assigned for
doublet due one proton of aromatic ring of phenyl. The signal obtained at (δ 8.20) ppm was assigned for singlet due
CH=N linkage in the ligand. This confirms the formations of imine ligand. This observation was also
ted by the FTIR data of the ligand discussed earlier. One group of four resonance signals attributed to (S–
3.660) ppm, Three groups of double peaks given by
ring and (NH sec.) amide appeared at (δ 4.8), (δ 4.9) and (δ 8.2) ppm,
δ 9.67) ppm (17).
Figure (2): 1H NMR spectrum of the ligand (HL) in DMSO-d6
spectrum of (HL)
IR of spectral data for the Schiff base mixed ligands complexes
Cl](3),[Cu(L)(NA)2Cl](4), [Zn(L)(NA)2Cl](5):
is due to υ (HC=N-) group of the azomethine
stretching vibrations of the ligand [5,6],on complexation these band has been shifted to higher frequencies (1624),
for complexes (1), (2), (3), (4),(5).Infra red spectra for the prepared
compounds revealed the presence of wide strong bands between (3541-3317) cm-1
due to the stretching vibration υ
H) in accord with the results in found it difficult to get reasonable resolution between bands due to
is definitely due to OH and NH stretching. The bands at
(COOH) asymmetric and symmetric stretching
bands have been shifted to higher frequencies [(1599), (1600),
COO)asy], and lower frequencies [(1363), (1366), (1366), (1367), and
] for the compounds (1) , (2) , (3) ,(4) , and (5), that the coordination with metal was
occurred through the oxygen atom of carboxylate ion. The overlap band at (1658) cm-1
stretching vibration is due to
Lactam group, these band has been shifted to higher frequency at (1670-1689) cm-1
for complexes
showing that the coordination is through the Oxygen atom of β-Lactam group. [6] .The bands at (497),
1231
______________________________________________________________________________
(COOH) asymmetric and symmetric stretching
υ(C=C)
1
O) stretching vibration.
is
14]. The
assignment of the characteristic bands for the starting materials, intermediate compounds and the ligand are
d6 Figure (2), single peaks attributed to methyl groups appeared
m was assigned for
8.20) ppm was assigned for singlet due
CH=N linkage in the ligand. This confirms the formations of imine ligand. This observation was also
–
3.660) ppm, Three groups of double peaks given by
8.2) ppm,
) group of the azomethine
stretching vibrations of the ligand [5,6],on complexation these band has been shifted to higher frequencies (1624),
for the prepared
due to the stretching vibration υ
H) in accord with the results in found it difficult to get reasonable resolution between bands due to
is definitely due to OH and NH stretching. The bands at
(COOH) asymmetric and symmetric stretching
bands have been shifted to higher frequencies [(1599), (1600),
COO)asy], and lower frequencies [(1363), (1366), (1366), (1367), and
the coordination with metal was
stretching vibration is due to
exes
.The bands at (497),
5. Taghreed H. Al-Noor
______________________________________________________________________________
(486),(470),(489), and (474) cm
to the carbocylic oxygen, and oxygen of
The bands at (540), (520),(578), (547) and (505) cm
(5), respectively , indicating that the nitrogen of (NA) is involved in coordination with metal ions.
(U.V-Vis) Spectrum for the Schiff base ligand:
Magnetic susceptibility was determined
correction of metal- ligand system was calculated using the Pascal's constant. .The magnetic moments of the
complexes shown in (Table
diamagnetic corrections .
The electronic spectrum of the ligand has been measured in DMSO solution between 200
temperature .In the spectrum of the Schiff base ligand (HL),the absorption band observed at 232 nm (431
1
),and 336 nm(29761cm-1
) which are assigned to benzene (
The UV-Visible Spectroscopy and Magnetic measurements
The absorption data for complexes are given in Table (3).
[Fe(L)(NA)2Cl]: The (U.V
=431 molar-1
.cm-1
) is due to the ligand field and, the second high peak at (345 nm)(28985 cm
1
.cm-1
) is due to the (C.T), the third wea
(5
T2g→5
Eg), transition , in an octahedral geometry. in an octahedral geometry.Also, the values of the magnetic
moments 3.77 B.M. may be taken as additional evidence for a high spin
[Co(L)(NA)2Cl]: The (U.V
1
)( εmax =1321 molar-1
.cm-1
), is due to the ligand field and (L.F), while the second third and fourth weak pe
nm)( (υ3=12048 cm-1
)( εmax
nm)(10080 cm-1
)( εmax =9 molar
(4T1g(F) →4T2g(F) transition respectively ,[17]
υ2/ υ1 =1.019, , υ1/ υ2 =0. 98, , from Tanabe
10. 080 cm-1
, The room temperature magnetic moment (µ
symmetry.[17-18,4]
[Ni(L)(NA)2Cl]: The (U.V
εmax =1643 molar-1
.cm-1
), is due to the ligand field the second small peak at (345 nm)(28985 cm
1
.cm-1
) is due to the (C.T), while the third fourth and fifth weak peaks at(412 nm)(24271 cm
1
), (770 nm)(12987 cm-1
)( ε
to 3
A2g → 3
T2g(υ1)
(d–d), 3
A2g → 3
T1g(F)(υ2) (d
values of the magnetic moments 3.11 B.M, may be taken as additional evidence for octahedral nickel (II) geometry .
[17-18]
[Cu(L)(NA)2Cl]: The (U.V
εmax =2100 molar-1
.cm-1
) is due to the (C.T) , while the second weak broad peak at (974 nm)(10266 cm
molar-1
.cm-1
), which assigned
magnetic moment in 2.04 B.M .corresponding to one unpaired electron .
[Zn(L)(NA)2Cl]: The (U.V
molar-1
.cm-1
) is due to the ligand field and, the second high peak at (342 nm)(29239 cm
Noor et al J. Chem. Pharm. Res., 2014, 6(4):
______________________________________________________________________________
1229
(486),(470),(489), and (474) cm-1
were assigned to υ(M–O) for compounds (1), (2), (3), (4),and (5), indicating that
to the carbocylic oxygen, and oxygen of β-Lactam group of the ligand are involved in coordination with metal ions.
The bands at (540), (520),(578), (547) and (505) cm-1
were assigned to υ
(5), respectively , indicating that the nitrogen of (NA) is involved in coordination with metal ions.
Vis) Spectrum for the Schiff base ligand:
Magnetic susceptibility was determined at room temperature using solid sample by Gouy method.
ligand system was calculated using the Pascal's constant. .The magnetic moments of the
complexes shown in (Table-3)were calculated from the measured magnetic susceptib
The electronic spectrum of the ligand has been measured in DMSO solution between 200
temperature .In the spectrum of the Schiff base ligand (HL),the absorption band observed at 232 nm (431
) which are assigned to benzene (π-π*), and ( n
Visible Spectroscopy and Magnetic measurements:
The absorption data for complexes are given in Table (3).
The (U.V- Vis) spectrum, exhibits three peaks, the first middle peak at (286 nm)(34965 cm
) is due to the ligand field and, the second high peak at (345 nm)(28985 cm
) is due to the (C.T), the third weak peak at (815 nm)(12269 cm
Eg), transition , in an octahedral geometry. in an octahedral geometry.Also, the values of the magnetic
moments 3.77 B.M. may be taken as additional evidence for a high spin
The (U.V- Vis) spectrum, exhibits four peaks , the first high intense peak at (267 nm)(37453 cm
), is due to the ligand field and (L.F), while the second third and fourth weak pe
max =5 molar-1
.cm-1
), ((υ2=976 nm)(10245 cm
=9 molar-1
.cm-1
), which assigned to (5
Eg → 5
T2
4T2g(F) transition respectively ,[17]
=0. 98, , from Tanabe-Sugano diagram for d7
, The room temperature magnetic moment (µ eff = 4.52 B.M) corresponded to a high
The (U.V- Vis) spectrum, exhibits five peaks , the first high intense peak at (269 nm)(37174 cm
), is due to the ligand field the second small peak at (345 nm)(28985 cm
) is due to the (C.T), while the third fourth and fifth weak peaks at(412 nm)(24271 cm
)( εmax =10 molar-1
.cm-1
), and (956 nm)(10460 cm
) (d–d), and 3
A2g→3
T1g(P)(υ3) transition respectively in an octahedral geometry. Also, the
values of the magnetic moments 3.11 B.M, may be taken as additional evidence for octahedral nickel (II) geometry .
The (U.V- Vis) spectrum exhibits two peaks , the first high broad peak at (275 nm)(36363 cm
) is due to the (C.T) , while the second weak broad peak at (974 nm)(10266 cm
), which assigned to (2
Eg→2
T2g), transition in a high spin octahedral geometry. The complex show a
magnetic moment in 2.04 B.M .corresponding to one unpaired electron .
Chart (1) Chart of biological effects of some of the studied complexes
The (U.V- Vis) spectrum, two high peaks, the first high peak at
) is due to the ligand field and, the second high peak at (342 nm)(29239 cm
13
000
18
20
17
20
0
15
12
00
16
1415
00 0
22
1314
0
18
22
20
22
18
E‐coli Pseudomonas
Staphylococcus aureus Klebsiella pneumoniae
Salmonella Acinetobacter baumannii
J. Chem. Pharm. Res., 2014, 6(4):1225-1231
______________________________________________________________________________
O) for compounds (1), (2), (3), (4),and (5), indicating that
Lactam group of the ligand are involved in coordination with metal ions.
assigned to υ(M–N)for compounds (1), (2), (3), (4), and
(5), respectively , indicating that the nitrogen of (NA) is involved in coordination with metal ions. [13-15]
at room temperature using solid sample by Gouy method. Diamagnetic
ligand system was calculated using the Pascal's constant. .The magnetic moments of the
calculated from the measured magnetic susceptibilities after employing
The electronic spectrum of the ligand has been measured in DMSO solution between 200- 1100 nm at room
temperature .In the spectrum of the Schiff base ligand (HL),the absorption band observed at 232 nm (43103 cm-
*), and ( n-π*) transition, respectively. [10-11,17].
Vis) spectrum, exhibits three peaks, the first middle peak at (286 nm)(34965 cm-1
)( εmax
) is due to the ligand field and, the second high peak at (345 nm)(28985 cm-1
)( εmax =1110 molar-
k peak at (815 nm)(12269 cm-1
)( εmax =9 molar-1
.cm-1
), which assigned to
Eg), transition , in an octahedral geometry. in an octahedral geometry.Also, the values of the magnetic
moments 3.77 B.M. may be taken as additional evidence for a high spin octahedral Iron(II) geometry.[17]
Vis) spectrum, exhibits four peaks , the first high intense peak at (267 nm)(37453 cm-
), is due to the ligand field and (L.F), while the second third and fourth weak peaks at(830
2=976 nm)(10245 cm-1
)( εmax =6 molar-1
.cm-1
), and (υ1= 992
2g) (3A2g → 4T1g(P), (4
T1g(F) →4
T1g), and
7
octahedral field the value of 10Dq equal to
= 4.52 B.M) corresponded to a high spin octahedral
Vis) spectrum, exhibits five peaks , the first high intense peak at (269 nm)(37174 cm-1
)(
), is due to the ligand field the second small peak at (345 nm)(28985 cm-1
)( εmax =153 molar-
) is due to the (C.T), while the third fourth and fifth weak peaks at(412 nm)(24271 cm-1
)( εmax =20 molar-1
.cm-
), and (956 nm)(10460 cm-1
)( εmax =8 molar-1
.cm-1
), which assigned
) transition respectively in an octahedral geometry. Also, the
values of the magnetic moments 3.11 B.M, may be taken as additional evidence for octahedral nickel (II) geometry .
Vis) spectrum exhibits two peaks , the first high broad peak at (275 nm)(36363 cm-1
)(
) is due to the (C.T) , while the second weak broad peak at (974 nm)(10266 cm-1
)( εmax =42
), transition in a high spin octahedral geometry. The complex show a
magnetic moment in 2.04 B.M .corresponding to one unpaired electron . [6,17-18]
.
Chart (1) Chart of biological effects of some of the studied complexes
Vis) spectrum, two high peaks, the first high peak at (279 nm)(35842 cm-1
)( εmax =998
) is due to the ligand field and, the second high peak at (342 nm)(29239 cm-1
)( εmax =1700 molar-1
.cm-
5
0
7
19
5
0
6
16
0
55
0
5
10
15
20
25
Pseudomonas
Klebsiella pneumoniae
Acinetobacter baumannii
1231
______________________________________________________________________________
O) for compounds (1), (2), (3), (4),and (5), indicating that
Lactam group of the ligand are involved in coordination with metal ions.
N)for compounds (1), (2), (3), (4), and
Diamagnetic
ligand system was calculated using the Pascal's constant. .The magnetic moments of the
ilities after employing
1100 nm at room
-
max
-
), which assigned to
Eg), transition , in an octahedral geometry. in an octahedral geometry.Also, the values of the magnetic
-
aks at(830
1= 992
g), and
octahedral field the value of 10Dq equal to
spin octahedral
)(
-
-
), which assigned
) transition respectively in an octahedral geometry. Also, the
)(
=42
), transition in a high spin octahedral geometry. The complex show a
=998
-
6. Taghreed H. Al-Noor et al J. Chem. Pharm. Res., 2014, 6(4):1225-1231
______________________________________________________________________________
1230
1
) is due to the (C.T) in an octahedral geometry. this diamagnetic complex show no appreciable absorptions in the
region below 26000 cm-1
in DMSO solutions. In accordance with the d10 electronic configuration of Zn(II) .
[6,18,20]
Also, the values of the magnetic moment Table (3).may be taken as additional evidence3’32 for their octahedral
structure. Molecular weight determined by Rast Camphor method and were found in accordance with calculated
value the range of metal complexes (852-858) [6].
Antimicrobial activity:
The in vitro antimicrobial screening results are given in Table 4,Chart (1).On the basis of observed zones of
inhibition, all the metal-mixed ligand complexes are active against all six tested organisms which in fact is in
agreement with the literature [18-23]. The antibacterial results evidently show that the activity of the Schiff base
became more upon coordination to the metal atoms.
Table (1): The physical properties of the compounds
M. wt = Molecular Weight, Λm = Molar Conductivity, dec. = decomposition , Calc.= calculation
Table (2) FTIR spectral data of the Ligands and there complexes
*overlap
Table 3- Electronic Spectral data, magnetic moment, of the studied compounds
Cl%
Metal%
Λm
Ω-1
cm2
mol-1
M .p°c
(de) °c theory (exp)Yield %Colour
M. wt
Rast method.
M. wt
Calc.
Compounds
4.27
(4.32)
6.72
7.10
9.4172 Dec.77Grey Green852.81831.11
[Fe(L)(NA)2Cl]
C37H39ClFeN8O7S
4.25
(4.22)
7.06
7.96
10.2300 Dec.72Brown817.7834.20
[Co(L)(NA)2Cl]
C37H39ClCoN8O7S
4.25
(4.19)
7.04
6.06
13.1300 Dec.80Yellow830.6833.96
[Ni(L)(NA)2Cl]
C37H39ClN8NiO7S
4.23
(4.26)
7.58
7.06
10.1260-26681Green858.0838.81
[Cu(L)(NA)2Cl]
C37H39ClCuN8O7S
4.22
(4.29)
7.78
8.06
12.3234-14074Brown853. 8840.68
[Zn(L)(NA)2Cl]
C37H39ClN8O7SZn
Compound
Υ
(O-H)
Υ
(N-H)
primaryamine
Υ
(N-H)
Secondaryamide
Υ
(C=O)
β-lactam
υ
(HC=N-)
υas(COO)
υs(COO)
Υ
(C=C
arom.)
Υ
(C-C
aliph.)
Υ
(C-N)
Υ
(C-O)
Υ
(C-S)
Υ
(C-H)
arom.
Υ
(C-H)
aliph.
Υ
(M-N)
Υ
(M-O)
HL 3298* ------- 3298* 1658* 1658 1597 1377 1546 1168 1315 1230 555 2962 2823
----
-
-----
Nicotine amide ------
3367
3259
-------- ------- ------ ----- ------ 1593 1124 1201 ----- ------ 3061 2787
----
--
-----
[Fe(L)(NA)2Cl] 3464 3410 3232 1684* 1624* 1599 1363 1543 1166 1246 1230 553 3060 2970 540 497
[Co(L)(NA)2Cl] 3402 3317
3261,
3197
1684* 1624 1600 1366 1577 1199 1292 1230 552 3078 2754 520 486
[Ni(L)(NA)2Cl] 3406 3321
3267,
3213
1684* 1624 1604 1366 1581 1149 1246 1199 553 3078 2754 578 470
[Cu(L)(NA)2Cl] 3475 3402
3305,
3159
1670 1630 1604 1367 1550 1184 1300 1203 553 3062 2769 547 489
[Zn(L)(NA)2Cl] 3541 3471 3259 1689 1630 1620* 1363 1512 1130 1230 1180 552 2978 2885 505 474
Compound λ nm ABS ύ cm-1
εmax (molar-1
.cm-1
) Assignments µeff (BM)
Amox.
277
330
0.732
0.057
36101
30303
732
57
π→ π*
n→ π*
-
NA
220
261
1.548
1.104
45454
38314
1548
1104
π→ π*
π→ π*
-
4DMAB
208
342
336
0.338
0.493
1.961
48007
29239
29761
338
493
1961
π→ π*
n→ π*
n→ π*
-
H L
232
336
1.035
1.952
43103
29761
1035
1952
π→ π*
n→ π*
-
[Fe(L)(NA)2Cl]
286
345
815
0.431
1.110
0.009
34965
28985
12269
431
1110
9
L-F
C-T
5
T2g→5
Eg
3.77
[Co(L)(NA)2Cl]
267
830
976
992
1.321
0.005
0.006
0.009
37453
12048
10245
10080
1321
5
6
9
L.f
3
A2g → 4
T1g(P)
3
A2g → 4
T1g(F)
3
A2g (F) →3
T1g(F)
4.52
[Ni(L)(NA)2Cl]
269
345
412
770
956
1.643
0.153
0.020
0.010
0.008
37174
28985
24271
12987
10460
1643
153
20
10
8
L-F
C-T
3
A2g (F) → 3
T1g (P) (ν3)
3
A2g(F) → 3
T1g(F) (ν2)
3
A2g(F) → 3
T2g(F) (ν1)
3.11
[Cu(L)(NA)2Cl]
275
974
2.100
0.042
36363
10266
2100
42
L.F
2
Eg→2
T2g
2.04
[Zn(L)(NA)2Cl]
279
342
1.288
1.700
35842
29239
1288
1700
C-T
C-T
0.0
7. Taghreed H. Al-Noor et al J. Chem. Pharm. Res., 2014, 6(4):1225-1231
______________________________________________________________________________
1231
Table(4):Biological activity of the Schiff bases mixed ligands complexes Zone of inhibition (mm)
Compound
E
coli
P
aeruginosa
Staphylococcus
aureus
Klebsiella
pneumoniae
Salmonella
Typhi
Acinetobacter
baumannii
Control 5 7 5 6 5 5
[Fe(L)(NA)2Cl] 0 19 0 16 0 18
[Co(L)(NA)2Cl] 13 18 15 14 22 22
[Ni(L)(NA)2Cl] 0 20 12 15 13 20
[Cu(L)(NA)2Cl] 0 17 0 0 14 22
[Zn(L)(NA)2Cl] 0 20 0 0 0 18
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