The document summarizes the IDeA Program, which includes several components aimed at supporting biomedical research in US states that historically receive lower levels of NIH funding. The key components are the Centers of Biomedical Research Excellence (COBRE) program, which provides funding to establish multidisciplinary research centers focused on a specific scientific theme and mentoring junior researchers; the IDeA Networks of Biomedical Research Excellence (INBRE) program, which supports statewide networks; and the IDeA Clinical and Translational Research program. Examples are provided of specific COBRE centers established in Oklahoma that have helped increase biomedical research funding and capacity in the state.

1. The IDeA Program
• Centers of Biomedical Excellence (COBRE)
• IDeA Clinical and Translational Research (IDeA CTR)
• IDeA Networks of Biomedical Research Excellence
(INBRE)
• IDeA Community-Based Research
• Selected Examples
• IDeA Co-funding
• IDeA Net
• Selected Examples
• National Association of IDeA Principal Investigators
(NAIPI)
• Selected Science Advances

2. INBRE: 24 statewide networks
COBRE: 84 thematic research centers
VT ME
MT ND
NH
ID SD
WY RI
NE
NV
DE
WV
KS
KY
OK
AR SC
NM
MS
LA
AK
HI PR

3. $1,800
$1,631 $1,550
$1,580
$1,546
$1,600 $1,523
$1,558 $1,585
$1,552
$1,400 $1,458
$1,305
$1,200
MILLION
$1,000 $1,064
$885
$800
$596
$700
$600
$461 $462
$555
$400 $424 $463
$214 $222 $220 $218 $224 $224 $229 $229
$210
$200 $160
$100
$40
$1 $1 $1 $2 $2 $5 $10
$0
'93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 06 07 08 09 10 11
FISCAL YEAR
IDeA Program Appropriations Total NIH Funding to IDeA states

4. Centers of Biomedical Research Excellence (COBRE)
Background
• COBRE center grant program launched in fiscal year 2000
• To expand and develop biomedical faculty research capability
• To enhance research infrastructure including core facilities
• To build multidisciplinary research centers with a thematic scientific
focus at doctoral institutions or research institutes
Center Characteristics
• Led by an established investigator, funded by NIH, NSF or other
comparable Federal or private sector source
• At least 3 research sub-projects, all supervised by junior investigators
• A clear plan for mentoring, career development and graduation and
replacement of junior investigators
• Long-term plans for developing and sustaining the
center, investigators, collaborations, and physical infrastructure

5. Model of COBRE
Pilot
Projects External
Advisory
Board
research
cores bioinformatics
administrative
Administrative
Mentored
and Research
Junior Investigator
Cores Mentors
•workshops Subprojects
•training courses

6. Develop advanced research infrastructure and a
critical mass of investigators in thematic areas
Research Research Cores
Research
Infrastructure that are essential
Infrastructure
for basic and
Research Projects
Research Projects clinical research
(Junior and Senior
(Junior Investigators)
Investigators) Pilot Project
Program

7. The COBRE Program in Oklahoma

9. Expected: $14.5M
Actual: $18M or 125% more than expected by doubling and
increase in faculty number by 33%

10. Figure 3. Transition of RR15577 COBRE supported cores from initial funding to current plans. Blue designates RR15577
COBRE support. Purple denotes proposed RR15577 support and white outline only denotes institutional or other forms of
independent support from grants, charge backs or other funding sources.

11. NIH Funding – OUHSC
$70,000,000
Total OUHSC NIH Funding 2000-2011 – 152% increase ($21 – $53 million)*
$60,000,000
Total NIH Budget Allocation 2000-2011 – 67% increase ($18 - $30 billion)
$50,000,000
$40,000,000
Begin
INBRE/COBRE
$30,000,000
$20,000,000
$10,000,000
98 99 00 01 02 03 04 05 06 07 08 09 10 11
NIH Fiscal Year
*Comparative increases: Non IDeA State Med Schools 2000-2011 IDeA State Med Schools 2000-2011
Virginia Comm Univ – 62% (Ranked 59/57) KUMC – 104% (Ranked 71/59)
PSU at Hershey Med Ctr – 50% (Ranked 64/61) Nebraska Med Ctr – 154% (Ranked 74/68)
Univ Conn SOM – 26% (Ranked 68/74) Univ Louisville – 154% (Ranked 79/72)
(Blue Ridge Inst. For Med Res: Ranking 2001-2011) OUHSC – 152% (Ranked 78/73)

12. “Science in a Culture of
Mentoring”
 Operational from 2000-2014
 Awarded $21.7M plus $28.8M in additional grants:
* 14 RO1’s
* 9 R21’s
* 1 RO3
* 18 non-NIH grants
 Launched 12 independent research careers
 Advances immunology research in Oklahoma through recruiting
junior scientists. Their research topics include vaccine immunology,
autoimmunity, Alzheimer’s research, and other complex human
diseases.

13. “Biofilm Formation and
Metabolism on Dental
Surfaces”
 Operational from 2000-2010
 Awarded $9.7M, with the junior investigators receiving an
additional $14M:
* 9 RO1’s
* 24 non-NIH grants
 Recruits investigators to examine microbial formation on
teeth in order to translate research knowledge into treatment
and prevention of oral disease.

14. “Functional Genomic/Proteomic
Analysis of Bacterial/Host
Interactions”
 Operational from 2000-2010
 Awarded $20.9M plus $31M in additional grants:
* 10 RO1’s
* 7 R21’s
* 1 RO3
* 27 non-NIH grants
 Supported 8 junior investigators
 Used genome-scale and proteomic analysis of bacterial
pathogenesis in order to increase the understanding of bacterial and
host interactions.

15. “Mentoring Vision
Research in Oklahoma”
 Operational from 2002-2012
 Awarded $23.8M plus $33.5M in additional grants:
* 13 RO1’s
* 5 R21’s
* 1 RO3
* 6 non-NIH grants
 Improves vision research through the mentoring of early career
investigators and develops support for the infrastructure of vision
research programs

16. “Post-Translational Modification
in Host Defense: Interdisciplinary
Research in Vascular Biology”
 Operational from 2003-2015
 Awarded $22.2M plus an additional $11M:
* 6 RO1’s
* 25 non-NIH grants
 Studies the function of diverse protein modifications used in
host defense; builds interdisciplinary program in
cardiovascular biology.

17. “Molecular Mechanisms
and Genetics of
Autoimmunity”
 Operational from 2004-2014
 Awarded $24.9M plus $10.7M in additional grants:
* 4 RO1’s
* 2 R21’s
* 1 RO3
* 13 non-NIH grants
 Recruited 8 new faculty members
 Examines disease processes and potential genetic risk factors in
order to understand development and progression of autoimmune
disorders

18. “Mentoring Diabetes
Research in Oklahoma”
 Operational from 2007-2012
 Supports 5 junior investigators
* 3 RO1’s
* 3 additional NIH grants
*13 non-NIH grants
 Mentors junior investigators in diabetes research to facilitate
translational research toward the development of new
treatments and preventive measures for diabetes.

20. Per Capita NIH Dollars
(Selected States)
2011 2011 Dollars
State NIH dollars Population Per Capita
VT $ 53M 626,431 $ 85
HI $ 61M 1,374,810 $ 44
OK $ 82M 3,791,508 $ 22
MD $1.69B 5,828,289 $290
MA $2.51B 6,587,536 $381

21. The IDeA program has
transformed biomedical science at the
Oklahoma Medical Research Foundation
and in the state of Oklahoma as a whole.

22. IDeA has been the
best investment ever made
by Congress or the NIH in the history of
biomedical research.

23. Thank you