This document summarizes the synthesis and characterization of a new thio-triazole ligand and its complexes with selected metals. A new ligand, thiocarboxyphenyl-4-allyl-5-phenyl-4H-1,2,4-triazole (L), was prepared and characterized using micro elemental analysis and infrared spectroscopy. This ligand was then reacted with Fe(III), Cu(II), Cd(II), Hg(II) and Au(III) to form new complexes. These complexes were identified through various techniques and their chemical formulas and geometries were suggested. The biological activity of the complexes against selected microorganisms was also examined.
Complexation, Spectroscopic, Thermal, Magnetic And Conductimetric Studies On ...IOSR Journals
7-hydroxy-4-methyl-8-(phenylazo) coumarin (L1)and 7-hydroxy-4-methyl-8-(o-carboxyphenylazo) coumarin (L2) have been prepared and characterized by elemental analysis, infrared (IR), proton nuclear magnetic resonance (1H NMR) and Mass spectra. The important infrared (IR) spectral bands corresponding to the active groups in the two ligands and the solid complexes under investigation were studied. Also the important fragments in the ligands and the complexes were done using mass spectra and the main peaks were corresponding to the molecular weights of the ligands and complexes. The solid complexes have been synthesized and studied by elemental and thermal analyses (TG and DTA) as well as by IR, 1H NMR, magnetic measurements, electronic transition, molar conductance, mass spectra and electron spin resonance (ESR) spectra. The proposed steriochemical structures for the investigated metal complexes suggest octahedral geometry with respect to Mn, Co, Ni, Cu and Zn metal ions and all of the formed complexes contain coordinated and hydrated water molecules. All of the prepared solid complexes behave as non-electrolytes in chloroform.
Synthesis, characterization, antimicrobial, anticancer and antidiabetic activ...inventionjournals
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Synthesis and characterization of new derivatives of thiazole with liquid cry...Alexander Decker
This document describes the synthesis and characterization of new derivatives of thiazole with liquid crystalline properties. Two series of Schiff bases containing thiazole moiety were synthesized with different length alkoxy spacers. All compounds displayed nematic liquid crystalline mesophase as determined by polarized optical microscopy and differential scanning calorimetry. The compounds were characterized using elemental analysis, FTIR, 1H NMR, and 13C NMR spectroscopy. The liquid crystalline behavior was found to depend on the structural properties, particularly the length of the alkoxy spacers.
Synthesis and Characterization of Schiff Base from Aromatic Amine and Aromati...ijtsrd
The synthesis of Schiff base From Aromatic Amine And Aromatic P Nitro benzaldehyde was performed by a novel method of stirring followed by the addition of p nitro benzaldehydeandm nitro aniline 0.02M . Characterization of the synthesized compounds, determination of purity and identity of the compounds using following spectroscopic and chromatographic techniques Solubility, Thin Layer Chromatographic studies, Ultra Violet studied rotational and vibrational studies FT IR studies. The compounds were investigated for their Antimicrobial activity by cup plate method. Compound1 nitro 4 1 imino,4 nitrophenyl benzene was found to be the most active according to pharmacological evaluation exhibited antimicrobial. Ms. Chetana D. Patil | Mr. Digamber N. Bhosale | Ms. Smita P. Bedis "Synthesis and Characterization of Schiff Base from Aromatic Amine and Aromatic P-Nitro Benzaldehyde" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-5 , August 2019, URL: https://www.ijtsrd.com/papers/ijtsrd26401.pdfPaper URL: https://www.ijtsrd.com/pharmacy/medicinal-chemistry/26401/synthesis-and-characterization-of-schiff-base-from-aromatic-amine-and-aromatic-p-nitro-benzaldehyde/ms-chetana-d-patil
A new Schiff base 4-chlorophenyl)methanimine
(6R,7R)-3-methyl-8-oxo-7-(2-phenylpropanamido)-5-thia-1-
azabicyclo[4.2.0]oct-2-ene-2-carboxylate= (HL)= C23H20
ClN3O4S) has been synthesized from β-lactam antibiotic
(cephalexin mono hydrate(CephH)=(C16H19N3O5S.H2O) and 4-
chlorobenzaldehyde . Figure(1) Metal mixed ligand complexes
of the Schiff base were prepared from chloride salt of
Fe(II),Co(II),Ni(II),Cu(II),Zn(II) and Cd (II), in 50% (v/v)
ethanol –water medium (SacH ) .in aqueous ethanol(1:1)
containing and Saccharin(C7H5NO3S) = sodium hydroxide.
Several physical tools in particular; IR, CHN, 1H NMR, 13C
NMR for ligand and melting point molar conductance, magnetic
moment. and determination the percentage of the metal in the
complexes by flame(AAS). The ligands and there metal
complexes were screened for their antimicrobial activity against
four bacteria (gram + ve) and (gram -ve) {Escherichia coli,
Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus}.
The proposed structure of the complexes using program, Chem
office 3D(2006). The general formula have been given for the
prepared mixed ligand complexes Na2[M(Sac)3(L)], M(II) = Fe
(II), Co(II) , Ni(II), Cu (II), Zn(II) , and Cd(II).
HL= C29H24 ClN3O4S, L= C29H23 ClN3O4S -.
This document summarizes the synthesis of new C-2, C-3 substituted heterocyclic derivatives of L-ascorbic acid and their characterization and evaluation of bacterial activity. Specifically, it describes the multi-step synthesis of Schiff bases and 1,3-oxazepine derivatives from L-ascorbic acid, including protection of hydroxyl groups, esterification, hydrazide formation, Schiff base formation with substituted benzaldehydes, and Diels-Alder reaction with phthalic anhydride to form 1,3-oxazepines. The synthesized compounds were characterized using melting point, FTIR, and 1H NMR spectroscopy and tested for antibacterial activity against gram-positive and
The document provides information about Schiff bases:
- Schiff bases are organic compounds formed by the condensation of carbonyl compounds with primary amines, first reported in 1864.
- There are several methods for synthesizing Schiff bases, including microwave, reflux, stirring, and grinding methods. Spectroscopic techniques like FT-IR, UV-Vis, and X-ray spectroscopy are used to characterize Schiff bases and their complexes.
- Schiff bases have applications in coordination chemistry and as intermediates in organic synthesis. They also show biological activities like antimicrobial and anticancer properties.
New Schiff base ligand (E)-6-(2-(4-
(dimethylamino)benzylideneamino)-2-phenylacetamido)-3,3-
dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic
acid = (HL) Figure(1) was prepared via condensation of
Ampicillin and 4(dimethylamino)benzaldehyde in methanol
.Polydentate mixed ligand complexes were obtained from 1:1:2
molar ratio reactions with metal ions and HL, 2NA on reaction
with MCl2 .nH2O salt yields complexes corresponding to the
formulas [M(L)(NA)2Cl] ,where M =
Fe(II),Co(II),Ni(II),Cu(II),and Zn(II) and NA=nicotinamide.
The 1H-NMR, FT-IR, UV-Vis and elemental analysis
were used for the characterization of the ligand. The complexes
were structurally studied through AAS, FT-IR, UV-Vis,
chloride contents, conductance, and magnetic susceptibility
measurements. All complexes are non-electrolytes in DMSO
solution. Octahedral geometries have been suggested for each
of the complexes. The Schiff base ligands function as
tridentates and the deprotonated enolic form is preferred for
coordination. In order to evaluate the effect of the bactericidal
activity, these synthesized complexes, in comparison to the un
complexed Schiff base has been screened against bacterial
species, Staphy
Complexation, Spectroscopic, Thermal, Magnetic And Conductimetric Studies On ...IOSR Journals
7-hydroxy-4-methyl-8-(phenylazo) coumarin (L1)and 7-hydroxy-4-methyl-8-(o-carboxyphenylazo) coumarin (L2) have been prepared and characterized by elemental analysis, infrared (IR), proton nuclear magnetic resonance (1H NMR) and Mass spectra. The important infrared (IR) spectral bands corresponding to the active groups in the two ligands and the solid complexes under investigation were studied. Also the important fragments in the ligands and the complexes were done using mass spectra and the main peaks were corresponding to the molecular weights of the ligands and complexes. The solid complexes have been synthesized and studied by elemental and thermal analyses (TG and DTA) as well as by IR, 1H NMR, magnetic measurements, electronic transition, molar conductance, mass spectra and electron spin resonance (ESR) spectra. The proposed steriochemical structures for the investigated metal complexes suggest octahedral geometry with respect to Mn, Co, Ni, Cu and Zn metal ions and all of the formed complexes contain coordinated and hydrated water molecules. All of the prepared solid complexes behave as non-electrolytes in chloroform.
Synthesis, characterization, antimicrobial, anticancer and antidiabetic activ...inventionjournals
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Synthesis and characterization of new derivatives of thiazole with liquid cry...Alexander Decker
This document describes the synthesis and characterization of new derivatives of thiazole with liquid crystalline properties. Two series of Schiff bases containing thiazole moiety were synthesized with different length alkoxy spacers. All compounds displayed nematic liquid crystalline mesophase as determined by polarized optical microscopy and differential scanning calorimetry. The compounds were characterized using elemental analysis, FTIR, 1H NMR, and 13C NMR spectroscopy. The liquid crystalline behavior was found to depend on the structural properties, particularly the length of the alkoxy spacers.
Synthesis and Characterization of Schiff Base from Aromatic Amine and Aromati...ijtsrd
The synthesis of Schiff base From Aromatic Amine And Aromatic P Nitro benzaldehyde was performed by a novel method of stirring followed by the addition of p nitro benzaldehydeandm nitro aniline 0.02M . Characterization of the synthesized compounds, determination of purity and identity of the compounds using following spectroscopic and chromatographic techniques Solubility, Thin Layer Chromatographic studies, Ultra Violet studied rotational and vibrational studies FT IR studies. The compounds were investigated for their Antimicrobial activity by cup plate method. Compound1 nitro 4 1 imino,4 nitrophenyl benzene was found to be the most active according to pharmacological evaluation exhibited antimicrobial. Ms. Chetana D. Patil | Mr. Digamber N. Bhosale | Ms. Smita P. Bedis "Synthesis and Characterization of Schiff Base from Aromatic Amine and Aromatic P-Nitro Benzaldehyde" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-5 , August 2019, URL: https://www.ijtsrd.com/papers/ijtsrd26401.pdfPaper URL: https://www.ijtsrd.com/pharmacy/medicinal-chemistry/26401/synthesis-and-characterization-of-schiff-base-from-aromatic-amine-and-aromatic-p-nitro-benzaldehyde/ms-chetana-d-patil
A new Schiff base 4-chlorophenyl)methanimine
(6R,7R)-3-methyl-8-oxo-7-(2-phenylpropanamido)-5-thia-1-
azabicyclo[4.2.0]oct-2-ene-2-carboxylate= (HL)= C23H20
ClN3O4S) has been synthesized from β-lactam antibiotic
(cephalexin mono hydrate(CephH)=(C16H19N3O5S.H2O) and 4-
chlorobenzaldehyde . Figure(1) Metal mixed ligand complexes
of the Schiff base were prepared from chloride salt of
Fe(II),Co(II),Ni(II),Cu(II),Zn(II) and Cd (II), in 50% (v/v)
ethanol –water medium (SacH ) .in aqueous ethanol(1:1)
containing and Saccharin(C7H5NO3S) = sodium hydroxide.
Several physical tools in particular; IR, CHN, 1H NMR, 13C
NMR for ligand and melting point molar conductance, magnetic
moment. and determination the percentage of the metal in the
complexes by flame(AAS). The ligands and there metal
complexes were screened for their antimicrobial activity against
four bacteria (gram + ve) and (gram -ve) {Escherichia coli,
Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus}.
The proposed structure of the complexes using program, Chem
office 3D(2006). The general formula have been given for the
prepared mixed ligand complexes Na2[M(Sac)3(L)], M(II) = Fe
(II), Co(II) , Ni(II), Cu (II), Zn(II) , and Cd(II).
HL= C29H24 ClN3O4S, L= C29H23 ClN3O4S -.
This document summarizes the synthesis of new C-2, C-3 substituted heterocyclic derivatives of L-ascorbic acid and their characterization and evaluation of bacterial activity. Specifically, it describes the multi-step synthesis of Schiff bases and 1,3-oxazepine derivatives from L-ascorbic acid, including protection of hydroxyl groups, esterification, hydrazide formation, Schiff base formation with substituted benzaldehydes, and Diels-Alder reaction with phthalic anhydride to form 1,3-oxazepines. The synthesized compounds were characterized using melting point, FTIR, and 1H NMR spectroscopy and tested for antibacterial activity against gram-positive and
The document provides information about Schiff bases:
- Schiff bases are organic compounds formed by the condensation of carbonyl compounds with primary amines, first reported in 1864.
- There are several methods for synthesizing Schiff bases, including microwave, reflux, stirring, and grinding methods. Spectroscopic techniques like FT-IR, UV-Vis, and X-ray spectroscopy are used to characterize Schiff bases and their complexes.
- Schiff bases have applications in coordination chemistry and as intermediates in organic synthesis. They also show biological activities like antimicrobial and anticancer properties.
New Schiff base ligand (E)-6-(2-(4-
(dimethylamino)benzylideneamino)-2-phenylacetamido)-3,3-
dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic
acid = (HL) Figure(1) was prepared via condensation of
Ampicillin and 4(dimethylamino)benzaldehyde in methanol
.Polydentate mixed ligand complexes were obtained from 1:1:2
molar ratio reactions with metal ions and HL, 2NA on reaction
with MCl2 .nH2O salt yields complexes corresponding to the
formulas [M(L)(NA)2Cl] ,where M =
Fe(II),Co(II),Ni(II),Cu(II),and Zn(II) and NA=nicotinamide.
The 1H-NMR, FT-IR, UV-Vis and elemental analysis
were used for the characterization of the ligand. The complexes
were structurally studied through AAS, FT-IR, UV-Vis,
chloride contents, conductance, and magnetic susceptibility
measurements. All complexes are non-electrolytes in DMSO
solution. Octahedral geometries have been suggested for each
of the complexes. The Schiff base ligands function as
tridentates and the deprotonated enolic form is preferred for
coordination. In order to evaluate the effect of the bactericidal
activity, these synthesized complexes, in comparison to the un
complexed Schiff base has been screened against bacterial
species, Staphy
Synthesis and characterization of some metal complexes of 2- Phenyl-3,4-dihyd...IOSRJAC
2-Phenyl-3,4-dihydro-quinazolin-4-yloxy)-acetic acid (L1) metal complexes with Mn2+ , Co2+, Ni2+ Cu2+ , and Zn2+ ions were studied and the structure of the complexes were elucidated using elemental analyses, infrared (IR), 1H nuclear magnetic resonance (NMR), magnetic moment and thermal analysis measurements. Besides the characterization of complexes by physicochemical technique, Biological activities of the synthesized complexes were examined against some microbial strains for evaluation of antibacterial and antifungal activities.
SYNTHESIS AND CHARACTERIZATION OF SCHIFF BASE METAL COMPLEXES DERIVED FROM NA...chemsurya
New Schiff base metal complexes having general structural formulae ML2Cl2 where M= Co(II), Ni(II) and Cu(II), and MLCl2 where M=Zn(II), Cd(II) and Hg(II) were synthesized by the condensation of indoline-2,3-dione (Isatin) and naphtho[2,1-b]furan-2-carbohydrazide. Tentative structures for the synthesized compounds have been elucidated based on analytical, IR, 1HNMR, and Mass spectral studies. Further selected compounds were tested for their antimicrobial activity.
Targeted Intermediates of Eudesmic Acid: Synthesis and X-ray Investigationsijtsrd
it was carried out synthesis of esters and their dinitro derivatives of 3,4,5-trimethoxybenzoic (eudesmic) acid. Esterification of eudesmic acid carried out n absolute methanol or ethanol and corresponding methyl and ethyl 3,4,5-trimethoxybenzoates (2, 3) have been synthesized in good yields. It was revealed that nitration of these esters gives only dinitro products. The structure of the synthesized compounds of the methyl and ethyl 2,6-dinitro-3,4,5-trimethoxybenzoates (4, 5) was determined by X-ray diffraction analysis (XRD). In the asymmetric part of the crystal structures of 4, 5 one and two molecules are observed, respectively. In crystalline structures a flat nitro groups and carboxylic groups do not participate in the conjugation with aromatic rings. In the crystal structure of 4, an intermolecular C8-H...O9 hydrogen bond is observed, these H bonds link the molecules along the [010] axis. In the crystal structure of 5, intermolecular C9B-H...O4A and C10B-H...O8A hydrogen bonds form chains along the [011] axis. The formed chains are cross linked by the intermolecular C9B-H...O5A hydrogen bonds. Olimova M.I. | Okmanov R. Ya. | Elmuradov B. Zh."Targeted Intermediates of Eudesmic Acid: Synthesis and X-ray Investigations" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-6 , October 2017, URL: http://www.ijtsrd.com/papers/ijtsrd2417.pdf http://www.ijtsrd.com/chemistry/other/2417/targeted-intermediates-of-eudesmic-acid--synthesis-and-x-ray-investigations/olimova-mi
Mixed Ligand, Palladium(II) and Platinum(II) Complexes of Tertiary Diphosphin...Karwan Omer
This document summarizes a study that synthesized and characterized mixed ligand palladium(II), platinum(II) complexes with tertiary diphosphine and S-1H benzo[d]imidazole-2-yl benzothioate ligands. The complexes were synthesized in two steps, first forming metal complexes with tertiary diphosphines, then adding the S-1H benzimidazole ligand. The complexes were characterized using techniques such as elemental analysis, infrared spectroscopy, UV-Vis spectroscopy, magnetic susceptibility, and X-ray crystallography. The results indicate the ligand bonds to the metal through the nitrogen atom and the complexes have square planar geometries.
Synthesis, Characterization and Antibacterial Activity of New Complexes of So...IOSR Journals
Complexes of some lanthanide picrates (Ln3+ = Pr3+, Nd3+ and Dy3+) with benzo-18-crown-6 and 221-cryptand were synthesized and characterized by elemental analysis, FTIR, and UV-Visible. Spectrophotometric methods, thermal analysis (TGA & DTG), melting point, magnetic susceptibility and molar conductance. Also an in-vitro study on gram positive (Staphylococcus aureus) and gram negative bacteria (Escherichia coli, Salmonella and pseudomonas aeruginosa) was performed and the results were compared to those of the broad spectrum antibiotic Chloramphinicol. The benzo-18-crown-6 complexes have the general formula of [Ln.L.(Pic)2]Pic.nH2O , where; (Ln3+ = Pr3+, Nd3+, and Dy3+) , (L = Benzo-18-crown-6) , (Pic = Picrate anion) , (n = 1-2). In these complexes two picrate anions are coordinated to the metal ion through the phenolic oxygen and oxygen of the ortho nitro group, thus, the metal ions in these complexes have a coordination number of (10). The complexes of 221-cryptand have the general formula of [Ln.L.(Pic)]Pic2.nH2O where; (Ln3+ = Pr3+, Nd3+, and Dy3+), (L = 221-cryptand), (Pic = Picrate anion), (n = 1,2 or 7). In these complexes one picrate anion is coordinated to the metal ion, also through the phenolic oxygen and the oxygen from the ortho nitro group, thus the metal ions in the cryptand complexes have a coordination number of (9).
This document summarizes the synthesis and characterization of lanthanide complexes with the drug cloxacillin. Cloxacillin is an antibiotic drug that is commonly used to treat bacterial infections. Seven lanthanide complexes of the form [Ln(Clox)2(H2O)2]Cl where Ln = La(III), Pr(III), Nd(III), Sm(III), Dy(III), Ho(III) and Er(III) were synthesized. The complexes were characterized using elemental analysis, infrared spectroscopy, electronic spectroscopy, magnetic susceptibility measurements, and thermal analysis. Elemental analysis showed a 1:2 metal to ligand ratio in the complexes. Infrared spectroscopy indicated that cloxacillin binds in
SYNTHESIS AND CHARACTERIZATION OF THERMAL ANALYSIS OF La (II) MACROCYCLIC COM...inventionjournals
This document summarizes the synthesis and characterization of lanthanum (II) macrocyclic complexes and their biological activity. Lanthanum complexes were synthesized by reacting malonodihydrazide with lanthanum perchlorate hexahydrate in the presence of various aldehydes. The complexes were characterized using elemental analysis, infrared spectroscopy, UV-visible spectroscopy, magnetic moment measurements, and thermal analysis. The complexes exhibited antibacterial activity against several pathogenic bacteria.
Project_Ionic_Liquid_Master 1 of Chemistry and BiologyJing YI
This document summarizes the synthesis of new imidazolium salts intended for use as vectors for siRNA transfection. It describes the step-by-step synthesis of intermediates including 1-alkyl-3-[3,4-bis(dodecyloxy)benzyl]-4H-imidazolium chloride and its deprotected form. It also discusses the inhibition of lactoperoxidase-catalyzed oxidation by an imidazole-based thione synthesized from one of the intermediates. The synthesis routes achieved good yields for the intermediates and products, which were characterized by various analytical techniques. The document concludes by discussing the different potential applications of the synthesized compounds.
IJERA (International journal of Engineering Research and Applications) is International online, ... peer reviewed journal. For more detail or submit your article, please visit www.ijera.com
synthesis and characterization of hydrazone ligand and their metal complexesMUBASHIRA M
This slide mainly contain the synthesis, characterization of a few hydrazine based heterocyclic ligand such as hydralazone and phenyl hydralazone and also their metal complexes. so in this work, my aim is to synthesise the ligands; 2-thiophenecarboxylaldehydehydralazone and 2,3-butanedionephenylhydrazone. also to characterized the synthesised hydrazones by different physiochemical techniques.
The document summarizes research on the synthesis and characterization of mixed ligand metal complexes derived from ampicillin drug and 4-(dimethylamino)benzaldehyde. A Schiff base ligand was prepared via the condensation of these compounds. Metal complexes were synthesized using Fe(II), Co(II), Ni(II), Cu(II), and Zn(II) with the ligand and nicotinamide. The complexes were characterized using various analytical techniques and showed octahedral geometry. The complexes and ligand were screened for antimicrobial activity against bacteria. The complexes demonstrated higher antimicrobial activity than the free ligand.
This article describes the synthesis of unusual trimers from 1,3-indandione using DMSO-acetic anhydride. When 1,3-indandione was reacted with pre-heated DMSO-acetic anhydride at waterbath temperature, it produced an unusual trimer (4) and a novel compound (5), methine-tris-1,3-indandione, along with the ylide (2). The structures of the trimer (4) and novel compound (5) were determined using spectral data and proposed reaction mechanisms. This research demonstrated the first observation of a methine-tris derivative being formed from the reaction of 1,3-indand
The International Journal of Engineering and Science (The IJES)theijes
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
Synthesis and Studies of Some New Dioxouranium (VI) Complexes with Azoester L...IOSRJAC
A1004010111Some new complexes of uranyl (VI) metal ion with different anions (viz. Cl- ,I- ,NO- 3 and OAc- ) have been synthesized using azoester ligand. Complexes were characterized by traditional methods viz. melting point measurements, conductivity measurements. These were also characterized by modern spectral methods viz. IR including far IR, UV –vis. spectra. Thermal studies specially DTA studies of representative have also been done and reported. Some of the complexes were also screened against selected microbes to check their antimicrobial activities. Coordination number of these complexes are proposed to be 8, 10 and 12 and tentative structures of the complexes are also reported in the present paper.
This document summarizes research into the effects of methoxy-substituted metalloporphyrins as catalysts in the epoxidation of alkenes. Five different manganese tetraphenylporphyrin acetates were synthesized with varying numbers and positions of methoxy substituents on the phenyl rings. These porphyrins were then used as catalysts for the epoxidation of various alkenes using tetra-n-butylammonium hydrogen monopersulfate as the oxidant and imidazole as the axial ligand. The catalytic activity of the porphyrins followed the order: unmodified TPPMnOAc ≥ di-methoxy substituted T(2,3-
Spectral studies of 5-({4-amino-2-[(Z)-(2-hydroxybenzylidene) amino] pyrimidi...IOSR Journals
Some transition metal ions Complexes with 5-({4-amino-2-[(Z)-(2-hydroxybenzylidene) amino]
pyrimidin-5-yl} methyl)-2,3,4-trimethoxybenzene were prepared and characterized by elemental analyses,
Infrared , magnetic moment, electronic spectra , mass spectra, X-ray powder diffraction, molar conductance
and thermal analysis (TGA). The complexes have general formulae [ML2.2H2O] {where M = Mn (II), Co (II), Ni
(II), Cu (II), Zn (II), Pd (II) and Pt (II). The coordination behavior of the metal ions towards to the investigated
Schiff base takes place through –C=N,-NH2 and –OH groups. The obtained C, H and N elemental analysis data
showed the Metal: Ligand ratio is 1:2 [M: L] ratio. The molar conductance data reveal that all the metal
complexes are non-electrolytic in nature. From the magnetic moments the complexes are paramagnetic except
Zn metal ion complexes have octahedral geometry with coordination number eight. The thermal behavior of
these complexes shows that, the hydrated complexes have loses two water molecules and immediately followed
by decomposition of the anions and ligand molecules in the second and third stage. The Schiff bases and metal
complexes show good activity against some bacteria. The antimicrobial results indicate that, the metal
complexes have better antimicrobial activity as compared to the prepared Schiff base.
Preparation , characterization and antimicrobial activities of mixed ligand c...Alexander Decker
This document describes the preparation, characterization, and antimicrobial activities of mixed ligand complexes of Fe(II), Co(II), Ni(II), Cu(II), and Zn(II) with a Schiff base ligand derived from cephalexin drug and 4(dimethylamino)benzaldehyde combined with nicotinamide. The ligand and complexes were characterized using techniques such as NMR, FT-IR, UV-Vis, elemental analysis, conductivity measurements, and magnetic susceptibility. The complexes showed octahedral geometry and were found to be non-electrolytes. The complexes and free ligand were screened for antibacterial activity against Staphylococcus aureus and Escherichia coli.
This document summarizes the preparation, characterization, and antimicrobial activities of mixed ligand complexes of Fe(II), Co(II), Ni(II), Cu(II), and Zn(II) with a Schiff base ligand derived from cephalexin drug and 4(dimethylamino)benzaldehyde combined with nicotinamide. The ligand and complexes were characterized using various analytical techniques. The complexes were found to be non-electrolytes with octahedral geometry. Antimicrobial testing showed the complexes had antibacterial activity against Staphylococcus aureus and Escherichia coli.
Shalini Thapa is an experienced retail professional seeking a role as an Area Manager or in international business development. She has over 8 years of experience in operations management, new store openings, recruitment, sourcing, business development, and training. Currently she is an Area Manager at BEBE Major Brands India, where she manages 8 stores across 2 states, a team of over 70 employees, and annual revenue of 32 crores. She has a strong track record of achieving organizational objectives through strategic resource utilization and process improvement.
Synthesis and characterization of some metal complexes of 2- Phenyl-3,4-dihyd...IOSRJAC
2-Phenyl-3,4-dihydro-quinazolin-4-yloxy)-acetic acid (L1) metal complexes with Mn2+ , Co2+, Ni2+ Cu2+ , and Zn2+ ions were studied and the structure of the complexes were elucidated using elemental analyses, infrared (IR), 1H nuclear magnetic resonance (NMR), magnetic moment and thermal analysis measurements. Besides the characterization of complexes by physicochemical technique, Biological activities of the synthesized complexes were examined against some microbial strains for evaluation of antibacterial and antifungal activities.
SYNTHESIS AND CHARACTERIZATION OF SCHIFF BASE METAL COMPLEXES DERIVED FROM NA...chemsurya
New Schiff base metal complexes having general structural formulae ML2Cl2 where M= Co(II), Ni(II) and Cu(II), and MLCl2 where M=Zn(II), Cd(II) and Hg(II) were synthesized by the condensation of indoline-2,3-dione (Isatin) and naphtho[2,1-b]furan-2-carbohydrazide. Tentative structures for the synthesized compounds have been elucidated based on analytical, IR, 1HNMR, and Mass spectral studies. Further selected compounds were tested for their antimicrobial activity.
Targeted Intermediates of Eudesmic Acid: Synthesis and X-ray Investigationsijtsrd
it was carried out synthesis of esters and their dinitro derivatives of 3,4,5-trimethoxybenzoic (eudesmic) acid. Esterification of eudesmic acid carried out n absolute methanol or ethanol and corresponding methyl and ethyl 3,4,5-trimethoxybenzoates (2, 3) have been synthesized in good yields. It was revealed that nitration of these esters gives only dinitro products. The structure of the synthesized compounds of the methyl and ethyl 2,6-dinitro-3,4,5-trimethoxybenzoates (4, 5) was determined by X-ray diffraction analysis (XRD). In the asymmetric part of the crystal structures of 4, 5 one and two molecules are observed, respectively. In crystalline structures a flat nitro groups and carboxylic groups do not participate in the conjugation with aromatic rings. In the crystal structure of 4, an intermolecular C8-H...O9 hydrogen bond is observed, these H bonds link the molecules along the [010] axis. In the crystal structure of 5, intermolecular C9B-H...O4A and C10B-H...O8A hydrogen bonds form chains along the [011] axis. The formed chains are cross linked by the intermolecular C9B-H...O5A hydrogen bonds. Olimova M.I. | Okmanov R. Ya. | Elmuradov B. Zh."Targeted Intermediates of Eudesmic Acid: Synthesis and X-ray Investigations" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-6 , October 2017, URL: http://www.ijtsrd.com/papers/ijtsrd2417.pdf http://www.ijtsrd.com/chemistry/other/2417/targeted-intermediates-of-eudesmic-acid--synthesis-and-x-ray-investigations/olimova-mi
Mixed Ligand, Palladium(II) and Platinum(II) Complexes of Tertiary Diphosphin...Karwan Omer
This document summarizes a study that synthesized and characterized mixed ligand palladium(II), platinum(II) complexes with tertiary diphosphine and S-1H benzo[d]imidazole-2-yl benzothioate ligands. The complexes were synthesized in two steps, first forming metal complexes with tertiary diphosphines, then adding the S-1H benzimidazole ligand. The complexes were characterized using techniques such as elemental analysis, infrared spectroscopy, UV-Vis spectroscopy, magnetic susceptibility, and X-ray crystallography. The results indicate the ligand bonds to the metal through the nitrogen atom and the complexes have square planar geometries.
Synthesis, Characterization and Antibacterial Activity of New Complexes of So...IOSR Journals
Complexes of some lanthanide picrates (Ln3+ = Pr3+, Nd3+ and Dy3+) with benzo-18-crown-6 and 221-cryptand were synthesized and characterized by elemental analysis, FTIR, and UV-Visible. Spectrophotometric methods, thermal analysis (TGA & DTG), melting point, magnetic susceptibility and molar conductance. Also an in-vitro study on gram positive (Staphylococcus aureus) and gram negative bacteria (Escherichia coli, Salmonella and pseudomonas aeruginosa) was performed and the results were compared to those of the broad spectrum antibiotic Chloramphinicol. The benzo-18-crown-6 complexes have the general formula of [Ln.L.(Pic)2]Pic.nH2O , where; (Ln3+ = Pr3+, Nd3+, and Dy3+) , (L = Benzo-18-crown-6) , (Pic = Picrate anion) , (n = 1-2). In these complexes two picrate anions are coordinated to the metal ion through the phenolic oxygen and oxygen of the ortho nitro group, thus, the metal ions in these complexes have a coordination number of (10). The complexes of 221-cryptand have the general formula of [Ln.L.(Pic)]Pic2.nH2O where; (Ln3+ = Pr3+, Nd3+, and Dy3+), (L = 221-cryptand), (Pic = Picrate anion), (n = 1,2 or 7). In these complexes one picrate anion is coordinated to the metal ion, also through the phenolic oxygen and the oxygen from the ortho nitro group, thus the metal ions in the cryptand complexes have a coordination number of (9).
This document summarizes the synthesis and characterization of lanthanide complexes with the drug cloxacillin. Cloxacillin is an antibiotic drug that is commonly used to treat bacterial infections. Seven lanthanide complexes of the form [Ln(Clox)2(H2O)2]Cl where Ln = La(III), Pr(III), Nd(III), Sm(III), Dy(III), Ho(III) and Er(III) were synthesized. The complexes were characterized using elemental analysis, infrared spectroscopy, electronic spectroscopy, magnetic susceptibility measurements, and thermal analysis. Elemental analysis showed a 1:2 metal to ligand ratio in the complexes. Infrared spectroscopy indicated that cloxacillin binds in
SYNTHESIS AND CHARACTERIZATION OF THERMAL ANALYSIS OF La (II) MACROCYCLIC COM...inventionjournals
This document summarizes the synthesis and characterization of lanthanum (II) macrocyclic complexes and their biological activity. Lanthanum complexes were synthesized by reacting malonodihydrazide with lanthanum perchlorate hexahydrate in the presence of various aldehydes. The complexes were characterized using elemental analysis, infrared spectroscopy, UV-visible spectroscopy, magnetic moment measurements, and thermal analysis. The complexes exhibited antibacterial activity against several pathogenic bacteria.
Project_Ionic_Liquid_Master 1 of Chemistry and BiologyJing YI
This document summarizes the synthesis of new imidazolium salts intended for use as vectors for siRNA transfection. It describes the step-by-step synthesis of intermediates including 1-alkyl-3-[3,4-bis(dodecyloxy)benzyl]-4H-imidazolium chloride and its deprotected form. It also discusses the inhibition of lactoperoxidase-catalyzed oxidation by an imidazole-based thione synthesized from one of the intermediates. The synthesis routes achieved good yields for the intermediates and products, which were characterized by various analytical techniques. The document concludes by discussing the different potential applications of the synthesized compounds.
IJERA (International journal of Engineering Research and Applications) is International online, ... peer reviewed journal. For more detail or submit your article, please visit www.ijera.com
synthesis and characterization of hydrazone ligand and their metal complexesMUBASHIRA M
This slide mainly contain the synthesis, characterization of a few hydrazine based heterocyclic ligand such as hydralazone and phenyl hydralazone and also their metal complexes. so in this work, my aim is to synthesise the ligands; 2-thiophenecarboxylaldehydehydralazone and 2,3-butanedionephenylhydrazone. also to characterized the synthesised hydrazones by different physiochemical techniques.
The document summarizes research on the synthesis and characterization of mixed ligand metal complexes derived from ampicillin drug and 4-(dimethylamino)benzaldehyde. A Schiff base ligand was prepared via the condensation of these compounds. Metal complexes were synthesized using Fe(II), Co(II), Ni(II), Cu(II), and Zn(II) with the ligand and nicotinamide. The complexes were characterized using various analytical techniques and showed octahedral geometry. The complexes and ligand were screened for antimicrobial activity against bacteria. The complexes demonstrated higher antimicrobial activity than the free ligand.
This article describes the synthesis of unusual trimers from 1,3-indandione using DMSO-acetic anhydride. When 1,3-indandione was reacted with pre-heated DMSO-acetic anhydride at waterbath temperature, it produced an unusual trimer (4) and a novel compound (5), methine-tris-1,3-indandione, along with the ylide (2). The structures of the trimer (4) and novel compound (5) were determined using spectral data and proposed reaction mechanisms. This research demonstrated the first observation of a methine-tris derivative being formed from the reaction of 1,3-indand
The International Journal of Engineering and Science (The IJES)theijes
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
Synthesis and Studies of Some New Dioxouranium (VI) Complexes with Azoester L...IOSRJAC
A1004010111Some new complexes of uranyl (VI) metal ion with different anions (viz. Cl- ,I- ,NO- 3 and OAc- ) have been synthesized using azoester ligand. Complexes were characterized by traditional methods viz. melting point measurements, conductivity measurements. These were also characterized by modern spectral methods viz. IR including far IR, UV –vis. spectra. Thermal studies specially DTA studies of representative have also been done and reported. Some of the complexes were also screened against selected microbes to check their antimicrobial activities. Coordination number of these complexes are proposed to be 8, 10 and 12 and tentative structures of the complexes are also reported in the present paper.
This document summarizes research into the effects of methoxy-substituted metalloporphyrins as catalysts in the epoxidation of alkenes. Five different manganese tetraphenylporphyrin acetates were synthesized with varying numbers and positions of methoxy substituents on the phenyl rings. These porphyrins were then used as catalysts for the epoxidation of various alkenes using tetra-n-butylammonium hydrogen monopersulfate as the oxidant and imidazole as the axial ligand. The catalytic activity of the porphyrins followed the order: unmodified TPPMnOAc ≥ di-methoxy substituted T(2,3-
Spectral studies of 5-({4-amino-2-[(Z)-(2-hydroxybenzylidene) amino] pyrimidi...IOSR Journals
Some transition metal ions Complexes with 5-({4-amino-2-[(Z)-(2-hydroxybenzylidene) amino]
pyrimidin-5-yl} methyl)-2,3,4-trimethoxybenzene were prepared and characterized by elemental analyses,
Infrared , magnetic moment, electronic spectra , mass spectra, X-ray powder diffraction, molar conductance
and thermal analysis (TGA). The complexes have general formulae [ML2.2H2O] {where M = Mn (II), Co (II), Ni
(II), Cu (II), Zn (II), Pd (II) and Pt (II). The coordination behavior of the metal ions towards to the investigated
Schiff base takes place through –C=N,-NH2 and –OH groups. The obtained C, H and N elemental analysis data
showed the Metal: Ligand ratio is 1:2 [M: L] ratio. The molar conductance data reveal that all the metal
complexes are non-electrolytic in nature. From the magnetic moments the complexes are paramagnetic except
Zn metal ion complexes have octahedral geometry with coordination number eight. The thermal behavior of
these complexes shows that, the hydrated complexes have loses two water molecules and immediately followed
by decomposition of the anions and ligand molecules in the second and third stage. The Schiff bases and metal
complexes show good activity against some bacteria. The antimicrobial results indicate that, the metal
complexes have better antimicrobial activity as compared to the prepared Schiff base.
Preparation , characterization and antimicrobial activities of mixed ligand c...Alexander Decker
This document describes the preparation, characterization, and antimicrobial activities of mixed ligand complexes of Fe(II), Co(II), Ni(II), Cu(II), and Zn(II) with a Schiff base ligand derived from cephalexin drug and 4(dimethylamino)benzaldehyde combined with nicotinamide. The ligand and complexes were characterized using techniques such as NMR, FT-IR, UV-Vis, elemental analysis, conductivity measurements, and magnetic susceptibility. The complexes showed octahedral geometry and were found to be non-electrolytes. The complexes and free ligand were screened for antibacterial activity against Staphylococcus aureus and Escherichia coli.
This document summarizes the preparation, characterization, and antimicrobial activities of mixed ligand complexes of Fe(II), Co(II), Ni(II), Cu(II), and Zn(II) with a Schiff base ligand derived from cephalexin drug and 4(dimethylamino)benzaldehyde combined with nicotinamide. The ligand and complexes were characterized using various analytical techniques. The complexes were found to be non-electrolytes with octahedral geometry. Antimicrobial testing showed the complexes had antibacterial activity against Staphylococcus aureus and Escherichia coli.
Shalini Thapa is an experienced retail professional seeking a role as an Area Manager or in international business development. She has over 8 years of experience in operations management, new store openings, recruitment, sourcing, business development, and training. Currently she is an Area Manager at BEBE Major Brands India, where she manages 8 stores across 2 states, a team of over 70 employees, and annual revenue of 32 crores. She has a strong track record of achieving organizational objectives through strategic resource utilization and process improvement.
This document is a resume for Samantha Leitao, who is an aspiring teacher with over two years of experience working with children, including as a teacher aide in a special education classroom and behavioral technician. She has demonstrated skills in individualizing lessons, classroom management, and implementing behavioral support plans. Her education includes a bachelor's degree in psychology and various certifications.
Este documento presenta los resultados de una encuesta realizada por un equipo de estudiantes de primer grado sobre la importancia de continuar estudiando la materia de Comunicación y Lingüística. El objetivo de la encuesta era determinar las razones por las cuales más jóvenes deberían terminar sus estudios de nivel medio superior. Los resultados mostraron que la mayoría de los encuestados consideran que el estudio es importante para lograr metas en la vida y los ayuda en el trabajo.
This document provides an interim review of two proposals for an art project focused on war. For proposal 1, the artist painted motifs from a war poem and other sources in acrylic on a textured bubble wrap ground with white highlights. For proposal 2, the artist was considering changing from a portrait to a landscape format with less clutter and a focus on fewer colors, and looking more at the emotional response to war rather than a literal interpretation. Key motifs included a gas mask, wagon, and trench. The artist's primary research and drawings were inspired by a war poem and the works of Otto Dix.
Este documento describe los componentes básicos de un ordenador, incluyendo el lenguaje binario, hardware como la placa base, microprocesador, memoria y periféricos, y software. Explica que el hardware son los componentes físicos y el software las instrucciones para que funcione. Además, detalla los diferentes tipos de memoria, buses, ranuras de expansión y puertos que permiten la comunicación entre componentes.
Bassent Arafa has over 13 years of experience in project coordination and office management roles for multinational companies in Egypt. He has a background in interior architectural engineering and is fluent in French, English, Arabic, and conversational in Spanish. Arafa seeks a new career opportunity where he can apply his skills and multilingual abilities.
La gestión de proyectos artísticos involucra organizar proyectos que promueven la cultura y las artes. Estos proyectos tienen el potencial de impactar a la sociedad a corto y largo plazo, ya sea cambiando las perspectivas de las personas o fomentando un mayor interés en las artes. Los gestores de proyectos deben considerar factores como el tipo de proyecto, su objetivo y público, y coordinar a todos los involucrados como artistas, productores y audiencia. El liderazgo efectivo es fundamental para garantizar que
New benzotriozole phthalocyanine nickel(ii) photostabilizer for low density p...Alexander Decker
This document summarizes the synthesis and characterization of a new benzotriazole phthalocyanine nickel(II) complex to be used as a photostabilizer for low density polyethylene. The complex was prepared and characterized using elemental analysis and FT-IR spectroscopy. Experimental investigation showed that this complex acts as an excellent photostabilizer for LDPE, providing stabilization through multiple pathways, unlike commercial antioxidants which typically offer only single mechanisms of protection. Testing revealed that the complex performed better than LDPE samples containing other common antioxidants at preventing degradation when exposed to UV light over time. Therefore, the complex is a promising new photostabilizer for improving the UV resistance of LDPE.
The DNA cleavage and antimicrobial studies of Co(II), Ni(II), Cu(II) and Zn(I...IOSR Journals
This document summarizes a study on the synthesis and characterization of Schiff base complexes of Co(II), Ni(II), Cu(II) and Zn(II) using 4-pyridinecarboxaldehyde and 4-aminopyridine. The complexes were characterized using elemental analysis, magnetic susceptibility, IR spectroscopy, XRD and SEM. The complexes showed antimicrobial activity against bacteria and fungi. The metal complexes exhibited higher antimicrobial activity than the Schiff base ligand. Gel electrophoresis studies showed the complexes were able to cleave DNA, indicating their potential as chemical nucleases.
This document describes the synthesis, spectral characterization, and biological screening of transition metal complexes of the ligand 2-(5-mercapto-1,3,4-oxadiazol-2-yl)phenol. A series of complexes were prepared using Cu(II), Co(II), Ni(II), and Zn(II) and characterized using analytical data, magnetic susceptibility, IR, UV-Vis, 1H NMR, 13C NMR, EPR, and other techniques. Spectral data suggest an octahedral geometry around the metal ion. Biological screening showed the complexes have antibacterial, antifungal, and DNA cleavage activities.
Complexes of m(ii)sulphates with 4 cyanobenzaldehyde andAlexander Decker
This document describes the synthesis and characterization of ten complexes of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) sulphates with two organic ligands, 4-cynobenzaldehydecyclopropanecarboxylicacidhydrazone (CBHN) and 4-ethylbenzaldehydecyclopropanecarboxylicacidhydrazones (EBHN). The complexes were characterized using techniques such as melting point determination, IR spectroscopy, elemental analysis, conductivity measurements, and electronic spectroscopy. IR data showed that the ligands coordinate to the metal ions through the carbonyl oxygen and azomethine nitrogen. Electronic spectroscopy indicated octahedral geometry for most complexes except for
Complexes of m(ii)sulphates with 4 cyanobenzaldehyde andAlexander Decker
This document describes the synthesis and characterization of ten complexes of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) sulphates with two organic ligands, 4-cynobenzaldehydecyclopropanecarboxylicacidhydrazone (CBHN) and 4-ethylbenzaldehydecyclopropanecarboxylicacidhydrazones (EBHN). The complexes were characterized using techniques such as melting point determination, IR spectroscopy, elemental analysis, molar conductivity measurements, and electronic spectroscopy. IR data showed that the ligands coordinate to the metal ions through the carbonyl oxygen and azomethine nitrogen. Electronic spectra indicate octahedral geometry for most complexes
This document describes the synthesis and characterization of a Schiff base ligand and its complexes with various metal ions. The ligand (HL) was prepared in two steps by reacting 3-aminoacetophenone with hydrazine monohydrate to form an intermediate, which was then reacted with salicylaldehyde. The ligand was characterized using various techniques. The metal complexes were prepared by reacting the ligand with metal chlorides in a 1:1 molar ratio. The complexes were characterized using techniques such as elemental analysis, molar conductivity, IR spectroscopy, UV-Vis spectroscopy, and magnetic susceptibility measurements. Based on the data, the complexes were found to have tetrahedral geometry except for the nickel complex which was square planar.
Synthesis and characterization of complexes of schiff base [1, 2 diphenyl -...Alexander Decker
This document describes the synthesis and characterization of a Schiff base ligand and its complexes with various metal ions. The ligand (HL) was prepared in two steps by reacting 3-aminoacetophenone with hydrazine monohydrate to form an intermediate, which was then reacted with salicylaldehyde. The ligand was characterized using various techniques. The metal complexes were prepared by reacting the ligand with metal chlorides in a 1:1 molar ratio. The complexes were characterized using techniques such as elemental analysis, conductivity, IR spectroscopy, UV-Vis spectroscopy, and magnetic susceptibility measurements. Based on the data, the complexes were found to have tetrahedral geometry except for the nickel complex which was square planar.
This document describes the synthesis of novel spirooxindole derivatives via a three-component 1,3-dipolar cycloaddition reaction. Various spirooxindole-spiropiperidinone-pyrrolidine and spirooxindole-spiropiperidinone-pyrrolizine derivatives were synthesized in good yields from isatin, sarcosine or L-proline, and Knoevenagel adducts under optimized reaction conditions. The antimicrobial activities of the synthesized compounds were evaluated, with some compounds exhibiting excellent activity against bacteria and fungi, comparable or superior to standard antimicrobial drugs.
This document summarizes the synthesis and characterization of mixed ligand complexes of a symmetrical Schiff base ligand and nicotinamide with various metal ions. A new symmetrical Schiff base ligand was prepared via the condensation of hydrazine hydrate and 4-hydroxy-3-methoxybenzaldehyde. Mixed ligand complexes were synthesized using a 1:1:2 molar ratio of metal salt, Schiff base ligand, and nicotinamide. The complexes were characterized using various techniques such as elemental analysis, conductivity measurements, IR and UV-Vis spectroscopy, and magnetic susceptibility measurements. The ligand and complexes were also tested for their antimicrobial activity against various bacteria. In general, the complexes showed enhanced antibacterial activity compared to the free ligands
Chelation Trends and Antibacterial Activity of Some Mixed Ligand ChelatesTaghreed Al-Noor
Synthesis and investigation of new Co(II), Ni(II), Cu(II), Zn(II) and Cr(III)chelates of mixed ligands including
aSchiff base [(E)-2-(4-(dimethylamino)benzylideneamino)phenol] (C15H16N2O) derived from the condensation of 4-
dimethylaminobenzaldehyde with 2-aminophenol as main ligand (L1) and an amino acid; L-Histidine as co-ligand (L2)
were studied. The obtained Schiff base and the mixed ligand chelates were subjected to several physiochemical
techniques, in terms of CHN elemental analyses, molar conductivity, magnetic moment measurements, infrared,
electronic and mass spectroscopies. The CHN analytical data showed the formation of the Schiff base compound and the
mixed ligand chelates in 1:1:1[M:L1:L2] ratio. All the prepared mixed ligand chelates were non-electrolyte in nature.
The infrared spectral data exhibited that the used ligands behaving as bidentate ligands towards the metal ions. The
1HNMR spectra of the ligands and their Zn(II) mixed ligand chelate exhibited the effect of the activated groups of the
ligands by the metal ion. The electronic spectral results showed the existence of π→π* (phenyl ring) and n→π*(HC=N)
and suggested the geometrical structures of the chelates. Meanwhile, the mass spectral data revealed the fragmentations
of the Schiff base, Histidine and their Cu(II) mixed ligand chelate. The studies made on these chelates proposed a six
coordinated octahedral geometry for all these chelates. The antibacterial activities of the Schiff base, Histidine, metal
salts and mixed ligand chelates were screened. It is found that the mixed ligand chelates have the most biological activity
in comparison to the free ligands and salts.
Keywords: Schiff base; 4-dimethylaminobenzaldehyde; 2-aminophenol; Histidine; mixed ligand chelates;
Physiochemical techniques; Antibacterial activity.
METALLO - BIOACTIVE COMPOUNDS AS POTENTIAL NOVEL ANTICANCER THERAPYijac123
Mono and bi-organometallic complexes of Cu(II), Ni(II), Mn(II), Zn(II) and Ag(I) complexes with
oxaloamide ligand has much potential as therapeutic and diagnostic agents. The ligand allows the
thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for
functionalization. Specific examples involving the design of metal complexes as anticancer agents are
discussed. These complexes have been synthesized and characterized by (1H-NMR, mass, IR, UV-VIS,
ESR) spectra, magnetic moments and conductance measurements, elemental and thermal analyses. Molar
conductances in DMF solution indicates that, the complexes are non-electrolytes. The ESR spectra of solid
Cu(II) complexes (2-5) show an axial type indicating a d(X2-y2) ground state with a significant covalent
bond character. However, Mn(II) complex(9), shows an isotropic type indicating an octahedral geometry.
Cytotoxic evolution IC50 of the ligand and its complexes have been carried out. Cu(II) Complexes show
enhanced activity in comparison to the parent ligand or standard drug. Copper is enriched in various
human cancer tissues and is a co-factor essential for tumor angiogenesis processes. However, the use of
copper binding ligand to target tumor, copper could provide a novel strategy for cancer selective
treatment.
A Study of Synthesis and Characterization of Liquid Crystalline Substancesijtsrd
Synthesis of homologous series is achieved and having favourable geometry for the formation of mesophase along with formation of nano sized liquid crystal having good stability with metal free formulation which may be utilized further for the industrial application. The formation of liquid crystal with help of homologous series synthesized and characterization showed it to be metal free liquid crystal made up of oil, surfactant and co surfactant mixture which may open doors of nano gels, gels or microemulsion for liquid crystal. This along with texture study and magnetic study shows that unique properties were characterized and showed that metal free formation of liquid crystals with very less particle size and very good particle stability. M. H. Shah | D. K. Bhoi | M. B. Chauhan | N. B. Patel "A Study of Synthesis and Characterization of Liquid Crystalline Substances" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-6 , October 2022, URL: https://www.ijtsrd.com/papers/ijtsrd51848.pdf Paper URL: https://www.ijtsrd.com/physics/other/51848/a-study-of-synthesis-and-characterization-of-liquid-crystalline-substances/m-h-shah
Bidentate Schiff base ligand 3-(3,4-Dihydroxy-phenyl)-2-[(4-dimethylamino-benzylidene)-amino]-2-methyl-propionic acid was prepared and characterized by spectroscopic techniques studies and elemental analysis. The Cd(II), Ni(II), Cu(II), Co(II), Cr(III),and Fe(III) of mixed-ligand complexes were structural explicate through moler conductance , [FT-IR, UV-Vis & AAS], chloride contents, , and magnetic susceptibility measurements. Octahedral geometries have been suggested for all complexes. The Schiff base and its complexes were tested against various bacterial species, two of {gram(G+) and gram(G-)} were shown weak to good activity against all bacteria.
International Journal of Engineering and Science Invention (IJESI)inventionjournals
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
This study synthesized a Schiff base ligand (N, N’ (2 hydroxybenzaldehyde) diamino diphenyl ether [HL]) and its Co(II) and Cu(II) metal complexes. The ligand and complexes were characterized using techniques like UV-visible, FTIR, and 1H NMR spectroscopy. The ligand and complexes were also screened for their antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa bacteria. The Co and Cu complexes showed octahedral geometry and moderate activity against S. aureus, with the Cu complex exhibiting the highest activity.
This document reports on the synthesis and characterization of a Schiff base ligand and its cobalt and copper metal complexes. The ligand N,N’-(2-hydroxybenzaldehyde)diamino diphenyl ether was synthesized by condensing 2-hydroxybenzaldehyde and 4,4’-diaminodiphenyl ether. Cobalt and copper complexes were prepared by reacting the ligand with cobalt chloride and copper chloride respectively. The ligand and complexes were characterized using techniques such as UV-visible, FTIR, and NMR spectroscopy. They exhibited octahedral geometry. The ligand and complexes were also screened for antimicrobial activity, with the copper complex showing the highest activity against Staphylococcus aureus.
1. A new Schiff base ligand was synthesized by condensing amoxicillin and 4-(dimethylamino)benzaldehyde. Mixed ligand complexes were synthesized from reactions of the Schiff base ligand with metal salts such as Fe(II), Co(II), Ni(II), Cu(II), and Zn(II) along with nicotinamide.
2. The complexes were characterized using various techniques such as elemental analysis, FT-IR, UV-Vis, magnetic susceptibility measurements, and evaluating their conductivities. The data indicated the complexes had octahedral geometries and were non-electrolytes.
3. The antimicrobial activities of the complexes were evaluated against various bacteria and found to have
1. A new Schiff base ligand was synthesized from amoxicillin and 4-(dimethylamino)benzaldehyde. Mixed ligand complexes were synthesized from reactions of the ligand with Fe(II), Co(II), Ni(II), Cu(II), and Zn(II) and nicotinamide in a 1:1:2 ratio.
2. The ligand and complexes were characterized using various spectroscopic and analytical techniques. Octahedral geometries were suggested for the complexes.
3. The antimicrobial activities of the complexes were evaluated against various bacterial species and found to have enhanced activity compared to the uncomplexed ligand.
1. IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
ISSN: 2278-3008. Volume 4, Issue 5 (Nov. – Dec. 2012), PP 09-14
www.iosrjournals.org
www.iosrjournals.org 9 | Page
Synthesis and Characterization of New Thio-Triazole Ligand and
Complexes with Selected Metals
1
Ahmed Majeed and 2
Khalid W.Y.Zain Alabdeen
1,2
Department of Chemistry, College of Science, Al-Nahrain University, Baghdad-Iraq.
Abstract: The new ligand, thiocarboxyphenyl-4-allyl-5-phenyl-4H-1,2,4-triazole (L) was prepared and
characterized by micro elemental analysis (CHN) and Infrared spectroscopy. Selected metals, which were
Fe(III), Cu(II), Cd(II), Hg(II) and Au(III) where reacted with (L) to produce new complexes. These complexes
were identified through micro elemental analysis, Infrared and ultraviolet-visible spectroscopy and other
techniques. Depending on the data obtained, chemical formula and geometry of complexes were suggested.
Biological activity of the complexes against selected types of microorganisms was also examined.
Keywords: 1,2,4- triazole, thioamide ligands, chelating ligands, metal complexes.
I. Introduction:
1,2,4-Triazole derivatives have consistently attracted scientific and practical interest because of their
widely varying chemical properties, synthetic versatility, and pharmacological activities, such as antibacterial,
antifungal, anti-tubercular, analgesic, anti-inflammatory, anticancer [1-2]Metal complexes are suggested as a
possible measure of drugs, since the action of many drugs is based on the ability of complex compound of metal
ions to traverse bio membranes, whereas individual aquo-ions and ligands almost or completely lack this ability.
Metal chelates differ in their mode of action and activity in biological systems in accord with their structural
considerations, e.g. inert, highly stable metal chelate have a considerable activity against microorganisms, fungi
and viruses and are used in controlling the speed of neoplastic tissue[3]. An important and versatile class of well
established biologically active compounds are those with the –N-C=S moiety (" soft" sulfur atom besides the "
hard" nitrogen). This group is found in many basic structures of drugs either to be part of an open chain ,e.g.
thiocarbamates, isothiocynates and thiosemicarbazides or involved in heterocyclic ring,e.g. mercapto derivatives
of triazoles, oxadizoles and thiodiazoles [4-6].
In the search for new chemical reagents with strong affinity for certain metal ions, many researchers
have indicated that chelating reagents have the advantage of offering better selectivity and specificity as flotation
collectors. Therefore, the use of chelating reagents in the flotation process has been paid much attention for
many years [7]. Le Borgene et al. reported letrozole analogues having an arylindole moiety with imidazole or
1,2,4-triazole heterocycles , structure activity relationships identified the importance of electron withdrawing
groups at the para position of the phenyl with nitrile group being best [8]. The use of triazole complexes of silver
for applications in the photographic industry, Another property of triazoles as ligands is that the ligand strength
is just in the region to give spin crossover compounds with iron(II) salts. Depending on the substituents the
transition temperatures range from about 100 to 400 K. This property means that triazole complexes of iron(II)
are studied in the search for spin crossovers at room temperature .Such systems are applicable for information
storage . A review on iron(II) triazole complexes was published in 1996 [9].
In this work, we report the preparation of the new ligand " thiocarboxyphenyl-4-allyl-5-phenyl-4H-
1,2,4-triazole " (L), and some metal complexes. These compounds were prepared with the intention of finding
new potentially biologically active compounds.
II. Experimental:
Instrumentation
Melting points were recorded by using Gallenkamp M.F.B. 600.01F of melting point apparatus .
Infrared spectra were recorded using Perkin-Elmer 1130 Infrared spectrophotometer as KBr disk in the range
(4000 - 600) cm-
.UV-Visible spectra were measured using Shimadzu UV-Vis 160A Ultra-violet
spectrophotometer at room temperature using silica cells of 1.0 cm length. The metal percent in the prepared
complexes were determined using atomic absorption technique by Pye Unicam of Philips Scientific Instrument
which employed the hollow cathode lamp of the Pye Unicam Itd. Cambridge. Elemental microanalysis was
carried out using CHN elemental analyzer model 5500 Carlo-Erba instruments (Italy). Magnetic susceptibility
for the prepared complexes were obtained at room temperature using Farady method ,by placing the sample in a
small pyrex container suspended from a balance through a fine, Nylon thread to the center of electric magnet.
For this purpose, Bruker Magnet B.M.6 has been employed. The diamagnetic correction factor D was calculated
using Pascal constants. Electric molar conductivity measurements were carried out at room temperature at the
2. Synthesis and Characterization of New Thio-Triazole Ligand and Complexes with Selected Metals
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concentration (103-
M) using digital conduct meter type LF521 (WTW). All chemicals were of high purity are
used as the manufacturers supplied them. Pyridine was distilled and dried over KOH pellets. Allyl isothiocynate
was redistilled prior to use. The ligand, was prepared according to the following procedure:
NN
N
CH2CH CH2
S C
O
O
The Ligand (L)
The compound 3-mercapto-4-allyl-5-phenyl-4H-1,2,4-triazole was prepared[10 ] and used as a
precursor for the ligand (L). The suspension of 3-mercapto-4-allyl-5-phenyl-4H-1,2,4-triazole (0.025 mole,
5.4g) in pyridine (50 ml) was cooled in ice bath and stirred. To this suspension, chlorophenylformate (0.025
mole, 3.9g) was added very slowly and drop wisely. The mixture was then stirred at 50 o
C for 1 hr. The resulting
faint rosy suspension was kept at room temperature overnight with continuous stirring. It was poured in ice
containing water (~ 250 ml) to give oily product. Dilute HCl was added until a faint rosy product was formed,
filtered and washed several times with water. Recrystallization from ethanol was carried out to produce pale
pink 87.50 % yield with a melting point (106 – 108) o
C.
Metal complexes of L were prepared as follows:
(A) Cu(II), Cu(I),Cd(II), Hg(II) , and Au(I) complexes:
Ethanolic solution of (1 mmole) of the metal salt [ chlorides of Cu(II), Cd(II), Hg (II), Au(III)] were
added to (2 mmole) of L dissolved in ethanol. The mixture was stirred at room temperature for 1 hr. fine
precipitate was formed in all cases which was filtered on sintered glass crucible and recrystallized using ethanol
: water mixture, then dried under vacuum. Two different complexes were isolated in the case of copper. The first
green was isolated immediately after mixing the reagents while the second off- white complex was formed after
stirring for a longer time 1 hr.
(B) Fe(III) complex:
The procedure described above was followed to prepare the Fe(III) complex except the reaction mixture
was refluxed for 1 hr and the precipitate was then washed several times with ethanol and diethyl ether.
Bacteriology:
Biological activity of L and complexes were evaluated against representative gram-positive and gram-
negative bacteria by agar plate method[11]. All the compounds were prepared freshly by dissolving them in
cultivated in nutrient agar. The results are found in table (4). The solvent DMF was used to obtain a final
concentration of 1000 mg/ml. All bacteria were placed on the nutrient agar surface using the loop and by
streaking processor.
III. Discussion:
The identification of the ligand L was carried out through elemental analysis : C, 64.31% (calc.64.09%
) ; H,4.30% (4.45%) ;N,12.32% (12.465%). The olefinic group in the ligand responded positively to both Br2/
CCl4 and KMnO4 tests. The ligand was found to be soluble in ethanol, acetone, carbon tetrachloride, diethyl
ether and DMF. It is found to be insoluble in the n-hexane. Identification of the complexes was done using
different available techniques. Among these techniques are the determinations of metal percentage by atomic
absorption, infrared, magnetic susceptibility and conductivity measurements.
Table(1) lists some physical data of the prepared complexes.
Complex of L
with metal ion
Color Yield% Melting point,
ᵒC
M% calculated M%
found
Hg(II),C1 White 80 (140-143) 30.65 30. 54
Au(I),C2 White 51 (131-134) 21.73 22.57
Cd(II),C3 White 86 (146-148) 19.85 20.23
Cu(I),C5 Off white 75 (168-170) 11.07 11.33
Fe(III),C6 Brown 34 (>250) d 14.57 14.80
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IV. Identification
The ligand is characterized by the presence of the ester group that is incorporated in the triazole
structure at the sulfur atom in the form of phenyl formate as shown above. The IR spectrum of L exhibited a
strong band at 1770 cm-1
and another strong band at 1240 cm-1
. These are diagnostic bands or the ester group
corresponding to υ(C=O) and υ(C-O) respectively [12]. Table(2) shows the vibration bands exhibited by the
ligand and its complexes. It is noticed that in ester metal complex υ(C=O) is shifted to lower frequency, while
υ(C-O) is shifted to higher frequency by complex formation. These shifts are depending on the metal ion. The
magnitude of the hit follows the well-known Irving-William's order [13].
A-Mercury (II) complex; C1
The IR spectrum of C1 shows a marked change in the ester group vibrations. The band at 1770 cm-1
disappeared and it was suggested that it underwent a red shift to a region less than 1600 cm-1
which already
contains strong bands of other vibration[13]. A new band was observed at 1290 which refers to the blue shift of
the υ(C-O) by 50 cm-
. These observations indicate the coordination of Hg (II) with the oxygen of the carbonyl
group. A broad band at 3400 cm-1
indicates the presence of ethanol molecule in the structure of the complex.
Conductivity measurements show the complex to be non-ionic, Table (3), therefore the following bridging
structure can be suggested:
B-Gold (I) complex, C2:
The IR spectrum of C2 shows no change in the ester group vibrations, while a change in the olefinic
group has been noticed for both υ(C=C) and out of plane δ (=CH2). The first stretching vibration was shifted to a
region lower than 1550 cm-1
, while the second bending vibration was observed at 845 cm-1
. (55 cm-1
lower than
the free ligand)[13]. A shift was also observed for the υ (N…C…S) thioamide band III [14 ] by 10 cm-1
.These
observations suggest that the bonding of Au(I) ion with the ligand was through the olefinic group and the sulfur
atom. This behavior is expected for the soft Au (I) ion should seek to bind to the soft sulfur atom rather than the
hard oxygen atom [13]. As a result of these observations the following structure can be supposed:
ph
ph
N N
N
S
O
H2C
O
O
NN
N
H2C
HC
CO
CH2
Au
S
C
CH2
CH
Cl
This type of coordination has been documented in the literature[15 ]. Conductivity measurements shows
that the above complex is ionic, Table (3).
N N
N
CHCH2H2C
SCO
O
Hg
Cl
Hg
Cl Cl
Cl
O
C OS
NN
N
CH2CH CH2
2EtOH
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C-Cadmium (II) complex; C3:
The IR spectrum of C3 complex shows the shifting of the υ(C=O) band to a region lower than 1650 cm-1
. The band that corresponds to υ(C-O) was shifted to a lower frequency by 20 cm-1
, moreover the band at 1550
cm-1
which corresponds to υ(C=N) was shifted to a lower frequency by 10 cm-1
. These observations indicate the
participation of both oxygen of carbonyl group and the nitrogen of the thioamide group in the coordination to the
metal. A broad band appeared at 3450 cm-1
indicating the presence of ethanol molecule in the structure.
Conductivity measurements showed that the complex is non-ionic and the structure of this complex can be
depicted as follows:
NN
N
S C
O
O
CH2CH
Cd
CH2
Cl
Cl
2EtOH
D-Copper (II) complex; C4:
The IR spectrum of C4 complex showed the shifting of the υ(C=O) band to a lower frequency at region
below 1650 cm-1
. A new band was observed at 1290 cm-1
that may refer to the shifting of υ(C-O) to a higher
frequency. The υ(C=N) was also shifted to a lower frequency by 10 cm-1
. Metal analysis pointed out to the
presence of two copper atoms per each molecule of the complex. Infrared data indicate that the first Cu (II) ion
coordinates to the ligand through the oxygen of the carbonyl group and the nitrogen of the thioamide group. The
other copper ion coordinates to the oxygen of the ester group only. A broad band appeared at 3500 cm-1
indicates
the presence of water molecule in the structure .
The structure of complex may be suggested:
NN
N
CH2CH CH2
S C
O
O
Cu
Cl
Cl
OH2
OH2
4H2O
Cu
H2O
ClCl
O2H
O2H
E-Copper (I) complex; C5:
The IR spectrum of C5 complex shows the following changes compared to the free ligand : the υ(C=O)
band was shifted to a region below 1650 cm-1
. The band that corresponds to υ(C-O) was also shifted to a higher
frequency by 20 cm-1
. The υ(C=N) was shifted to a lower frequency by 10 cm-1
.Therefore, Cu(I) may
coordinate with L through oxygen of the carbonyl group and nitrogen of the thioamide group. A broad band
appeared at 3400 cm-1
indicates the presence of ethanol molecule in the structure. The structure of the complex
may be suggested as follows:
N N
N
CHCH2H2C
SC
O
O
Cu
ClCl
Cu
O
C OS
NN
N
CH2CH CH2
6EtOH
5. Synthesis and Characterization of New Thio-Triazole Ligand and Complexes with Selected Metals
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F- Iron (III) complex; C6 :
The IR spectrum of C6 complex was characterized by a broad in the region ( 300-3600) cm-1
which
could be attributed to the υ(O-H) of water molecule bonded to the Fe(III) ion. This is expected in iron (III)
complexes due to its high affinity for water. The ligand can not displace all the water molecules found in the
coordination sphere of the metal ion[15]. The broadening of the band was also noticed in the region ( 1600-
1700) cm-1
which is attributed to the vibration of water molecule. This broadening affects the shape of the
spectrum and makes the interpretation more difficult. No absorption band was found at 1770 cm-1
and the
carbonyl group is then expected to coordinate with the iron (III) ion through oxygen atom. Furthermore, the
υ(C=N) band was shifted to a lower frequency by 20 cm-1
. This may suggest the participation of the nitrogen
atom of the thioamide group in addition to the oxygen of the carbonyl group in coordination. According to the
metal analysis percentage, one molecule of complex contains two atoms of iron and the following structure is
suggested:
ONO2
NN
N
S
CH2CH CH2
C
O
O
Fe
Fe
H2O OH2
O2NO
HO OH
ONO2O2NO
Table (2) Absorption bands of infrared spectra of the L and its complexes
Symbol υ(O-H) Thioamide
band(II)
υ(C=N+ C=S)
Thioamid
band(IV)
υ(C-S)
υ(C=N) υ(C=O) υ(C-O) δ (O-H)
L - 1270(m) 770(m) 1550(m) 1770(s) 1240(m) -
C1 3400(b) 1280(w) 770(m) 1550(m) - 1290(w) 920(w)
C2 - 1280(w) 760(m) 1550(m) 1760(w) 1240(m) -
C3 3450(b) 1275(m) 770(m) 1540(w) 1650 1260(m) 920(w)
C4 3500(b) 1280(w) 770(m) 1540(w) 1600 1290(w) 915(w)
C5 3400(b) 1280(w) 770(m) 1540(w) 1650 1260(w) 920(w)
C6 (3000-
3600) (b)
1280(w) 770(m) 1530(w) - 1260(w) 915(w)
Where s= strong, m= medium, w= weak, b= broad
Table (3) shows the magnetic moment and conductivity measurement results for the complexes at room
temperature.
Table (3) Magnetic moment, conductivity and suggested structure for complexes
Complex Magnetic moment
µeff(B.M.)
Conductivity
Ms.cm-
Suggested structure
C1 Diamagnetic 29 Tetrahedral
C2 Diamagnetic 72 Tetrahedral
C3 Diamagnetic 22 Tetrahedral
C4 2.00 31 Octahedral
C5 Diamagnetic 19 Square planar
C6 5.15 21 Octahedral
Electronic spectral analysis and magnetic measurements
The electronic spectra of Hg(II), Cd(II), Cu(I) and Au(I) complexes in the visible region are of little
help. These ions have the d10
configuration and therefore their complexes should not exhibit any d-d transition.
All the complexes of these metal ions were found to be diamagnetic.
Cu (II) complex, C4:
Cu (II) compounds are blue or green because of a single broad absorption band in the region (11000-
16000) cm-1
[16]. The d9
ion is characterized by large distortion from octahedral symmetry and the band is
6. Synthesis and Characterization of New Thio-Triazole Ligand and Complexes with Selected Metals
www.iosrjournals.org 14 | Page
unsymmetrical, being the result of a number of transitions, which are by no means easy to assign
unambiguously. However, the band could be assigned to the 2
B1g →
2
B2g , 2
B1g → 2
Eg transitions.
The magnetic moment of C4 was (2.0 B.M.) which refers to mononuclear Cu( II) octahedral complex.[17]
Fe (III) complex C6 :
The electronic spectrum of C6 shows two bands, the first one at 20,408cm-1
.
6
A 1g → 4
T1g (20,408 cm-1
)
6
A 1g → 4
T2g (G) (26,455 cm-1
)
The value of the measured magnetic moment for C6 is (5.15 B.M.), which could be related to high spin
d5
ferric ion octahedral geometry is suggested to this complex. From Tanabe-sugano diagram for d5
octahedral
field, the value of 10Dq was found to equal to 20,695 cm-1
and the high value of nephelauxetic factor (β) (0.88)
indicated the ionic character of the complex[18].
Bactericidal activity:
Preliminary screening experiments are intended to detect the in vitro activity of L and its metal
complexes [19]. The complexation of L with all the metal ions use exhibited no activity except Cu (II); C4 and
Cu (I); C5 complexes .These two complexes showed noticeable activity against Staph. Aureus. This activity
however was lower than the free ligand, as shown in Table(4).
Table (4) Biological activity for ligand and complexes (at concentration of 1mg/ mL)
Symbols Staphylococcus aureus Escherichia Coli
L +++ ++
C3 - -
C4 ++ -
C5 ++ -
C6 - -
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