The document describes the synthesis and characterization of new imidazole derivatives derived from D-erythroascorbic acid. D-erythroascorbic acid was modified through multi-step reactions to yield Schiff bases containing heterocyclic units like 1,3,4-oxadiazole and 1,3,4-thiadiazole. These Schiff bases were further derivatized to yield N-acyl, thiourea, and imidazole compounds. The structures of the synthesized compounds were characterized using techniques like elemental analysis, FTIR, NMR, and mass spectrometry. The compounds exhibited good antibacterial activity against Escherichia coli and Staphylococcus aureus.
Synthesis, Characterization and Study of Antioxidant Activities of Some New P...IJRES Journal
A series of substituted pyrazoline derivatives 5(a-c) have been synthesized by the reaction of substituted chalcones 4(a-c) with isatinhydrazide. The starting materials, chalcones were prepared by clasien schimidt condensation of appropriate 1-hydroxy-2-acetonaphthone with substituted aldehydes in the presence of sodium hydroxide and in poly ethylene glycol (PEG-400). The structures of the synthesized compounds were confirmed by IR, 1HNMR & Mass spectral data. The synthesized compounds were screened for Antioxidant Activity by DPPH method.
Synthesis And Antibacterial Activity Of 3-[(3-Phenyl-5-Thioxo-1, 5-Dihydro-4h...inventionjournals
A series of 3-[(3-phenyl-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)imino]-1,3-dihydro-2Hindole-2-one derivatives were synthesised through the nucleophilic substitution at carbonyl carbon of Isatin. Structure of synthesized compounds were elucidated by using IR, 1H NMR & 13C NMR spectrometry. Synthesised compounds showed significant antibacterial activity against E.coli (ATCC 35218), S.aureus (ATCC 25323), E.faecalis (Clinical isolate), K. Pneumonia, P. aeruginosa (ATCC 27893) using agar well diffusion method.
Synthesis and Characterization O-, M- and Para-Toluyl Thiourea Substituted Pa...IOSR Journals
Abstract: Six new derivatives of carbonyl thiourea comprises of o-,m- and p-toluyl at one end of Nitrogen atom and p-methylpyridine or ethyl pyridine at another one end of Nitrogen atom has been synthesized. The compounds are, 2-methyl-N-[(4-methylpyridine-2-yl) carbamothiol] benzamide (I), 3-methyl-N-[(4-methylpyridine-2-yl) carbamothiol] benzamide (II) and 4-N-[(4-methylpyridine-2-yl) carbamothiol] benzamide (III) for Toluyl-MP while 2-methyl-N-[(2-pyridine-2-yl-ethyl) carbamothiol] benzamide (IV), 3- methyl-N-[(2-pyridine-2-yl-ethyl) carbamothiol] benzamide (V) and 4- methyl-N-[(2-pyridine-2-yl-ethyl) carbamothiol] benzamide (VI) for isomer Toluidal-AEP have been successfully synthesized and characterized by elemental analysis, Infrared Spectroscopy analysis (FT-IR), Nuclear Magnetic Resonance Spectroscopy (NMR) and Ultraviolet-visible (UV-vis). All products shown stretching modes of ν(N-H), ν(C=O), ν(C-N), and ν(C=S) around 3276 cm-1, 1671 cm-1, 1315cm-1 and 1148 cm-1 respectively. All products shown two maximum absorption around 262 nm and 290 nm respectively for carbonyl C=O and thione C=S chromophore. Those both values contributed by n -п* transition. 1H nuclear magnetic resonance spectrum showed presence of aromatic, methyl, methine and amide protons except for product III. All products showed presence of carbon thione in 13C nuclear magnetic resonance except for product III. Ionophor interpretation with acetate anion shows color changes by naked eye for compound (I) and (III).
In this work a new prodrug polymer was
prepared with two attachment groups (amid-ester), using di
functional spacer such as ethanol amine, which could react with
polyacrylic acid producing amide group, with remain ethanol
terminal group which could react with captopril acyl chloride,
producing ester group with extended the arm substituted drug to
improve the hydrolysis and to prevent the steric effect of polymer
chains. Many advantages enhanced the prodrug of polymer. The
prepared polymers were characterized by FTIR, 1H –NMR
spectroscopies. Controlled drug release was studied in different
pH values at 37℃, using UV. Spectra with comparing with
calibration curve. The modification percentage test was studied,and swelling percentage was calculated and all physical properties were observed.
Synthesis, Characterization and Study of Antioxidant Activities of Some New P...IJRES Journal
A series of substituted pyrazoline derivatives 5(a-c) have been synthesized by the reaction of substituted chalcones 4(a-c) with isatinhydrazide. The starting materials, chalcones were prepared by clasien schimidt condensation of appropriate 1-hydroxy-2-acetonaphthone with substituted aldehydes in the presence of sodium hydroxide and in poly ethylene glycol (PEG-400). The structures of the synthesized compounds were confirmed by IR, 1HNMR & Mass spectral data. The synthesized compounds were screened for Antioxidant Activity by DPPH method.
Synthesis And Antibacterial Activity Of 3-[(3-Phenyl-5-Thioxo-1, 5-Dihydro-4h...inventionjournals
A series of 3-[(3-phenyl-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)imino]-1,3-dihydro-2Hindole-2-one derivatives were synthesised through the nucleophilic substitution at carbonyl carbon of Isatin. Structure of synthesized compounds were elucidated by using IR, 1H NMR & 13C NMR spectrometry. Synthesised compounds showed significant antibacterial activity against E.coli (ATCC 35218), S.aureus (ATCC 25323), E.faecalis (Clinical isolate), K. Pneumonia, P. aeruginosa (ATCC 27893) using agar well diffusion method.
Synthesis and Characterization O-, M- and Para-Toluyl Thiourea Substituted Pa...IOSR Journals
Abstract: Six new derivatives of carbonyl thiourea comprises of o-,m- and p-toluyl at one end of Nitrogen atom and p-methylpyridine or ethyl pyridine at another one end of Nitrogen atom has been synthesized. The compounds are, 2-methyl-N-[(4-methylpyridine-2-yl) carbamothiol] benzamide (I), 3-methyl-N-[(4-methylpyridine-2-yl) carbamothiol] benzamide (II) and 4-N-[(4-methylpyridine-2-yl) carbamothiol] benzamide (III) for Toluyl-MP while 2-methyl-N-[(2-pyridine-2-yl-ethyl) carbamothiol] benzamide (IV), 3- methyl-N-[(2-pyridine-2-yl-ethyl) carbamothiol] benzamide (V) and 4- methyl-N-[(2-pyridine-2-yl-ethyl) carbamothiol] benzamide (VI) for isomer Toluidal-AEP have been successfully synthesized and characterized by elemental analysis, Infrared Spectroscopy analysis (FT-IR), Nuclear Magnetic Resonance Spectroscopy (NMR) and Ultraviolet-visible (UV-vis). All products shown stretching modes of ν(N-H), ν(C=O), ν(C-N), and ν(C=S) around 3276 cm-1, 1671 cm-1, 1315cm-1 and 1148 cm-1 respectively. All products shown two maximum absorption around 262 nm and 290 nm respectively for carbonyl C=O and thione C=S chromophore. Those both values contributed by n -п* transition. 1H nuclear magnetic resonance spectrum showed presence of aromatic, methyl, methine and amide protons except for product III. All products showed presence of carbon thione in 13C nuclear magnetic resonance except for product III. Ionophor interpretation with acetate anion shows color changes by naked eye for compound (I) and (III).
In this work a new prodrug polymer was
prepared with two attachment groups (amid-ester), using di
functional spacer such as ethanol amine, which could react with
polyacrylic acid producing amide group, with remain ethanol
terminal group which could react with captopril acyl chloride,
producing ester group with extended the arm substituted drug to
improve the hydrolysis and to prevent the steric effect of polymer
chains. Many advantages enhanced the prodrug of polymer. The
prepared polymers were characterized by FTIR, 1H –NMR
spectroscopies. Controlled drug release was studied in different
pH values at 37℃, using UV. Spectra with comparing with
calibration curve. The modification percentage test was studied,and swelling percentage was calculated and all physical properties were observed.
Synthesis and characterization of resin copolymer derived from cardanol-furfu...ijceronline
International Journal of Computational Engineering Research (IJCER) is dedicated to protecting personal information and will make every reasonable effort to handle collected information appropriately. All information collected, as well as related requests, will be handled as carefully and efficiently as possible in accordance with IJCER standards for integrity and objectivity.
IJERA (International journal of Engineering Research and Applications) is International online, ... peer reviewed journal. For more detail or submit your article, please visit www.ijera.com
Bidentate Schiff base ligand 3-(3,4-Dihydroxy-phenyl)-2-[(4-dimethylamino-benzylidene)-amino]-2-methyl-propionic acid was prepared and characterized by spectroscopic techniques studies and elemental analysis. The Cd(II), Ni(II), Cu(II), Co(II), Cr(III),and Fe(III) of mixed-ligand complexes were structural explicate through moler conductance , [FT-IR, UV-Vis & AAS], chloride contents, , and magnetic susceptibility measurements. Octahedral geometries have been suggested for all complexes. The Schiff base and its complexes were tested against various bacterial species, two of {gram(G+) and gram(G-)} were shown weak to good activity against all bacteria.
Polycondensation of Ethylenediaminetetraacetic Acid with SomeTaghreed Al-Noor
Many condensed polymers [A1-A7] were prepared via reaction of (Ethylenediaminetetraacetic acid = EDTA),
with different prepared imide-diamines by modification [ modification of amino acids and antibiotics (B1-
B7)]
Imide-diamines were prepared by chlorination of L-amino acids such as
[ L-Histidine, L-Alanine, L-Valine, L-Glycine and L-Aspargine ] or selected antibiotics such as [Cephallixine
monohydrate and Amoxilline ] with thionyl chloride at 0°C, then reacted with ammonia to obtain imidediamines
[B1-B7] .
The physical properties of all prepared condensed polymers [A1-A7], new prepared diamines [B1-B7] were
studied and characterized by FT -IR spectroscope to certify the structural formulas.
The thermal analysis (TGA, DTA) were studied, and the intrinsic viscosities were measured at 30°C using
Ostwald viscometer.
Synthesis and Characterization of Schiff Base from Aromatic Amine and Aromati...ijtsrd
The synthesis of Schiff base From Aromatic Amine And Aromatic P Nitro benzaldehyde was performed by a novel method of stirring followed by the addition of p nitro benzaldehydeandm nitro aniline 0.02M . Characterization of the synthesized compounds, determination of purity and identity of the compounds using following spectroscopic and chromatographic techniques Solubility, Thin Layer Chromatographic studies, Ultra Violet studied rotational and vibrational studies FT IR studies. The compounds were investigated for their Antimicrobial activity by cup plate method. Compound1 nitro 4 1 imino,4 nitrophenyl benzene was found to be the most active according to pharmacological evaluation exhibited antimicrobial. Ms. Chetana D. Patil | Mr. Digamber N. Bhosale | Ms. Smita P. Bedis "Synthesis and Characterization of Schiff Base from Aromatic Amine and Aromatic P-Nitro Benzaldehyde" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-5 , August 2019, URL: https://www.ijtsrd.com/papers/ijtsrd26401.pdfPaper URL: https://www.ijtsrd.com/pharmacy/medicinal-chemistry/26401/synthesis-and-characterization-of-schiff-base-from-aromatic-amine-and-aromatic-p-nitro-benzaldehyde/ms-chetana-d-patil
ABSTRACT- L-Ascorbic acid derivatives was synthesized on treatment with acetone and acetyl chloride afforded 5,6-acetal of L-ascorbic acid then benzylation of C-2 and C-3 hydroxyl groups of the lactone ring was accomplished using K2CO3 and benzyl bromide in DMF, then deblocking of the 5,6-O,O-protected derivative of L-Ascorbic acid with acetic acid and methanol gave 2,3-O,O-dibenzyl-L-Ascorbic acid. Subsequently mono-tosylation at 6 position of 2,3-O, O-dibenzyl-L-Ascorbic acid was carried out with addition of p-toluenetosylchloride (PTSC) in Pyridine and MDC solvent medium gave 2,3-O,O-dibenzyl-6-O-tosyl-L-Ascorbic acid. All the structures were characterized by 1H NMR, 13C NMR and Mass Spectroscopy.
Key-words- L-Ascorbic acid, 5,6-Acetal, Benzylation, Hydrolysis, Tosylation
Synthesis and Characterization of New Complexes of 2-(6-Methoxybenzo[d]thiazo...IOSR Journals
Abstract: The synthesis and characterization of manganese (ІІ), cobalt (ІІ), nickel (ІІ), copper (ІІ), zinc (ІІ), cadmium (ІІ) and mercury (ІІ) bidentate 2-(6-methoxybenzo[d]thiazol-2-ylamino)-2-phenyl acetonitrile ligand which was prepared from Benz aldehyde and 6-methoxybenzo[d]thiazol-2-amine in the presence of KCN and acidic medium. The complexes were synthesized by treating an ethanolic solution of the ligand with appropriate amount of metal salts [1:2] [M: L] ratio. The complexes were characterized by using metal and elemental chemical analysis, molar conductance, magnetic susceptibility measurements, FTIR , electronic spectral and mole ratio method. According to the obtained data the probable coordination geometries of manganese (ІІ), cobalt (ІІ), nickel (ІІ), copper (ІІ) zinc (ІІ), cadmium (ІІ) and mercury (ІІ) in these complexes are octahedral. All complexes were found to be non-electrolyte in absolute ethanol, and the complexes were formulated as [ML2Cl2] XH2O. Keywords: 2-(6-methoxybenzo[d]thiazol-2-ylamino)-2-phenyl acetonitrile, N2-donor, transition metals.
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Study of the Electric Properties of Azo/Hydrazone Tautomeric Mixture of the ...Scientific Review SR
An azo/hydrazone mixture of the phenolic azo dye 4-(9-Anthrylazo)-1-naphthol was obtained in 58%
yield. The product was characterized using spectroscopic techniques such as IR, NMR and ms. The electric
conductivity of the tautomeric mixture was investigated in solid phase at ambient temperature. The electric
measurements revealed that the azo derivative has an electric conductivity equals 0.657 10
7
1
cm
1
and
electric resistivity of 1.521545 10
7
cm which falls within the range of the semiconductors’ electric resistivity that ranges between 10
2 and 109cm.
Synthesis and characterization of resin copolymer derived from cardanol-furfu...ijceronline
International Journal of Computational Engineering Research (IJCER) is dedicated to protecting personal information and will make every reasonable effort to handle collected information appropriately. All information collected, as well as related requests, will be handled as carefully and efficiently as possible in accordance with IJCER standards for integrity and objectivity.
IJERA (International journal of Engineering Research and Applications) is International online, ... peer reviewed journal. For more detail or submit your article, please visit www.ijera.com
Bidentate Schiff base ligand 3-(3,4-Dihydroxy-phenyl)-2-[(4-dimethylamino-benzylidene)-amino]-2-methyl-propionic acid was prepared and characterized by spectroscopic techniques studies and elemental analysis. The Cd(II), Ni(II), Cu(II), Co(II), Cr(III),and Fe(III) of mixed-ligand complexes were structural explicate through moler conductance , [FT-IR, UV-Vis & AAS], chloride contents, , and magnetic susceptibility measurements. Octahedral geometries have been suggested for all complexes. The Schiff base and its complexes were tested against various bacterial species, two of {gram(G+) and gram(G-)} were shown weak to good activity against all bacteria.
Polycondensation of Ethylenediaminetetraacetic Acid with SomeTaghreed Al-Noor
Many condensed polymers [A1-A7] were prepared via reaction of (Ethylenediaminetetraacetic acid = EDTA),
with different prepared imide-diamines by modification [ modification of amino acids and antibiotics (B1-
B7)]
Imide-diamines were prepared by chlorination of L-amino acids such as
[ L-Histidine, L-Alanine, L-Valine, L-Glycine and L-Aspargine ] or selected antibiotics such as [Cephallixine
monohydrate and Amoxilline ] with thionyl chloride at 0°C, then reacted with ammonia to obtain imidediamines
[B1-B7] .
The physical properties of all prepared condensed polymers [A1-A7], new prepared diamines [B1-B7] were
studied and characterized by FT -IR spectroscope to certify the structural formulas.
The thermal analysis (TGA, DTA) were studied, and the intrinsic viscosities were measured at 30°C using
Ostwald viscometer.
Synthesis and Characterization of Schiff Base from Aromatic Amine and Aromati...ijtsrd
The synthesis of Schiff base From Aromatic Amine And Aromatic P Nitro benzaldehyde was performed by a novel method of stirring followed by the addition of p nitro benzaldehydeandm nitro aniline 0.02M . Characterization of the synthesized compounds, determination of purity and identity of the compounds using following spectroscopic and chromatographic techniques Solubility, Thin Layer Chromatographic studies, Ultra Violet studied rotational and vibrational studies FT IR studies. The compounds were investigated for their Antimicrobial activity by cup plate method. Compound1 nitro 4 1 imino,4 nitrophenyl benzene was found to be the most active according to pharmacological evaluation exhibited antimicrobial. Ms. Chetana D. Patil | Mr. Digamber N. Bhosale | Ms. Smita P. Bedis "Synthesis and Characterization of Schiff Base from Aromatic Amine and Aromatic P-Nitro Benzaldehyde" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-5 , August 2019, URL: https://www.ijtsrd.com/papers/ijtsrd26401.pdfPaper URL: https://www.ijtsrd.com/pharmacy/medicinal-chemistry/26401/synthesis-and-characterization-of-schiff-base-from-aromatic-amine-and-aromatic-p-nitro-benzaldehyde/ms-chetana-d-patil
ABSTRACT- L-Ascorbic acid derivatives was synthesized on treatment with acetone and acetyl chloride afforded 5,6-acetal of L-ascorbic acid then benzylation of C-2 and C-3 hydroxyl groups of the lactone ring was accomplished using K2CO3 and benzyl bromide in DMF, then deblocking of the 5,6-O,O-protected derivative of L-Ascorbic acid with acetic acid and methanol gave 2,3-O,O-dibenzyl-L-Ascorbic acid. Subsequently mono-tosylation at 6 position of 2,3-O, O-dibenzyl-L-Ascorbic acid was carried out with addition of p-toluenetosylchloride (PTSC) in Pyridine and MDC solvent medium gave 2,3-O,O-dibenzyl-6-O-tosyl-L-Ascorbic acid. All the structures were characterized by 1H NMR, 13C NMR and Mass Spectroscopy.
Key-words- L-Ascorbic acid, 5,6-Acetal, Benzylation, Hydrolysis, Tosylation
Synthesis and Characterization of New Complexes of 2-(6-Methoxybenzo[d]thiazo...IOSR Journals
Abstract: The synthesis and characterization of manganese (ІІ), cobalt (ІІ), nickel (ІІ), copper (ІІ), zinc (ІІ), cadmium (ІІ) and mercury (ІІ) bidentate 2-(6-methoxybenzo[d]thiazol-2-ylamino)-2-phenyl acetonitrile ligand which was prepared from Benz aldehyde and 6-methoxybenzo[d]thiazol-2-amine in the presence of KCN and acidic medium. The complexes were synthesized by treating an ethanolic solution of the ligand with appropriate amount of metal salts [1:2] [M: L] ratio. The complexes were characterized by using metal and elemental chemical analysis, molar conductance, magnetic susceptibility measurements, FTIR , electronic spectral and mole ratio method. According to the obtained data the probable coordination geometries of manganese (ІІ), cobalt (ІІ), nickel (ІІ), copper (ІІ) zinc (ІІ), cadmium (ІІ) and mercury (ІІ) in these complexes are octahedral. All complexes were found to be non-electrolyte in absolute ethanol, and the complexes were formulated as [ML2Cl2] XH2O. Keywords: 2-(6-methoxybenzo[d]thiazol-2-ylamino)-2-phenyl acetonitrile, N2-donor, transition metals.
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Study of the Electric Properties of Azo/Hydrazone Tautomeric Mixture of the ...Scientific Review SR
An azo/hydrazone mixture of the phenolic azo dye 4-(9-Anthrylazo)-1-naphthol was obtained in 58%
yield. The product was characterized using spectroscopic techniques such as IR, NMR and ms. The electric
conductivity of the tautomeric mixture was investigated in solid phase at ambient temperature. The electric
measurements revealed that the azo derivative has an electric conductivity equals 0.657 10
7
1
cm
1
and
electric resistivity of 1.521545 10
7
cm which falls within the range of the semiconductors’ electric resistivity that ranges between 10
2 and 109cm.
Synthesis, characterization and antimicrobial evaluation of novel diethyl (2-...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Synthesis and antimicrobial activity of some methyl (4- (benzo[d]oxazol-2-yl)...QUESTJOURNAL
ABSTRACT: In the present study, a new series of methyl (4-(benzo[d]oxazol-2-yl)phenyl) carbamodithioate amine derived from methyl (4-(benzo[d]oxazol-2-yl)phenyl) carbamodithioate (4TO1-TO6) have been synthesized by reacting the thio methyl group with different amines in presence of ethenol. The structural assessment of the compounds (TO 1- TO 6) was made on the basis of spectral data. The synthesized compounds were screened for their in vitro growth inhibiting activity against different strains of bacteria and fungi viz., Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, S. aureus, Candida albicans and Cryptococcus neoformans were compared with standard agents such as Norfloxacin (10μg/ml) and Amphotericin B (10μg/ml) using broth dilution method. Compounds exhibit moderate to high antibacterial and antifungal activity
Synthesis and Biological Evaluation of Novel3, 5-Disubstituted 4h-1, 2, 4-Tri...IOSR Journals
A general method was developed for the synthesis of novel unsymmetrical 3, 5-disubstituted 4H-1, 2,
4-triazoles with benzyl group in the 4-ring position (5a-j). A series of novel N-acyl amidrazone derivatives (4a-j)
have been synthesized. The chemical structures of newly synthesis zed compounds were characterized by IR,
H1NMR,C13NMR and mass. The newly synthesized compounds were screened for antimicrobial activity
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
Facial and Simple Synthesis of Some New (Pyrazole and Triazole) Coumarin Deri...IOSRJAC
2-oxo-2H-coumarin-3-carbohydrazide (2) which prepared from the reaction of ethyl-2-oxo-2Hcoumarin-3-carboxylate (1) with hydrazine hydrate in ethanol containing a catalytic amount of piperidine mixture consider a good and available starting intermediate for synthesis of series of functionalized coumarins. So, compound (2) was utilized as a key for the synthesis of some new (pyrazole, triazole)-2H- coumarin-2-one derivatives by the reaction with some selected reagents.
Synthesis, Characterization and invitro Anti- inflammatory activity of 1, 3, ...SriramNagarajan19
Oxadiazole derivatives have played a vital part in the development of heterocyclic compounds. In this present work, a series of 5-(2-aminophenyl)-1,3,4-oxadiazole-2(3H)-thione derivatives (1-10) have been synthesized by Mannich reaction. The reaction progress of the synthesized compounds was checked by TLC. The structures of the newly synthesized compounds were confirmed by IR and 1H NMR spectral data. The in-vitro anti-inflammatory activity of 1, 3, 4-oxadiazole compounds (1-10) was assessed by HRBC Membrane Stabilization Method. Among the newly synthesized 1,3,4-oxadiazole derivatives, compounds OFP, OAP, OBNP, OPBNP, ORP, OUP, OPClBP, OFD, OAD and OBND possessed highly significant anti-inflammatory activity at a dose of 1000µg/ml when compared with standard, Diclofenac potassium.
Synthesis and Antimicrobial Evaluation of Some Nitro-Mannich Bases Derived fr...peertechzpublication
The present work focused on exploring the reactivity of β-nitrostyrene towards Mannich reaction
with different approaches. The synthesized nitro-Mannich bases were tested as antimicrobial agents
that showed high activity against both gram positive and gram negative bacteria.
A series of novel 5-[2-(4-fluorobenzyl)-6-aryl-imidazo[2,1-b][1,3,4]thiadiazol-5-ylmethylene] thiazolidine-2,4-dione derivatives (4a-d) were synthesized. These final compounds (4a-d) were synthesized by Knoevenagel condensation of 2-(4-fluorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehydes (3a-d) with thiazolidine-2,4-dione. All the newly synthesized compounds were screened for their invivo hypoglycemic and hypolipidemic activity in male Wister rats. The Structures of all the newly synthesized compounds were established by analytical and spectral data.
An efficient synthesis, characterization and antibacterial activity of novel ...iosrjce
IOSR Journal of Applied Chemistry (IOSR-JAC) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of applied chemistry and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Chemical Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Synthesis, Characterization, and Antibacterial Activity of Some Novel 5-Chlor...IJERA Editor
The development of potential antibacterial requires the synthesis of a new series of 5- Chloroisatin derivatives incorporating various aromatic aldehydes in the case 1,3-Dipolar Cycloaddition including Nitrile oxide, as well as the cycloaddition Alcyne-Azide Catalytic with Copper. The charcterization of the structure of the synthesized compounds was confirmed by means of their IR, 1H-NMR and 13C-NMR spectral data. In addition, the antibacterial properties in vitro were tested against certain microorganisms using the disk diffusion technique. A majority of compounds show better activity against several of the microorganisms.
It is my Journal club presentation on Docking studies, synthesis, characterization of some novel Oxazine substituted 9-anilinoacridine derivatives and evaluation for their Antioxidant and Anticancer activities as topoisomerase II inhibitors.
I sincerely thank the authors R. Kalirajan*, Vivek Kulshrestha, S. Sankar, S. Jubie, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, (Off Campus, JSS University, Mysore), Udhagamandalam 643001, Tamilnadu, India
Oxidation of 7-Methyl Sulfanyl-5-Oxo-5H-Benzothiazolo-[3, 2-A]-Pyrimidine-6-...inventionjournals
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
2. 2 Muna S. Al-Rawi et al.: Synthesis and Characterization of New Schiff Bases Heterocyclic Compounds
and their N-Acyl, Thiourea and Imidazole Derived from D-Erythroascorbic Acid
2.2. Synthesis Procedures All compounds were synthesized according to Schemes 1 to 3, and the following procedures. All known compounds gave acceptable elemental analysis, FTIR and NMR spectra that matched data reported in the cited references. Compounds[I] to[IV] were synthesised following the Scheme 1.
Scheme 1. The synthesis rout for Compounds[I] to[IV]
2.2.1. Preparation of 5,6-O-isopropylidene-L-ascorbic
acid[I]
This compound was prepared from the reaction of
L-ascorbic acid with Acetone in a acidic media, following
Salomon method[16].
2.2.2. Preparation of 2,3-O-dianisoyl-5,6-O-isopropylidene-
L- ascorbic acid[II]
To a cold solution of[I] (10 g, 46 mmol) in pyridine (50 mL), anisoyl chloride was added (22.3 g, 129 mmol) with stirring for 2 hrs, then kept in dark place at room temperature for 24 hrs. The mixture was poured into ice-water the oil layer was extracted with (150 mL) chloroform, washed with water and dried over anhydrous magnesium sulfate. Filtered and the solvent evaporated, purified from chloroform: petroleum ether (1:5) to give[II] (76.5%) as a pale yellow solid, m.p (102 -104℃), Rf = 0.80 (benzene/heptanol 5:5).
2.2.3. Preparation of 2,3-O-dianisoyl-L-ascorbic acid[III]
Compound[II] (10 g, 24 mmol) was dissolved in a mixture of (65%) acetic acid (30 mL), absolute methanol (10 mL) and stirred for 48 hrs at room temperature. To the resulting solution a benzene (40mL) was added and evaporated to yield[III],[17] (78%) as a white crystals, m.p (130-132℃), Rf = 0.42 (benzene/methanol 4:6). 2.2.4. Preparation of pentulosono-lacton-2,3-ene-dianisoate [IV] To a stirred solution of sodium periodate (5.6 g) in distilled water ( 60 mL) at (0℃), a solution of[III] (10 g, 26 mmol) in absolute ethanol (60 mL) was added dropwise. After stirring15 min, ethylene glycol (0.5 mL) was added and stirring for one hour. The mixture was extracted with ethyl acetate (3x50 mL)[17]. The extracts dried over anhydrouse MgSO4, filtered and the solvent evaporated, the residue recrystallized from benzene to yield[IV] (45%) as a white crystals, m.p (156-158℃), Rf=0.70 (benzene / methanol 6:4). Compounds[V] to[XI] were synthesised following the Scheme 2. 2.2.5. Preparation of Methyl 4-Methoxybenzoate[V] This compound was prepared following the procedure described by Vog el[18], m.p.(49-51℃). 2.2.6. Preparation of Methoxy Benzoyl Hydrazine[VI] This compound was prepared following the procedure described by Smith[19]. m.p.(135-137℃). 2.2.7. Preparation of 2-(4′-aminophenyl)-5-(4′′-methoxy - phenyl) -1,3,4-oxadiazole[VII]
A mixture of 4-methoxybenzoyl hydrazine (10 mmol), 4-aminobenzoic acid (10 mmol) and phosphorus oxy chloride (5 mL) was refluxed for 7 hrs. The cold reaction mixture was poured into ice-water and made basic by adding sodium bicarbonate solution. The formed solid was filtered, dried and purified. Yield: 89%; m.p. = 196 oC (ethanol);[20]. IR(KBr) cm-1: 3350-3200 (NH2), 2935-2841(C-H), 1610 (C=N), 1245 ( sym. C-O-C), 1070 (asym. C-O-C); 1H NMR (TMS) δ ppm: 6.70-8.01 (m, 8 H, ArH ), 3.90 (s, 3 H, OCH3), 1.60-1.75 (s, 2H, NH2) 13C NMR (CDCl3,75 MHz): δ 162.2 ( C- NH2), 114.5-128.6 (aromatic and olefinic carbons), 101.8 (C-1), 80.0, 79.1, (O-C=N), 55.5 (OCH3); Anal. Calcd. for C15H13O2N3 (267): C, 67.42; H, 4.87; N, 15.73. Found: C, 67.89; H, 5.44; N, 15.49. 2.2.8. Preparation of Schiff bases[VIII]
A mixture of new primary amine compounds[VII] (10 mmol), aldehyde[IV] (10 mmol), dry benzene (15 mL) and 2 drops of glacial acetic acid was refluxed for 6hrs. The ν
3. American Journal of Organic Chemistry 2013, 3(1): 1-8 3
solvent was evaporated under vacuum and the residue crystallized from chloroform.
Scheme 2. The synthesis rout for Compounds[V] to[XI]
2.2.9. Compound[VIII]
Yield: 75%; m.p. = 178-180 oC (chloroform); IR(KBr) cm-1: 1635 (C=N), 1685 (C=C), 1770 (C=O); 1H NMR (TMS) δ ppm: 10.3 (s, 1H, CH=N ), 7.10-8.20 (m, 16 H, ArH ), 3.85 (s, 9 H, OCH3), 3.99 (s, 1H, lacton); Anal. Calcd. for C36H27O10N3 (661): C, 65.36; H, 4.08; N, 6.35. Found: C, 65.18; H, 4.28; N, 6.45. 2.2.10. Preparation of N-(acetyl or anisoyl) Derivatives[IX] a,b To a stirred solution of Schiff bases[VIII] (10 mmol) in 10 mL dry benzene was added dropwise acetyl or anisoyl chloride (12 mmol) after cooling , the reaction mixture was refluxed for 1 hour. The solvent was evaporated and the residue was washed with water for many times and recrystallized from petroleum ether. 2.2.11. Compound[IX]a
Yield: 60%; m.p. = 122-124 oC (petroleum ether); IR(KBr) cm-1: 2939-2843 (C-H), 1767(C=O lactone), 1687(C=C), 1708 (C=O amide), 748 (C-Cl); 1H NMR (TMS) δ ppm: 7.30 (s, 1H, CH=N ), 7.00-8.04 (m, 16 H, ArH ), 3.85 (s, 9 H, OCH3), 2.88 (s, 3 H, CH3), 3.98 (s, 1H, lacton); Anal. Calcd. for C38H30O11N3Cl (739.5): C, 61.66; H, 4.06; N, 5.68. Found: C, 61.53; H, 4.31; N, 5.79.
2.2.12. Compound[IX]b
Yield: 65%; m.p. = 146-148℃ (petroleum ether); IR(KBr) cm-1: 2935-2839 (C-H), 1771(C=O lactone), 1686(C=C), 1700(C=O amide), 767 (C-Cl); Anal. Calcd. for C44H34O12N3Cl (831.5): C, 63.50; H, 4.09; N, 5.05. Found: C, 63.37; H, 4.28; N, 5.19. 2.2.13. Preparation of N-(acetyl or anisoyl )Thioureas Derivatives[X]a,b A mixture of compound[IX]a,b (10 mmol), thiourea (10 mmol), anhydrous sodium carbonate (10 mmol), 20 mL analar acetone was refluxed for 4 hrs with stirring. The reaction mixture was cooled and poured into ice water. The product was filtered off and recrystalized from ethyl acetate to give colored compounds[X]a,b. 2.2.14. Compound[X]a
Yield: 60%; m.p. = 240-242 oC (petroleum ether); IR(KBr) cm-1: 3393-3200 (NH2), 1700 (C=C), 1630 (C=N), 840 (C-S); 1H NMR (TMS) δ ppm: 7.88 (s, 1H, NH ), 6.95-7.08 (m, 12 H, ArH ), 3.44-3.49 (s, 2 H, NH2 ), 3.79 (s, 6 H, OCH3), 2.07 (s, 3 H, CH3), 2.72 (s, 3 H, COCH3), 3.88 (s, 1H, lacton); Anal. Calcd. for C39H33O11N5S (779): C, 60.08; H, 4.24; N, 8.99. Found: C, 59.89; H, 4.23; N, 8.74. 2.2.15. Compound[X]b
Yield: 45%; m.p.=213-215℃ (petroleum ether); IR(KBr) cm-1: 3375-3232(NH2), 2924-2850 (C-H), 1721(C=C), 1640(C=N), 841 (C-S); Anal. Calcd. for C45H37O12N5S (871): C, 62.00; H, 4.25; N, 8.04. Found: C, 61.98; H, 4.21, N, 8.17. 2.2.16. Preparation of Diphenylimidazoles Derivatives[XI] a,b To a stirred solution of compound[X] (10 mmol) in dry DMF (10 mL), the benzoin (10 mmol) was added. The reaction mixture was refluxed for 5 hrs. After cooling, drops of water were added with stirring until a precipitate separated out. The precipitate was filtered, dried and recrystalized from petroleum ether. 2.2.17. Compound[XI]a
Yield: 50%; m.p. = 112-114 oC (petroleum ether); IR(KBr) cm-1: 3280(NH2),, 2926-2854(C-H), 1685(C=C), 1591(C=N), 875 (C-S); Anal. Calcd. for C53H41O11N5S (855): C, 74.39; H, 4.80; N, 8.19. Found: C, 74.53; H, 4.71; N, 8.29. 2.2.18. Compound[XI]b
Yield: 40%; m.p. = 120 oC (petroleum ether); IR(KBr) cm-1: 3236(NH2), 2924-2846(C-H), 1685(C=C), 1597(C=N), 841 (C-S); 1H NMR (TMS) δ ppm: 8.06 (s, 1H, NH ), 7.07-7.20 (m, 10 H, ph ), 7.66-7.93 (s, 20 H, ArH ), 3.86 (s, 12 H, OCH3), 3.74 (s, 1 H, C4 lacton), 7.35 (s, 1 H, C5 lacton), ννννννν
4. 4 Muna S. Al-Rawi et al.: Synthesis and Characterization of New Schiff Bases Heterocyclic Compounds
and their N-Acyl, Thiourea and Imidazole Derived from D-Erythroascorbic Acid
3.88 (s, 1H, lacton); Anal. Calcd. for C59H45O12N5S (1047): C, 67.62; H, 4.30; N, 6.69. Found: C, 67.77; H, 4.17; N, 6.79. Compounds[XII] to[XVI] were synthesised following the Scheme 3.
Scheme 3. The synthesis rout for Compounds[XII] to[XVI]
2.2.19. preparation of 2-amino-5-(4`-tolyl)-1,3,4-thiad ia-zole[
XII ]
A mixture of tuloic acid (10 mmol), thiosemicarbazide (10
mmol), and phosphorus oxy chloride (5 mL) was refluxed
gently for 6 hrs. After cooling, ice water (50 mL) was added
in portions with stirring. The yellow precipitate was filtered,
washed with water , dried and crystallized from ethanol
yield(68%), m.p.(246-248℃)[21].
2.2.20. Preparation of Schiff bases [XIII]
A mixture of new primary amine compounds[VIII] (10
mmol), aldehyde[IV] (10 mmol), dry benzene (15 mL) and 2
drops of glacial acetic acid was refluxed for 6hrs. The
solvent was evaporated under vacuum and the residue
crystallized from chloroform.
2.2.21. Compound[XIII]
Yield: 60%; m.p. = 162-164 oC (chloroform); IR(KBr) cm-1: 1636(C=N), 1685 (C=C), 1771(C=O); 1H NMR (TMS) δ ppm: 8.9 (s, 1H, CH=N ), 6.99-7.90 (m, 12 H, ArH ), 3.81 (s, 6 H, OCH3), 2.35 (s, 3 H, CH3), 3.98 (s, 1H, lacton); Anal. Calcd. for C30H23O8N3S (585): C, 61.45; H, 3.93; N, 7.18. Found: C, 61.44; H, 4.13; N, 7.91.
2.2.22. Preparation of N-(acetyl or Anisoyl) Derivatives [XIV] a, b To a stirred solution of Schiff bases[XIII] (10 mmol) in 10 mL dry benzene was added dropwise acetyl or anisoyl chloride (12 mmol) after cooling , the reaction mixture was refluxed for 1 hour. The solvent was evaporated and the residue was washed with water for many times and recrystallized from petroleum ether. 2.2.23. Compound[XIV]a
Yield: 65%; m.p. = 146-148 oC (petroleum ether); IR(KBr) cm-1: 2900-2843(C-H), 177(C=O lactone)0, 1685(C=C), 1708(C=O amide), 1685(C=C), 772 (C-Cl); Anal. Calcd. for C32H26O9N3SCl (663.5): C, 57.87; H, 3.92; N, 6.33. Found: C, 57.73; H, 4.10; N, 6.45. 2.2.24. Compound[XIV]b
Yield: 50%; m.p. = 179-180℃ (petroleum ether); IR(KBr) cm-1: 2925-2850(C-H), 1775(C=O lactone), 1685(C=C), 1720(C=O amide), 1687(C=C), 772 (C-Cl); Anal. Calcd. for C38H30O10N3SCl (655.5): C, 69.57; H, 4.58; N, 6.41. Found: C, 69.43; H, 4.54; N, 6.27 . 2.2.25. Preparation of N-(acetyl or anisoyl )Thioureas Derivatives[XV] a,b A mixture of compound[XIV]a,b (10 mmol), thiourea (10 mmol), anhydrous sodium carbonate (10 mmol), 20 mL analar acetone was refluxed for 4 hrs with stirring. The reaction mixture was cooled and poured into ice water. The product was filtered off and recrystalized from ethyl acetate to give colored compounds[XV]. 2.2.26. Compound[XV]a
Yield: 45%; m.p. = 213-215℃ (petroleum ether); IR(KBr) cm-1: 3421-3160(NH2), 2918-2856(C-H), 1730(C=C), 1610(C=N), 1560, 823 (C-S); Anal. Calcd. for C33H29O9N5S2 (703): C, 56.33; H, 4.13; N, 9.96. Found: C, 56.19; H, 4.01, N, 10.09. 2.2.27. Compound[XV]b
Yield: 45%; m.p. = 198-200℃ (petroleum ether); IR(KBr) cm-1: 3305-3109(NH2), 2924-2850(C-H), 1693(C=C), 1577(C=N), 817 (C-S); Anal. Calcd. for C39H33O10N5S2 (795): C, 58.87; H, 4.15; N, 8.81. Found: C, 58.77; H, 4.09, N, 8.41. 2.2.28. Preparation of Diphenylimidazoles Derivatives[XVI] a,b To a stirred solution of compound[XV] (10 mmol) in dry DMF (10 mL), the benzoin (10 mmol) was added. The reaction mixture was refluxed for 5 hrs. After cooling, drops of water were added with stirring until a precipitate separated out. The precipitate was filtered, dried and recrystallized from petroleum ether. ννννν
5. American Journal of Organic Chemistry 2013, 3(1): 1-8 5
2.2.29. Compound[XVI]a
Yield: 50%; m.p. = 90℃ (petroleum ether); IR(KBr) cm-1: 3317(NH2), 2924-2852(C-H), 1678(C=C), 1595(C=N), 875 (C-S); Anal. Calcd. for C47H37O9N5S2 (879): C, 64.16; H, 4.21; N, 7.96. Found: C, 64.24; H, 4.19; N, 8.09. 2.2.30. Compound[XVI]b
Yield: 50%; m.p. =130-132℃ (petroleum ether); IR(KBr) cm-1: 3228(NH2), 2926-2848(C-H), 1680(C=C), 1590(C=N), 840 (C-S); Anal. Calcd. for C53H41O11N5S (855): C, 74.39; H, 4.80; N, 8.19. Found: C, 74.53; H, 4.71; N, 8.29.
3. Results and Discussion
5,6-O-isopropylidene-L-ascorbic acid[I] was prepared by the reaction of L-ascorbic acid with acetone in dry HCl[16]. Compound[I] reacts with excess of anisoyl chloride in dry pyridine to give the corresponding ester[II].
Glycols[III] oxidized by periodate, which is cleaves the C5-C6 bond (bearing OH groups) and formation the aldehyde compound D-erythroascorbic acid[IV][22-24]. Methyl-4 - methoxy benzoate[V] was obtained by esterification of 4-methoxy benzoic acid (anisic acid) with methanol[25]. The reaction of 4-methoxybenzoate with hydrazine hydrate in ethanol under reflux give 4-methoxybenzoyl hydrazine[VI] in good yield. Condensation of acid hydrazid with 4-aminobenzoic acid in the presence of dehydrating agent phosphorus oxychloride yielded the oxadiazole derivative [VII].
The reaction of tuloic acid with thiosemicarbazide in the presence of phosphorous oxychloride under reflux for 8 hrs leads to formation 2-amino-5-(4′-tolyl)-1,3,4-thiodiazole [VIII].
The novel Schiff bases[VIII] and[XIII] were synthesized by refluxing equemolare of D-erythroascorbic acid[VI] with amino compounds[VII] or[XII] in dry benzene with some drops of glacial acetic acid.
Compounds[IX] or[XIV] were synthesized by refluxing acetyl or anisoyl chloride with Schiff bases[XIII] or[XIII] in dry benzene. The reaction is initiated by attack of the azomethine nitrogen at the carbonyl group of acid chloride (acetyl or anisoyl chloride)[26], displacing the chlorine as a chloride anion and forming the iminium cation[A] which can be represented by structure[B] too. In both structure[A] and[B] the positively charged on nitrogen in[A] and the positively charged on carbon in[B] are linked to strong electron withdrawing groups and are unlikely to form, therefore, N-acyl derivatives are best represented by the covalent structure[C] (Scheme 4).
Scheme 4. Mechanism for the synthesis of compounds[IX] or[XIV] A mixture of compound[IX] or[XIV], thiourea, anhydrous sodium carbonate in acetone was refluxed for 4 hrs with stirring to yield thiourea derivatives[X] or[XV]. The mechanism may be proposed for this reaction as indicated in Scheme 5[26]:
νν ëëOOAr-N=CHCClOR+ ClCORNArOOCHArOCOArCOO+ ArOCOArCOO- OON-CHCORClArOOArNCHClRCO+ _ OOArNCHClRCO+ _ [A] [B] [C] ArCOOArOCOArOCOArCOOArCOOArOCO
6. 6 Muna S. Al-Rawi et al.: Synthesis and Characterization of New Schiff Bases Heterocyclic Compounds
and their N-Acyl, Thiourea and Imidazole Derived from D-Erythroascorbic Acid
Scheme 5. Mechanism for the synthesis of compounds[X] or[XV] The reaction in basic medium is converted the thiourea into the sodium salt of thiourea[A], which is attacks the carbon of C-Cl group in an SN2 like mechanism as in T.S[B] with displacement of Cl− to yield thiourea derivatives[C]. The novel imidazole derivatives[XI] or[XVI] were synthesized by refluxing compounds[XII]a-d with benzoin in DMF for 5 hrs. The following mechanism is proposed[26] for this reaction (Scheme 6):
Scheme 6. Mechanism for the synthesis of compounds[XI] or[XVI]
OOCHCORClAr[A] [B][C] CNH2NH2SNa2CO3Na S+_ CNHNH2+NaCHO3_ +CNHNH2SCClHNArCORN-CHCORAr+ClSCNHNH2 SC - NH2NHT.SOONë ë + O -C-ArOOO -C-ArOAr C-OOOOO -C-ArOAr C-OOAr C-OCCHOOC HO OHH+ DMF , + N-CHCORArSCNH2NHPhPhN-CHCORArSCNH2NHOOCPhPhP.TOOC-ArAr-COOOOOOC-ArAr-COO-H2OOenol formketo formCOHHN-CHCORArSCNHNHCPhPhOHCN-CHCORArSCNHNHCPhPhOHCHN-CHCORArSCNHNHCPhPhOOOOC-ArAr-COOOOOOC-ArAr-COOOOOOC-ArAr-COOHOHN-CHCORArSPhPhNNHOOOOC-ArAr-COO-H2ON-CHCORArSPhPhNNHOOOOC-ArAr-COO
7. American Journal of Organic Chemistry 2013, 3(1): 1-8 7
3.1. Biological Activity The antibacterial activity of the synthesized compounds was performed according to the agar diffusion method[27]. The synthesized compounds were tested against E.coli and Staph. aureus. Each compound was dissolved in DMSO to give concentration 1ppm. The plates were then incubated at 37℃ and examined after 24 hrs. The zones of inhibition formed were measured in millimeter and are represented by (-), (+), (+ +) and (+ + +) depending upon the diameter and clarity as in Table 1. All the compounds exhibit the highest or low biological activity against both the organisms. Compounds showed good inhibition against of the two types of the bacteria, this could be related to the presence of the D-erythroascorbic acid, imine linkage or imidazole ring. Table 1. Antibacterial activity of the synthesized compounds[IV]-[XVI]
Comp. No.
E Coli(G-)
Staph. aurus(G+)
Comp. No.
E. Coli(G-)
Staph. aurus(G+)
[IV]
+ +a
+ +
[XI]a
+ + +
+ + +
[V]
+ + +
+ + +
[XI]b
+
+
[VI]
+ + +
+ + +
[XII]
+
+
[VII]
+
+ + +
[XIII]
+
+
[VIII]
+
+
[XIV]a
+
+
[IX]a
+ +
+ +
[XIV]b
+
+
[IX]b
+
+ +
[XV]a
+
+
[X]a
+
+
[XV]b
+
+
[X]b
+
+
[XVI]a
+ + +
+ + +
aKey to symbols: highly active = + + + (mor than)15 mm, moderately active = + + (11-15) mm and slightly active = + (5-10) mm REFERENCES
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